KEGG ORTHOLOGY: K04687

ORTHOLOGY: K04687

Entry

K04687                      KO

Symbol

IFNG

Name

interferon gamma

Pathway

map03050

Proteasome

map04060

Cytokine-cytokine receptor interaction

map04066

HIF-1 signaling pathway

map04217

Necroptosis

map04350

TGF-beta signaling pathway

map04380

Osteoclast differentiation

map04612

Antigen processing and presentation

map04630

JAK-STAT signaling pathway

map04650

Natural killer cell mediated cytotoxicity

map04657

IL-17 signaling pathway

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map04660

T cell receptor signaling pathway

map04940

Type I diabetes mellitus

map05140

Leishmaniasis

map05142

Chagas disease

map05143

African trypanosomiasis

map05144

Malaria

map05145

Toxoplasmosis

map05146

Amoebiasis

map05152

Tuberculosis

map05160

Hepatitis C

map05164

Influenza A

map05168

Herpes simplex virus 1 infection

map05200

Pathways in cancer

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05321

Inflammatory bowel disease

map05322

Systemic lupus erythematosus

map05323

Rheumatoid arthritis

map05330

Allograft rejection

map05332

Graft-versus-host disease

map05418

Fluid shear stress and atherosclerosis

Disease

H00083

Allograft rejection

H00084

Graft-versus-host disease

H00342

Tuberculosis

H01132

Aplastic anemia

H01563

HIV infection

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    K04687  IFNG; interferon gamma
09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    K04687  IFNG; interferon gamma
   04630 JAK-STAT signaling pathway
    K04687  IFNG; interferon gamma
   04066 HIF-1 signaling pathway
    K04687  IFNG; interferon gamma
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04687  IFNG; interferon gamma
09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K04687  IFNG; interferon gamma
09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K04687  IFNG; interferon gamma
   04612 Antigen processing and presentation
    K04687  IFNG; interferon gamma
   04660 T cell receptor signaling pathway
    K04687  IFNG; interferon gamma
   04658 Th1 and Th2 cell differentiation
    K04687  IFNG; interferon gamma
   04659 Th17 cell differentiation
    K04687  IFNG; interferon gamma
   04657 IL-17 signaling pathway
    K04687  IFNG; interferon gamma
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04687  IFNG; interferon gamma
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04687  IFNG; interferon gamma
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04687  IFNG; interferon gamma
  09172 Infectious disease: viral
   05160 Hepatitis C
    K04687  IFNG; interferon gamma
   05164 Influenza A
    K04687  IFNG; interferon gamma
   05168 Herpes simplex virus 1 infection
    K04687  IFNG; interferon gamma
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K04687  IFNG; interferon gamma
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K04687  IFNG; interferon gamma
   05144 Malaria
    K04687  IFNG; interferon gamma
   05145 Toxoplasmosis
    K04687  IFNG; interferon gamma
   05140 Leishmaniasis
    K04687  IFNG; interferon gamma
   05142 Chagas disease
    K04687  IFNG; interferon gamma
   05143 African trypanosomiasis
    K04687  IFNG; interferon gamma
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K04687  IFNG; interferon gamma
   05323 Rheumatoid arthritis
    K04687  IFNG; interferon gamma
   05321 Inflammatory bowel disease
    K04687  IFNG; interferon gamma
   05330 Allograft rejection
    K04687  IFNG; interferon gamma
   05332 Graft-versus-host disease
    K04687  IFNG; interferon gamma
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04687  IFNG; interferon gamma
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K04687  IFNG; interferon gamma
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome
    K04687  IFNG; interferon gamma
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K04687  IFNG; interferon gamma
   00536 Glycosaminoglycan binding proteins
    K04687  IFNG; interferon gamma
Proteasome [BR:ko03051]
Eukaryotic proteasome
  Assembling factors
   Other assembling factors
    K04687  IFNG; interferon gamma
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Interferons
   K04687  IFNG; interferon gamma
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Cytokines
   K04687  IFNG; interferon gamma

Other DBs

GO:

0005133

Genes

HSA:	3458(IFNG)

PTR:	449517(IFNG)

PPS:	100991779(IFNG)

GGO:	101151755(IFNG)

PON:	100444043(IFNG)

NLE:	100583022(IFNG)

HMH:	116479646(IFNG)

MCC:	574282(IFNG)

MCF:	102128291(IFNG)

MTHB:

126930989

MNI:	105473416(IFNG)

CSAB:

103238673(IFNG)

CATY:

105600509(IFNG)

PANU:

100126724(IFNG)

TGE:	112634767(IFNG)

MLEU:

105537103(IFNG)

RRO:	104664085(IFNG)

RBB:	108532274(IFNG)

TFN:	117089783(IFNG)

PTEH:

111528616(IFNG)

CANG:

105502648(IFNG)

CJC:	100388952(IFNG)

SBQ:	101033464(IFNG)

CIMI:

108291791(IFNG)

CSYR:

103269019(IFNG)

MMUR:

105880942(IFNG)

LCAT:

123640661(IFNG)

PCOQ:

105808396(IFNG)

OGA:	100945607(IFNG)

MMU:	15978(Ifng)

MCAL:

110303854(Ifng)

MPAH:

110326932(Ifng)

RNO:	25712(Ifng)

MCOC:

116076208(Ifng)

ANU:	117696651(Ifng)

MUN:	110561827(Ifng)

CGE:	100768486(Ifng)

MAUA:

101825431(Ifng)

PROB:

127215720(Ifng)

PLEU:

114693330(Ifng)

MORG:

121456003(Ifng)

MFOT:

126515663

AAMP:

119803682(Ifng)

NGI:	103745085(Ifng)

HGL:	101700722(Ifng)

CPOC:

100379568(Ifng)

CCAN:

109676142(Ifng)

DORD:

105988764(Ifng)

DSP:	122124303(Ifng)

PLOP:

125347731(Ifng)

NCAR:

124983352

MMMA:

107140076(Ifng)

OCU:	100008602(IFNG)

OPI:	101517557(IFNG)

TUP:	102470542(IFNG)

GVR:	103605815 103609732

CFA:	403801(IFNG)

CLUD:

112677888(IFNG)

VVP:	112922237(IFNG)

VLG:	121491993(IFNG)

NPO:	129512215(IFNG)

AML:	100462659(IFNG)

UMR:	103656858(IFNG)

UAH:	113256304(IFNG)

UAR:	123787294(IFNG)

ELK:

111142126

LLV:

125107054

MPUF:

101693741(IFNG)

MNP:	132020570(IFNG)

MLK:	131839127(IFNG)

NVS:	122891375(IFNG)

ORO:	101382125(IFNG)

EJU:	114214991(IFNG)

ZCA:	113922097(IFNG)

MLX:	118008418(IFNG)

NSU:	110570569(IFNG)

LWW:	102733689(IFNG)

FCA:	493965(IFNG)

PYU:	121041076(IFNG)

PCOO:

112863468(IFNG)

PBG:	122473187(IFNG)

PVIV:

125170497(IFNG)

LRUF:

124502020

PTG:	102963756(IFNG)

PPAD:

109270472(IFNG)

PUC:

125919316

AJU:

106966359

HHV:	120240808(IFNG)

BTA:	281237(IFNG)

BOM:	102267095(IFNG)

BIU:	109558719(IFNG)

BBUB:

102416494(IFNG)

BBIS:

104989779(IFNG)

CHX:	100860815(IFNG)

OAS:	443396(IFNG)

BTAX:

128048506(IFNG)

ODA:	120857709(IFNG)

CCAD:

122427438(IFNG)

MBEZ:

129536468(IFNG)

SSC:	396991(IFNG)

CFR:	102504614(IFNG)

CBAI:

105081344(IFNG)

CDK:	105101111(IFNG)

VPC:	102534412(IFNG)

BACU:

103020304(IFNG)

BMUS:

118902104(IFNG)

LVE:	103085542(IFNG)

OOR:	101282933(IFNG)

DLE:	111173770(IFNG)

PCAD:

102981551(IFNG)

PSIU:

116760539(IFNG)

NASI:

112394138(IFNG)

ECB:	100034181(IFNG)

EPZ:	103559339(IFNG)

EAI:	106843591(IFNG)

MYB:	102254028(IFNG)

MYD:	102774208(IFNG)

MMYO:

118651276(IFNG)

MLF:	102438946(IFNG)

PKL:	118729249(IFNG)

EFUS:

103292513(IFNG)

MNA:	107527227(IFNG)

DRO:	112319176(IFNG)

SHON:

118989641(IFNG)

AJM:	119042309(IFNG)

PDIC:

114514094(IFNG)

PHAS:

123812973(IFNG)

MMF:	118624687(IFNG)

PPAM:

129076046(IFNG)

HAI:	109381671(IFNG)

RFQ:	117029185(IFNG)

PALE:

102882436(IFNG)

PGIG:

120604831(IFNG)

PVP:	105301262(IFNG)

RAY:	107512682(IFNG)

MJV:	108384008(IFNG)

TOD:	119248294(IFNG)

SARA:

101540972(IFNG)

LAV:	100663285(IFNG)

TMU:

101346429

ETF:	101644328(IFNG)

DNM:	101422877(IFNG)

GAS:	123250180(IFNG)

SHR:	105750683(IFNG)

AFZ:

127564234

PCW:	110211092(IFNG)

GGA:	396054(IFNG)

PCOC:

116226684(IFNG)

MGP:	100543502(IFNG)

CJO:	107310263(IFNG)

TPAI:

128073421(IFNG)

LMUT:

125688071(IFNG)

NMEL:

110392776(IFNG)

APLA:

101790439(IFNG)

ACYG:

106047018(IFNG)

CATA:

118246753(IFNG)

AFUL:

116498468(IFNG)

TGU:	100226664(IFNG)

LSR:	110479845(IFNG)

SCAN:

103820410(IFNG)

PMOA:

120499851(IFNG)

OTC:	121339489(IFNG)

PRUF:

121352566(IFNG)

GFR:	102042890(IFNG)

FAB:	101811885(IFNG)

OMA:	130266695(IFNG)

PHI:	102099074(IFNG)

PMAJ:

107204252(IFNG)

CCAE:

111937200(IFNG)

CCW:	104698369(IFNG)

CBRC:

103614813(IFNG)

ETL:	114062162(IFNG) 114073130

ZAB:	102062818(IFNG)

ACHL:

103808539(IFNG)

SVG:	106854918(IFNG)

MMEA:

130580121(IFNG)

HRT:	120751919(IFNG)

FPG:	101924637(IFNG)

FCH:	102047662(IFNG)

CLV:	102098930(IFNG)

EGZ:	104132906(IFNG)

NNI:	104011009(IFNG)

PCRI:

104028074(IFNG)

PLET:

104616955(IFNG)

EHS:	104515339(IFNG)

PCAO:

104047403(IFNG)

ACUN:

113491294(IFNG)

TALA:

104360421(IFNG)

PADL:

103919962(IFNG)

AFOR:

103893931(IFNG)

ACHC:

115336262(IFNG)

HALD:

104313019(IFNG)

HLE:	104828216(IFNG)

AGEN:

126034474

GCL:

127025501

CCRI:

104162832(IFNG)

CSTI:

104560655(IFNG)

CMAC:

104480124(IFNG)

MUI:	104548570(IFNG)

BREG:

104637613(IFNG)

FGA:	104076437(IFNG)

GSTE:

104256440(IFNG)

LDI:	104350455(IFNG)

MNB:	103777845(IFNG)

OHA:	104326770(IFNG)

NNT:	104405137(IFNG)

SHAB:

115605193(IFNG)

DPUB:

104305556(IFNG)

PGUU:

104459797(IFNG)

ACAR:

104524308(IFNG)

CPEA:

104388818(IFNG)

AVIT:

104277230

CVF:	104288925(IFNG)

RTD:	128917981(IFNG)

CUCA:

104061369(IFNG)

TEO:	104380718(IFNG)

BRHI:

104490459(IFNG)

AAM:	106488479(IFNG)

AROW:

112970486(IFNG)

NPD:	112958855(IFNG)

TGT:	104574442(IFNG)

DNE:	112983337(IFNG)

SCAM:

104142049(IFNG)

ASN:	102383803 102384045

AMJ:	102563354(IFNG)

CPOO:

109315524(IFNG)

GGN:	109295707(IFNG)

PSS:	102444608(IFNG)

CMY:	102947470(IFNG)

CCAY:

125630233(IFNG)

DCC:	119849774(IFNG)

CPIC:

101934164(IFNG)

TST:	117868677(IFNG)

CABI:

116823551(IFNG)

MRV:	120387499(IFNG)

ASAO:

PVT:

SUND:

PBI:

PMUR:

107284417(IFNG)

CTIG:

120307681(IFNG)

PGUT:

117655711

APRI:

131202531(IFNG)

PTEX:

113438270(IFNG)

NSS:	113412210(IFNG)

VKO:

PMUA:

PRAF:

ZVI:

HCG:	128327334(IFNG)

GJA:

107105706

STOW:

125435373

EMC:

129335334

XLA:	101027283(ifng.L) 108712369

XTR:	100216446(ifng)

BBUF:

120980459

BGAR:

122928019

MUO:

115477759

GSH:	117363664(IL26)

DRE:	405790(ifng1)

CCAR:

109053615

CAUA:

113048607 113071150

CGIB:

127956722 127970345

PTET:

122342532(ifng1)

LROH:

127164339(ifng1)

OMC:	131539259(ifng1)

PPRM:

120476548(ifng1)

RKG:	130078769(ifng1)

MAMB:

125245511(ifng1)

MASI:

127436954

TROS:

130547821(ifng1)

TDW:	130421118(ifng1)

MANU:

129432285(ifng1)

IPU:	100305073(ifng1)

IFU:	128623397(ifng1)

PHYP:

113532282

SMEO:

124401508(ifng1)

TFD:	113645804(ifng1)

TVC:	132859071(ifng1)

CMAO:

118812488(ifng1)

PPRL:

129352836

SASA:

100329178

STRU:

115181896 115184184

OTW:	112237988(ifng1)

OMY:	100136643(ifng) 100301675(ifngamma2) 118938933

OGO:	124025543 124025544(ifng1)

OKI:	109885241 109885975 116360501 116364607 116364608

OKE:

127928176

SNH:	120049426 120049427 120049428

ELS:	105017796(ifng1)

SFM:

114909445

AANG:

118218838

LOC:

102691411

PSPA:

121317940(ifng1) 121319149

ARUT:

117415132 117419385(ifng1)

CMK:

RTP:

CPLA:

HOC:

Reference

PMID:24088808

Authors

Kunis G, Baruch K, Rosenzweig N, Kertser A, Miller O, Berkutzki T, Schwartz M

Title

IFN-gamma-dependent activation of the brain's choroid plexus for CNS immune surveillance and repair.

Journal

Brain 136:3427-40 (2013)
DOI:10.1093/brain/awt259

Sequence

[hsa:3458]

Reference

PMID:2860101

Authors

Nishi T, Fujita T, Nishi-Takaoka C, Saito A, Matsumoto T, Sato M, Oka T, Itoh S, Yip YK, Vilcek J, et al.

Title

Cloning and expression of a novel variant of human interferon-gamma cDNA.

Journal

J Biochem 97:153-9 (1985)
DOI:10.1093/oxfordjournals.jbchem.a135039

Sequence

[hsa:3458]

All links

Ontology (5)   
   KEGG BRITE (4)   
   GO (1)   
Pathway (64)   
   KEGG PATHWAY (64)   
Disease (5)   
   KEGG DISEASE (5)   
Drug (2)   
   KEGG DRUG (2)   
Gene (335)   
   KEGG GENES (315)   
   KEGG MGENES (18)   
   OC (2)   
Literature (2)   
   PubMed (2)   
All databases (413)   

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