KEGG   ORTHOLOGY: K04603Help
Entry
K04603                      KO                                     

Name
GRM1
Definition
metabotropic glutamate receptor 1
Pathway
ko04020  Calcium signaling pathway
ko04068  FoxO signaling pathway
ko04072  Phospholipase D signaling pathway
ko04080  Neuroactive ligand-receptor interaction
ko04540  Gap junction
ko04720  Long-term potentiation
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04730  Long-term depression
ko04742  Taste transduction
ko04915  Estrogen signaling pathway
Disease
H01891  Autosomal recessive spinocerebellar ataxias
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    K04603  GRM1; metabotropic glutamate receptor 1
   04020 Calcium signaling pathway
    K04603  GRM1; metabotropic glutamate receptor 1
   04072 Phospholipase D signaling pathway
    K04603  GRM1; metabotropic glutamate receptor 1
  Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04603  GRM1; metabotropic glutamate receptor 1
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    K04603  GRM1; metabotropic glutamate receptor 1
 Organismal Systems
  Endocrine system
   04915 Estrogen signaling pathway
    K04603  GRM1; metabotropic glutamate receptor 1
  Nervous system
   04724 Glutamatergic synapse
    K04603  GRM1; metabotropic glutamate receptor 1
   04720 Long-term potentiation
    K04603  GRM1; metabotropic glutamate receptor 1
   04730 Long-term depression
    K04603  GRM1; metabotropic glutamate receptor 1
   04723 Retrograde endocannabinoid signaling
    K04603  GRM1; metabotropic glutamate receptor 1
  Sensory system
   04742 Taste transduction
    K04603  GRM1; metabotropic glutamate receptor 1
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K04603  GRM1; metabotropic glutamate receptor 1
G protein-coupled receptors [BR:ko04030]
 Class C. Metabotropic glutamate receptor family
  Biogenic amine
   Glutamate (metabotropic) [OT]
    K04603  GRM1; metabotropic glutamate receptor 1
BRITE hierarchy
Other DBs
GO: 0001639
TC: 9.A.14.7.1
Genes
HSA: 2911(GRM1)
PTR: 463049(GRM1)
PPS: 100968079(GRM1)
GGO: 101150458(GRM1)
PON: 100451342(GRM1)
NLE: 100592587(GRM1)
MCC: 698736(GRM1)
MCF: 102145647(GRM1)
CSAB: 103240205(GRM1)
RRO: 104653776(GRM1)
RBB: 108533191(GRM1)
CJC: 100410312(GRM1)
SBQ: 101036619(GRM1)
MMU: 14816(Grm1)
RNO: 24414(Grm1)
CGE: 100751598(Grm1)
NGI: 103737030(Grm1)
HGL: 101712477(Grm1)
OCU: 100356201(GRM1)
TUP: 102479064(GRM1)
CFA: 484024(GRM1)
AML: 100479929(GRM1)
UMR: 103666935(GRM1)
ORO: 101366183 101370296(GRM1)
FCA: 101094104(GRM1)
PTG: 102961964(GRM1) 107180681
AJU: 106965803
BTA: 540485(GRM1)
BOM: 102280395(GRM1)
BIU: 109563668(GRM1)
PHD: 102325561(GRM1)
CHX: 102185002(GRM1)
OAS: 443101(GRM1)
SSC: 100625610(GRM1)
CFR: 102522216 102523079(GRM1)
CDK: 105092074(GRM1)
BACU: 102999780(GRM1)
LVE: 103085587(GRM1)
OOR: 101286756(GRM1)
ECB: 100060603(GRM1)
EPZ: 103564725(GRM1)
EAI: 106837226(GRM1)
MYB: 102262360(GRM1)
MYD: 102757163 102768205(GRM1)
HAI: 109380898(GRM1)
RSS: 109454117(GRM1)
PALE: 102878912(GRM1)
TMU: 101357087
MDO: 100026724(GRM1)
SHR: 100919608 100929416(GRM1)
OAA: 100075372 103165077(GRM1)
GGA: 421614(GRM1)
MGP: 100540165(GRM1)
CJO: 107311576(GRM1)
APLA: 101803914(GRM1)
ACYG: 106034294(GRM1)
TGU: 751999(GRM1)
GFR: 102038278(GRM1)
FAB: 101807135(GRM1)
PHI: 102107527(GRM1)
PMAJ: 107202384(GRM1)
CCW: 104689210(GRM1)
FPG: 101920400(GRM1)
FCH: 102046326 102050937(GRM1)
CLV: 102091439(GRM1)
EGZ: 104133563(GRM1)
AAM: 106486778(GRM1)
ASN: 102378290(GRM1)
AMJ: 102563002(GRM1)
PSS: 102460135(GRM1)
CMY: 102932638(GRM1)
CPIC: 101940955(GRM1)
ACS: 100564433(grm1)
PVT: 110088369(GRM1)
PBI: 103054361 103054861(GRM1)
GJA: 107111120(GRM1)
XTR: 100495945(grm1)
NPR: 108787741(GRM1)
DRE: 100150246(grm1b) 555576(grm1a)
IPU: 108270069(grm1) 108279026
LCO: 104929400 104934310(grm1)
MZE: 101467938 101483242(grm1)
OLA: 101165118(grm1) 101170976
XMA: 102224833(grm1) 102226132
PRET: 103457526(grm1) 103458356
NFU: 107377567(grm1) 107391977
CSEM: 103380242 103381085(grm1)
HCQ: 109527746(grm1)
BPEC: 110155964(grm1) 110172139
ELS: 105015396 105029905(grm1)
LCM: 102359097(GRM1)
CMK: 103179290(grm1)
SKO: 100366462(GRM5) 100368806
NVI: 100118400(GRM1)
DPA: 109543383
NVL: 108560290
DPX: DAPPUDRAFT_64876(Grm5)
MYI: 110452574
EPA: 110248569
HMG: 100206629
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Niswender CM, Conn PJ
  Title
Metabotropic glutamate receptors: physiology, pharmacology, and disease.
  Journal
Annu Rev Pharmacol Toxicol 50:295-322 (2010)
DOI:10.1146/annurev.pharmtox.011008.145533
Reference
  Authors
Pin JP, Galvez T, Prezeau L
  Title
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.
  Journal
Pharmacol Ther 98:325-54 (2003)
DOI:10.1016/S0163-7258(03)00038-X
Reference
PMID:1847995
  Authors
Masu M, Tanabe Y, Tsuchida K, Shigemoto R, Nakanishi S
  Title
Sequence and expression of a metabotropic glutamate receptor.
  Journal
Nature 349:760-5 (1991)
DOI:10.1038/349760a0
  Sequence
[rno:24414]

KEGG   ORTHOLOGY: K04604Help
Entry
K04604                      KO                                     

Name
GRM5
Definition
metabotropic glutamate receptor 5
Pathway
ko04020  Calcium signaling pathway
ko04072  Phospholipase D signaling pathway
ko04080  Neuroactive ligand-receptor interaction
ko04540  Gap junction
ko04720  Long-term potentiation
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko05016  Huntington's disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04020 Calcium signaling pathway
    K04604  GRM5; metabotropic glutamate receptor 5
   04072 Phospholipase D signaling pathway
    K04604  GRM5; metabotropic glutamate receptor 5
  Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04604  GRM5; metabotropic glutamate receptor 5
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    K04604  GRM5; metabotropic glutamate receptor 5
 Organismal Systems
  Nervous system
   04724 Glutamatergic synapse
    K04604  GRM5; metabotropic glutamate receptor 5
   04720 Long-term potentiation
    K04604  GRM5; metabotropic glutamate receptor 5
   04723 Retrograde endocannabinoid signaling
    K04604  GRM5; metabotropic glutamate receptor 5
 Human Diseases
  Neurodegenerative diseases
   05016 Huntington's disease
    K04604  GRM5; metabotropic glutamate receptor 5
G protein-coupled receptors [BR:ko04030]
 Class C. Metabotropic glutamate receptor family
  Biogenic amine
   Glutamate (metabotropic) [OT]
    K04604  GRM5; metabotropic glutamate receptor 5
BRITE hierarchy
Other DBs
GO: 0001639
Genes
HSA: 2915(GRM5)
PTR: 451472(GRM5)
PPS: 100988134(GRM5)
GGO: 101148125(GRM5)
PON: 100452002(GRM5)
NLE: 100595085(GRM5)
MCC: 705445(GRM5)
MCF: 101926080(GRM5)
CSAB: 103248193(GRM5)
RRO: 104657433(GRM5)
RBB: 108539155(GRM5)
CJC: 100400074(GRM5)
SBQ: 101043023(GRM5) 104652498
MMU: 108071(Grm5)
RNO: 24418(Grm5)
CGE: 100763614(Grm5)
NGI: 103742957(Grm5)
HGL: 101696979(Grm5)
CCAN: 109674757
OCU: 100340633(GRM5)
TUP: 102486954(GRM5)
CFA: 485146(GRM5)
AML: 100466868(GRM5)
UMR: 103675379(GRM5)
ORO: 101364945(GRM5) 101372426
FCA: 101091895(GRM5)
PTG: 102957191(GRM5)
AJU: 106967780(GRM5)
BTA: 100336861(GRM5)
BOM: 102273282(GRM5)
BIU: 109554000(GRM5)
PHD: 102331335(GRM5)
CHX: 102182568(GRM5)
OAS: 443069(GRM5)
SSC: 102161751(GRM5)
CFR: 102510039(GRM5)
CDK: 105098361(GRM5)
BACU: 103017209(GRM5)
LVE: 103089884(GRM5)
OOR: 101280226(GRM5)
ECB: 100060364(GRM5)
EPZ: 103547854(GRM5)
EAI: 106822674 106848216(GRM5)
MYB: 102243205(GRM5) 102261422
MYD: 102763091(GRM5)
HAI: 109375479(GRM5)
RSS: 109451409(GRM5)
PALE: 102894122(GRM5)
LAV: 100676641(GRM5)
TMU: 101340926
MDO: 100009917(GRM5)
SHR: 100913241(GRM5)
OAA: 100080549(GRM5)
GGA: 373933(GRM5)
CJO: 107308455(GRM5)
APLA: 101805339(GRM5) 106018480
ACYG: 106034184(GRM5)
TGU: 752008(GRM5)
GFR: 102035609(GRM5)
FAB: 101814322(GRM5)
PHI: 102104616(GRM5)
PMAJ: 107207537(GRM5)
CCW: 104690322(GRM5)
FPG: 101915830(GRM5)
FCH: 102054087(GRM5)
CLV: 102093525(GRM5)
EGZ: 104128833(GRM5)
AAM: 106482085(GRM5)
ASN: 102385450(GRM5)
AMJ: 102576482(GRM5)
PSS: 102454127(GRM5)
CMY: 102935827(GRM5)
CPIC: 101935299(GRM5)
ACS: 100563209(grm5)
PVT: 110088579(GRM5)
PBI: 103056145(GRM5) 103060240
GJA: 107113358(GRM5)
XTR: 100485273(grm5)
NPR: 108794764(GRM5)
DRE: 100332913(grm5b) 568406(grm5a)
IPU: 108277301(grm5) 108277953
TRU: 101064551(grm5) 101079916
LCO: 104920135(grm5) 104923830
NCC: 104959637 104963006(grm5)
OLA: 101164491(grm5) 101173805
XMA: 102230735 102230987(grm5)
PRET: 103474487(grm5) 103475526
NFU: 107380453(grm5) 107386961
LCF: 108886623(grm5) 108893271
HCQ: 109509731 109525514(grm5)
BPEC: 110158381 110174304(grm5)
ELS: 105024084(grm5) 105026648
SFM: 108923808 108932228(grm5)
LCM: 102352410 102366420(GRM5)
CMK: 103184347(grm5)
TCA: 657397
NVL: 108556944
CEL: CELE_F45H11.4(mgl-2)
CBR: CBG02196(Cbr-mgl-2)
BMY: Bm1_13620
TSP: Tsp_11217
MYI: 110446254
EPA: 110245306
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Niswender CM, Conn PJ
  Title
Metabotropic glutamate receptors: physiology, pharmacology, and disease.
  Journal
Annu Rev Pharmacol Toxicol 50:295-322 (2010)
DOI:10.1146/annurev.pharmtox.011008.145533
Reference
  Authors
Pin JP, Galvez T, Prezeau L
  Title
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.
  Journal
Pharmacol Ther 98:325-54 (2003)
DOI:10.1016/S0163-7258(03)00038-X
Reference
  Authors
Xiao XL, Ma DL, Wu J, Tang FR
  Title
Metabotropic glutamate receptor 5 (mGluR5) regulates proliferation and differentiation of neuronal progenitors in the developmental hippocampus.
  Journal
Brain Res 1493:1-12 (2013)
DOI:10.1016/j.brainres.2012.11.015
  Sequence
[mmu:108071]

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