KEGG   ORTHOLOGY: K05412Help
Entry
K05412                      KO                                     

Name
CD80
Definition
CD80 antigen
Pathway
Cell adhesion molecules (CAMs)
Toll-like receptor signaling pathway
Intestinal immune network for IgA production
Type I diabetes mellitus
Autoimmune thyroid disease
Systemic lupus erythematosus
Rheumatoid arthritis
Allograft rejection
Graft-versus-host disease
Viral myocarditis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signaling molecules and interaction
   04514 Cell adhesion molecules (CAMs)
    K05412  CD80; CD80 antigen
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K05412  CD80; CD80 antigen
   04672 Intestinal immune network for IgA production
    K05412  CD80; CD80 antigen
 Human Diseases
  Immune diseases
   05322 Systemic lupus erythematosus
    K05412  CD80; CD80 antigen
   05323 Rheumatoid arthritis
    K05412  CD80; CD80 antigen
   05320 Autoimmune thyroid disease
    K05412  CD80; CD80 antigen
   05330 Allograft rejection
    K05412  CD80; CD80 antigen
   05332 Graft-versus-host disease
    K05412  CD80; CD80 antigen
  Cardiovascular diseases
   05416 Viral myocarditis
    K05412  CD80; CD80 antigen
  Endocrine and metabolic diseases
   04940 Type I diabetes mellitus
    K05412  CD80; CD80 antigen
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Immune system
   B7-CD28 family
    CD28; CD28 antigen
     K05412 CD80; CD80 antigen
    CTLA4, CD152; cytotoxic T-lymphocyte-associated protein 4
     K05412 CD80; CD80 antigen
    PDCD1LG1, CD274; programmed cell death 1 ligand 1
     K05412 CD80; CD80 antigen
CD molecules [BR:ko04090]
 Proteins
  K05412  CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
BRITE hierarchy
Genes
HSA: 
941(CD80)
PTR: 
470892(CD80)
PPS: 
100967832(CD80)
GGO: 
101149580(CD80)
PON: 
100441390(CD80)
NLE: 
100602167(CD80)
MCC: 
732518(CD80)
MCF: 
102140078(CD80)
CSAB: 
103228228(CD80)
RRO: 
104657616(CD80)
RBB: 
108541888(CD80)
CJC: 
100392260(CD80)
SBQ: 
101027898(CD80)
MMU: 
12519(Cd80)
RNO: 
25408(Cd80)
CGE: 
100760030(Cd80)
NGI: 
HGL: 
101722924(Cd80)
CCAN: 
109694534(Cd80)
OCU: 
100009377(CD80)
TUP: 
102479721(CD80)
CFA: 
403765(CD80)
AML: 
100480227(CD80)
UMR: 
103678791(CD80)
FCA: 
493786(CD80)
PTG: 
102965184(CD80)
AJU: 
106968282(CD80)
BTA: 
407131(CD80)
BOM: 
102277340(CD80)
BIU: 
109576990(CD80)
PHD: 
102338923(CD80)
CHX: 
102168389(CD80)
OAS: 
554317(CD80)
SSC: 
397161(CD80)
CFR: 
102524123(CD80)
CDK: 
105090327(CD80)
BACU: 
103003018(CD80)
LVE: 
103085940(CD80)
ECB: 
100071012(CD80)
EPZ: 
103547416(CD80)
EAI: 
106823733(CD80)
MYB: 
102263238(CD80)
MYD: 
102766781(CD80)
HAI: 
109388468(CD80)
RSS: 
109446367(CD80)
PALE: 
102893707(CD80)
LAV: 
100661159(CD80)
MDO: 
103097997(CD80)
SHR: 
105749825(CD80)
GGA: 
768950(CD80)
MGP: 
100540827(CD80)
CJO: 
107322032(CD80)
APLA: 
101796029(CD80)
ACYG: 
106039956(CD80)
TGU: 
100223361(CD80)
GFR: 
102041110(CD80)
FAB: 
101805959(CD80)
PHI: 
102100062(CD80)
PMAJ: 
107210846(CD80)
CCW: 
104689398(CD80)
FPG: 
101919028(CD80)
FCH: 
102049492(CD80)
CLV: 
102092429(CD80)
AAM: 
106490585(CD80)
ASN: 
102385905(CD80)
AMJ: 
102566599(CD80)
PSS: 
CMY: 
102931306(CD80)
CPIC: 
ACS: 
103278386(vtcn1)
PVT: 
XLA: 
XTR: 
101733943(cd80)
DRE: 
SRX: 
SGH: 
IPU: 
TRU: 
HCQ: 
SASA: 
ELS: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2794510
  Authors
Freeman GJ, Freedman AS, Segil JM, Lee G, Whitman JF, Nadler LM
  Title
B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells.
  Journal
J Immunol 143:2714-22 (1989)
  Sequence
[hsa:941]
Reference
  Authors
Chen L.
  Title
Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity.
  Journal
Nat Rev Immunol 4:336-47 (2004)
DOI:10.1038/nri1349

KEGG   ORTHOLOGY: K05413Help
Entry
K05413                      KO                                     

Name
CD86
Definition
CD86 antigen
Pathway
Cell adhesion molecules (CAMs)
Toll-like receptor signaling pathway
Intestinal immune network for IgA production
Type I diabetes mellitus
Kaposi's sarcoma-associated herpesvirus infection
Transcriptional misregulation in cancer
Autoimmune thyroid disease
Systemic lupus erythematosus
Rheumatoid arthritis
Allograft rejection
Graft-versus-host disease
Viral myocarditis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signaling molecules and interaction
   04514 Cell adhesion molecules (CAMs)
    K05413  CD86; CD86 antigen
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K05413  CD86; CD86 antigen
   04672 Intestinal immune network for IgA production
    K05413  CD86; CD86 antigen
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    K05413  CD86; CD86 antigen
  Immune diseases
   05322 Systemic lupus erythematosus
    K05413  CD86; CD86 antigen
   05323 Rheumatoid arthritis
    K05413  CD86; CD86 antigen
   05320 Autoimmune thyroid disease
    K05413  CD86; CD86 antigen
   05330 Allograft rejection
    K05413  CD86; CD86 antigen
   05332 Graft-versus-host disease
    K05413  CD86; CD86 antigen
  Cardiovascular diseases
   05416 Viral myocarditis
    K05413  CD86; CD86 antigen
  Endocrine and metabolic diseases
   04940 Type I diabetes mellitus
    K05413  CD86; CD86 antigen
  Infectious diseases
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K05413  CD86; CD86 antigen
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K05413  CD86; CD86 antigen
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Immune system
   B7-CD28 family
    CD28; CD28 antigen
     K05413 CD86; CD86 antigen
    CTLA4, CD152; cytotoxic T-lymphocyte-associated protein 4
     K05413 CD86; CD86 antigen
CD molecules [BR:ko04090]
 Proteins
  K05413  CD86; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
BRITE hierarchy
Genes
HSA: 
942(CD86)
PTR: 
470900(CD86)
PPS: 
100981251(CD86)
GGO: 
101139275(CD86)
PON: 
100432838(CD86)
NLE: 
100601902(CD86)
MCC: 
714390(CD86)
MCF: 
102147235(CD86)
CSAB: 
103228192(CD86)
RRO: 
104667916(CD86)
RBB: 
108541474(CD86)
CJC: 
100407388(CD86)
SBQ: 
101043934(CD86)
MMU: 
12524(Cd86)
RNO: 
56822(Cd86)
CGE: 
100769382(Cd86)
NGI: 
103741969(Cd86)
HGL: 
101724342(Cd86)
CCAN: 
109682249(Cd86)
OCU: 
100008999(CD86)
TUP: 
102478707(CD86)
CFA: 
403764(CD86)
AML: 
100483382(CD86)
UMR: 
103678768(CD86)
FCA: 
493704(CD86)
PTG: 
102954528(CD86)
AJU: 
106984101(CD86)
BTA: 
414345(CD86)
BOM: 
102275701(CD86)
BIU: 
109554436(CD86)
PHD: 
102327160(CD86)
CHX: 
102184760(CD86)
OAS: 
554318(CD86)
SSC: 
397441(CD86)
CFR: 
102521515(CD86)
CDK: 
105090303(CD86)
BACU: 
102998972(CD86)
LVE: 
103068685(CD86)
ECB: 
100060767(CD86)
EPZ: 
103548423(CD86)
EAI: 
106823736(CD86)
MYB: 
102256413(CD86)
MYD: 
102769844(CD86)
HAI: 
109386841(CD86)
RSS: 
109435884(CD86)
PALE: 
102897001(CD86)
LAV: 
100656594(CD86)
MDO: 
100018203(CD86)
SHR: 
100926378(CD86)
OAA: 
100086970(CD86)
GGA: 
427944(CD86)
MGP: 
100544635(CD86)
CJO: 
107319044(CD86)
APLA: 
ACYG: 
106049293(CD86)
TGU: 
100218239(CD86)
GFR: 
102039756(CD86)
FAB: 
101817056(CD86)
PHI: 
102114181(CD86)
PMAJ: 
107211329(CD86)
CCW: 
104687108(CD86)
FPG: 
101921390(CD86)
FCH: 
102052355(CD86)
CLV: 
102087829(CD86)
AAM: 
106497203(CD86)
ASN: 
102369398(CD86)
AMJ: 
102564301(CD86)
XLA: 
XTR: 
LCO: 
104940372(cd86)
MZE: 
OLA: 
LCM: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7694153
  Authors
Azuma M, Ito D, Yagita H, Okumura K, Phillips JH, Lanier LL, Somoza C
  Title
B70 antigen is a second ligand for CTLA-4 and CD28.
  Journal
Nature 366:76-9 (1993)
DOI:10.1038/366076a0
  Sequence
[hsa:942]
Reference
  Authors
Collins M, Ling V, Carreno BM
  Title
The B7 family of immune-regulatory ligands.
  Journal
Genome Biol 6:223 (2005)
DOI:10.1186/gb-2005-6-6-223

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