KEGG   ORTHOLOGY: K04603Help
Entry
K04603                      KO                                     

Name
GRM1
Definition
metabotropic glutamate receptor 1
Pathway
Calcium signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Long-term depression
Taste transduction
Estrogen signaling pathway
Disease
H01891  
Autosomal recessive spinocerebellar ataxias
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    K04603  GRM1; metabotropic glutamate receptor 1
   04020 Calcium signaling pathway
    K04603  GRM1; metabotropic glutamate receptor 1
   04072 Phospholipase D signaling pathway
    K04603  GRM1; metabotropic glutamate receptor 1
  Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04603  GRM1; metabotropic glutamate receptor 1
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    K04603  GRM1; metabotropic glutamate receptor 1
 Organismal Systems
  Endocrine system
   04915 Estrogen signaling pathway
    K04603  GRM1; metabotropic glutamate receptor 1
  Nervous system
   04724 Glutamatergic synapse
    K04603  GRM1; metabotropic glutamate receptor 1
   04720 Long-term potentiation
    K04603  GRM1; metabotropic glutamate receptor 1
   04730 Long-term depression
    K04603  GRM1; metabotropic glutamate receptor 1
   04723 Retrograde endocannabinoid signaling
    K04603  GRM1; metabotropic glutamate receptor 1
  Sensory system
   04742 Taste transduction
    K04603  GRM1; metabotropic glutamate receptor 1
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K04603  GRM1; metabotropic glutamate receptor 1
G protein-coupled receptors [BR:ko04030]
 Class C. Metabotropic glutamate receptor family
  Biogenic amine
   Glutamate (metabotropic) [OT]
    K04603  GRM1; metabotropic glutamate receptor 1
BRITE hierarchy
Other DBs
Genes
HSA: 
2911(GRM1)
PTR: 
463049(GRM1)
PPS: 
100968079(GRM1)
GGO: 
101150458(GRM1)
PON: 
100451342(GRM1)
NLE: 
100592587(GRM1)
MCC: 
698736(GRM1)
MCF: 
102145647(GRM1)
CSAB: 
103240205(GRM1)
RRO: 
104653776(GRM1)
RBB: 
108533191(GRM1)
CJC: 
100410312(GRM1)
SBQ: 
101036619(GRM1)
MMU: 
14816(Grm1)
RNO: 
24414(Grm1)
CGE: 
100751598(Grm1)
NGI: 
103737030(Grm1)
HGL: 
101712477(Grm1)
CCAN: 
OCU: 
100356201(GRM1)
TUP: 
102479064(GRM1)
CFA: 
484024(GRM1)
AML: 
100479929(GRM1)
UMR: 
103666935(GRM1)
FCA: 
101094104(GRM1)
PTG: 
AJU: 
BTA: 
540485(GRM1)
BOM: 
102280395(GRM1)
BIU: 
109563668(GRM1)
PHD: 
102325561(GRM1)
CHX: 
102185002(GRM1)
OAS: 
443101(GRM1)
SSC: 
100625610(GRM1)
CFR: 
CDK: 
105092074(GRM1)
BACU: 
102999780(GRM1)
LVE: 
103085587(GRM1)
ECB: 
100060603(GRM1)
EPZ: 
103564725(GRM1)
EAI: 
106837226(GRM1)
MYB: 
102262360(GRM1)
MYD: 
HAI: 
109380898(GRM1)
RSS: 
109454117(GRM1)
PALE: 
102878912(GRM1)
LAV: 
100658721(GRM1)
MDO: 
100026724(GRM1)
SHR: 
OAA: 
GGA: 
421614(GRM1)
MGP: 
100540165(GRM1)
CJO: 
107311576(GRM1)
APLA: 
101803914(GRM1)
ACYG: 
106034294(GRM1)
TGU: 
751999(GRM1)
GFR: 
102038278(GRM1)
FAB: 
101807135(GRM1)
PHI: 
102107527(GRM1)
PMAJ: 
107202384(GRM1)
CCW: 
104689210(GRM1)
FPG: 
101920400(GRM1)
FCH: 
CLV: 
102091439(GRM1)
AAM: 
106486778(GRM1)
ASN: 
102378290(GRM1)
AMJ: 
102563002(GRM1)
PSS: 
102460135(GRM1)
CMY: 
102932638(GRM1)
CPIC: 
101940955(GRM1)
ACS: 
100564433(grm1)
PVT: 
110088369(GRM1)
PBI: 
GJA: 
107111120(GRM1)
XLA: 
XTR: 
100495945(grm1)
NPR: 
108787741(GRM1)
DRE: 
100150246(grm1b) 555576(grm1a)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
109527746(grm1)
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
102359097(GRM1)
CMK: 
103179290(grm1)
BFO: 
SPU: 
SKO: 
CQU: 
NVI: 
100118400(GRM1)
DPA: 
NVL: 
DPX: 
ISC: 
LGI: 
LAK: 
HMG: 
TAD: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Niswender CM, Conn PJ
  Title
Metabotropic glutamate receptors: physiology, pharmacology, and disease.
  Journal
Annu Rev Pharmacol Toxicol 50:295-322 (2010)
DOI:10.1146/annurev.pharmtox.011008.145533
Reference
  Authors
Pin JP, Galvez T, Prezeau L
  Title
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.
  Journal
Pharmacol Ther 98:325-54 (2003)
DOI:10.1016/S0163-7258(03)00038-X
Reference
PMID:1847995
  Authors
Masu M, Tanabe Y, Tsuchida K, Shigemoto R, Nakanishi S
  Title
Sequence and expression of a metabotropic glutamate receptor.
  Journal
Nature 349:760-5 (1991)
DOI:10.1038/349760a0
  Sequence
[rno:24414]

KEGG   ORTHOLOGY: K04604Help
Entry
K04604                      KO                                     

Name
GRM5
Definition
metabotropic glutamate receptor 5
Pathway
Calcium signaling pathway
Phospholipase D signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04020 Calcium signaling pathway
    K04604  GRM5; metabotropic glutamate receptor 5
   04072 Phospholipase D signaling pathway
    K04604  GRM5; metabotropic glutamate receptor 5
  Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04604  GRM5; metabotropic glutamate receptor 5
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    K04604  GRM5; metabotropic glutamate receptor 5
 Organismal Systems
  Nervous system
   04724 Glutamatergic synapse
    K04604  GRM5; metabotropic glutamate receptor 5
   04720 Long-term potentiation
    K04604  GRM5; metabotropic glutamate receptor 5
   04723 Retrograde endocannabinoid signaling
    K04604  GRM5; metabotropic glutamate receptor 5
 Human Diseases
  Neurodegenerative diseases
   05016 Huntington's disease
    K04604  GRM5; metabotropic glutamate receptor 5
G protein-coupled receptors [BR:ko04030]
 Class C. Metabotropic glutamate receptor family
  Biogenic amine
   Glutamate (metabotropic) [OT]
    K04604  GRM5; metabotropic glutamate receptor 5
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
2915(GRM5)
PTR: 
451472(GRM5)
PPS: 
100988134(GRM5)
GGO: 
101148125(GRM5)
PON: 
100452002(GRM5)
NLE: 
100595085(GRM5)
MCC: 
705445(GRM5)
MCF: 
101926080(GRM5)
CSAB: 
103248193(GRM5)
RRO: 
104657433(GRM5)
RBB: 
108539155(GRM5)
CJC: 
100400074(GRM5)
SBQ: 
MMU: 
108071(Grm5)
RNO: 
24418(Grm5)
CGE: 
100763614(Grm5)
NGI: 
103742957(Grm5)
HGL: 
101696979(Grm5)
CCAN: 
OCU: 
100340633(GRM5)
TUP: 
102486954(GRM5)
CFA: 
485146(GRM5)
AML: 
100466868(GRM5)
UMR: 
103675379(GRM5)
FCA: 
101091895(GRM5)
PTG: 
102957191(GRM5)
AJU: 
106967780(GRM5)
BTA: 
100336861(GRM5)
BOM: 
102273282(GRM5)
BIU: 
109554000(GRM5)
PHD: 
102331335(GRM5)
CHX: 
102182568(GRM5)
OAS: 
443069(GRM5)
SSC: 
102161751(GRM5)
CFR: 
102510039(GRM5)
CDK: 
105098361(GRM5)
BACU: 
103017209(GRM5)
LVE: 
103089884(GRM5)
ECB: 
100060364(GRM5)
EPZ: 
103547854(GRM5)
EAI: 
MYB: 
MYD: 
102763091(GRM5)
HAI: 
109375479(GRM5)
RSS: 
109451409(GRM5)
PALE: 
102894122(GRM5)
LAV: 
100676641(GRM5)
MDO: 
100009917(GRM5)
SHR: 
100913241(GRM5)
OAA: 
100080549(GRM5)
GGA: 
373933(GRM5)
CJO: 
107308455(GRM5)
APLA: 
ACYG: 
106034184(GRM5)
TGU: 
752008(GRM5)
GFR: 
102035609(GRM5)
FAB: 
101814322(GRM5)
PHI: 
102104616(GRM5)
PMAJ: 
107207537(GRM5)
CCW: 
104690322(GRM5)
FPG: 
101915830(GRM5)
FCH: 
102054087(GRM5)
CLV: 
102093525(GRM5)
AAM: 
106482085(GRM5)
ASN: 
102385450(GRM5)
AMJ: 
102576482(GRM5)
PSS: 
102454127(GRM5)
CMY: 
102935827(GRM5)
CPIC: 
101935299(GRM5)
ACS: 
100563209(grm5)
PVT: 
110088579(GRM5)
PBI: 
GJA: 
107113358(GRM5)
XLA: 
XTR: 
100485273(grm5)
NPR: 
108794764(GRM5)
DRE: 
100332913(grm5b) 568406(grm5a)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
103184347(grm5)
TCA: 
NVL: 
ISC: 
TUT: 
CEL: 
CBR: 
CBG02196(Cbr-mgl-2)
NAI: 
BMY: 
LOA: 
TSP: 
LGI: 
OBI: 
LAK: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Niswender CM, Conn PJ
  Title
Metabotropic glutamate receptors: physiology, pharmacology, and disease.
  Journal
Annu Rev Pharmacol Toxicol 50:295-322 (2010)
DOI:10.1146/annurev.pharmtox.011008.145533
Reference
  Authors
Pin JP, Galvez T, Prezeau L
  Title
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.
  Journal
Pharmacol Ther 98:325-54 (2003)
DOI:10.1016/S0163-7258(03)00038-X
Reference
  Authors
Xiao XL, Ma DL, Wu J, Tang FR
  Title
Metabotropic glutamate receptor 5 (mGluR5) regulates proliferation and differentiation of neuronal progenitors in the developmental hippocampus.
  Journal
Brain Res 1493:1-12 (2013)
DOI:10.1016/j.brainres.2012.11.015
  Sequence
[mmu:108071]

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