KEGG   ORTHOLOGY: K04513Help
Entry
K04513                      KO                                     

Name
RHOA
Definition
Ras homolog gene family, member A
Pathway
ko04011  MAPK signaling pathway - yeast
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04144  Endocytosis
ko04150  mTOR signaling pathway
ko04270  Vascular smooth muscle contraction
ko04310  Wnt signaling pathway
ko04350  TGF-beta signaling pathway
ko04360  Axon guidance
ko04510  Focal adhesion
ko04520  Adherens junction
ko04530  Tight junction
ko04611  Platelet activation
ko04621  NOD-like receptor signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04660  T cell receptor signaling pathway
ko04670  Leukocyte transendothelial migration
ko04722  Neurotrophin signaling pathway
ko04810  Regulation of actin cytoskeleton
ko04921  Oxytocin signaling pathway
ko04928  Parathyroid hormone synthesis, secretion and action
ko04972  Pancreatic secretion
ko05100  Bacterial invasion of epithelial cells
ko05130  Pathogenic Escherichia coli infection
ko05133  Pertussis
ko05152  Tuberculosis
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04015 Rap1 signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04011 MAPK signaling pathway - yeast
    K04513  RHOA; Ras homolog gene family, member A
   04310 Wnt signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04350 TGF-beta signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04072 Phospholipase D signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04071 Sphingolipid signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04024 cAMP signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04022 cGMP - PKG signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04150 mTOR signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K04513  RHOA; Ras homolog gene family, member A
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04513  RHOA; Ras homolog gene family, member A
   04520 Adherens junction
    K04513  RHOA; Ras homolog gene family, member A
   04530 Tight junction
    K04513  RHOA; Ras homolog gene family, member A
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04513  RHOA; Ras homolog gene family, member A
 Organismal Systems
  Immune system
   04611 Platelet activation
    K04513  RHOA; Ras homolog gene family, member A
   04621 NOD-like receptor signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04625 C-type lectin receptor signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04660 T cell receptor signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04670 Leukocyte transendothelial migration
    K04513  RHOA; Ras homolog gene family, member A
   04062 Chemokine signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
  Endocrine system
   04921 Oxytocin signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04928 Parathyroid hormone synthesis, secretion and action
    K04513  RHOA; Ras homolog gene family, member A
  Circulatory system
   04270 Vascular smooth muscle contraction
    K04513  RHOA; Ras homolog gene family, member A
  Digestive system
   04972 Pancreatic secretion
    K04513  RHOA; Ras homolog gene family, member A
  Nervous system
   04722 Neurotrophin signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
  Development
   04360 Axon guidance
    K04513  RHOA; Ras homolog gene family, member A
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04513  RHOA; Ras homolog gene family, member A
   05206 MicroRNAs in cancer
    K04513  RHOA; Ras homolog gene family, member A
   05205 Proteoglycans in cancer
    K04513  RHOA; Ras homolog gene family, member A
   05203 Viral carcinogenesis
    K04513  RHOA; Ras homolog gene family, member A
   05210 Colorectal cancer
    K04513  RHOA; Ras homolog gene family, member A
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04513  RHOA; Ras homolog gene family, member A
  Infectious diseases
   05130 Pathogenic Escherichia coli infection
    K04513  RHOA; Ras homolog gene family, member A
   05133 Pertussis
    K04513  RHOA; Ras homolog gene family, member A
   05152 Tuberculosis
    K04513  RHOA; Ras homolog gene family, member A
   05100 Bacterial invasion of epithelial cells
    K04513  RHOA; Ras homolog gene family, member A
Membrane trafficking [BR:ko04131]
 Endocytosis
  Lipid raft mediated endocytosis
   RhoA-dependent endocytosis
    K04513  RHOA; Ras homolog gene family, member A
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K04513  RHOA; Ras homolog gene family, member A
  Exosomal proteins of other body fluids (saliva and urine)
   K04513  RHOA; Ras homolog gene family, member A
  Exosomal proteins of colorectal cancer cells
   K04513  RHOA; Ras homolog gene family, member A
  Exosomal proteins of bladder cancer cells
   K04513  RHOA; Ras homolog gene family, member A
GTP-binding proteins [BR:ko04031]
 Small (Monomeric) G-proteins
  Rho Family
   RhoA/B/C [OT]
    K04513  RHOA; Ras homolog gene family, member A
BRITE hierarchy
Other DBs
COG: COG1100
Genes
HSA: 387(RHOA)
PTR: 461014(RHOA)
PPS: 100995642(RHOA)
GGO: 101134778(RHOA)
PON: 100171605(RHOA)
NLE: 100600848 100607291(RHOA)
MCC: 706455(RHOA)
MCF: 101865630(RHOA)
CSAB: 103227629(RHOA)
RRO: 104667372(RHOA)
RBB: 108526989(RHOA)
CJC: 100393236(RHOA)
SBQ: 101052068(RHOA) 104650592
MMU: 11848(Rhoa) 67653(4930544G11Rik)
RNO: 117273(Rhoa) 297173(RSA-14-44)
CGE: 100757042 100762797(Rhoa)
NGI: 103743359 103750189(Rhoa)
HGL: 101710109(Rhoa)
CCAN: 109690388 109697844(Rhoa)
TUP: 102487039(RHOA)
CFA: 403954(RHOA)
AML: 100476723(RHOA)
UMR: 103674825(RHOA)
ORO: 101383468(RHOA)
FCA: 101084011(RHOA)
PTG: 102952555(RHOA)
AJU: 106979239(RHOA)
BTA: 338049(RHOA)
BOM: 102280554(RHOA)
BIU: 109576171(RHOA)
PHD: 102341767(RHOA)
CHX: 102181169(RHOA)
OAS: 100302078(RHOA)
SSC: 396849(RHOA)
CFR: 102507993(RHOA)
CDK: 105087723(RHOA)
BACU: 103019793(RHOA)
LVE: 103074732(RHOA)
OOR: 101273830(RHOA)
ECB: 100053343(RHOA)
EPZ: 103553409(RHOA)
EAI: 106830690(RHOA)
MYB: 102244315(RHOA)
MYD: 102751353(RHOA) 107184191
HAI: 109376114(RHOA)
RSS: 109443465(RHOA)
PALE: 102891515(RHOA)
LAV: 100677447(RHOA)
TMU: 101356840
MDO: 100021110(RHOA)
SHR: 100921931(RHOA) 100926337
OAA: 100073519(RHOA) 100079193
GGA: 395442(RHOA)
MGP: 100547488(RHOA)
CJO: 107319611(RHOA)
APLA: 101797910(RHOA) 101798663
ACYG: 106049491(RHOA)
TGU: 100190386(RHOA)
GFR: 102034459(RHOA)
FAB: 101806310(RHOA)
PHI: 102104637(RHOA)
PMAJ: 107210352(RHOA)
CCW: 104683253(RHOA) 104685411
FPG: 101911200(RHOA)
FCH: 102049160(RHOA) 102053607(RHOC)
CLV: 102086675(RHOA)
EGZ: 104126734(RHOA) 104129583
AAM: 106491145(RHOA)
ASN: 102377583(RHOA) 102383248
AMJ: 102560127 102563558(RHOA)
CMY: 102933456 102939658(RHOA)
ACS: 100552508 100566989(rhoa)
PVT: 110076866(RHOA) 110081153
PBI: 103048136 103049329(RHOA)
XLA: 108709436 108715815 379326(rhoc.L) 379416(rhoa.L) 380133(rhoa.S)
XTR: 448080(rhoa) 549323(rhoc) 549402(rhoa.2)
DRE: 100006041(rhoab) 406411(rhoaa) 406659(rhoac) 436718(rhocb) 751630(zgc:153713)
SASA: 100195933(rho1) 106565140(RHOA) 106566794(RHOA) 106566835 106572042(RHOA) 106572261(RHOA) 106572962 106582735(RHOC) 106583462(RHOA) 106592002(RHOA)
LCM: 102348524 102351192(RHOC) 102363105(RHOA)
CMK: 103172913 103176633(rhoa)
CIN: 445700(rhoc) 493871(rhoa)
APLC: 110974181
SKO: 100370332
DME: Dmel_CG8416(Rho1)
DSI: Dsimw501_GD11158(Dsim_GD11158)
MDE: 101900695
AAG: 5577289
AME: 409910(Rho1)
BIM: 100740548
BTER: 100649013
SOC: 105199785
AEC: 105148010
ACEP: 105623459
PBAR: 105427880
HST: 105190197
CFO: 105249999
LHU: 105676157
PGC: 109856895
NVI: 100114100(RHOA)
TCA: 661700 663316 663337(Rho1)
DPA: 109544337
NVL: 108568533
BMOR: 101739657
PMAC: 106716548
PRAP: 111002669
TUT: 107371599
CEL: CELE_Y51H4A.3(rho-1)
CBR: CBG13664(Cbr-rho-1)
TSP: Tsp_08554
OBI: 106867931
SCE: YPR165W(RHO1)
ERC: Ecym_7212
KMX: KLMA_70268(RHO1)
NCS: NCAS_0A15070(NCAS0A15070) NCAS_0H00220(NCAS0H00220)
NDI: NDAI_0D00180(NDAI0D00180) NDAI_0J00230(NDAI0J00230)
TPF: TPHA_0I03130(TPHA0I03130) TPHA_0I03140(TPHA0I03140)
TBL: TBLA_0J00210(TBLA0J00210)
TDL: TDEL_0H00500(TDEL0H00500)
KAF: KAFR_0A03120(KAFR0A03120) KAFR_0B00480(KAFR0B00480)
CAL: CAALFM_CR02860WA(RHO1)
CDU: CD36_27930(RHO1)
SLB: AWJ20_2815(RHO1)
NCR: NCU01484(rho-1)
NTE: NEUTE1DRAFT117265(NEUTE1DRAFT_117265)
SMP: SMAC_06239(rho1)
MGR: MGG_07176
MAJ: MAA_05388
CMT: CCM_01759
MBE: MBM_05097
ANI: AN5740.2
ANG: ANI_1_802164(An18g05980)
ABE: ARB_01565
TVE: TRV_02099
ZTR: MYCGRDRAFT_106397(MgRho1)
SPO: SPAC1F7.04(rho1) SPAC20H4.11c(rho5)
CNE: CNG02630
CNB: CNBG2140
ABP: AGABI1DRAFT87772(AGABI1DRAFT_87772)
ABV: AGABI2DRAFT139932(AGABI2DRAFT_139932)
MGL: MGL_3754
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Stirling L, Williams MR, Morielli AD
  Title
Dual roles for RHOA/RHO-kinase in the regulated trafficking of a voltage-sensitive potassium channel.
  Journal
Mol Biol Cell 20:2991-3002 (2009)
DOI:10.1091/mbc.E08-10-1074
Reference
PMID:8195291
  Authors
Yamochi W, Tanaka K, Nonaka H, Maeda A, Musha T, Takai Y
  Title
Growth site localization of Rho1 small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae.
  Journal
J Cell Biol 125:1077-93 (1994)
DOI:10.1083/jcb.125.5.1077
Reference
PMID:8039707
  Authors
Moscow JA, He R, Gudas JM, Cowan KH
  Title
Utilization of multiple polyadenylation signals in the human RHOA protooncogene.
  Journal
Gene 144:229-36 (1994)
DOI:10.1016/0378-1119(94)90382-4
  Sequence
[hsa:387]

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