KEGG   ORTHOLOGY: K04630Help
Entry
K04630                      KO                                     

Name
GNAI
Definition
guanine nucleotide-binding protein G(i) subunit alpha
Pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
Sphingolipid signaling pathway
Adrenergic signaling in cardiomyocytes
Axon guidance
Apelin signaling pathway
Gap junction
Platelet activation
Leukocyte transendothelial migration
Circadian entrainment
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Long-term depression
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Oxytocin signaling pathway
Regulation of lipolysis in adipocytes
Renin secretion
Relaxin signaling pathway
Gastric acid secretion
Parkinson's disease
Cocaine addiction
Morphine addiction
Alcoholism
Pertussis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Pathways in cancer
Module
M00695  
cAMP signaling
Disease
H00033  
Adrenal carcinoma
H01019  
Catecholaminergic polymorphic ventricular tachycardia
H01884  
Auriculocondylar syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04371 Apelin signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04071 Sphingolipid signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04024 cAMP signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04022 cGMP - PKG signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
 Organismal Systems
  Immune system
   04611 Platelet activation
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04670 Leukocyte transendothelial migration
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04062 Chemokine signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  Endocrine system
   04923 Regulation of lipolysis in adipocyte
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04915 Estrogen signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04914 Progesterone-mediated oocyte maturation
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04921 Oxytocin signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04926 Relaxin signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04916 Melanogenesis
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04924 Renin secretion
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  Digestive system
   04971 Gastric acid secretion
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  Nervous system
   04724 Glutamatergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04727 GABAergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04725 Cholinergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04728 Dopaminergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04726 Serotonergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04730 Long-term depression
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04723 Retrograde endocannabinoid signaling
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  Development
   04360 Axon guidance
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  Environmental adaptation
   04713 Circadian entrainment
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  Neurodegenerative diseases
   05012 Parkinson's disease
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  Substance dependence
   05030 Cocaine addiction
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05032 Morphine addiction
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05034 Alcoholism
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  Infectious diseases
   05133 Pertussis
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05145 Toxoplasmosis
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05142 Chagas disease (American trypanosomiasis)
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00695  cAMP signaling
     K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
Exosome [BR:ko04147]
 Exosomal proteins
  Proteins found in most exosomes
   K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 1 (Gi/o) [OT]
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
BRITE hierarchy
Genes
HSA: 
2770(GNAI1) 2771(GNAI2) 2773(GNAI3)
PTR: 
457093(GNAI3) 472425(GNAI1) 744773(GNAI2)
PPS: 
100968961(GNAI3) 100974334(GNAI2) 100985590(GNAI1)
GGO: 
101125616(GNAI3) 101150178(GNAI2) 101154597(GNAI1)
PON: 
100172679(GNAI1) 100456074(GNAI3) 100458137(GNAI2)
NLE: 
100583621(GNAI3) 100588993(GNAI2) 100604896(GNAI1)
MCC: 
699310(GNAI3) 703780(GNAI2) 708940(GNAI1)
MCF: 
101926144(GNAI2) 102119905(GNAI3) 102140224(GNAI1)
CSAB: 
103224284(GNAI3) 103226652(GNAI1) 103227664(GNAI2)
RRO: 
RBB: 
108519632(GNAI3) 108526962(GNAI2) 108534866(GNAI1)
CJC: 
100388113(GNAI1) 100404474(GNAI2) 100405745(GNAI3)
SBQ: 
101032105(GNAI3) 101041681(GNAI2) 101042629(GNAI1)
MMU: 
14677(Gnai1) 14678(Gnai2) 14679(Gnai3)
RNO: 
25643(Gnai3) 25686(Gnai1) 81664(Gnai2)
CGE: 
100689068(Gnai2) 100689070(Gnai1) 100689072(Gnai3)
NGI: 
103724646 103732220(Gnai1) 103747835(Gnai3) 103750163(Gnai2)
HGL: 
101698645(Gnai2) 101702965(Gnai1) 101703043(Gnai3)
CCAN: 
109688838(Gnai3) 109693226(Gnai2) 109702253(Gnai1)
OCU: 
100338391(GNAI1) 100339066(GNAI2) 100359147(GNAI3)
TUP: 
102475420(GNAI2) 102476737(GNAI3) 102479323(GNAI1)
CFA: 
442957(GNAI2) 478227(GNAI1) 611810(GNAI3)
AML: 
100471767(GNAI2) 100484933(GNAI1)
UMR: 
103658775(GNAI1) 103674803(GNAI2) 103675000(GNAI3)
FCA: 
101089679(GNAI2) 101092837(GNAI1) 101100320(GNAI3)
PTG: 
102951159(GNAI3) 102954501(GNAI1) 102962946(GNAI2)
AJU: 
106977809(GNAI3) 106979196(GNAI2) 106982494(GNAI1)
BTA: 
281790(GNAI1) 281791(GNAI2) 539521(GNAI3)
BOM: 
102273920(GNAI1) 102274651(GNAI2) 102285228(GNAI3)
BIU: 
109555970(GNAI3) 109557337(GNAI1) 109576257(GNAI2)
PHD: 
102319715(GNAI1) 102322883(GNAI2) 102326697(GNAI3)
CHX: 
100860765(GNAI2) 102185804(GNAI1) 108635583(GNAI3)
OAS: 
100302341(GNAI2) 101103693(GNAI3) 101116393(GNAI1)
SSC: 
100144419(GNAI1) 100144421(GNAI3) 397523(GNAI2)
CFR: 
102504487(GNAI3) 102518290(GNAI1) 102522331(GNAI2)
CDK: 
105085647(GNAI3) 105087520(GNAI2) 105100375(GNAI1)
BACU: 
103008589(GNAI3) 103010531(GNAI2) 103017385(GNAI1)
LVE: 
103077308(GNAI2) 103080185(GNAI3) 103081367(GNAI1)
ECB: 
100055673(GNAI1) 100062085(GNAI2)
EPZ: 
EAI: 
106827362(GNAI3) 106830727(GNAI2) 106833450(GNAI1)
MYB: 
102239557(GNAI3) 102249318(GNAI2) 102256872(GNAI1)
MYD: 
102754275(GNAI2) 102765504(GNAI3) 102766400(GNAI1)
HAI: 
109375288(GNAI3) 109377665(GNAI2) 109392892(GNAI1)
RSS: 
109435292(GNAI1) 109443439(GNAI2) 109446758(GNAI3)
PALE: 
102885642(GNAI1) 102892785(GNAI3) 102898665(GNAI2)
LAV: 
100666344(GNAI1) 100667957(GNAI3) 100670234(GNAI2)
MDO: 
100013052(GNAI1) 100030095(GNAI3) 100032986(GNAI2)
SHR: 
100914706(GNAI2) 100916740(GNAI1) 100928725(GNAI3)
OAA: 
GGA: 
374097(GNAI3) 396367(GNAI2) 396368(GNAI1)
MGP: 
CJO: 
APLA: 
101789621 101797591(GNAI1) 101798529(GNAI2) 101803759(GNAI3)
ACYG: 
TGU: 
100219656(GNAI1) 100225910(GNAI2) 100232622(GNAI3)
GFR: 
102034568(GNAI2) 102042928(GNAI1) 102045421(GNAI3)
FAB: 
101806522(GNAI3) 101807650(GNAI2) 101818889(GNAI1)
PHI: 
102100320(GNAI3) 102105798(GNAI2) 102111212(GNAI1)
PMAJ: 
CCW: 
FPG: 
101917880(GNAI1) 101918521(GNAI3) 101924920(GNAI2)
FCH: 
102051232(GNAI2) 102056299(GNAI3) 102059982(GNAI1)
CLV: 
AAM: 
ASN: 
102377099(GNAI2) 102379966(GNAI3) 102383800(GNAI1)
AMJ: 
102567683(GNAI3) 102571369(GNAI1) 106737098(GNAI2)
PSS: 
CMY: 
102932239(GNAI3) 102934526(GNAI2) 102948273(GNAI1)
CPIC: 
101941167(GNAI3) 101946186(GNAI2) 101948588(GNAI1)
ACS: 
100553120(gnai3) 100559069(gnai1) 100562211(gnai2)
PVT: 
110076779(GNAI2) 110077193(GNAI1) 110085272(GNAI3)
PBI: 
GJA: 
107118867(GNAI2) 107120788(GNAI3) 107121247(GNAI1)
XLA: 
108714595 379236(gnai3.S) 380034(gnai1.L) 399463(gnai1.S) 779438(gnai2.S)
XTR: 
100038283(gnai1) 394861(gnai2) 496962(gnai3)
NPR: 
DRE: 
100006888(gnai3) 323509(gnaia) 327650(gnai2b) 336421(gnai2a) 393946(gnai1)
SRX: 
SANH: 
SGH: 
IPU: 
100526828(gnai1) 108254730(gnai2) 108265813(GNAI3) 108271854(GNAI2) 108279833(Gnai1)
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
Dmel_CG10060(Galphai)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD13099(Dsim_GD13099)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
DPA: 
NVL: 
API: 
DNX: 
PHU: 
DPX: 
ISC: 
TUT: 
CEL: 
CBR: 
CBG13491(Cbr-gpa-4) CBG18548(Cbr-gpa-16)
NAI: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
LAK: 
SMM: 
SHX: 
OVI: 
NVE: 
ADF: 
HMG: 
100192225(gnai4)
TAD: 
EGR: 
PVU: 
NTA: 
SIND: 
BVG: 
DOSA: 
Os10t0117800-01(Os10g0117800)
PPP: 
SCE: 
YER020W(GPA2)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A14970(NCAS0A14970)
NDI: 
NDAI_0J00490(NDAI0J00490)
TPF: 
TPHA_0I02990(TPHA0I02990)
TBL: 
TBLA_0J00340(TBLA0J00340)
TDL: 
TDEL_0H00740(TDEL0H00740)
KAF: 
KAFR_0B00560(KAFR0B00560)
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
CAUR: 
NCR: 
NCU05206(gna-3) NCU06493(gna-1)
NTE: 
NEUTE1DRAFT62526(NEUTE1DRAFT_62526) NEUTE1DRAFT80570(NEUTE1DRAFT_80570)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
FVR: 
FOX: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
PLJ: 
VAL: 
VDA: 
CFJ: 
ELA: 
PFY: 
SSL: 
BFU: 
MBE: 
PSCO: 
GLZ: 
ANI: 
AFM: 
AOR: 
AOR_1_1002194(AO090012000577) AOR_1_1046194(AO090012000600)
ANG: 
ANI_1_824074(An08g05820) ANI_1_860074(An08g06130)
AFV: 
ACT: 
NFI: 
PCS: 
PDP: 
CIM: 
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
SNOG_06158(SNOG_06157) SNOG_10086(AY327542)
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
PPL: 
TVS: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT102615(AGABI1DRAFT_102615) AGABI1DRAFT116493(AGABI1DRAFT_116493) AGABI1DRAFT123478(AGABI1DRAFT_123478) AGABI1DRAFT132402(AGABI1DRAFT_132402) AGABI1DRAFT36876(AGABI1DRAFT_36876)
ABV: 
AGABI2DRAFT150479(AGABI2DRAFT_150479) AGABI2DRAFT151207(AGABI2DRAFT_151207) AGABI2DRAFT188871(AGABI2DRAFT_188871) AGABI2DRAFT196019(AGABI2DRAFT_196019) AGABI2DRAFT211352(AGABI2DRAFT_211352)
CPUT: 
SLA: 
WSE: 
WIC: 
UMA: 
PFP: 
MGL: 
PGR: 
MLR: 
DDI: 
DPP: 
DFA: 
EHI: 
EHI_140350(150.t00020)
EDI: 
EIV: 
ACAN: 
AAF: 
EHX: 
NGR: 
TVA: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3110783
  Authors
Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A, Nirenberg M
  Title
Human cDNA clones for an alpha subunit of Gi signal-transduction protein.
  Journal
Proc Natl Acad Sci U S A 84:5115-9 (1987)
DOI:10.1073/pnas.84.15.5115
  Sequence
[hsa:2770]
Reference
PMID:3120178
  Authors
Beals CR, Wilson CB, Perlmutter RM
  Title
A small multigene family encodes Gi signal-transduction proteins.
  Journal
Proc Natl Acad Sci U S A 84:7886-90 (1987)
DOI:10.1073/pnas.84.22.7886
  Sequence
[hsa:2771 2773]

KEGG   ORTHOLOGY: K04534Help
Entry
K04534                      KO                                     

Name
GNAO, G-ALPHA-O
Definition
guanine nucleotide-binding protein G(o) subunit alpha
Pathway
Rap1 signaling pathway
Circadian entrainment
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Long-term depression
Estrogen signaling pathway
Melanogenesis
Oxytocin signaling pathway
Relaxin signaling pathway
Morphine addiction
Alcoholism
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Disease
H00606  
Early infantile epileptic encephalopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
 Organismal Systems
  Endocrine system
   04915 Estrogen signaling pathway
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04921 Oxytocin signaling pathway
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04926 Relaxin signaling pathway
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04916 Melanogenesis
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
  Nervous system
   04724 Glutamatergic synapse
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04727 GABAergic synapse
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04725 Cholinergic synapse
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04728 Dopaminergic synapse
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04726 Serotonergic synapse
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04730 Long-term depression
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04723 Retrograde endocannabinoid signaling
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
  Environmental adaptation
   04713 Circadian entrainment
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
 Human Diseases
  Substance dependence
   05032 Morphine addiction
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   05034 Alcoholism
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
  Infectious diseases
   05145 Toxoplasmosis
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   05142 Chagas disease (American trypanosomiasis)
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 1 (Gi/o) [OT]
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
BRITE hierarchy
Genes
HSA: 
2775(GNAO1)
PTR: 
450173(GNAO1)
PPS: 
100991540(GNAO1)
GGO: 
101150695(GNAO1)
PON: 
100454626(GNAO1)
NLE: 
MCC: 
574394(GNAO1)
MCF: 
102131761(GNAO1)
CSAB: 
103233012(GNAO1)
RRO: 
RBB: 
108533839(GNAO1)
CJC: 
100389396(GNAO1) 103789429(GNAO1)
SBQ: 
101049046(GNAO1)
MMU: 
14681(Gnao1)
RNO: 
50664(Gnao1)
CGE: 
100689069(Gnao1)
NGI: 
103749858(Gnao1)
HGL: 
101723580(Gnao1)
CCAN: 
109700326(Gnao1)
OCU: 
100342283(GNAO1)
TUP: 
102483059(GNAO1)
CFA: 
609157(GNAO1)
AML: 
100466130(GNAO1)
UMR: 
FCA: 
101101353(GNAO1)
PTG: 
102958483(GNAO1)
AJU: 
BTA: 
281792(GNAO1)
BOM: 
102280695(GNAO1)
BIU: 
109572786(GNAO1)
PHD: 
102320226(GNAO1)
CHX: 
102186145(GNAO1)
OAS: 
101119495(GNAO1)
SSC: 
100516976(GNAO1)
CFR: 
CDK: 
105096168(GNAO1)
BACU: 
103011674(GNAO1)
LVE: 
103091025(GNAO1)
ECB: 
100051282(GNAO1)
EPZ: 
103555391(GNAO1)
EAI: 
106822188(GNAO1)
MYB: 
102263380(GNAO1)
MYD: 
102765603(GNAO1)
HAI: 
RSS: 
109459434(GNAO1)
PALE: 
102884654(GNAO1)
LAV: 
100658419(GNAO1)
MDO: 
100015137(GNAO1)
SHR: 
100914773(GNAO1)
OAA: 
100074566(GNAO1)
GGA: 
415698(GNAO1)
MGP: 
100543011(GNAO1)
CJO: 
107319187(GNAO1)
APLA: 
ACYG: 
106043102(GNAO1)
TGU: 
100226617(GNAO1)
GFR: 
102040380(GNAO1)
FAB: 
101810253(GNAO1)
PHI: 
102101605(GNAO1)
PMAJ: 
107209802(GNAO1)
CCW: 
104687499(GNAO1)
FPG: 
101920934(GNAO1)
FCH: 
102052678(GNAO1)
CLV: 
102098346(GNAO1)
AAM: 
106496793(GNAO1)
ASN: 
102370246(GNAO1)
AMJ: 
102575346(GNAO1)
PSS: 
102448010(GNAO1)
CMY: 
102938723(GNAO1)
CPIC: 
101939865(GNAO1)
ACS: 
PVT: 
110085725(GNAO1)
PBI: 
GJA: 
107118988(GNAO1)
XLA: 
108714022 394423(gnao1.L) 397896(gna0) 398037
XTR: 
549749(gnao1)
NPR: 
108793915(GNAO1)
DRE: 
393760(gnao1a) 393801(gnao1b)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
101079681(gnao1)
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
108918980(gnao1)
LCM: 
102363494(GNAO1)
CMK: 
BFO: 
SPU: 
SKO: 
DME: 
Dmel_CG2204(Galphao)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD10742(Dsim_GD10742)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
100118592(Gnao)
TCA: 
DPA: 
NVL: 
BMOR: 
692460(Go)
DPL: 
PXY: 
API: 
100168757(Gnao1)
DNX: 
PHU: 
DPX: 
ISC: 
TUT: 
CEL: 
CBR: 
CBG08377(Cbr-gpa-7) CBG11277(Cbr-gpa-2) CBG19263(Cbr-gpa-3) CBG23127(Cbr-gpa-1) CBG24698(Cbr-goa-1)
NAI: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
LAK: 
SMM: 
SHX: 
OVI: 
NVE: 
ADF: 
HMG: 
MBR: 
SRE: 
DPP: 
ACAN: 
PTI: 
FCY: 
TPS: 
AAF: 
PIF: 
PSOJ: 
NGR: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1901650
  Authors
Tsukamoto T, Toyama R, Itoh H, Kozasa T, Matsuoka M, Kaziro Y
  Title
Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing.
  Journal
Proc Natl Acad Sci U S A 88:2974-8 (1991)
  Sequence
[hsa:2775]

KEGG   ORTHOLOGY: K04535Help
Entry
K04535                      KO                                     

Name
GNAZ
Definition
guanine nucleotide-binding protein G(z) subunit alpha
Pathway
Long-term depression
Brite
KEGG Orthology (KO) [BR:ko00001]
 Organismal Systems
  Nervous system
   04730 Long-term depression
    K04535  GNAZ; guanine nucleotide-binding protein G(z) subunit alpha
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 1 (Gi/o) [OT]
    K04535  GNAZ; guanine nucleotide-binding protein G(z) subunit alpha
BRITE hierarchy
Genes
HSA: 
2781(GNAZ)
PTR: 
458693(GNAZ)
PPS: 
100973910(GNAZ)
GGO: 
101130405(GNAZ)
PON: 
100461603(GNAZ)
NLE: 
100592745(GNAZ)
MCC: 
706704(GNAZ)
MCF: 
102143621(GNAZ)
CSAB: 
103222900(GNAZ)
RRO: 
104672492(GNAZ)
RBB: 
108540632(GNAZ)
CJC: 
100391403(GNAZ)
SBQ: 
101043815(GNAZ)
MMU: 
14687(Gnaz)
RNO: 
25740(Gnaz)
CGE: 
100767381(Gnaz)
NGI: 
103734697(Gnaz)
HGL: 
101714256(Gnaz)
CCAN: 
109698317(Gnaz)
OCU: 
100356759(GNAZ)
TUP: 
102490381(GNAZ)
CFA: 
607445(GNAZ)
AML: 
100467701(GNAZ)
UMR: 
103669195(GNAZ)
FCA: 
101100923(GNAZ)
PTG: 
102956507(GNAZ)
AJU: 
106979694(GNAZ)
BOM: 
102282969(GNAZ)
PHD: 
CHX: 
106501838(GNAZ)
OAS: 
106991715(GNAZ)
SSC: 
100151867(GNAZ)
CFR: 
102510081(GNAZ)
CDK: 
105095185(GNAZ)
BACU: 
103009880(GNAZ)
LVE: 
103078351(GNAZ)
ECB: 
100049992(GNAZ)
EPZ: 
103560313(GNAZ)
EAI: 
106847135(GNAZ)
MYB: 
102242558(GNAZ)
MYD: 
102759123(GNAZ)
HAI: 
109394891(GNAZ)
RSS: 
109433821(GNAZ)
PALE: 
107195444(GNAZ)
LAV: 
100673517(GNAZ)
MDO: 
100016996(GNAZ)
SHR: 
100916887(GNAZ)
OAA: 
100088957(GNAZ)
GGA: 
770226(GNAZ)
MGP: 
100547187(GNAZ)
CJO: 
107321383(GNAZ)
APLA: 
101799262(GNAZ)
ACYG: 
106031320(GNAZ)
TGU: 
100227663(GNAZ)
GFR: 
102041313(GNAZ)
FAB: 
101813576(GNAZ)
PHI: 
102100063(GNAZ)
PMAJ: 
107211761(GNAZ)
CCW: 
104688566(GNAZ)
FPG: 
101923915(GNAZ)
FCH: 
102053137(GNAZ)
CLV: 
102095261(GNAZ)
AAM: 
106486304(GNAZ)
ASN: 
102378442(GNAZ)
AMJ: 
102560086(GNAZ)
PSS: 
CMY: 
102945651(GNAZ)
CPIC: 
101945996(GNAZ)
ACS: 
100557798(gnaz)
PVT: 
110081941(GNAZ)
PBI: 
103053469(GNAZ)
GJA: 
107115084(GNAZ)
XLA: 
108707114(gnaz.S) 108716026(gnaz.L)
XTR: 
780044(gnaz)
NPR: 
108787775(GNAZ)
DRE: 
564915(gnaz)
SRX: 
SANH: 
SGH: 
IPU: 
108277250(gnaz)
TRU: 
101066109(gnaz)
TNG: 
LCO: 
104923426(gnaz)
NCC: 
104961029(gnaz)
MZE: 
101463857(gnaz)
OLA: 
101167809(gnaz)
XMA: 
102228140(gnaz)
CSEM: 
103389074(gnaz)
LCF: 
108879282(gnaz)
HCQ: 
109517063(gnaz)
BPEC: 
110174131(gnaz)
SASA: 
ELS: 
105014976(gnaz)
SFM: 
LCM: 
102353158(GNAZ)
CMK: 
103188671(gnaz)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Milligan G, Kostenis E
  Title
Heterotrimeric G-proteins: a short history.
  Journal
Br J Pharmacol 147 Suppl 1:S46-55 (2006)
DOI:10.1038/sj.bjp.0706405
Reference
  Authors
Wettschureck N, Offermanns S.
  Title
Mammalian G proteins and their cell type specific functions.
  Journal
Physiol Rev 85:1159-204 (2005)
DOI:10.1152/physrev.00003.2005

KEGG   ORTHOLOGY: K04632Help
Entry
K04632                      KO                                     

Name
GNAS
Definition
guanine nucleotide-binding protein G(s) subunit alpha
Pathway
Endocrine resistance
Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Phospholipase D signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Gap junction
Platelet activation
Circadian entrainment
Glutamatergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Ovarian steroidogenesis
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Oxytocin signaling pathway
Glucagon signaling pathway
Regulation of lipolysis in adipocytes
Renin secretion
Aldosterone synthesis and secretion
Relaxin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Vasopressin-regulated water reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholism
Vibrio cholerae infection
Chagas disease (American trypanosomiasis)
Amoebiasis
Human papillomavirus infection
Pathways in cancer
Dilated cardiomyopathy (DCM)
Module
M00695  
cAMP signaling
Disease
H00244  
Pseudohypoparathyroidism
H00441  
Progressive osseous heteroplasia (POH)
H00501  
Fibrous dysplasia, polyostotic
H01431  
Cushing's syndrome
H01483  
Acromegaly
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04020 Calcium signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04072 Phospholipase D signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04024 cAMP signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
 Organismal Systems
  Immune system
   04611 Platelet activation
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Endocrine system
   04911 Insulin secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04922 Glucagon signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04923 Regulation of lipolysis in adipocyte
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04912 GnRH signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04913 Ovarian Steroidogenesis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04915 Estrogen signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04921 Oxytocin signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04926 Relaxin signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04918 Thyroid hormone synthesis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04916 Melanogenesis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04924 Renin secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04925 Aldosterone synthesis and secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04270 Vascular smooth muscle contraction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Digestive system
   04970 Salivary secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04971 Gastric acid secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04972 Pancreatic secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04976 Bile secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Excretory system
   04962 Vasopressin-regulated water reabsorption
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04961 Endocrine and other factor-regulated calcium reabsorption
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Nervous system
   04724 Glutamatergic synapse
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04728 Dopaminergic synapse
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04726 Serotonergic synapse
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04730 Long-term depression
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Environmental adaptation
   04713 Circadian entrainment
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Substance dependence
   05030 Cocaine addiction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05031 Amphetamine addiction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05032 Morphine addiction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05034 Alcoholism
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Cardiovascular diseases
   05414 Dilated cardiomyopathy (DCM)
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Infectious diseases
   05110 Vibrio cholerae infection
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05165 Human papillomavirus infection
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05146 Amoebiasis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05142 Chagas disease (American trypanosomiasis)
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Drug resistance
   01522 Endocrine resistance
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00695  cAMP signaling
     K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Exosomal proteins of other body fluids (saliva and urine)
   K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Exosomal proteins of colorectal cancer cells
   K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Exosomal proteins of bladder cancer cells
   K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 2 (Gs)
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
BRITE hierarchy
Genes
HSA: 
2778(GNAS)
PTR: 
469986(GNAS)
PPS: 
GGO: 
PON: 
100442753(GNAS)
NLE: 
100604281(GNAS)
MCC: 
694289(GNAS)
MCF: 
102145630(GNAS)
CSAB: 
103243509(GNAS)
RRO: 
RBB: 
108541624(GNAS)
CJC: 
100408515(GNAS)
SBQ: 
101043452(GNAS)
MMU: 
14683(Gnas)
RNO: 
24896(Gnas)
CGE: 
NGI: 
103741475(Gnas)
HGL: 
CCAN: 
109692784(Gnas)
OCU: 
100008904(GNAS)
TUP: 
102489563(GNAS)
CFA: 
AML: 
100473680(GNAS)
UMR: 
FCA: 
101098453(GNAS)
PTG: 
102964541(GNAS)
AJU: 
106969942(GNAS)
BTA: 
281793(GNAS)
BOM: 
BIU: 
PHD: 
CHX: 
OAS: 
SSC: 
100049657(GNAS)
CFR: 
102513869(GNAS)
CDK: 
BACU: 
LVE: 
103089051(GNAS)
ECB: 
100056464(GNAS1)
EPZ: 
EAI: 
MYB: 
MYD: 
HAI: 
RSS: 
PALE: 
102889764(GNAS)
LAV: 
MDO: 
SHR: 
100930666(GNAS)
OAA: 
100080392(GNAS)
GGA: 
419313(GNAS)
MGP: 
100550361(GNAS)
CJO: 
107323051(GNAS)
APLA: 
101791631(GNAS)
ACYG: 
106042176(GNAS)
TGU: 
100232476(GNAS)
GFR: 
102041915(GNAS)
FAB: 
101810765(GNAS)
PHI: 
102103803(GNAS)
PMAJ: 
107213286(GNAS)
CCW: 
104687623(GNAS)
FPG: 
101922321(GNAS)
FCH: 
102059934(GNAS)
CLV: 
AAM: 
ASN: 
102384106(GNAS)
AMJ: 
102563836(GNAS)
PSS: 
102447036(GNAS)
CMY: 
CPIC: 
101939195(GNAS)
ACS: 
PVT: 
110084741(GNAS)
PBI: 
GJA: 
107119835(GNAS)
XLA: 
394414(gnas.S) 399059
XTR: 
407931(gnas)
NPR: 
DRE: 
557353(gnas)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
102352483(GNAS)
CMK: 
103171631(gnas)
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
Dmel_CG2835(Galphas)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD11812(Dsim_GD11812)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AgaP_AGAP012095(GNAS_ANOGA)
AAG: 
CQU: 
AME: 
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
DPA: 
NVL: 
BMOR: 
DPL: 
PXY: 
API: 
DNX: 
PHU: 
DPX: 
TUT: 
CEL: 
CBR: 
CBG22078(Cbr-gsa-1)
NAI: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
LAK: 
SMM: 
SHX: 
OVI: 
NVE: 
ADF: 
HMG: 
TAD: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3093273
  Authors
Mattera R, Codina J, Crozat A, Kidd V, Woo SL, Birnbaumer L
  Title
Identification by molecular cloning of two forms of the alpha-subunit of the human liver stimulatory (GS) regulatory component of adenylyl cyclase.
  Journal
FEBS Lett 206:36-42 (1986)
DOI:10.1016/0014-5793(86)81336-9
  Sequence
[hsa:2778]
Reference
  Authors
Wettschureck N, Offermanns S.
  Title
Mammalian G proteins and their cell type specific functions.
  Journal
Physiol Rev 85:1159-204 (2005)
DOI:10.1152/physrev.00003.2005

KEGG   ORTHOLOGY: K04346Help
Entry
K04346                      KO                                     

Name
GNA12
Definition
guanine nucleotide-binding protein subunit alpha-12
Pathway
MAPK signaling pathway
cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Vascular smooth muscle contraction
Long-term depression
Regulation of actin cytoskeleton
Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04072 Phospholipase D signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04071 Sphingolipid signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04022 cGMP - PKG signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 Organismal Systems
  Circulatory system
   04270 Vascular smooth muscle contraction
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  Nervous system
   04730 Long-term depression
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of hepatic cells
   K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 4 (G12/13)
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
BRITE hierarchy
Genes
HSA: 
2768(GNA12)
PTR: 
463234(GNA12)
PPS: 
100979605(GNA12)
GGO: 
101147243(GNA12)
PON: 
100173387(GNA12)
NLE: 
100591916(GNA12)
MCC: 
100429106(GNA12)
MCF: 
101867258(GNA12)
CSAB: 
103246857(GNA12)
RRO: 
104664964(GNA12)
RBB: 
108543875(GNA12)
CJC: 
100387912(GNA12)
SBQ: 
101042405(GNA12)
MMU: 
14673(Gna12)
RNO: 
81663(Gna12)
CGE: 
100760944(Gna12)
NGI: 
103748670(Gna12)
HGL: 
101697421(Gna12)
CCAN: 
109683409(Gna12)
OCU: 
100347293(GNA12)
TUP: 
102501406(GNA12)
CFA: 
102154318(GNA12)
AML: 
100465369(GNA12)
UMR: 
103669942(GNA12)
FCA: 
101093316(GNA12)
PTG: 
102961052(GNA12)
AJU: 
106984497(GNA12)
BTA: 
515159(GNA12)
BOM: 
102265273(GNA12)
BIU: 
109578204(GNA12)
PHD: 
102322053(GNA12)
CHX: 
102185175(GNA12)
OAS: 
101111070(GNA12)
SSC: 
100525156(GNA12)
CFR: 
102524525(GNA12)
CDK: 
105090390(GNA12)
BACU: 
103009974(GNA12)
LVE: 
103069136(GNA12)
ECB: 
100060005(GNA12)
EPZ: 
103549418(GNA12)
EAI: 
106834780(GNA12)
MYB: 
102260289(GNA12)
MYD: 
102763801(GNA12)
HAI: 
109380223(GNA12)
RSS: 
109461354(GNA12)
PALE: 
102891706(GNA12)
LAV: 
100676444(GNA12)
MDO: 
100010453(GNA12)
SHR: 
100916443(GNA12)
OAA: 
100082592(GNA12)
GGA: 
769924(GNA12)
MGP: 
100550659(GNA12)
CJO: 
107320696(GNA12)
APLA: 
101798445(GNA12)
ACYG: 
106032065(GNA12)
TGU: 
100225137(GNA12)
GFR: 
102044790(GNA12)
FAB: 
101818259(GNA12)
PHI: 
102104762(GNA12)
PMAJ: 
107211274(GNA12)
CCW: 
104684810(GNA12)
FPG: 
101917262(GNA12)
FCH: 
102059010(GNA12)
CLV: 
102088372(GNA12)
AAM: 
106483939(GNA12)
ASN: 
102377286(GNA12)
AMJ: 
102559993(GNA12)
PSS: 
102445616(GNA12)
CMY: 
102931254(GNA12)
CPIC: 
101947834(GNA12)
ACS: 
100564021(gna12)
PVT: 
110083721(GNA12)
PBI: 
103050241(GNA12)
GJA: 
DRE: 
503589(gna12a)
SRX: 
SANH: 
SGH: 
IPU: 
108257129(gna12)
TRU: 
101078184(gna12)
TNG: 
LCO: 
104929956(gna12)
NCC: 
MZE: 
101473086(gna12)
OLA: 
101166935(gna12)
XMA: 
CSEM: 
103383240(gna12)
LCF: 
108888452(gna12)
HCQ: 
109511425(gna12)
BPEC: 
110153513(gna12)
SASA: 
ELS: 
105006302(gna12)
SFM: 
108927048(gna12)
LCM: 
102367557(GNA12)
CMK: 
103185131(gna12)
BFO: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD17672(Dsim_GD17672)
DWI: 
DYA: 
Dyak_GE22695(Dyak_cta)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
410906(GB12482) 727645
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
DPA: 
NVL: 
BMOR: 
100862775(Galpha12)
DPL: 
PXY: 
API: 
DNX: 
PHU: 
DPX: 
ISC: 
TUT: 
CEL: 
CELE_F18G5.3(gpa-12)
CBR: 
CBG16182(Cbr-gpa-12)
NAI: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
LAK: 
SHX: 
NVE: 
ADF: 
HMG: 
100192290(gna12)
TAD: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Milligan G, Kostenis E
  Title
Heterotrimeric G-proteins: a short history.
  Journal
Br J Pharmacol 147 Suppl 1:S46-55 (2006)
DOI:10.1038/sj.bjp.0706405
Reference
  Authors
Gan X, Wang J, Wang C, Sommer E, Kozasa T, Srinivasula S, Alessi D, Offermanns S, Simon MI, Wu D
  Title
PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12.
  Journal
Nat Cell Biol 14:686-96 (2012)
DOI:10.1038/ncb2507
  Sequence
[hsa:2768]

KEGG   ORTHOLOGY: K04639Help
Entry
K04639                      KO                                     

Name
GNA13
Definition
guanine nucleotide-binding protein subunit alpha-13
Pathway
cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Vascular smooth muscle contraction
Apelin signaling pathway
Platelet activation
Long-term depression
Regulation of actin cytoskeleton
Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04371 Apelin signaling pathway
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
   04072 Phospholipase D signaling pathway
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
   04071 Sphingolipid signaling pathway
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
   04022 cGMP - PKG signaling pathway
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
 Organismal Systems
  Immune system
   04611 Platelet activation
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
  Circulatory system
   04270 Vascular smooth muscle contraction
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
  Nervous system
   04730 Long-term depression
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
  Exosomal proteins of colorectal cancer cells
   K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 4 (G12/13)
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
BRITE hierarchy
Genes
HSA: 
10672(GNA13)
PTR: 
454827(GNA13)
PPS: 
100988877(GNA13)
GGO: 
101152866(GNA13)
PON: 
100461065(GNA13)
NLE: 
100589821(GNA13)
MCC: 
718144(GNA13)
MCF: 
102127819(GNA13)
CSAB: 
103243186(GNA13)
RRO: 
104675436(GNA13)
RBB: 
108517753(GNA13)
CJC: 
100394016(GNA13)
SBQ: 
101034540(GNA13)
MMU: 
14674(Gna13)
RNO: 
303634(Gna13)
CGE: 
100689071(Gna13)
NGI: 
103742208(Gna13)
HGL: 
101719378(Gna13)
CCAN: 
109696711(Gna13)
OCU: 
100352794(GNA13)
TUP: 
102488219(GNA13)
CFA: 
490901(GNA13)
AML: 
100474482(GNA13)
UMR: 
103665670(GNA13)
FCA: 
101087625(GNA13)
PTG: 
102964498(GNA13)
AJU: 
106975340(GNA13)
BTA: 
505611(GNA13)
BOM: 
102275435(GNA13)
BIU: 
109573379(GNA13)
PHD: 
102344724(GNA13)
CHX: 
102170818(GNA13)
OAS: 
101117003(GNA13)
SSC: 
100522824(GNA13)
CFR: 
102523556(GNA13)
CDK: 
105085708(GNA13)
BACU: 
103007094(GNA13)
LVE: 
103071564(GNA13)
ECB: 
100062972(GNA13)
EPZ: 
103553497(GNA13)
EAI: 
106835353(GNA13)
MYB: 
102252423(GNA13)
MYD: 
102764420(GNA13)
HAI: 
109380315(GNA13)
RSS: 
109448066(GNA13)
PALE: 
102891607(GNA13)
LAV: 
100664965(GNA13)
MDO: 
100024566(GNA13)
SHR: 
100932191(GNA13)
GGA: 
417434(GNA13)
MGP: 
100540964(GNA13)
CJO: 
107322109(GNA13)
APLA: 
101801355(GNA13)
ACYG: 
106034698(GNA13)
GFR: 
102040291(GNA13)
FAB: 
101812192(GNA13)
PHI: 
102099584(GNA13)
PMAJ: 
107212551(GNA13)
CCW: 
104696029(GNA13)
FPG: 
101922831(GNA13)
FCH: 
102052233(GNA13)
CLV: 
102084052(GNA13)
AAM: 
106493143(GNA13)
ASN: 
102376261(GNA13)
AMJ: 
102568562(GNA13)
PSS: 
102458860(GNA13)
CMY: 
102940587(GNA13)
CPIC: 
101953084(GNA13)
ACS: 
100554119(gna13)
PVT: 
110085885(GNA13)
PBI: 
103050681(GNA13)
GJA: 
107105951(GNA13)
XLA: 
108701204(gna13.L) 496349(gna13.S)
XTR: 
100145489(gna13)
NPR: 
108802992(GNA13)
DRE: 
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
110164386(gna13)
SASA: 
ELS: 
SFM: 
LCM: 
102364864(GNA13)
CMK: 
103175515(gna13)
CIN: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2508088
  Authors
Strathmann M, Wilkie TM, Simon MI
  Title
Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse.
  Journal
Proc Natl Acad Sci U S A 86:7407-9 (1989)
DOI:10.1073/pnas.86.19.7407
Reference
PMID:7791744
  Authors
Kabouridis PS, Waters ST, Escobar S, Stanners J, Tsoukas CD
  Title
Expression of GTP-binding protein alpha subunits in human thymocytes.
  Journal
Mol Cell Biochem 144:45-51 (1995)
  Sequence
[hsa:10672]

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