KEGG   ORTHOLOGY: K04707Help
Entry
K04707                      KO                                     

Name
CBL
Definition
E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]
Pathway
ko04012  ErbB signaling pathway
ko04120  Ubiquitin mediated proteolysis
ko04144  Endocytosis
ko04910  Insulin signaling pathway
ko05100  Bacterial invasion of epithelial cells
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05220  Chronic myeloid leukemia
Disease
H00523  Noonan syndrome and related disorders
H01738  Noonan syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K04707  CBL; E3 ubiquitin-protein ligase CBL
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    K04707  CBL; E3 ubiquitin-protein ligase CBL
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K04707  CBL; E3 ubiquitin-protein ligase CBL
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K04707  CBL; E3 ubiquitin-protein ligase CBL
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04707  CBL; E3 ubiquitin-protein ligase CBL
   05205 Proteoglycans in cancer
    K04707  CBL; E3 ubiquitin-protein ligase CBL
   05220 Chronic myeloid leukemia
    K04707  CBL; E3 ubiquitin-protein ligase CBL
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    K04707  CBL; E3 ubiquitin-protein ligase CBL
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K04707  CBL; E3 ubiquitin-protein ligase CBL
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    K04707  CBL; E3 ubiquitin-protein ligase CBL
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   CBL proteins
    K04707  CBL; E3 ubiquitin-protein ligase CBL
BRITE hierarchy
Genes
HSA: 867(CBL)
PTR: 451690(CBL)
PPS: 100988815(CBL)
GGO: 101140325(CBL)
PON: 100462634(CBL)
NLE: 100607272(CBL)
MCC: 704311(CBL)
MCF: 102137660(CBL)
CSAB: 103248629(CBL)
RRO: 104657236(CBL)
RBB: 108528599(CBL) 108542282
CJC: 100408313(CBL)
SBQ: 101053489(CBL)
MMU: 12402(Cbl)
RNO: 500985(Cbl)
CGE: 100754737(Cbl)
NGI: 103727895(Cbl)
HGL: 101710004(Cbl)
CCAN: 109696224(Cbl)
OCU: 100342595(CBL)
TUP: 102469580(CBL)
CFA: 489369(CBL)
AML: 100470573(CBL)
UMR: 103662312(CBL)
ORO: 101377544(CBL)
PTG: 102960753(CBL)
AJU: 106983886(CBL)
BTA: 527418(CBL)
BOM: 102279176(CBL)
BIU: 109568806(CBL)
PHD: 102324436(CBL)
CHX: 102185385(CBL)
OAS: 101115401(CBL)
SSC: 100518854(CBL)
CFR: 102504124(CBL)
CDK: 105090203(CBL)
BACU: 103016132(CBL)
LVE: 103082495(CBL)
OOR: 101270049(CBL)
ECB: 100071403(CBL)
EPZ: 103546643(CBL)
EAI: 106840308(CBL)
MYB: 102242908(CBL)
MYD: 102763080(CBL)
HAI: 109393876(CBL)
RSS: 109437227(CBL)
PALE: 102895335(CBL)
LAV: 100658892(CBL)
TMU: 101342874
MDO: 100031184(CBL)
SHR: 100920890(CBL)
OAA: 100091424
GGA: 374038(CBL)
MGP: 100549952(CBL)
CJO: 107324207(CBL)
APLA: 101789789(CBL)
ACYG: 106039784(CBL)
TGU: 100227293(CBL)
GFR: 102036440(CBL)
FAB: 101810639(CBL)
PHI: 102103093(CBL)
PMAJ: 107214346(CBL)
CCW: 104692188(CBL)
FPG: 101919050(CBL)
FCH: 102058724(CBL)
CLV: 102096530(CBL)
EGZ: 104125948(CBL)
AAM: 106495869(CBL)
ASN: 102372644(CBL)
AMJ: 106737050(CBL)
PSS: 102450818(CBL)
CMY: 102937369(CBL)
CPIC: 101937375(CBL)
ACS: 100568145(cbl)
PVT: 110078535(CBL)
PBI: 103056422(CBL)
GJA: 107105501(CBL)
XLA: 108705407(cbl.S) 398194(cbl.L)
XTR: 594900(cbl)
NPR: 108797509(CBL)
DRE: 492364(cbl)
SANH: 107683813(cbl) 107690460
SGH: 107585540(cbl) 107601723
IPU: 108277804(cbl)
AMEX: 103032411(cbl)
TRU: 101070370 101078613(cbl)
LCO: 104921108 104936425(cbl)
OLA: 101163758 101170289(cbl)
XMA: 102233950 102234614(cbl)
PRET: 103474573(cbl) 103476312
NFU: 107380353(cbl) 107387219
CSEM: 103378406(cbl) 103395395
LCF: 108886386(cbl) 108893685
HCQ: 109517915 109529378(cbl)
BPEC: 110154105(cbl) 110174966
ELS: 105011087 105012434(cbl)
LCM: 102345712(CBL) 102349292(CBLC)
CMK: 103191373
CIN: 100176362
APLC: 110989191
DME: Dmel_CG7037(Cbl)
DSI: Dsimw501_GD14094(Dsim_GD14094)
AAG: 5572351
AME: 411982
BIM: 100745466
BTER: 100642596
SOC: 105202310
AEC: 105147762
ACEP: 105620476
PBAR: 105429426
HST: 105191070
CFO: 105249224
LHU: 105673746
NVI: 100119672
TCA: 656167
DPA: 109541931
NVL: 108569006
BMOR: 101740182
PMAC: 106709441
PRAP: 110993846
PXY: 105391330
API: 100159071
DNX: 107164289
ZNE: 110833897
FCD: 110842987
TUT: 107370090
CEL: CELE_M02A10.3(sli-1)
CBR: CBG08124(Cbr-sli-1)
BMY: Bm1_05660
TSP: Tsp_01088
CRG: 105342258
MYI: 110444983
OBI: 106869207
LAK: 106177307
SHX: MS3_04067
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Wehrle C, Van Slyke P, Dumont DJ
  Title
Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation.
  Journal
Biochem J 423:375-80 (2009)
DOI:10.1042/BJ20091010
Reference
  Authors
Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC
  Title
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.
  Journal
Science 286:309-12 (1999)
DOI:10.1126/science.286.5438.309
  Sequence
[hsa:867]

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