ko:K04606 : No such data.
ko:K04609 : No such data.
ko:K04610 : No such data.

KEGG   ORTHOLOGY: K04603Help
Entry
K04603                      KO                                     

Name
GRM1
Definition
metabotropic glutamate receptor 1
Pathway
Calcium signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Long-term depression
Taste transduction
Estrogen signaling pathway
Disease
H01891  
Autosomal recessive spinocerebellar ataxias
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    K04603  GRM1; metabotropic glutamate receptor 1
   04020 Calcium signaling pathway
    K04603  GRM1; metabotropic glutamate receptor 1
   04072 Phospholipase D signaling pathway
    K04603  GRM1; metabotropic glutamate receptor 1
  Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04603  GRM1; metabotropic glutamate receptor 1
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    K04603  GRM1; metabotropic glutamate receptor 1
 Organismal Systems
  Endocrine system
   04915 Estrogen signaling pathway
    K04603  GRM1; metabotropic glutamate receptor 1
  Nervous system
   04724 Glutamatergic synapse
    K04603  GRM1; metabotropic glutamate receptor 1
   04720 Long-term potentiation
    K04603  GRM1; metabotropic glutamate receptor 1
   04730 Long-term depression
    K04603  GRM1; metabotropic glutamate receptor 1
   04723 Retrograde endocannabinoid signaling
    K04603  GRM1; metabotropic glutamate receptor 1
  Sensory system
   04742 Taste transduction
    K04603  GRM1; metabotropic glutamate receptor 1
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K04603  GRM1; metabotropic glutamate receptor 1
G protein-coupled receptors [BR:ko04030]
 Class C. Metabotropic glutamate receptor family
  Biogenic amine
   Glutamate (metabotropic) [OT]
    K04603  GRM1; metabotropic glutamate receptor 1
BRITE hierarchy
Other DBs
Genes
HSA: 
2911(GRM1)
PTR: 
463049(GRM1)
PPS: 
100968079(GRM1)
GGO: 
101150458(GRM1)
PON: 
100451342(GRM1)
NLE: 
100592587(GRM1)
MCC: 
698736(GRM1)
MCF: 
102145647(GRM1)
CSAB: 
103240205(GRM1)
RRO: 
104653776(GRM1)
RBB: 
108533191(GRM1)
CJC: 
100410312(GRM1)
SBQ: 
101036619(GRM1)
MMU: 
14816(Grm1)
RNO: 
24414(Grm1)
CGE: 
100751598(Grm1)
NGI: 
103737030(Grm1)
HGL: 
101712477(Grm1)
CCAN: 
OCU: 
100356201(GRM1)
TUP: 
102479064(GRM1)
CFA: 
484024(GRM1)
AML: 
100479929(GRM1)
UMR: 
103666935(GRM1)
FCA: 
101094104(GRM1)
PTG: 
AJU: 
BTA: 
540485(GRM1)
BOM: 
102280395(GRM1)
BIU: 
109563668(GRM1)
PHD: 
102325561(GRM1)
CHX: 
102185002(GRM1)
OAS: 
443101(GRM1)
SSC: 
100625610(GRM1)
CFR: 
CDK: 
105092074(GRM1)
BACU: 
102999780(GRM1)
LVE: 
103085587(GRM1)
ECB: 
100060603(GRM1)
EPZ: 
103564725(GRM1)
EAI: 
106837226(GRM1)
MYB: 
102262360(GRM1)
MYD: 
HAI: 
109380898(GRM1)
RSS: 
109454117(GRM1)
PALE: 
102878912(GRM1)
LAV: 
100658721(GRM1)
MDO: 
100026724(GRM1)
SHR: 
OAA: 
GGA: 
421614(GRM1)
MGP: 
100540165(GRM1)
CJO: 
107311576(GRM1)
APLA: 
101803914(GRM1)
ACYG: 
106034294(GRM1)
TGU: 
751999(GRM1)
GFR: 
102038278(GRM1)
FAB: 
101807135(GRM1)
PHI: 
102107527(GRM1)
PMAJ: 
107202384(GRM1)
CCW: 
104689210(GRM1)
FPG: 
101920400(GRM1)
FCH: 
CLV: 
102091439(GRM1)
AAM: 
106486778(GRM1)
ASN: 
102378290(GRM1)
AMJ: 
102563002(GRM1)
PSS: 
102460135(GRM1)
CMY: 
102932638(GRM1)
CPIC: 
101940955(GRM1)
ACS: 
100564433(grm1)
PVT: 
110088369(GRM1)
PBI: 
GJA: 
107111120(GRM1)
XLA: 
XTR: 
100495945(grm1)
NPR: 
108787741(GRM1)
DRE: 
100150246(grm1b) 555576(grm1a)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
109527746(grm1)
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
102359097(GRM1)
CMK: 
103179290(grm1)
BFO: 
SPU: 
SKO: 
CQU: 
NVI: 
100118400(GRM1)
DPA: 
NVL: 
DPX: 
ISC: 
LGI: 
LAK: 
HMG: 
TAD: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Niswender CM, Conn PJ
  Title
Metabotropic glutamate receptors: physiology, pharmacology, and disease.
  Journal
Annu Rev Pharmacol Toxicol 50:295-322 (2010)
DOI:10.1146/annurev.pharmtox.011008.145533
Reference
  Authors
Pin JP, Galvez T, Prezeau L
  Title
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.
  Journal
Pharmacol Ther 98:325-54 (2003)
DOI:10.1016/S0163-7258(03)00038-X
Reference
PMID:1847995
  Authors
Masu M, Tanabe Y, Tsuchida K, Shigemoto R, Nakanishi S
  Title
Sequence and expression of a metabotropic glutamate receptor.
  Journal
Nature 349:760-5 (1991)
DOI:10.1038/349760a0
  Sequence
[rno:24414]

KEGG   ORTHOLOGY: K04605Help
Entry
K04605                      KO                                     

Name
GRM2_3
Definition
metabotropic glutamate receptor 2/3
Pathway
Phospholipase D signaling pathway
Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04072 Phospholipase D signaling pathway
    K04605  GRM2_3; metabotropic glutamate receptor 2/3
  Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04605  GRM2_3; metabotropic glutamate receptor 2/3
 Organismal Systems
  Nervous system
   04724 Glutamatergic synapse
    K04605  GRM2_3; metabotropic glutamate receptor 2/3
 Human Diseases
  Substance dependence
   05030 Cocaine addiction
    K04605  GRM2_3; metabotropic glutamate receptor 2/3
G protein-coupled receptors [BR:ko04030]
 Class C. Metabotropic glutamate receptor family
  Biogenic amine
   Glutamate (metabotropic) [OT]
    K04605  GRM2_3; metabotropic glutamate receptor 2/3
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
2912(GRM2) 2913(GRM3)
PTR: 
100611779(GRM2) 746019(GRM3)
PPS: 
100979630(GRM3) 100994960(GRM2)
GGO: 
101136022(GRM3) 101141235(GRM2)
PON: 
NLE: 
100594386(GRM3) 100599760(GRM2)
MCC: 
700214(GRM2) 706645(GRM3)
MCF: 
101925540(GRM3) 102126215(GRM2)
CSAB: 
103226618(GRM3) 103227697(GRM2)
RRO: 
104668024(GRM3) 104676756(GRM2)
RBB: 
108515138(GRM3) 108539926(GRM2)
CJC: 
SBQ: 
101033315(GRM2) 101049103(GRM3)
MMU: 
108068(Grm2) 108069(Grm3)
RNO: 
24415(Grm2) 24416(Grm3)
CGE: 
100760036(Grm3) 100772929(Grm2)
NGI: 
103725169(Grm3) 103747305(Grm2)
HGL: 
101713039(Grm3) 101722804(Grm2)
CCAN: 
109689413(Grm2) 109702358(Grm3)
OCU: 
100343810(GRM2) 100356452(GRM3)
TUP: 
102474413(GRM2) 102483840(GRM3)
CFA: 
100683236(GRM3) 484751(GRM2)
AML: 
100474356(GRM3) 100475146(GRM2)
UMR: 
103658785(GRM3) 103674782(GRM2)
FCA: 
PTG: 
AJU: 
106971747(GRM3) 106987051(GRM2)
BTA: 
519904(GRM2) 541056(GRM3)
BOM: 
102280421(GRM3) 102282435(GRM2)
BIU: 
109557324(GRM3) 109575969(GRM2)
PHD: 
102323701(GRM3) 102331452(GRM2)
CHX: 
102181359(GRM3) 102190178(GRM2)
OAS: 
101113057(GRM3) 101116870(GRM2)
SSC: 
100520271(GRM2) 100521916(GRM3)
CFR: 
102513392(GRM3) 102516735(GRM2)
CDK: 
105087246(GRM2) 105087351(GRM3)
BACU: 
102997832(GRM2) 102999582(GRM3)
LVE: 
103079932(GRM2) 103089829(GRM3)
ECB: 
100049918(GRM3) 100052178(GRM2)
EPZ: 
103562299(GRM3) 103566922(GRM2)
EAI: 
106830749(GRM2) 106838945(GRM3)
MYB: 
102240199(GRM2) 102262324(GRM3)
MYD: 
102764328(GRM3) 102774795(GRM2)
HAI: 
109371302(GRM3) 109375835(GRM2)
RSS: 
109457107(GRM3) 109459079(GRM2)
PALE: 
102881876(GRM3) 102883719(GRM2)
LAV: 
100663502(GRM3) 100664937(GRM2)
MDO: 
100012410(GRM3)
SHR: 
100914275(GRM2) 100929851(GRM3)
OAA: 
100085098(GRM3) 100089261(GRM2)
GGA: 
418644(GRM3) 427575(GRM2)
MGP: 
100549789(GRM2) 100549860(GRM3)
CJO: 
107319627(GRM2) 107320082(GRM3)
APLA: 
101798622(GRM2) 101803353(GRM3)
ACYG: 
106035553(GRM3) 106049494(GRM2)
TGU: 
751955(GRM2) 751962(GRM3)
GFR: 
102035741(GRM2) 102044527(GRM3)
FAB: 
101806833(GRM2) 101817776(GRM3)
PHI: 
102105121(GRM2) 102113129(GRM3)
PMAJ: 
107205045(GRM3) 107210417(GRM2)
CCW: 
104683251(GRM2) 104694485(GRM3)
FPG: 
101911554(GRM2) 101913502(GRM3)
FCH: 
102049507(GRM2) 102057003(GRM3)
CLV: 
102084053(GRM3) 102086489(GRM2)
AAM: 
106485312(GRM3) 106495124(GRM2)
ASN: 
102383301(GRM2) 102387340(GRM3)
AMJ: 
102562670(GRM3) 102568116(GRM2)
PSS: 
102447321(GRM3) 102456777(GRM2)
CMY: 
CPIC: 
101930971(GRM2) 101948606(GRM3)
ACS: 
100554492(grm3) 100566733(grm2)
PVT: 
110082715(GRM3) 110084471(GRM2)
PBI: 
103048220(GRM2) 103057760(GRM3)
GJA: 
107115924(GRM2) 107125951(GRM3)
XLA: 
108711210(grm3.L) 108713057(grm3.S) 108714614(grm2.L) 108715835(grm2.S)
XTR: 
100380092(grm2) 100492610(grm3)
NPR: 
108793453(GRM2) 108794073(GRM3)
DRE: 
336153(grm2a) 564461(grm2b) 565256(grm3)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
102362012(GRM2) 102363231(GRM3)
CMK: 
BFO: 
SPU: 
579746(grm3)
SKO: 
DME: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD28322(Dsim_GD28322)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AME: 
406151(mGlutR1)
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
TCA: 
DPA: 
DPX: 
TUT: 
CEL: 
CBR: 
CBG01949(Cbr-mgl-1)
NAI: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
LAK: 
SHX: 
OVI: 
NVE: 
ADF: 
HMG: 
TAD: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Niswender CM, Conn PJ
  Title
Metabotropic glutamate receptors: physiology, pharmacology, and disease.
  Journal
Annu Rev Pharmacol Toxicol 50:295-322 (2010)
DOI:10.1146/annurev.pharmtox.011008.145533
Reference
  Authors
Pin JP, Galvez T, Prezeau L
  Title
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.
  Journal
Pharmacol Ther 98:325-54 (2003)
DOI:10.1016/S0163-7258(03)00038-X
Reference
PMID:7620613
  Authors
Flor PJ, Lindauer K, Puttner I, Ruegg D, Lukic S, Knopfel T, Kuhn R
  Title
Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2.
  Journal
Eur J Neurosci 7:622-9 (1995)
DOI:10.1111/j.1460-9568.1995.tb00666.x
  Sequence
[hsa:2912]

KEGG   ORTHOLOGY: K04607Help
Entry
K04607                      KO                                     

Name
GRM4
Definition
metabotropic glutamate receptor 4
Pathway
Phospholipase D signaling pathway
Neuroactive ligand-receptor interaction
Glutamatergic synapse
Taste transduction
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04072 Phospholipase D signaling pathway
    K04607  GRM4; metabotropic glutamate receptor 4
  Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04607  GRM4; metabotropic glutamate receptor 4
 Organismal Systems
  Nervous system
   04724 Glutamatergic synapse
    K04607  GRM4; metabotropic glutamate receptor 4
  Sensory system
   04742 Taste transduction
    K04607  GRM4; metabotropic glutamate receptor 4
G protein-coupled receptors [BR:ko04030]
 Class C. Metabotropic glutamate receptor family
  Biogenic amine
   Glutamate (metabotropic) [OT]
    K04607  GRM4; metabotropic glutamate receptor 4
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
2914(GRM4)
PTR: 
471986(GRM4)
PPS: 
100978855(GRM4)
GGO: 
101128354(GRM4)
PON: 
100434887(GRM4)
NLE: 
100589155(GRM4)
MCC: 
718489(GRM4)
MCF: 
102144159(GRM4)
CSAB: 
103221643(GRM4)
RRO: 
104658139(GRM4)
RBB: 
108516261(GRM4)
CJC: 
SBQ: 
101050705(GRM4)
MMU: 
268934(Grm4)
RNO: 
24417(Grm4)
CGE: 
100757229(Grm4)
NGI: 
103739690(Grm4)
HGL: 
101704191(Grm4)
CCAN: 
109686662(Grm4)
OCU: 
100347907(GRM4)
TUP: 
CFA: 
481749(GRM4)
AML: 
100470828(GRM4)
UMR: 
103665551(GRM4)
FCA: 
101094419(GRM4)
PTG: 
102952540(GRM4)
AJU: 
BTA: 
790333(GRM4)
BOM: 
BIU: 
109577410(GRM4)
PHD: 
102332685(GRM4)
CHX: 
102171388(GRM4)
OAS: 
101119427(GRM4)
SSC: 
100152616(GRM4)
CFR: 
102512191(GRM4)
CDK: 
105101369(GRM4)
BACU: 
103020258(GRM4)
LVE: 
103071494(GRM4)
ECB: 
100061879(GRM4)
EPZ: 
EAI: 
106834580(GRM4)
MYB: 
102258679(GRM4)
MYD: 
102755234(GRM4)
HAI: 
109392436(GRM4)
RSS: 
109450967(GRM4)
PALE: 
102882871(GRM4)
LAV: 
100668676(GRM4)
MDO: 
100027811(GRM4)
SHR: 
100919335(GRM4)
OAA: 
GGA: 
419906(GRM4)
CJO: 
107324919(GRM4)
APLA: 
101791483(GRM4)
ACYG: 
106046173(GRM4)
TGU: 
752006(GRM4)
GFR: 
102040405(GRM4)
FAB: 
101809082(GRM4)
PHI: 
102110281(GRM4)
PMAJ: 
107214967(GRM4)
CCW: 
104692379(GRM4)
FPG: 
101911115(GRM4)
FCH: 
102056863(GRM4)
CLV: 
102098023(GRM4)
AAM: 
106490932(GRM4)
ASN: 
102377568(GRM4)
AMJ: 
102568871(GRM4)
PSS: 
102450322(GRM4)
CMY: 
102938268(GRM4)
CPIC: 
101946270(GRM4)
ACS: 
100563466(grm4)
PVT: 
110080204(GRM4)
PBI: 
GJA: 
XLA: 
XTR: 
NPR: 
DRE: 
567181(grm4)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
101061936(grm4)
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
108939353(grm4)
LCM: 
102365100(GRM4)
CMK: 
103179169(grm4)
CIN: 
ADF: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Niswender CM, Conn PJ
  Title
Metabotropic glutamate receptors: physiology, pharmacology, and disease.
  Journal
Annu Rev Pharmacol Toxicol 50:295-322 (2010)
DOI:10.1146/annurev.pharmtox.011008.145533
Reference
  Authors
Pin JP, Galvez T, Prezeau L
  Title
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.
  Journal
Pharmacol Ther 98:325-54 (2003)
DOI:10.1016/S0163-7258(03)00038-X
Reference
PMID:1309649
  Authors
Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S
  Title
A family of metabotropic glutamate receptors.
  Journal
Neuron 8:169-79 (1992)
DOI:10.1016/0896-6273(92)90118-W
  Sequence
[rno:24417]

KEGG   ORTHOLOGY: K04604Help
Entry
K04604                      KO                                     

Name
GRM5
Definition
metabotropic glutamate receptor 5
Pathway
Calcium signaling pathway
Phospholipase D signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04020 Calcium signaling pathway
    K04604  GRM5; metabotropic glutamate receptor 5
   04072 Phospholipase D signaling pathway
    K04604  GRM5; metabotropic glutamate receptor 5
  Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04604  GRM5; metabotropic glutamate receptor 5
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    K04604  GRM5; metabotropic glutamate receptor 5
 Organismal Systems
  Nervous system
   04724 Glutamatergic synapse
    K04604  GRM5; metabotropic glutamate receptor 5
   04720 Long-term potentiation
    K04604  GRM5; metabotropic glutamate receptor 5
   04723 Retrograde endocannabinoid signaling
    K04604  GRM5; metabotropic glutamate receptor 5
 Human Diseases
  Neurodegenerative diseases
   05016 Huntington's disease
    K04604  GRM5; metabotropic glutamate receptor 5
G protein-coupled receptors [BR:ko04030]
 Class C. Metabotropic glutamate receptor family
  Biogenic amine
   Glutamate (metabotropic) [OT]
    K04604  GRM5; metabotropic glutamate receptor 5
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
2915(GRM5)
PTR: 
451472(GRM5)
PPS: 
100988134(GRM5)
GGO: 
101148125(GRM5)
PON: 
100452002(GRM5)
NLE: 
100595085(GRM5)
MCC: 
705445(GRM5)
MCF: 
101926080(GRM5)
CSAB: 
103248193(GRM5)
RRO: 
104657433(GRM5)
RBB: 
108539155(GRM5)
CJC: 
100400074(GRM5)
SBQ: 
MMU: 
108071(Grm5)
RNO: 
24418(Grm5)
CGE: 
100763614(Grm5)
NGI: 
103742957(Grm5)
HGL: 
101696979(Grm5)
CCAN: 
OCU: 
100340633(GRM5)
TUP: 
102486954(GRM5)
CFA: 
485146(GRM5)
AML: 
100466868(GRM5)
UMR: 
103675379(GRM5)
FCA: 
101091895(GRM5)
PTG: 
102957191(GRM5)
AJU: 
106967780(GRM5)
BTA: 
100336861(GRM5)
BOM: 
102273282(GRM5)
BIU: 
109554000(GRM5)
PHD: 
102331335(GRM5)
CHX: 
102182568(GRM5)
OAS: 
443069(GRM5)
SSC: 
102161751(GRM5)
CFR: 
102510039(GRM5)
CDK: 
105098361(GRM5)
BACU: 
103017209(GRM5)
LVE: 
103089884(GRM5)
ECB: 
100060364(GRM5)
EPZ: 
103547854(GRM5)
EAI: 
MYB: 
MYD: 
102763091(GRM5)
HAI: 
109375479(GRM5)
RSS: 
109451409(GRM5)
PALE: 
102894122(GRM5)
LAV: 
100676641(GRM5)
MDO: 
100009917(GRM5)
SHR: 
100913241(GRM5)
OAA: 
100080549(GRM5)
GGA: 
373933(GRM5)
CJO: 
107308455(GRM5)
APLA: 
ACYG: 
106034184(GRM5)
TGU: 
752008(GRM5)
GFR: 
102035609(GRM5)
FAB: 
101814322(GRM5)
PHI: 
102104616(GRM5)
PMAJ: 
107207537(GRM5)
CCW: 
104690322(GRM5)
FPG: 
101915830(GRM5)
FCH: 
102054087(GRM5)
CLV: 
102093525(GRM5)
AAM: 
106482085(GRM5)
ASN: 
102385450(GRM5)
AMJ: 
102576482(GRM5)
PSS: 
102454127(GRM5)
CMY: 
102935827(GRM5)
CPIC: 
101935299(GRM5)
ACS: 
100563209(grm5)
PVT: 
110088579(GRM5)
PBI: 
GJA: 
107113358(GRM5)
XLA: 
XTR: 
100485273(grm5)
NPR: 
108794764(GRM5)
DRE: 
100332913(grm5b) 568406(grm5a)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
103184347(grm5)
TCA: 
NVL: 
ISC: 
TUT: 
CEL: 
CBR: 
CBG02196(Cbr-mgl-2)
NAI: 
BMY: 
LOA: 
TSP: 
LGI: 
OBI: 
LAK: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Niswender CM, Conn PJ
  Title
Metabotropic glutamate receptors: physiology, pharmacology, and disease.
  Journal
Annu Rev Pharmacol Toxicol 50:295-322 (2010)
DOI:10.1146/annurev.pharmtox.011008.145533
Reference
  Authors
Pin JP, Galvez T, Prezeau L
  Title
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.
  Journal
Pharmacol Ther 98:325-54 (2003)
DOI:10.1016/S0163-7258(03)00038-X
Reference
  Authors
Xiao XL, Ma DL, Wu J, Tang FR
  Title
Metabotropic glutamate receptor 5 (mGluR5) regulates proliferation and differentiation of neuronal progenitors in the developmental hippocampus.
  Journal
Brain Res 1493:1-12 (2013)
DOI:10.1016/j.brainres.2012.11.015
  Sequence
[mmu:108071]

KEGG   ORTHOLOGY: K04608Help
Entry
K04608                      KO                                     

Name
GRM6_7_8
Definition
metabotropic glutamate receptor 6/7/8
Pathway
Phospholipase D signaling pathway
Neuroactive ligand-receptor interaction
Glutamatergic synapse
Disease
H00787  
Congenital stationary night blindness (CSNB)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04072 Phospholipase D signaling pathway
    K04608  GRM6_7_8; metabotropic glutamate receptor 6/7/8
  Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04608  GRM6_7_8; metabotropic glutamate receptor 6/7/8
 Organismal Systems
  Nervous system
   04724 Glutamatergic synapse
    K04608  GRM6_7_8; metabotropic glutamate receptor 6/7/8
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K04608  GRM6_7_8; metabotropic glutamate receptor 6/7/8
G protein-coupled receptors [BR:ko04030]
 Class C. Metabotropic glutamate receptor family
  Biogenic amine
   Glutamate (metabotropic) [OT]
    K04608  GRM6_7_8; metabotropic glutamate receptor 6/7/8
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
2916(GRM6) 2917(GRM7) 2918(GRM8)
PTR: 
460140(GRM7) 462323(GRM6) 472502(GRM8) 743409
PPS: 
GGO: 
PON: 
100171884(GRM7) 100436264(GRM8) 100447061(GRM6)
NLE: 
MCC: 
697465(GRM8) 702731(GRM7) 713339(GRM6)
MCF: 
102127153(GRM6) 102128797(GRM8)
CSAB: 
103226837(GRM8) 103227955(GRM7) 103245094(GRM6)
RRO: 
RBB: 
CJC: 
100390040(GRM8) 100390090(GRM7) 100395536(GRM6)
SBQ: 
MMU: 
108072(Grm6) 108073(Grm7) 14823(Grm8)
RNO: 
24419(Grm6) 60590(Grm8) 81672(Grm7)
CGE: 
NGI: 
103744576(Grm8) 103749383(Grm6) 103751403(Grm7)
HGL: 
101697666(Grm8) 101711694(Grm7) 101717017(Grm6)
CCAN: 
OCU: 
100009501(GRM6) 100344818(GRM8) 100346053(GRM7)
TUP: 
CFA: 
481452(GRM6) 482270(GRM8) 484674(GRM7)
AML: 
100471025(GRM6) 100472571(GRM8)
UMR: 
103669589(GRM7) 103676623(GRM8) 103680010(GRM6)
FCA: 
101090088(GRM7) 101097449(GRM6) 101098127(GRM8)
PTG: 
AJU: 
BTA: 
529656(GRM6) 535362(GRM7) 538360(GRM8)
BOM: 
102266408(GRM8) 102278887(GRM7) 102285964(GRM6)
BIU: 
PHD: 
102321557(GRM7) 102323128(GRM8) 102344482(GRM6)
CHX: 
102170113(GRM8) 102182961(GRM6) 102190560(GRM7)
OAS: 
101108742(GRM8) 443292(GRM6) 443520(GRM7)
SSC: 
100524120(GRM8) 100621119(GRM7) 102162790(GRM6)
CFR: 
CDK: 
105085351(GRM8) 105093150(GRM7) 105100644(GRM6)
BACU: 
103008338(GRM8) 103012357(GRM6) 103012850(GRM7)
LVE: 
ECB: 
100052696(GRM7) 100067731(GRM6) 100071655(GRM8)
EPZ: 
103540009(GRM6) 103546392(GRM8) 103549493(GRM7)
EAI: 
MYB: 
MYD: 
HAI: 
RSS: 
PALE: 
102878333(GRM7) 102894346(GRM6) 102898832(GRM8)
LAV: 
100662461(GRM8) 100664172(GRM7) 100673918(GRM6)
MDO: 
100013595(GRM7) 100014205(GRM8) 100018484(GRM6)
SHR: 
100921583(GRM7) 100922771(GRM6) 100927951(GRM8)
OAA: 
GGA: 
416112(GRM7) 427853(GRM8)
MGP: 
100540879(GRM8) 104913208(GRM7)
CJO: 
APLA: 
101791637(GRM7) 101796179(GRM8)
ACYG: 
106036762(GRM7) 106040497(GRM8)
TGU: 
100220449(GRM7) 751963(GRM8)
GFR: 
102035073(GRM7) 102038282(GRM8)
FAB: 
101815638(GRM8) 101817877(GRM7)
PHI: 
102104191(GRM6) 102107228(GRM7) 102110564(GRM8)
PMAJ: 
107204551(GRM8) 107210125(GRM7)
CCW: 
104683518(GRM7) 104686828(GRM8)
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
PSS: 
CMY: 
CPIC: 
101934943(GRM8) 101943447(GRM7) 101952037(GRM6)
ACS: 
100564323(grm8) 100565811(grm6) 100567449(grm7)
PVT: 
110077874(GRM7) 110080934(GRM8) 110081176(GRM6)
PBI: 
GJA: 
XLA: 
XTR: 
NPR: 
DRE: 
100331190 565450(grm6b) 568484(grm6a) 569768(grm8b) 792371(grm8a)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
BFO: 
SPU: 
SKO: 
AME: 
411760(mGlutR2)
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
100123431(GRM7)
TCA: 
NVL: 
PHU: 
DPX: 
TUT: 
CEL: 
CBR: 
CBG19941(Cbr-mgl-3)
BMY: 
LOA: 
HRO: 
LGI: 
CRG: 
OBI: 
LAK: 
NVE: 
ADF: 
HMG: 
TAD: 
AQU: 
AAF: 
EHX: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Niswender CM, Conn PJ
  Title
Metabotropic glutamate receptors: physiology, pharmacology, and disease.
  Journal
Annu Rev Pharmacol Toxicol 50:295-322 (2010)
DOI:10.1146/annurev.pharmtox.011008.145533
Reference
  Authors
Pin JP, Galvez T, Prezeau L
  Title
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.
  Journal
Pharmacol Ther 98:325-54 (2003)
DOI:10.1016/S0163-7258(03)00038-X
Reference
  Authors
Devi S, Markandeya Y, Maddodi N, Dhingra A, Vardi N, Balijepalli RC, Setaluri V
  Title
Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium channel function and increases melanin content in human melanocytes.
  Journal
Pigment Cell Melanoma Res 26:348-56 (2013)
DOI:10.1111/pcmr.12083
  Sequence
[hsa:2916]

KEGG   ORTHOLOGY: K04611Help
Entry
K04611                      KO                                     

Name
MXR
Definition
metabotropic X receptor
Brite
G protein-coupled receptors [BR:ko04030]
 Class C. Metabotropic glutamate receptor family
  Biogenic amine
   Glutamate (metabotropic) [OT]
    K04611  MXR; metabotropic X receptor
BRITE hierarchy
Genes
BFO: 
CIN: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD15273(Dsim_GD15273)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
AME: 
406150(Glurb) 726424
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
DPA: 
NVL: 
BMOR: 
DPL: 
PXY: 
API: 
DNX: 
PHU: 
DPX: 
ISC: 
TUT: 
LGI: 
CRG: 
OBI: 
LAK: 
SMM: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Pin JP, Galvez T, Prezeau L
  Title
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.
  Journal
Pharmacol Ther 98:325-54 (2003)
DOI:10.1016/S0163-7258(03)00038-X
Reference
  Authors
Mitri C, Parmentier ML, Pin JP, Bockaert J, Grau Y
  Title
Divergent evolution in metabotropic glutamate receptors. A new receptor activated by an endogenous ligand different from glutamate in insects.
  Journal
J Biol Chem 279:9313-20 (2004)
DOI:10.1074/jbc.M310878200

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