KEGG   ORTHOLOGY: K04448Help
Entry
K04448                      KO                                     

Name
JUN
Definition
transcription factor AP-1
Pathway
Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
MAPK signaling pathway - fly
cAMP signaling pathway
Mitophagy - animal
Apoptosis
Apoptosis - fly
Wnt signaling pathway
Osteoclast differentiation
Focal adhesion
Tight junction
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
Toll and Imd signaling pathway
IL-17 signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
B cell receptor signaling pathway
TNF signaling pathway
Neurotrophin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Oxytocin signaling pathway
Relaxin signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
AGE-RAGE signaling pathway in diabetic complications
Cocaine addiction
Amphetamine addiction
Epithelial cell signaling in Helicobacter pylori infection
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Hepatitis B
Influenza A
HTLV-I infection
Kaposi's sarcoma-associated herpesvirus infection
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Colorectal cancer
Renal cell carcinoma
Breast cancer
Choline metabolism in cancer
Inflammatory bowel disease (IBD)
Rheumatoid arthritis
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04448  JUN; transcription factor AP-1
   04013 MAPK signaling pathway - fly
    K04448  JUN; transcription factor AP-1
   04012 ErbB signaling pathway
    K04448  JUN; transcription factor AP-1
   04310 Wnt signaling pathway
    K04448  JUN; transcription factor AP-1
   04668 TNF signaling pathway
    K04448  JUN; transcription factor AP-1
   04024 cAMP signaling pathway
    K04448  JUN; transcription factor AP-1
 Cellular Processes
  Transport and catabolism
   04137 Mitophagy - animal
    K04448  JUN; transcription factor AP-1
  Cell growth and death
   04210 Apoptosis
    K04448  JUN; transcription factor AP-1
   04214 Apoptosis - fly
    K04448  JUN; transcription factor AP-1
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04448  JUN; transcription factor AP-1
   04530 Tight junction
    K04448  JUN; transcription factor AP-1
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04448  JUN; transcription factor AP-1
   04624 Toll and Imd signaling pathway
    K04448  JUN; transcription factor AP-1
   04621 NOD-like receptor signaling pathway
    K04448  JUN; transcription factor AP-1
   04660 T cell receptor signaling pathway
    K04448  JUN; transcription factor AP-1
   04658 Th1 and Th2 cell differentiation
    K04448  JUN; transcription factor AP-1
   04659 Th17 cell differentiation
    K04448  JUN; transcription factor AP-1
   04657 IL-17 signaling pathway
    K04448  JUN; transcription factor AP-1
   04662 B cell receptor signaling pathway
    K04448  JUN; transcription factor AP-1
  Endocrine system
   04912 GnRH signaling pathway
    K04448  JUN; transcription factor AP-1
   04915 Estrogen signaling pathway
    K04448  JUN; transcription factor AP-1
   04921 Oxytocin signaling pathway
    K04448  JUN; transcription factor AP-1
   04926 Relaxin signaling pathway
    K04448  JUN; transcription factor AP-1
  Nervous system
   04722 Neurotrophin signaling pathway
    K04448  JUN; transcription factor AP-1
  Development
   04380 Osteoclast differentiation
    K04448  JUN; transcription factor AP-1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04448  JUN; transcription factor AP-1
   05231 Choline metabolism in cancer
    K04448  JUN; transcription factor AP-1
   05203 Viral carcinogenesis
    K04448  JUN; transcription factor AP-1
   05210 Colorectal cancer
    K04448  JUN; transcription factor AP-1
   05211 Renal cell carcinoma
    K04448  JUN; transcription factor AP-1
   05224 Breast cancer
    K04448  JUN; transcription factor AP-1
  Immune diseases
   05323 Rheumatoid arthritis
    K04448  JUN; transcription factor AP-1
   05321 Inflammatiory bowel disease (IBD)
    K04448  JUN; transcription factor AP-1
  Substance dependence
   05030 Cocaine addiction
    K04448  JUN; transcription factor AP-1
   05031 Amphetamine addiction
    K04448  JUN; transcription factor AP-1
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04448  JUN; transcription factor AP-1
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04448  JUN; transcription factor AP-1
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04448  JUN; transcription factor AP-1
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04448  JUN; transcription factor AP-1
   05132 Salmonella infection
    K04448  JUN; transcription factor AP-1
   05133 Pertussis
    K04448  JUN; transcription factor AP-1
   05166 HTLV-I infection
    K04448  JUN; transcription factor AP-1
   05164 Influenza A
    K04448  JUN; transcription factor AP-1
   05161 Hepatitis B
    K04448  JUN; transcription factor AP-1
   05168 Herpes simplex infection
    K04448  JUN; transcription factor AP-1
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K04448  JUN; transcription factor AP-1
   05169 Epstein-Barr virus infection
    K04448  JUN; transcription factor AP-1
   05140 Leishmaniasis
    K04448  JUN; transcription factor AP-1
   05142 Chagas disease (American trypanosomiasis)
    K04448  JUN; transcription factor AP-1
  Drug resistance
   01522 Endocrine resistance
    K04448  JUN; transcription factor AP-1
Transcription factors [BR:ko03000]
 Eukaryotic Type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, Jun
    K04448  JUN; transcription factor AP-1
BRITE hierarchy
Genes
HSA: 
3725(JUN)
PTR: 
456893(JUN)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
716452(JUN)
MCF: 
CSAB: 
RRO: 
RBB: 
CJC: 
SBQ: 
MMU: 
16476(Jun)
RNO: 
24516(Jun)
CGE: 
NGI: 
HGL: 
CCAN: 
OCU: 
100008856(JUN) 100338341(EIF5A)
TUP: 
CFA: 
609429(JUN)
AML: 
UMR: 
FCA: 
PTG: 
AJU: 
BTA: 
280831(JUN)
BOM: 
BIU: 
PHD: 
CHX: 
OAS: 
443219(JUN)
SSC: 
396913(JUN)
CFR: 
CDK: 
BACU: 
LVE: 
ECB: 
EAI: 
MYB: 
MYD: 
HAI: 
RSS: 
PALE: 
LAV: 
MDO: 
GGA: 
424673(JUN)
MGP: 
CJO: 
APLA: 
ACYG: 
TGU: 
GFR: 
FAB: 
PHI: 
PMAJ: 
CCW: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
PSS: 
CMY: 
CPIC: 
ACS: 
PVT: 
PBI: 
GJA: 
XLA: 
108700666 379050(jun.S) 399400(jun.L)
XTR: 
NPR: 
DRE: 
335916(jun)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
101064806(jun) 101077059(c-jun)
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
BFO: 
CIN: 
778972(jun)
SPU: 
APLC: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD15385(Dsim_GD15385)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
CQU: 
AME: 
726289(Jra)
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
663937(Jra)
DPA: 
NVL: 
BMOR: 
PXY: 
API: 
DNX: 
PHU: 
FCD: 
DPX: 
TUT: 
BMY: 
TSP: 
HRO: 
LGI: 
CRG: 
MYI: 
OBI: 
LAK: 
NVE: 
EPA: 
ADF: 
HMG: 
TAD: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Liu J, Han Q, Peng T, Peng M, Wei B, Li D, Wang X, Yu S, Yang J, Cao S, Huang K, Hutchins AP, Liu H, Kuang J, Zhou Z, Chen J, Wu H, Guo L, Chen Y, Chen Y, Li X, Wu H, Liao B, He W, Song H, Yao H, Pan G, Chen J, Pei D
  Title
The oncogene c-Jun impedes somatic cell reprogramming.
  Journal
Nat Cell Biol 17:856-67 (2015)
DOI:10.1038/ncb3193
Reference
PMID:3194415
  Authors
Hattori K, Angel P, Le Beau MM, Karin M
  Title
Structure and chromosomal localization of the functional intronless human JUN protooncogene.
  Journal
Proc Natl Acad Sci U S A 85:9148-52 (1988)
DOI:10.1073/pnas.85.23.9148
  Sequence
[hsa:3725]

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