KEGG   ORTHOLOGY: K04725Help
Entry
K04725                      KO                                     

Name
XIAP, BIRC4
Definition
E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
Pathway
ko01524  Platinum drug resistance
ko04064  NF-kappa B signaling pathway
ko04120  Ubiquitin mediated proteolysis
ko04210  Apoptosis
ko04214  Apoptosis - fly
ko04215  Apoptosis - multiple species
ko04217  Necroptosis
ko04510  Focal adhesion
ko04621  NOD-like receptor signaling pathway
ko05145  Toxoplasmosis
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05222  Small cell lung cancer
Disease
H00107  Other well-defined immunodeficiency syndromes
H01969  X-linked lymphoproliferative syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
 Environmental Information Processing
  Signal transduction
   04064 NF-kappa B signaling pathway
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
   04214 Apoptosis - fly
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
   04215 Apoptosis - multiple species
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
   04217 Necroptosis
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
 Organismal Systems
  Immune system
   04621 NOD-like receptor signaling pathway
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
   05222 Small cell lung cancer
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
  Infectious diseases
   05166 HTLV-I infection
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
   05145 Toxoplasmosis
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
  Drug resistance
   01524 Platinum drug resistance
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Mitochondrial dynamics
   Retention of mitochondria
    K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
BRITE hierarchy
Genes
HSA: 331(XIAP)
PTR: 473765(XIAP)
PPS: 100993738(XIAP)
GGO: 101133804(XIAP)
PON: 100449741(XIAP)
NLE: 100597865(XIAP)
MCC: 698057(XIAP)
MCF: 102131393(XIAP)
CSAB: 103247375(XIAP)
RRO: 104655196(XIAP)
CJC: 100402341(XIAP)
SBQ: 101031174(XIAP)
MMU: 11798(Xiap)
RNO: 63879(Xiap)
CGE: 100689374(Xiap)
NGI: 103734850(Xiap)
HGL: 101715865(Xiap)
CCAN: 109700263(Xiap)
OCU: 100328700(XIAP)
TUP: 102500839(XIAP)
CFA: 442989(XIAP)
AML: 100471203(XIAP)
UMR: 103680228(XIAP)
ORO: 101367150(XIAP)
FCA: 101090594(XIAP)
PTG: 102957920(XIAP)
AJU: 106972832(XIAP)
BTA: 281647(XIAP)
BOM: 102275096(XIAP)
PHD: 102333718(XIAP)
CHX: 102170035(XIAP)
OAS: 101116381(XIAP)
SSC: 100037300(XIAP)
CFR: 102507842(XIAP)
CDK: 105098886(XIAP)
BACU: 103010212(XIAP)
LVE: 103085092(XIAP)
OOR: 101290359(XIAP)
ECB: 100060870(XIAP)
EPZ: 103543512(XIAP)
EAI: 106829909(XIAP)
MYB: 102246972(XIAP)
MYD: 102755332(XIAP)
HAI: 109390892(XIAP)
RSS: 109438351(XIAP)
PALE: 102885349(XIAP)
LAV: 100657657(XIAP)
TMU: 101346318
MDO: 100016651(XIAP)
SHR: 100928240(XIAP)
OAA: 100079889(XIAP)
GGA: 395280(XIAP)
MGP: 100542540(XIAP)
CJO: 107312953(XIAP)
APLA: 101796377(XIAP)
TGU: 100231359(XIAP)
GFR: 102039585(XIAP)
FAB: 101819741(XIAP)
PHI: 102101552(XIAP)
PMAJ: 107203935(XIAP)
CCW: 104694440(XIAP)
FPG: 101916449(XIAP)
FCH: 102051757(XIAP)
CLV: 102088054(XIAP)
AAM: 106487581(XIAP)
ASN: 102386593(XIAP)
AMJ: 102570735(XIAP)
PSS: 102449987(XIAP)
CMY: 102939941(XIAP)
CPIC: 101937031(XIAP)
ACS: 100557644(xiap)
PVT: 110088616(XIAP)
PBI: 103053668(XIAP)
GJA: 107123686(XIAP)
XLA: 733235(xiap.L)
XTR: 594971(xiap)
NPR: 108788768(XIAP)
DRE: 373108(xiap)
SANH: 107666595
SGH: 107600151
IPU: 108269205(xiap)
AMEX: 103037921(xiap)
TRU: 101067395
LCO: 104938662(xiap)
MZE: 101472383
OLA: 101166883
XMA: 102236946
PRET: 103470906(xiap)
CSEM: 103391373
LCF: 108882775(xiap)
BPEC: 110158118(xiap)
SASA: 106604301 106612162(BIRC4)
ELS: 105024403(xiap)
SFM: 108925196
LCM: 102349446(XIAP)
CMK: 103178709(xiap)
CIN: 100177446 100186811 778999(zf(ring)-22)
AME: 726899(GB12440)
API: 100159652
MYI: 110457948
HMG: 100215590
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8654366
  Authors
Duckett CS, Nava VE, Gedrich RW, Clem RJ, Van Dongen JL, Gilfillan MC, Shiels H, Hardwick JM, Thompson CB
  Title
A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors.
  Journal
EMBO J 15:2685-94 (1996)
  Sequence
[hsa:331]
Reference
  Authors
MacFarlane M, Merrison W, Bratton SB, Cohen GM
  Title
Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro.
  Journal
J Biol Chem 277:36611-6 (2002)
DOI:10.1074/jbc.M200317200
  Sequence
[hsa:331]

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