KEGG   ORTHOLOGY: K04514Help
Entry
K04514                      KO                                     

Name
ROCK1
Definition
Rho-associated protein kinase 1 [EC:2.7.11.1]
Pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04071  Sphingolipid signaling pathway
ko04270  Vascular smooth muscle contraction
ko04350  TGF-beta signaling pathway
ko04360  Axon guidance
ko04510  Focal adhesion
ko04530  Tight junction
ko04611  Platelet activation
ko04670  Leukocyte transendothelial migration
ko04810  Regulation of actin cytoskeleton
ko04921  Oxytocin signaling pathway
ko05130  Pathogenic Escherichia coli infection
ko05131  Shigellosis
ko05132  Salmonella infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04350 TGF-beta signaling pathway
    K04514  ROCK1; Rho-associated protein kinase 1
   04071 Sphingolipid signaling pathway
    K04514  ROCK1; Rho-associated protein kinase 1
   04024 cAMP signaling pathway
    K04514  ROCK1; Rho-associated protein kinase 1
   04022 cGMP - PKG signaling pathway
    K04514  ROCK1; Rho-associated protein kinase 1
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04514  ROCK1; Rho-associated protein kinase 1
   04530 Tight junction
    K04514  ROCK1; Rho-associated protein kinase 1
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04514  ROCK1; Rho-associated protein kinase 1
 Organismal Systems
  Immune system
   04611 Platelet activation
    K04514  ROCK1; Rho-associated protein kinase 1
   04670 Leukocyte transendothelial migration
    K04514  ROCK1; Rho-associated protein kinase 1
   04062 Chemokine signaling pathway
    K04514  ROCK1; Rho-associated protein kinase 1
  Endocrine system
   04921 Oxytocin signaling pathway
    K04514  ROCK1; Rho-associated protein kinase 1
  Circulatory system
   04270 Vascular smooth muscle contraction
    K04514  ROCK1; Rho-associated protein kinase 1
  Development
   04360 Axon guidance
    K04514  ROCK1; Rho-associated protein kinase 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04514  ROCK1; Rho-associated protein kinase 1
   05206 MicroRNAs in cancer
    K04514  ROCK1; Rho-associated protein kinase 1
   05205 Proteoglycans in cancer
    K04514  ROCK1; Rho-associated protein kinase 1
  Infectious diseases
   05130 Pathogenic Escherichia coli infection
    K04514  ROCK1; Rho-associated protein kinase 1
   05132 Salmonella infection
    K04514  ROCK1; Rho-associated protein kinase 1
   05131 Shigellosis
    K04514  ROCK1; Rho-associated protein kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04514  ROCK1; Rho-associated protein kinase 1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: AGC group
  DMPK family [OT]
   K04514  ROCK1; Rho-associated protein kinase 1
Chromosome [BR:ko03036]
 Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Kinases and associated factors
    K04514  ROCK1; Rho-associated protein kinase 1
BRITE hierarchy
Genes
HSA: 6093(ROCK1)
PTR: 455326(ROCK1)
PPS: 100976232(ROCK1)
GGO: 101154194(ROCK1)
PON: 100432582(ROCK1)
NLE: 100586590(ROCK1)
MCC: 698223(ROCK1)
MCF: 102140851(ROCK1)
CSAB: 103222670(ROCK1)
RRO: 104655463(ROCK1)
RBB: 108530562(ROCK1)
CJC: 100394652(ROCK1)
SBQ: 101028677 101051787(ROCK1)
MMU: 19877(Rock1)
RNO: 81762(Rock1)
CGE: 100770074(Rock1)
NGI: 103728977(Rock1)
HGL: 101710589(Rock1) 106009735
CCAN: 109689990(Rock1)
OCU: 100009220(ROCK1)
TUP: 102481136(ROCK1)
CFA: 480181(ROCK1)
AML: 100474469(ROCK1)
UMR: 103662842(ROCK1)
ORO: 101386230(ROCK1)
FCA: 101092552(ROCK1)
PTG: 102963520(ROCK1)
AJU: 106970030(ROCK1)
BTA: 785911(ROCK1)
BOM: 102284712(ROCK1)
BIU: 109577829(ROCK1)
PHD: 102337207
CHX: 102171022(ROCK1)
OAS: 101102442(ROCK1)
SSC: 397447(ROCK1)
CFR: 102520724(ROCK1)
CDK: 105086272(ROCK1)
BACU: 103002971
LVE: 103082455
OOR: 101278979(ROCK1)
ECB: 100034056(ROCK1)
EPZ: 103543785 103552805(ROCK1)
EAI: 106843404(ROCK1)
MYB: 102252747(ROCK1)
MYD: 102757900(ROCK1)
HAI: 109388840(ROCK1)
RSS: 109452370(ROCK1)
PALE: 102879861(ROCK1)
LAV: 100657418(ROCK1)
TMU: 101343223
MDO: 100618269(ROCK1)
SHR: 100916611(ROCK1)
GGA: 373970(ROCK1)
MGP: 100539446(ROCK1)
CJO: 107310033(ROCK1)
APLA: 101797139 101797330(ROCK1)
ACYG: 106037590(ROCK1)
TGU: 100229794(ROCK1)
GFR: 102040824(ROCK1)
FAB: 101819345(ROCK1)
PHI: 102100951(ROCK1)
PMAJ: 107199098(ROCK1)
CCW: 104687309(ROCK1)
FPG: 101913286(ROCK1)
FCH: 102052286(ROCK1)
CLV: 102097361(ROCK1)
EGZ: 104134126(ROCK1)
AAM: 106484740(ROCK1)
ASN: 102377504(ROCK1)
AMJ: 102558298(ROCK1)
PSS: 102463968(ROCK1)
CMY: 102937514
CPIC: 101947074(ROCK1)
ACS: 100558337(rock1)
PVT: 110079445(ROCK1)
PBI: 103059344 103059736(ROCK1)
GJA: 107120578(ROCK1)
XLA: 108695261(rock1.S) 108719215(rock1.L)
XTR: 100496057(rock1)
NPR: 108797185(ROCK1)
DRE: 100329779(rock1) 321070(rock2b)
SRX: 107711696(rock1) 107727500
SGH: 107567877 107593752(rock1)
IPU: 108267074(rock1)
TRU: 101070472(rock1)
LCO: 104917703(rock1)
NCC: 104942430(rock1) 104960127
MZE: 101478273(rock1)
OLA: 101158388(rock1)
XMA: 102235948(rock1)
PRET: 103479725(rock1)
NFU: 107374628 107383841(rock1)
CSEM: 103396393(rock1)
LCF: 108883337(rock1)
HCQ: 109521247(rock1)
BPEC: 110166734(rock1) 110172119
ELS: 105019915(rock1)
SFM: 108937735(rock1)
LCM: 102350260(ROCK1)
CMK: 103183447(rock1)
DME: Dmel_CG9774(Rok)
DSI: Dsimw501_GD28097(Dsim_GD28097)
MDE: 101901648
AAG: 5579816
BIM: 100743707
BTER: 100650139
SOC: 105196658
AEC: 105145508
ACEP: 105626368
PBAR: 105431373
HST: 105191866
CFO: 105249459
LHU: 105667815
PGC: 109854274
TCA: 663533
DPA: 109540296
NVL: 108557646
BMOR: 100529202(rock1)
PMAC: 106713828
PRAP: 111003007
PXY: 105391577
DNX: 107166638
ZNE: 110831019
FCD: 110846763
TUT: 107359131
CEL: CELE_C10H11.9(let-502)
CBR: CBG03960(Cbr-let-502)
BMY: Bm1_49370
TSP: Tsp_09712
EPA: 110232888
AQU: 100641926
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Ferretti R, Palumbo V, Di Savino A, Velasco S, Sbroggio M, Sportoletti P, Micale L, Turco E, Silengo L, Palumbo G, Hirsch E, Teruya-Feldstein J, Bonaccorsi S, Pandolfi PP, Gatti M, Tarone G, Brancaccio M
  Title
Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis.
  Journal
Dev Cell 18:486-95 (2010)
DOI:10.1016/j.devcel.2009.12.020
Reference
PMID:8617235
  Authors
Ishizaki T, Maekawa M, Fujisawa K, Okawa K, Iwamatsu A, Fujita A, Watanabe N, Saito Y, Kakizuka A, Morii N, Narumiya S
  Title
The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.
  Journal
EMBO J 15:1885-93 (1996)
  Sequence
[hsa:6093]

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