KEGG   ORTHOLOGY: K05854Help
Entry
K05854                      KO                                     

Name
LYN
Definition
tyrosine-protein kinase Lyn [EC:2.7.10.2]
Pathway
ko04062  Chemokine signaling pathway
ko04064  NF-kappa B signaling pathway
ko04611  Platelet activation
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04730  Long-term depression
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05167  Kaposi's sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05203  Viral carcinogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04064 NF-kappa B signaling pathway
    K05854  LYN; tyrosine-protein kinase Lyn
 Organismal Systems
  Immune system
   04611 Platelet activation
    K05854  LYN; tyrosine-protein kinase Lyn
   04662 B cell receptor signaling pathway
    K05854  LYN; tyrosine-protein kinase Lyn
   04664 Fc epsilon RI signaling pathway
    K05854  LYN; tyrosine-protein kinase Lyn
   04666 Fc gamma R-mediated phagocytosis
    K05854  LYN; tyrosine-protein kinase Lyn
   04062 Chemokine signaling pathway
    K05854  LYN; tyrosine-protein kinase Lyn
  Nervous system
   04730 Long-term depression
    K05854  LYN; tyrosine-protein kinase Lyn
 Human Diseases
  Cancers
   05203 Viral carcinogenesis
    K05854  LYN; tyrosine-protein kinase Lyn
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K05854  LYN; tyrosine-protein kinase Lyn
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K05854  LYN; tyrosine-protein kinase Lyn
   05169 Epstein-Barr virus infection
    K05854  LYN; tyrosine-protein kinase Lyn
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K05854  LYN; tyrosine-protein kinase Lyn
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  SRC family
   K05854  LYN; tyrosine-protein kinase Lyn
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    K05854  LYN; tyrosine-protein kinase Lyn
BRITE hierarchy
Other DBs
GO: 0004715 0004716
Genes
HSA: 4067(LYN)
PTR: 472771(LYN)
PPS: 100996017(LYN)
GGO: 101145340(LYN)
PON: 100447326(LYN)
NLE: 100593961(LYN)
MCC: 698553(LYN)
MCF: 102118154(LYN)
CSAB: 103236819(LYN)
RRO: 104661780(LYN)
RBB: 108521691(LYN)
CJC: 100390096(LYN)
SBQ: 101036887(LYN)
MMU: 17096(Lyn) 666513(Gm11787)
RNO: 81515(Lyn)
CGE: 100754828(Lyn)
NGI: 103734185(Lyn)
HGL: 101696753(Lyn)
CCAN: 109696666(Lyn)
OCU: 100340056(LYN)
TUP: 102493585(LYN)
CFA: 477886(LYN)
AML: 100479606(LYN)
UMR: 103677438(LYN)
ORO: 101383639(LYN)
FCA: 101096633(LYN)
PTG: 102957150(LYN)
AJU: 106982528(LYN)
BTA: 534996(LYN)
BOM: 102276698(LYN)
BIU: 109568555(LYN)
PHD: 102335849(LYN)
CHX: 102184639(LYN)
OAS: 100302103(LYN)
SSC: 100152890(LYN)
CFR: 102515625(LYN)
CDK: 105097055(LYN)
BACU: 103001606(LYN)
LVE: 103074440(LYN)
OOR: 101280666(LYN)
ECB: 100053129(LYN)
EPZ: 103552502(LYN)
EAI: 106841654(LYN)
MYB: 102262917(LYN)
MYD: 102755397(LYN)
HAI: 109394449(LYN)
RSS: 109434266(LYN)
PALE: 102880204(LYN)
LAV: 100673903(LYN)
TMU: 101353037
MDO: 100616821(LYN)
SHR: 100929196(LYN)
OAA: 100079507(LYN)
GGA: 421127(LYN)
MGP: 100550537(LYN)
CJO: 107310194(LYN)
APLA: 101803881(LYN)
ACYG: 106039045(LYN)
TGU: 100230728(LYN)
GFR: 102032206(LYN)
FAB: 101812689(LYN)
PHI: 102103954(LYN)
PMAJ: 107200243(LYN)
CCW: 104690380(LYN)
FPG: 101914020(LYN)
FCH: 102048730(LYN)
CLV: 102084226(LYN)
EGZ: 104127723(LYN)
AAM: 106494468(LYN)
ASN: 102383816(LYN)
AMJ: 102566940(LYN)
PSS: 102462919(LYN)
CMY: 102931818(LYN)
CPIC: 101950325(LYN)
ACS: 100554372(lyn)
PVT: 110089695(LYN)
PBI: 103061071 103063509(LYN)
GJA: 107113876(LYN)
XLA: 108695301(lyn.S) 373649(lyn.L)
XTR: 549989(lyn)
NPR: 108789967(LYN)
DRE: 447804(lyn)
TRU: 101072875
LCO: 104929874(lyn)
NCC: 104963253
MZE: 101477890
OLA: 101167902
XMA: 102235662
PRET: 103478918
NFU: 107384206
LCF: 108883973
HCQ: 109515497
BPEC: 110170453
SASA: 100196779(lyn) 106569254
ELS: 105022707(lyn)
SFM: 108929639(lyn) 108937715
LCM: 102360998(LYN)
CMK: 103177046(lyn)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3561390
  Authors
Yamanashi Y, Fukushige S, Semba K, Sukegawa J, Miyajima N, Matsubara K, Yamamoto T, Toyoshima K
  Title
The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck.
  Journal
Mol Cell Biol 7:237-43 (1987)
DOI:10.1128/MCB.7.1.237
  Sequence
[hsa:4067]
Reference
  Authors
Gaul BS, Harrison ML, Geahlen RL, Burton RA, Post CB
  Title
Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor.
  Journal
J Biol Chem 275:16174-82 (2000)
DOI:10.1074/jbc.M909044199

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