KEGG   ORTHOLOGY: K05406Help
Entry
K05406                      KO                                     

Name
IL12A
Definition
interleukin 12A
Pathway
ko04060  Cytokine-cytokine receptor interaction
ko04620  Toll-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04630  Jak-STAT signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04940  Type I diabetes mellitus
ko05133  Pertussis
ko05134  Legionellosis
ko05140  Leishmaniasis
ko05142  Chagas disease (American trypanosomiasis)
ko05143  African trypanosomiasis
ko05144  Malaria
ko05145  Toxoplasmosis
ko05146  Amoebiasis
ko05152  Tuberculosis
ko05162  Measles
ko05164  Influenza A
ko05168  Herpes simplex infection
ko05200  Pathways in cancer
ko05321  Inflammatory bowel disease (IBD)
ko05330  Allograft rejection
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K05406  IL12A; interleukin 12A
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05406  IL12A; interleukin 12A
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K05406  IL12A; interleukin 12A
   04622 RIG-I-like receptor signaling pathway
    K05406  IL12A; interleukin 12A
   04625 C-type lectin receptor signaling pathway
    K05406  IL12A; interleukin 12A
   04658 Th1 and Th2 cell differentiation
    K05406  IL12A; interleukin 12A
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05406  IL12A; interleukin 12A
  Immune diseases
   05321 Inflammatiory bowel disease (IBD)
    K05406  IL12A; interleukin 12A
   05330 Allograft rejection
    K05406  IL12A; interleukin 12A
  Endocrine and metabolic diseases
   04940 Type I diabetes mellitus
    K05406  IL12A; interleukin 12A
  Infectious diseases
   05133 Pertussis
    K05406  IL12A; interleukin 12A
   05134 Legionellosis
    K05406  IL12A; interleukin 12A
   05152 Tuberculosis
    K05406  IL12A; interleukin 12A
   05162 Measles
    K05406  IL12A; interleukin 12A
   05164 Influenza A
    K05406  IL12A; interleukin 12A
   05168 Herpes simplex infection
    K05406  IL12A; interleukin 12A
   05146 Amoebiasis
    K05406  IL12A; interleukin 12A
   05144 Malaria
    K05406  IL12A; interleukin 12A
   05145 Toxoplasmosis
    K05406  IL12A; interleukin 12A
   05140 Leishmaniasis
    K05406  IL12A; interleukin 12A
   05142 Chagas disease (American trypanosomiasis)
    K05406  IL12A; interleukin 12A
   05143 African trypanosomiasis
    K05406  IL12A; interleukin 12A
Cytokines and growth factors [BR:ko04052]
 Cytokines
  Interleukins
   K05406  IL12A; interleukin 12A
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Cytokines
   K05406  IL12A; interleukin 12A
BRITE hierarchy
Other DBs
GO: 0005143
Genes
HSA: 3592(IL12A)
PTR: 460816(IL12A)
PPS: 100979574(IL12A)
GGO: 101150677(IL12A)
PON: 100444807(IL12A)
NLE: 100603245(IL12A)
MCC: 703205(IL12A)
MCF: 102115316(IL12A)
CSAB: 103241402(IL12A)
RRO: 104665012(IL12A)
RBB: 108514790(IL12A)
CJC: 100406669(IL12A)
SBQ: 101044358(IL12A)
MMU: 16159(Il12a)
RNO: 84405(Il12a)
CGE: 100760602(Il12a)
NGI: 103745345(Il12a)
HGL: 101701392(Il12a)
CCAN: 109692199(Il12a)
OCU: 100349007(IL12A)
TUP: 102493627(IL12A)
CFA: 403977(IL12A)
AML: 100470471(IL12A)
UMR: 103681335(IL12A)
ORO: 101367178(IL12A)
FCA: 493741(IL12A)
PTG: 102971802(IL12A)
AJU: 106969467(IL12A)
BTA: 281856(IL12A)
BOM: 102276398(IL12A)
BIU: 109564477(IL12A)
PHD: 102336917(IL12A)
CHX: 100861293(IL12A)
OAS: 443064(IL12A)
SSC: 397053(IL12A)
CFR: 102507202(IL12A)
CDK: 105094260(IL12A)
BACU: 103003516(IL12A)
LVE: 103079299(IL12A)
OOR: 101279088(IL12A)
ECB: 100034215(IL12A)
EPZ: 103562911(IL12A)
EAI: 106824114(IL12A)
MYB: 102251395(IL12A)
MYD: 102753538(IL12A)
HAI: 109373148(IL12A)
RSS: 109447501(IL12A)
PALE: 102887571(IL12A)
LAV: 100665137(IL12A)
TMU: 101353752
MDO: 100018516(IL12A)
SHR: 100914201(IL12A)
OAA: 100086041(IL12A)
GGA: 407090(IL12A)
MGP: 100542954(IL12A)
CJO: 107318422(IL12A)
APLA: 101805034(IL12A)
ACYG: 106043510(IL12A)
FAB: 101809609(IL12A)
PMAJ: 107199630(IL12A)
CCW: 104688158(IL12A)
FPG: 101915475(IL12A)
FCH: 102047690(IL12A)
CLV: 102091031(IL12A)
EGZ: 104122263(IL12A)
AAM: 106495099(IL12A)
ASN: 102368752(IL12A)
AMJ: 102576541(IL12A)
PSS: 102457029(IL12A)
CMY: 102945506(IL12A)
CPIC: 101945519(IL12A)
PVT: 110078051
PBI: 103063822(IL12A)
XTR: 101734580(il12a)
DRE: 100004358(zmp:0000001127) 445410(il12a)
SGH: 107551286
TRU: 101061955 446069(il12a) 777974
NFU: 107384455
HCQ: 109518416
SASA: 106580951
SFM: 108936659
CMK: 103176349(il12a)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1673147
  Authors
Wolf SF, Temple PA, Kobayashi M, Young D, Dicig M, Lowe L, Dzialo R, Fitz L, Ferenz C, Hewick RM, et al.
  Title
Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.
  Journal
J Immunol 146:3074-81 (1991)
  Sequence
[hsa:3592]
Reference
  Authors
Klinke DJ 2nd
  Title
A multiscale systems perspective on cancer, immunotherapy, and Interleukin-12.
  Journal
Mol Cancer 9:242 (2010)
DOI:10.1186/1476-4598-9-242

KEGG   ORTHOLOGY: K05425Help
Entry
K05425                      KO                                     

Name
IL12B
Definition
interleukin 12B
Pathway
ko04060  Cytokine-cytokine receptor interaction
ko04620  Toll-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04630  Jak-STAT signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04940  Type I diabetes mellitus
ko05133  Pertussis
ko05134  Legionellosis
ko05140  Leishmaniasis
ko05142  Chagas disease (American trypanosomiasis)
ko05143  African trypanosomiasis
ko05145  Toxoplasmosis
ko05146  Amoebiasis
ko05152  Tuberculosis
ko05162  Measles
ko05164  Influenza A
ko05168  Herpes simplex infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05321  Inflammatory bowel disease (IBD)
ko05330  Allograft rejection
Disease
H00089  IFN-gamma/IL-12 axis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K05425  IL12B; interleukin 12B
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05425  IL12B; interleukin 12B
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K05425  IL12B; interleukin 12B
   04622 RIG-I-like receptor signaling pathway
    K05425  IL12B; interleukin 12B
   04625 C-type lectin receptor signaling pathway
    K05425  IL12B; interleukin 12B
   04658 Th1 and Th2 cell differentiation
    K05425  IL12B; interleukin 12B
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05425  IL12B; interleukin 12B
   05205 Proteoglycans in cancer
    K05425  IL12B; interleukin 12B
  Immune diseases
   05321 Inflammatiory bowel disease (IBD)
    K05425  IL12B; interleukin 12B
   05330 Allograft rejection
    K05425  IL12B; interleukin 12B
  Endocrine and metabolic diseases
   04940 Type I diabetes mellitus
    K05425  IL12B; interleukin 12B
  Infectious diseases
   05133 Pertussis
    K05425  IL12B; interleukin 12B
   05134 Legionellosis
    K05425  IL12B; interleukin 12B
   05152 Tuberculosis
    K05425  IL12B; interleukin 12B
   05162 Measles
    K05425  IL12B; interleukin 12B
   05164 Influenza A
    K05425  IL12B; interleukin 12B
   05168 Herpes simplex infection
    K05425  IL12B; interleukin 12B
   05146 Amoebiasis
    K05425  IL12B; interleukin 12B
   05145 Toxoplasmosis
    K05425  IL12B; interleukin 12B
   05140 Leishmaniasis
    K05425  IL12B; interleukin 12B
   05142 Chagas disease (American trypanosomiasis)
    K05425  IL12B; interleukin 12B
   05143 African trypanosomiasis
    K05425  IL12B; interleukin 12B
Cytokines and growth factors [BR:ko04052]
 Cytokines
  Interleukins
   K05425  IL12B; interleukin 12B
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Cytokines
   K05425  IL12B; interleukin 12B
BRITE hierarchy
Other DBs
GO: 0005143
Genes
HSA: 3593(IL12B)
PTR: 471723(IL12B)
PPS: 100989950(IL12B)
GGO: 101141274(IL12B)
PON: 100435254(IL12B)
NLE: 100579267(IL12B)
MCC: 694747(IL12B)
MCF: 102124858(IL12B)
CSAB: 103244892(IL12B)
RRO: 104669104(IL12B)
RBB: 108537933(IL12B)
CJC: 100395403(IL12B)
SBQ: 101049311(IL12B)
MMU: 16160(Il12b)
RNO: 64546(Il12b)
CGE: 100764758(Il12b)
NGI: 103724546(Il12b)
HGL: 101701309(Il12b)
CCAN: 109677112(Il12b)
OCU: 100354852(IL12B)
TUP: 102499876(IL12B)
CFA: 403976(IL12B)
AML: 100477772(IL12B)
UMR: 103664531(IL12B)
ORO: 101372789(IL12B)
FCA: 768273(IL12B)
PTG: 102959546(IL12B)
AJU: 106967679(IL12B)
BTA: 281857(IL12B)
BOM: 102283689(IL12B)
BIU: 109561305(IL12B)
PHD: 102341688(IL12B)
CHX: 100860845(IL12B)
OAS: 443472(IL12B)
SSC: 397076(IL12B)
CFR: 102515488(IL12B)
CDK: 105099900(IL12B)
BACU: 103007028(IL12B)
LVE: 103083704(IL12B)
OOR: 101272835(IL12B)
ECB: 100034222(IL12B)
EPZ: 103547779(IL12B)
EAI: 106832166(IL12B)
MYB: 102253394(IL12B)
MYD: 102756968(IL12B)
HAI: 109388897(IL12B)
RSS: 109451641(IL12B)
PALE: 102884214(IL12B)
LAV: 100657211(IL12B)
TMU: 101344352
MDO: 100030276(IL12B)
SHR: 100932486(IL12B)
OAA: 100074930(IL12B)
GGA: 404671(IL12B)
MGP: 100303696(IL12B)
CJO: 107320334(IL12B)
APLA: 101800211(IL12B)
ACYG: 106034345(IL12B)
TGU: 100217488(IL12B)
GFR: 102044384(IL12B)
FAB: 101814108(IL12B)
PHI: 102100856(IL12B)
PMAJ: 107210594(IL12B)
CCW: 104689490(IL12B)
FPG: 101920686(IL12B)
FCH: 102046968(IL12B)
CLV: 102097579(IL12B)
EGZ: 104133653(IL12B)
AAM: 106493613(IL12B)
ASN: 102379831(IL12B)
AMJ: 102568125(IL12B) 106737635
PSS: 102449025(IL12B)
CMY: 102939116(IL12B)
CPIC: 101948692(IL12B)
ACS: 103277860(il12b)
PVT: 110072310(IL12B)
XLA: 108712268
DRE: 445373(il12ba)
IPU: 108264170 108278485(il12b)
TRU: 101066952 101077588 445913(IL-12_p40) 445964(il12b)
HCQ: 109524222(il12b) 109527235
LCM: 102348110(IL12B)
CMK: 103177387(il12b) 103188109
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1674604
  Authors
Gubler U, Chua AO, Schoenhaut DS, Dwyer CM, McComas W, Motyka R, Nabavi N, Wolitzky AG, Quinn PM, Familletti PC, et al.
  Title
Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.
  Journal
Proc Natl Acad Sci U S A 88:4143-7 (1991)
DOI:10.1073/pnas.88.10.4143
  Sequence
[hsa:3593]
Reference
  Authors
Klinke DJ 2nd
  Title
A multiscale systems perspective on cancer, immunotherapy, and Interleukin-12.
  Journal
Mol Cancer 9:242 (2010)
DOI:10.1186/1476-4598-9-242

DBGET integrated database retrieval system