KEGG   ORTHOLOGY: K05459Help
Entry
K05459                      KO                                     

Name
IGF1
Definition
insulin-like growth factor 1
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
Ras signaling pathway
Rap1 signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
p53 signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Long-term depression
Inflammatory mediator regulation of TRP channels
Ovarian steroidogenesis
Progesterone-mediated oocyte maturation
Aldosterone-regulated sodium reabsorption
Pathways in cancer
Transcriptional misregulation in cancer
Proteoglycans in cancer
Glioma
Prostate cancer
Melanoma
Breast cancer
Hypertrophic cardiomyopathy (HCM)
Dilated cardiomyopathy (DCM)
Disease
H00015  
Malignant pleural mesothelioma
H00254  
Pituitary Dwarfism (PD)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04015 Rap1 signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04066 HIF-1 signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04068 FoxO signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04151 PI3K-Akt signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04152 AMPK signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04150 mTOR signaling pathway
    K05459  IGF1; insulin-like growth factor 1
 Cellular Processes
  Cell growth and death
   04114 Oocyte meiosis
    K05459  IGF1; insulin-like growth factor 1
   04115 p53 signaling pathway
    K05459  IGF1; insulin-like growth factor 1
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05459  IGF1; insulin-like growth factor 1
   04550 Signaling pathways regulating pluripotency of stem cells
    K05459  IGF1; insulin-like growth factor 1
 Organismal Systems
  Endocrine system
   04913 Ovarian Steroidogenesis
    K05459  IGF1; insulin-like growth factor 1
   04914 Progesterone-mediated oocyte maturation
    K05459  IGF1; insulin-like growth factor 1
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K05459  IGF1; insulin-like growth factor 1
  Nervous system
   04730 Long-term depression
    K05459  IGF1; insulin-like growth factor 1
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K05459  IGF1; insulin-like growth factor 1
  Aging
   04211 Longevity regulating pathway - mammal
    K05459  IGF1; insulin-like growth factor 1
   04213 Longevity regulating pathway - multiple species
    K05459  IGF1; insulin-like growth factor 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05459  IGF1; insulin-like growth factor 1
   05202 Transcriptional misregulation in cancers
    K05459  IGF1; insulin-like growth factor 1
   05205 Proteoglycans in cancer
    K05459  IGF1; insulin-like growth factor 1
   05214 Glioma
    K05459  IGF1; insulin-like growth factor 1
   05218 Melanoma
    K05459  IGF1; insulin-like growth factor 1
   05215 Prostate cancer
    K05459  IGF1; insulin-like growth factor 1
   05224 Breast cancer
    K05459  IGF1; insulin-like growth factor 1
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K05459  IGF1; insulin-like growth factor 1
   05414 Dilated cardiomyopathy (DCM)
    K05459  IGF1; insulin-like growth factor 1
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05459  IGF1; insulin-like growth factor 1
   01522 Endocrine resistance
    K05459  IGF1; insulin-like growth factor 1
Cytokines [BR:ko04052]
 PDGF family
  Other growth factors
   K05459  IGF1; insulin-like growth factor 1
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
3479(IGF1)
PTR: 
741055(IGF1)
PPS: 
100982978(IGF1)
GGO: 
101154397(IGF1)
PON: 
100444645(IGF1)
NLE: 
100595306(IGF1)
MCC: 
698444(IGF1)
MCF: 
102128018(IGF1)
CSAB: 
103238957(IGF1)
RRO: 
104657459(IGF1)
RBB: 
108543134(IGF1)
CJC: 
100394985(IGF1)
SBQ: 
101036963(IGF1)
MMU: 
16000(Igf1)
RNO: 
24482(Igf1)
CGE: 
100751642(Igf1)
NGI: 
103733723(Igf1)
HGL: 
101707684(Igf1)
CCAN: 
OCU: 
100008668(IGF1)
TUP: 
102490248(IGF1)
CFA: 
610255(IGF1)
AML: 
100473254(IGF1)
UMR: 
103676495(IGF1)
FCA: 
101101237(IGF1)
PTG: 
102962543(IGF1)
AJU: 
106971906(IGF1)
BTA: 
281239(IGF1)
BOM: 
102272009(IGF1)
BIU: 
109559448(IGF1)
PHD: 
102318534(IGF1)
CHX: 
100860838(IGF1)
OAS: 
443318(IGF1)
SSC: 
397491(IGF1)
CFR: 
102506236(IGF1)
CDK: 
105097468(IGF1)
BACU: 
103014780(IGF1)
LVE: 
103078928(IGF1)
ECB: 
100034198(IGF1)
EPZ: 
103549360(IGF1)
EAI: 
106827264(IGF1)
MYB: 
102252071(IGF1)
MYD: 
102752580(IGF1)
HAI: 
109387785(IGF1)
RSS: 
109447628(IGF1)
PALE: 
102890331(IGF1)
LAV: 
100664710(IGF1)
MDO: 
100021295(IGF1)
SHR: 
100918816(IGF1)
OAA: 
100075905(IGF1)
GGA: 
418090(IGF1)
MGP: 
678666(IGF1)
CJO: 
107316281(IGF1)
APLA: 
101793597(IGF1)
ACYG: 
106035916(IGF1)
TGU: 
100226283(IGF1)
GFR: 
102032215(IGF1)
FAB: 
101808710(IGF1)
PHI: 
102112946(IGF1)
PMAJ: 
107204610(IGF1)
CCW: 
104696228(IGF1)
FPG: 
101922655(IGF1)
FCH: 
102060062(IGF1)
CLV: 
102092089(IGF1)
AAM: 
106488383(IGF1)
ASN: 
102372626(IGF1)
AMJ: 
102559209(IGF1)
PSS: 
102454948(IGF1)
CMY: 
102932263(IGF1)
CPIC: 
101939474(IGF1)
ACS: 
100566682(igf1)
PVT: 
110084792(IGF1)
PBI: 
103062109(IGF1)
GJA: 
107119991(IGF1)
XLA: 
108711020(igf1.L) 108712492 378699(igf1.S)
XTR: 
100486334(igf1)
NPR: 
108789614(IGF1)
DRE: 
114433(igf1)
SRX: 
SANH: 
SGH: 
IPU: 
100305062(igf1)
TRU: 
100462939(igf1)
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
108931632(igf1)
LCM: 
CMK: 
103179868(igf1)
CIN: 
100170003(ins-l1)
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD28130(Dsim_GD28130)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AME: 
BIM: 
BTER: 
SOC: 
AEC: 
HST: 
105186969(Insulin)
CFO: 
PGC: 
BMOR: 
100147697(Bbx-c2) 100169656(Bbx-b11) 100169718(Bbx-b8) 100169722(Bbx-b3) 100169724(Bbx-b5) 100270769(Igflp)
API: 
LGI: 
CRG: 
SMM: 
SHX: 
NVE: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3002851
  Authors
de Pagter-Holthuizen P, van Schaik FM, Verduijn GM, van Ommen GJ, Bouma BN, Jansen M, Sussenbach JS
  Title
Organization of the human genes for insulin-like growth factors I and II.
  Journal
FEBS Lett 195:179-84 (1986)
DOI:10.1016/0014-5793(86)80156-9
  Sequence
[hsa:3479]
Reference
  Authors
Zoidis E, Ghirlanda-Keller C, Schmid C
  Title
Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulin-like growth factor I.
  Journal
Mol Cell Biochem 348:33-42 (2011)
DOI:10.1007/s11010-010-0634-z
  Sequence
[hsa:3479]

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