KEGG   ORTHOLOGY: K04570Help
Entry
K04570                      KO                                     

Name
BCL2L1, bcl-xL
Definition
Bcl-2-like 1 (apoptosis regulator Bcl-X)
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01524  Platinum drug resistance
ko04014  Ras signaling pathway
ko04064  NF-kappa B signaling pathway
ko04137  Mitophagy - animal
ko04140  Autophagy - animal
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04215  Apoptosis - multiple species
ko04621  NOD-like receptor signaling pathway
ko04630  Jak-STAT signaling pathway
ko05014  Amyotrophic lateral sclerosis (ALS)
ko05145  Toxoplasmosis
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05212  Pancreatic cancer
ko05220  Chronic myeloid leukemia
ko05222  Small cell lung cancer
ko05225  Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
   04630 Jak-STAT signaling pathway
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
   04064 NF-kappa B signaling pathway
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
   04151 PI3K-Akt signaling pathway
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
   04137 Mitophagy - animal
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
  Cell growth and death
   04210 Apoptosis
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
   04215 Apoptosis - multiple species
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
 Organismal Systems
  Immune system
   04621 NOD-like receptor signaling pathway
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
   05202 Transcriptional misregulation in cancers
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
   05212 Pancreatic cancer
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
   05225 Hepatocellular carcinoma
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
   05220 Chronic myeloid leukemia
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
   05222 Small cell lung cancer
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
  Neurodegenerative diseases
   05014 Amyotrophic lateral sclerosis (ALS)
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
  Infectious diseases
   05166 HTLV-I infection
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
   05145 Toxoplasmosis
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
   01524 Platinum drug resistance
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Other centriole associated proteins
    K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
Transporters [BR:ko02000]
 Other Transporters
  Pores ion channels
   K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
BRITE hierarchy
Other DBs
TC: 1.A.21.1.1 1.A.21.1.6
Genes
HSA: 598(BCL2L1)
PTR: 458156(BCL2L1)
PPS: 100979809(BCL2L1)
GGO: 101142025(BCL2L1)
PON: 100453051(BCL2L1)
NLE: 100595330(BCL2L1)
MCC: 713035(BCL2L1)
MCF: 102140222(BCL2L1)
CSAB: 103248011(BCL2L1)
RRO: 104653720(BCL2L1)
RBB: 108524131(BCL2L1)
CJC: 100401978(BCL2L1)
SBQ: 101039294(BCL2L1)
MMU: 12048(Bcl2l1)
RNO: 24888(Bcl2l1)
CGE: 100689371(Bcl2l1)
NGI: 103731080(Bcl2l1)
HGL: 101713410(Bcl2l1) 101720105
CCAN: 109691766(Bcl2l1)
OCU: 100008875(BCL2L1)
TUP: 102486626(BCL2L1)
CFA: 403618(BCL2L1)
AML: 100469922(BCL2L1)
UMR: 103674345(BCL2L1)
ORO: 101380440(BCL2L1)
FCA: 493701(BCL2L1)
PTG: 102950221(BCL2L1)
AJU: 106986010(BCL2L1)
BTA: 282152(BCL2L1)
BOM: 102271380 102277355(BCL2L1)
BIU: 109565507 109567345(BCL2L1)
PHD: 102318766 102330304(BCL2L1)
CHX: 102180684(BCL2L1) 102183607
OAS: 101106158 105610887 443061(BCL2L1)
SSC: 397536(BCL2L1)
CFR: 102504996(BCL2L1)
CDK: 105100821(BCL2L1)
BACU: 103017903(BCL2L1)
LVE: 103080887(BCL2L1)
OOR: 101288063(BCL2L1)
ECB: 100053597(BCL2L1)
EPZ: 103559165(BCL2L1)
EAI: 106833712(BCL2L1)
MYB: 102260460(BCL2L1)
MYD: 102753986(BCL2L1)
HAI: 109373362 109384429(BCL2L1)
PALE: 102887704(BCL2L1)
LAV: 100655646(BCL2L1)
TMU: 101346361
MDO: 100010654(BCL2L1)
SHR: 100915548(BCL2L1)
GGA: 373954(BCL2L1)
MGP: 100539573(BCL2L1)
CJO: 107323111(BCL2L1)
APLA: 101803720
ACYG: 106047170(BCL2L1)
TGU: 100224900(BCL2L1)
GFR: 102036419(BCL2L1)
FAB: 101814183(BCL2L1)
PHI: 102102822(BCL2L1)
PMAJ: 107213269(BCL2L1)
CCW: 104687705(BCL2L1)
FPG: 101924628(BCL2L1)
FCH: 102056509(BCL2L1)
CLV: 102097802(BCL2L1)
EGZ: 104130016(BCL2L1)
AAM: 106497383(BCL2L1)
ASN: 102370658(BCL2L1)
AMJ: 102559904(BCL2L1)
PSS: 102460215(BCL2L1)
CMY: 102942240(BCL2L1)
CPIC: 101950816(BCL2L1)
ACS: 100561922(bcl2l1)
PVT: 110086731(BCL2L1)
PBI: 103061849(BCL2L1)
GJA: 107110471(BCL2L1)
XLA: 108700971 398251(bcl2l1.L)
XTR: 447991(bcl2l1)
NPR: 108786979(BCL2L1)
DRE: 114401(bcl2l1)
CCAR: 109078478(bcl2l1)
IPU: 108275903(bcl2l1)
AMEX: 103038148(bcl2l1)
LCO: 104929231(bcl2l1) 104939421
MZE: 101474628(bcl2l1) 101485344
XMA: 102221225(bcl2l1) 102221560
CSEM: 103384686(bcl2l1) 103386312
HCQ: 109513829(bcl2l1)
BPEC: 110169140(bcl2l1) 110170242
SFM: 108925659 108926435(bcl2l1)
LCM: 102358181(BCL2L1)
CMK: 103186250(bcl2l1)
APLC: 110989640
SOC: 105194262
AEC: 105154841
HST: 105183539
CFO: 105250488
LHU: 105671058
PGC: 109855578
FCD: 110852465
TSP: Tsp_00176
OBI: 106879288
ADF: 107358260
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kim R
  Title
Unknotting the roles of Bcl-2 and Bcl-xL in cell death.
  Journal
Biochem Biophys Res Commun 333:336-43 (2005)
DOI:10.1016/j.bbrc.2005.04.161
Reference
PMID:8358789
  Authors
Boise LH, Gonzalez-Garcia M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nunez G, Thompson CB
  Title
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.
  Journal
Cell 74:597-608 (1993)
DOI:10.1016/0092-8674(93)90508-N
  Sequence
[hsa:598]
Reference
  Authors
Terrano DT, Upreti M, Chambers TC
  Title
Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis.
  Journal
Mol Cell Biol 30:640-56 (2010)
DOI:10.1128/MCB.00882-09
  Sequence
[hsa:598]

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