KEGG   ORTHOLOGY: K04961Help
Entry
K04961                      KO                                     

Name
RYR1
Definition
ryanodine receptor 1
Pathway
Calcium signaling pathway
Apelin signaling pathway
Circadian entrainment
Long-term depression
Oxytocin signaling pathway
Disease
H00699  
Central core disease
H01310  
Multi-minicore disease (MmD)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04371 Apelin signaling pathway
    K04961  RYR1; ryanodine receptor 1
   04020 Calcium signaling pathway
    K04961  RYR1; ryanodine receptor 1
 Organismal Systems
  Endocrine system
   04921 Oxytocin signaling pathway
    K04961  RYR1; ryanodine receptor 1
  Nervous system
   04730 Long-term depression
    K04961  RYR1; ryanodine receptor 1
  Environmental adaptation
   04713 Circadian entrainment
    K04961  RYR1; ryanodine receptor 1
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K04961  RYR1; ryanodine receptor 1
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K04961  RYR1; ryanodine receptor 1
Ion channels [BR:ko04040]
 Ryanodine and IP3 receptors
  Ryanodine receptor (RYR)
   K04961  RYR1; ryanodine receptor 1
BRITE hierarchy
Other DBs
Genes
HSA: 
6261(RYR1)
PTR: 
100612063(RYR1)
PPS: 
100992272(RYR1)
GGO: 
101143735(RYR1)
PON: 
100447042(RYR1)
NLE: 
100592793(RYR1)
MCC: 
693612(RYR1)
MCF: 
102129553(RYR1)
CSAB: 
103234633(RYR1)
RRO: 
104679962(RYR1)
RBB: 
108538989(RYR1)
CJC: 
100405957(RYR1)
SBQ: 
101040405(RYR1)
MMU: 
20190(Ryr1)
RNO: 
114207(Ryr1)
CGE: 
100766013(Ryr1)
NGI: 
103750787(Ryr1)
HGL: 
101708954(Ryr1)
CCAN: 
109695821(Ryr1)
OCU: 
100009540(RYR1)
TUP: 
102475336(RYR1)
CFA: 
606491(RYR1)
AML: 
100471044(RYR1)
UMR: 
103661069(RYR1)
FCA: 
101094224(RYR1)
PTG: 
102971670(RYR1)
AJU: 
106980247(RYR1)
BTA: 
100139857(RYR1)
BOM: 
102275567(RYR1)
BIU: 
PHD: 
102342512(RYR1)
CHX: 
102179229(RYR1)
OAS: 
101112591(RYR1)
SSC: 
396718(RYR1)
CFR: 
102516436(RYR1)
CDK: 
BACU: 
103007765(RYR1)
LVE: 
103069357(RYR1)
ECB: 
100034090(RYR1)
EPZ: 
EAI: 
106836101(RYR1)
MYB: 
102253755(RYR1)
MYD: 
102763591(RYR1)
HAI: 
RSS: 
109458011(RYR1)
PALE: 
102891286(RYR1)
LAV: 
100655020(RYR1)
MDO: 
100013232(RYR1)
SHR: 
100916717(RYR1)
OAA: 
GGA: 
MGP: 
100008574(RYR1)
PHI: 
102114265(RYR1)
CLV: 
AAM: 
ASN: 
102379620(RYR1)
AMJ: 
CMY: 
CPIC: 
ACS: 
100558429(ryr1)
PVT: 
110075640(RYR1)
PBI: 
103063254(RYR1)
GJA: 
XLA: 
XTR: 
100495378(ryr1)
NPR: 
108786654(RYR1)
DRE: 
570245(ryr1b) 798565(ryr1a)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
106603084(ryr1)
ELS: 
SFM: 
LCM: 
102356360(RYR1)
CMK: 
103190328(ryr1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2298749
  Authors
Zorzato F, Fujii J, Otsu K, Phillips M, Green NM, Lai FA, Meissner G, MacLennan DH
  Title
Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum.
  Journal
J Biol Chem 265:2244-56 (1990)
  Sequence
[hsa:6261]

KEGG   ORTHOLOGY: K04962Help
Entry
K04962                      KO                                     

Name
RYR2
Definition
ryanodine receptor 2
Pathway
Calcium signaling pathway
cAMP signaling pathway
Cardiac muscle contraction
Adrenergic signaling in cardiomyocytes
Apelin signaling pathway
Circadian entrainment
Insulin secretion
Oxytocin signaling pathway
Pancreatic secretion
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy (DCM)
Disease
H00293  
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
H01019  
Catecholaminergic polymorphic ventricular tachycardia
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04371 Apelin signaling pathway
    K04962  RYR2; ryanodine receptor 2
   04020 Calcium signaling pathway
    K04962  RYR2; ryanodine receptor 2
   04024 cAMP signaling pathway
    K04962  RYR2; ryanodine receptor 2
 Organismal Systems
  Endocrine system
   04911 Insulin secretion
    K04962  RYR2; ryanodine receptor 2
   04921 Oxytocin signaling pathway
    K04962  RYR2; ryanodine receptor 2
  Circulatory system
   04260 Cardiac muscle contraction
    K04962  RYR2; ryanodine receptor 2
   04261 Adrenergic signaling in cardiomyocytes
    K04962  RYR2; ryanodine receptor 2
  Digestive system
   04972 Pancreatic secretion
    K04962  RYR2; ryanodine receptor 2
  Environmental adaptation
   04713 Circadian entrainment
    K04962  RYR2; ryanodine receptor 2
 Human Diseases
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K04962  RYR2; ryanodine receptor 2
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K04962  RYR2; ryanodine receptor 2
   05414 Dilated cardiomyopathy (DCM)
    K04962  RYR2; ryanodine receptor 2
Ion channels [BR:ko04040]
 Ryanodine and IP3 receptors
  Ryanodine receptor (RYR)
   K04962  RYR2; ryanodine receptor 2
BRITE hierarchy
Other DBs
GO: 
TC: 
Genes
HSA: 
6262(RYR2)
PTR: 
457846(RYR2)
PPS: 
100974705(RYR2)
GGO: 
101152456(RYR2)
PON: 
100173051(RYR2)
NLE: 
100598810(RYR2)
MCC: 
717179(RYR2)
MCF: 
102132307(RYR2)
CSAB: 
103230821(RYR2)
RRO: 
104679189(RYR2)
RBB: 
108522194(RYR2)
CJC: 
100406916(RYR2)
SBQ: 
101044099(RYR2)
MMU: 
20191(Ryr2)
RNO: 
689560(Ryr2)
CGE: 
100774683(Ryr2)
NGI: 
HGL: 
101703865(Ryr2)
CCAN: 
109682314(Ryr2)
OCU: 
100009536(RYR2)
TUP: 
102473653(RYR2)
CFA: 
403615(RYR2)
AML: 
100476576(RYR2)
UMR: 
103662005(RYR2)
FCA: 
PTG: 
102963018(RYR2)
AJU: 
106987226(RYR2)
BTA: 
537376(RYR2)
BOM: 
102280999(RYR2)
BIU: 
109553606(RYR2)
PHD: 
CHX: 
102180565(RYR2)
OAS: 
101118500(RYR2)
SSC: 
396856(RYR2)
CFR: 
CDK: 
BACU: 
103000050(RYR2)
LVE: 
103085414(RYR2)
ECB: 
100057437(RYR2)
EPZ: 
103554178(RYR2)
EAI: 
106834687(RYR2)
MYB: 
102263572(RYR2)
MYD: 
102765493(RYR2)
HAI: 
RSS: 
109455319(RYR2)
PALE: 
102877858(RYR2)
LAV: 
100676989(RYR2)
MDO: 
100028207(RYR2)
SHR: 
100916914(RYR2)
OAA: 
100084273(RYR2)
GGA: 
421508(RYR2)
MGP: 
100551096(RYR2)
CJO: 
107311396(RYR2)
APLA: 
101793907(RYR2)
ACYG: 
106048956(RYR2)
TGU: 
100225109(RYR2)
GFR: 
102039305(RYR2)
FAB: 
101815198(RYR2)
PHI: 
102105661(RYR2)
PMAJ: 
107201934(RYR2)
CCW: 
104684437(RYR2)
FPG: 
101913442(RYR2)
FCH: 
102053979(RYR2)
CLV: 
102091036(RYR2)
AAM: 
106485406(RYR2)
ASN: 
102379736(RYR2)
AMJ: 
102572051(RYR2)
PSS: 
102449862(RYR2)
CMY: 
102931487(RYR2)
CPIC: 
101950679(RYR2)
ACS: 
100555710(ryr2)
PVT: 
110076303(RYR2)
PBI: 
103059179(RYR2)
GJA: 
DRE: 
100126126(ryr2a) 568463(ryr2b)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
108939633(ryr2)
LCM: 
102353265(RYR2)
CMK: 
103178965(ryr2)
BFO: 
CIN: 
100178148(ryr2)
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD10606(Dsim_GD10606)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
408680(RyR)
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
DPA: 
NVL: 
BMOR: 
DPL: 
PXY: 
API: 
DNX: 
PHU: 
FCD: 
DPX: 
ISC: 
TUT: 
CEL: 
CELE_K11C4.5(unc-68)
CBR: 
CBG19042(Cbr-unc-68)
NAI: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
LAK: 
SMM: 
SHX: 
OVI: 
TAD: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8809036
  Authors
Tunwell RE, Wickenden C, Bertrand BM, Shevchenko VI, Walsh MB, Allen PD, Lai FA
  Title
The human cardiac muscle ryanodine receptor-calcium release channel: identification, primary structure and topological analysis.
  Journal
Biochem J 318 ( Pt 2):477-87 (1996)
DOI:10.1042/bj3180477
  Sequence
[hsa:6262]

KEGG   ORTHOLOGY: K04963Help
Entry
K04963                      KO                                     

Name
RYR3
Definition
ryanodine receptor 3
Pathway
Calcium signaling pathway
Apelin signaling pathway
Circadian entrainment
Oxytocin signaling pathway
Salivary secretion
Alzheimer's disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04371 Apelin signaling pathway
    K04963  RYR3; ryanodine receptor 3
   04020 Calcium signaling pathway
    K04963  RYR3; ryanodine receptor 3
 Organismal Systems
  Endocrine system
   04921 Oxytocin signaling pathway
    K04963  RYR3; ryanodine receptor 3
  Digestive system
   04970 Salivary secretion
    K04963  RYR3; ryanodine receptor 3
  Environmental adaptation
   04713 Circadian entrainment
    K04963  RYR3; ryanodine receptor 3
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K04963  RYR3; ryanodine receptor 3
Ion channels [BR:ko04040]
 Ryanodine and IP3 receptors
  Ryanodine receptor (RYR)
   K04963  RYR3; ryanodine receptor 3
BRITE hierarchy
Other DBs
GO: 
TC: 
Genes
HSA: 
6263(RYR3)
PTR: 
453296(RYR3)
PPS: 
100969544(RYR3)
GGO: 
101140612(RYR3)
PON: 
NLE: 
100587193(RYR3)
MCC: 
694996(RYR3)
MCF: 
102127531(RYR3)
CSAB: 
103246111(RYR3)
RRO: 
104680383(RYR3)
RBB: 
108518794(RYR3)
CJC: 
100397905(RYR3)
SBQ: 
101038051(RYR3)
MMU: 
20192(Ryr3)
RNO: 
170546(Ryr3)
CGE: 
100751569(Ryr3)
NGI: 
103740528(Ryr3)
HGL: 
101707544(Ryr3)
CCAN: 
109689421(Ryr3)
OCU: 
100009545(RYR3)
TUP: 
CFA: 
100686627(RYR3)
AML: 
100481196(RYR3)
UMR: 
103673560(RYR3)
FCA: 
101090190(RYR3)
PTG: 
102961931(RYR3)
AJU: 
106969802(RYR3)
BTA: 
539899(RYR3)
BOM: 
102270854(RYR3)
BIU: 
109564326(RYR3)
PHD: 
102335226(RYR3)
CHX: 
102191052(RYR3)
OAS: 
101111289(RYR3)
CFR: 
102522121(RYR3)
CDK: 
105090026(RYR3)
BACU: 
103008844(RYR3)
LVE: 
103087389(RYR3)
ECB: 
100071830(RYR3)
EPZ: 
103548546(RYR3)
EAI: 
106835144(RYR3)
MYB: 
102245812(RYR3)
MYD: 
102764809(RYR3)
HAI: 
109373426(RYR3)
RSS: 
109458882(RYR3)
PALE: 
102887448(RYR3)
LAV: 
100663737(RYR3)
MDO: 
100031570(RYR3)
SHR: 
100919981(RYR3)
OAA: 
100089020(RYR3)
GGA: 
396111(RYR3)
MGP: 
100189600(RYR3)
CJO: 
107314933(RYR3)
APLA: 
101789513(RYR3)
ACYG: 
106031696(RYR3)
TGU: 
100219104(RYR3)
GFR: 
102040023(RYR3)
FAB: 
101819363(RYR3)
PHI: 
102102931(RYR3)
PMAJ: 
107205563(RYR3)
CCW: 
104684110(RYR3)
FPG: 
101915080(RYR3)
FCH: 
102054164(RYR3)
CLV: 
102090203(RYR3)
AAM: 
106483024(RYR3)
ASN: 
102380078(RYR3)
AMJ: 
102564536(RYR3)
PSS: 
102453852(RYR3)
CMY: 
102929729(RYR3)
CPIC: 
101939298(RYR3)
ACS: 
100564297(ryr3)
PVT: 
PBI: 
103067988(RYR3)
GJA: 
107108803(RYR3)
XLA: 
XTR: 
101731188(ryr3)
NPR: 
108785164(RYR3)
DRE: 
561350(ryr3)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
108919534(ryr3)
LCM: 
102364131(RYR3)
CMK: 
103175198(ryr3)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9395096
  Authors
Nakashima Y, Nishimura S, Maeda A, Barsoumian EL, Hakamata Y, Nakai J, Allen PD, Imoto K, Kita T
  Title
Molecular cloning and characterization of a human brain ryanodine receptor.
  Journal
FEBS Lett 417:157-62 (1997)
DOI:10.1016/S0014-5793(97)01275-1
  Sequence
[hsa:6263]

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