KEGG   ORTHOLOGY: K05699Help
Entry
K05699                      KO                                     

Name
ACTN1_4
Definition
actinin alpha 1/4
Pathway
Focal adhesion
Adherens junction
Tight junction
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
Amoebiasis
Viral carcinogenesis
Systemic lupus erythematosus
Disease
H00626  
Focal segmental glomerulosclerosis
H01740  
Macrothrombocytopenia
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05699  ACTN1_4; actinin alpha 1/4
   04520 Adherens junction
    K05699  ACTN1_4; actinin alpha 1/4
   04530 Tight junction
    K05699  ACTN1_4; actinin alpha 1/4
  Cell motility
   04810 Regulation of actin cytoskeleton
    K05699  ACTN1_4; actinin alpha 1/4
 Organismal Systems
  Immune system
   04670 Leukocyte transendothelial migration
    K05699  ACTN1_4; actinin alpha 1/4
 Human Diseases
  Cancers
   05203 Viral carcinogenesis
    K05699  ACTN1_4; actinin alpha 1/4
  Immune diseases
   05322 Systemic lupus erythematosus
    K05699  ACTN1_4; actinin alpha 1/4
  Infectious diseases
   05146 Amoebiasis
    K05699  ACTN1_4; actinin alpha 1/4
Membrane trafficking [BR:ko04131]
 Exocytosis
  Small GTPases and associated proteins
   Rab associated proteins
    K05699  ACTN1_4; actinin alpha 1/4
Cytoskeleton proteins [BR:ko04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Cross-linking proteins
     K05699  ACTN1_4; actinin alpha 1/4
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K05699  ACTN1_4; actinin alpha 1/4
  Exosomal proteins of colorectal cancer cells
   K05699  ACTN1_4; actinin alpha 1/4
  Exosomal proteins of bladder cancer cells
   K05699  ACTN1_4; actinin alpha 1/4
BRITE hierarchy
Genes
HSA: 
81(ACTN4) 87(ACTN1)
PTR: 
452993(ACTN1) 456010(ACTN4)
PPS: 
100979183(ACTN1) 100981951(ACTN4)
GGO: 
101138551(ACTN1) 101144840(ACTN4)
PON: 
100174343(ACTN4) 100460195(ACTN1)
NLE: 
100588862(ACTN4) 100596303(ACTN1)
MCC: 
693666(ACTN4) 711994(ACTN1)
MCF: 
102125329(ACTN4) 102127552(ACTN1)
CSAB: 
103229232(ACTN1) 103234638(ACTN4)
RRO: 
104659630(ACTN1) 104679965(ACTN4)
RBB: 
108533731(ACTN1) 108539029(ACTN4)
CJC: 
100392168(ACTN4) 100406377(ACTN1)
SBQ: 
101039348(ACTN1) 101050047(ACTN4)
MMU: 
109711(Actn1) 60595(Actn4)
RNO: 
63836(Actn4) 81634(Actn1)
CGE: 
100755831(Actn1) 100766890(Actn4)
NGI: 
103749304(Actn1) 103750716(Actn4)
HGL: 
101710271(Actn4) 101711839(Actn1)
CCAN: 
109685991 109685993 109695844(Actn4)
OCU: 
100341378(ACTN1) 100351066(ACTN4)
TUP: 
102493901(ACTN4) 102494430(ACTN1)
CFA: 
480369(ACTN1) 484526(ACTN4)
AML: 
100467263(ACTN4) 100472341(ACTN1)
UMR: 
103661071(ACTN4) 103674291(ACTN1)
FCA: 
101093978(ACTN4) 101097986(ACTN1)
PTG: 
102963733(ACTN4) 102965456(ACTN1)
AJU: 
106971540(ACTN1) 106980245(ACTN4)
BTA: 
522269(ACTN4) 524770(ACTN1)
BOM: 
102275865(ACTN4) 102287647(ACTN1)
BIU: 
109565282(ACTN1) 109572506(ACTN4)
PHD: 
102336545(ACTN1) 102343227(ACTN4)
CHX: 
102176966(ACTN1) 102179802(ACTN4)
OAS: 
101111737(ACTN4) 101122194(ACTN1)
SSC: 
100513412(ACTN1) 100517284(ACTN4)
CFR: 
102511098(ACTN4) 102515180(ACTN1)
CDK: 
105086159(ACTN1) 105101782(ACTN4)
BACU: 
103010879(ACTN1) 103018854(ACTN4)
LVE: 
103070717(ACTN4) 103088628(ACTN1)
ECB: 
100053070(ACTN1) 100066343(ACTN4)
EPZ: 
103540812(ACTN4) 103547163(ACTN1)
EAI: 
106836069(ACTN4) 106843321(ACTN1)
MYB: 
102247194(ACTN1) 102250785(ACTN4)
MYD: 
102762055(ACTN4) 102773341(ACTN1)
HAI: 
109382080(ACTN1) 109395369(ACTN4)
RSS: 
109448310(ACTN1) 109458056(ACTN4)
PALE: 
102884236(ACTN4) 102887929(ACTN1)
LAV: 
100655307(ACTN4) 100661051(ACTN1)
MDO: 
100010983(ACTN4) 100023431(ACTN1)
SHR: 
100917501(ACTN4) 100924961(ACTN1)
OAA: 
100089387
GGA: 
373918(ACTN1) 396024(ACTN4)
MGP: 
100539916(ACTN1) 100547916
CJO: 
107307545 107314914
APLA: 
101795217(ACTN1)
ACYG: 
106031661(ACTN1)
TGU: 
100221879(ACTN1)
GFR: 
102033981 102042336(ACTN1)
FAB: 
101814028(ACTN1)
PHI: 
102100036(ACTN4) 102100480(ACTN1) 102102229
PMAJ: 
107206008(ACTN1)
CCW: 
104683694(ACTN1)
FPG: 
101912082(ACTN1)
FCH: 
102048669(ACTN1) 102059725
CLV: 
102088244(ACTN1) 102090066
AAM: 
106496060 106498254(ACTN1)
ASN: 
102378883(ACTN4) 102381557(ACTN1)
AMJ: 
102573872(ACTN4) 106736747(ACTN1)
PSS: 
102451042(ACTN4) 102453609(ACTN1)
CMY: 
102929632(ACTN4) 102932714(ACTN1)
CPIC: 
101932600(ACTN4) 101945411(ACTN1)
ACS: 
100553987(actn1) 100566396(actn4)
PVT: 
110075766(ACTN4) 110076389(ACTN1)
PBI: 
103053907(ACTN1) 103054269(ACTN4)
GJA: 
107106834(ACTN4) 107112209(ACTN1)
XLA: 
399422(actn1.L) 431885 446865(actn4.S) 734930
XTR: 
448522(actn4) 780123(actn1)
NPR: 
108794113(ACTN1) 108804987(ACTN4)
DRE: 
322221(actn4) 560400(actn1)
SRX: 
107705429 107722172 107731815 107731818 107737420 107739883
SANH: 
107654957 107669904 107680897
SGH: 
107553176 107558830 107570110 107580606 107602958
IPU: 
108261236 108280413(actn4)
AMEX: 
103022122(actn4) 103031817(actn1)
TRU: 
101075286 101078391(actn4)
TNG: 
GSTEN00012749G001 GSTEN00026683G001
LCO: 
104927498(actn4) 104929780(actn1) 109142870 109142913
NCC: 
104948803 104960263 104961894
MZE: 
101467576(actn4) 101469024(actn1)
OLA: 
101155449 101169077(actn1)
XMA: 
102222656(actn4) 102233488
CSEM: 
103377927(actn4) 103381068(actn1)
LCF: 
108872698 108886695
HCQ: 
109517259 109529370(actn4)
BPEC: 
110157588(actn1) 110165853
SASA: 
100380299(actn1) 106580854(actn4) 106600942 106612603
ELS: 
105025529 105026813(actn4)
SFM: 
108919448(actn1) 108924087 108928746(actn4)
LCM: 
102356889(ACTN4) 102358724(ACTN1)
CMK: 
103175234(actn1) 103190613
BFO: 
BRAFLDRAFT_275861
SPU: 
592971
SKO: 
100374060
DME: 
Dmel_CG4376(Actn)
DPO: 
Dpse_GA18143
DAN: 
Dana_GF21987
DER: 
Dere_GG12661
DPE: 
Dper_GL15130
DSE: 
Dsec_GM18928
DSI: 
Dsimw501_GD28856(Dsim_GD28856)
DWI: 
Dwil_GK25747
DYA: 
Dyak_GE16989
DGR: 
Dgri_GH24410
DMO: 
Dmoj_GI15429
DVI: 
Dvir_GJ16390
MDE: 
101887563
AGA: 
AgaP_AGAP001497(ACTN_ANOGA)
AAG: 
AaeL_AAEL007306
CQU: 
CpipJ_CPIJ019577
AME: 
725782(Actn)
BIM: 
100749119
BTER: 
100652204
SOC: 
105201176
AEC: 
105146320
ACEP: 
105620710
PBAR: 
105426241
HST: 
105189773
CFO: 
105250976
LHU: 
105673416
PGC: 
109863707
NVI: 
100118107
TCA: 
661042
DPA: 
109535688
NVL: 
108556321
BMOR: 
101742794
DPL: 
KGM_206602
PXY: 
105380431 105397193
API: 
100159279
DNX: 
107170710
PHU: 
Phum_PHUM299510
FCD: 
110844414
DPX: 
DAPPUDRAFT_99081
ISC: 
IscW_ISCW013566
TUT: 
107360403
CEL: 
CELE_W04D2.1(atn-1)
CBR: 
CBG23504(Cbr-atn-1)
NAI: 
NECAME_05472
BMY: 
Bm1_51465
LOA: 
LOAG_17738
TSP: 
Tsp_06092
HRO: 
HELRODRAFT_187038 HELRODRAFT_93275 HELRODRAFT_97639
LGI: 
LOTGIDRAFT_189716
CRG: 
105326760
OBI: 
106875711
LAK: 
106156043
SMM: 
Smp_034550
SHX: 
MS3_00361 MS3_04427
OVI: 
T265_02869 T265_07209
NVE: 
NEMVE_v1g206855
ADF: 
107344902
HMG: 
100215556
TAD: 
TRIADDRAFT_37811
AQU: 
100633045
SRE: 
PTSG_01737 PTSG_11778
DPP: 
DICPUDRAFT_54845
DFA: 
DFA_04278(abpA)
AAF: 
AURANDRAFT_61736
NGR: 
NAEGRDRAFT_56285
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2349951
  Authors
Youssoufian H, McAfee M, Kwiatkowski DJ
  Title
Cloning and chromosomal localization of the human cytoskeletal alpha-actinin gene reveals linkage to the beta-spectrin gene.
  Journal
Am J Hum Genet 47:62-72 (1990)
  Sequence
[hsa:87]
Reference
  Authors
Nikolopoulos SN, Spengler BA, Kisselbach K, Evans AE, Biedler JL, Ross RA
  Title
The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells.
  Journal
Oncogene 19:380-6 (2000)
DOI:10.1038/sj.onc.1203310
  Sequence
[hsa:81]
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