ko:K06239 : No such data.
ko:K06242 : No such data.

KEGG   ORTHOLOGY: K06236Help
Entry
K06236                      KO                                     

Name
COL1A
Definition
collagen, type I, alpha
Pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko04611  Platelet activation
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04974  Protein digestion and absorption
ko05146  Amoebiasis
ko05165  Human papillomavirus infection
Disease
H00506  Osteogenesis imperfecta
H00613  Infantile cortical hyperostosis
H00802  Ehlers-Danlos syndrome (EDS)
H01593  Osteoporosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06236  COL1A; collagen, type I, alpha
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06236  COL1A; collagen, type I, alpha
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06236  COL1A; collagen, type I, alpha
 Organismal Systems
  Immune system
   04611 Platelet activation
    K06236  COL1A; collagen, type I, alpha
  Endocrine system
   04926 Relaxin signaling pathway
    K06236  COL1A; collagen, type I, alpha
  Digestive system
   04974 Protein digestion and absorption
    K06236  COL1A; collagen, type I, alpha
 Human Diseases
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K06236  COL1A; collagen, type I, alpha
  Infectious diseases
   05165 Human papillomavirus infection
    K06236  COL1A; collagen, type I, alpha
   05146 Amoebiasis
    K06236  COL1A; collagen, type I, alpha
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta1 integrins
   VLA-1
    ITGB1; integrin beta 1
     K06236 COL1A; collagen, type I, alpha
   VLA-2
    ITGB1; integrin beta 1
     K06236 COL1A; collagen, type I, alpha
   alpha 11 beta 1
    ITGB1; integrin beta 1
     K06236 COL1A; collagen, type I, alpha
 4. Link Protein Family
  CD44; CD44 antigen
   K06236 COL1A; collagen, type I, alpha
 7. Others
  SDC1; syndecan 1
   K06236 COL1A; collagen, type I, alpha
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Extracellular matrix molecules
   K06236  COL1A; collagen, type I, alpha
BRITE hierarchy
Genes
HSA: 1277(COL1A1) 1278(COL1A2)
PTR: 104001053(COL1A1) 455117(COL1A2)
PPS: 100974826(COL1A2) 100991060(COL1A1)
GGO: 101130610(COL1A1) 101142769(COL1A2) 101143179
PON: 100438152(COL1A1) 100439107(COL1A2)
NLE: 100595865(COL1A2) 100604090(COL1A1) 101176823 101177005 101177525 105740205
MCC: 574201(COL1A1) 700359(COL1A2)
MCF: 102128759(COL1A1) 102130586(COL1A2)
CSAB: 103226536(COL1A2) 103239937 103242558 103242943(COL1A1) 103243832 103243871
RRO: 104680270(COL1A1) 104682783(COL1A2)
RBB: 108516437(COL1A1) 108517180(COL1A2)
CJC: 100386176(COL1A1) 100411438(COL1A2)
SBQ: 101045518(COL1A2) 101051510(COL1A1) 104651959
MMU: 12842(Col1a1) 12843(Col1a2)
RNO: 103689932(NEWGENE_621351) 29393(Col1a1) 84352(Col1a2)
CGE: 100759814(Col1a1) 100766269(Col1a2)
NGI: 103725222(Col1a2) 103738382(Col1a1)
HGL: 101703193(Col1a1) 101722393(Col1a2) 101726257
OCU: 100008997(COL1A2) 100347598(COL1A1) 103351483
TUP: 102469999(COL1A1) 102495359 102496034(COL1A2)
CFA: 403651(COL1A1) 403824(COL1A2)
AML: 100474885(COL1A2) 100476237(COL1A1)
UMR: 103658736(COL1A2) 103660945(COL1A1) 103675284
ORO: 101368204(COL1A1) 101374645(COL1A2) 105757367
FCA: 101089428(COL1A2) 101092216(COL1A1) 102901092 105261147
PTG: 102967512(COL1A1) 102971076(COL1A2)
AJU: 106969999(COL1A2) 106985166(COL1A1)
BTA: 282187(COL1A1) 282188(COL1A2)
BOM: 102265105(COL1A1) 102267202(COL1A2)
BIU: 109558214(COL1A2) 109573749(COL1A1) 109575219
PHD: 102324664(COL1A2) 102328226
SSC: 100626716(COL1A2) 100738123(COL1A1)
CFR: 102510097(COL1A1) 102520737(COL1A2)
CDK: 105088734(COL1A2) 105104820(COL1A1)
OOR: 101278764(COL1A1) 101289458(COL1A2)
ECB: 100033877(COL1A1) 100051715(COL1A2)
EPZ: 103549571(COL1A1) 103553631(COL1A2)
EAI: 106826321(COL1A1) 106838933(COL1A2)
MYB: 102253918(COL1A2) 102259707(COL1A1)
MYD: 102770947(COL1A2) 102772822(COL1A1)
HAI: 109371948(COL1A2) 109379905 109380648(COL1A1)
RSS: 109446389(COL1A2) 109447012(COL1A1)
PALE: 102878069(COL1A2) 102886463(COL1A1)
LAV: 100668620(COL1A2) 100671297(COL1A1)
MDO: 100019354(COL1A1)
SHR: 100916041(COL1A2) 100924667(COL1A1)
OAA: 100078516 100079519(COL1A1) 100681278(COL1A2)
GGA: 395532(COL1A1) 396243(COL1A2)
MGP: 100540436(COL1A2)
CJO: 107309082(COL1A2) 107325218(COL1A1)
APLA: 101794718(COL1A2) 101800457(COL1A1)
TGU: 100221003(COL1A2)
GFR: 102033823(COL1A2) 102034431
PHI: 102100227(COL1A2) 102104738(COL1A1) 106628211
PMAJ: 107199012(COL1A1) 107200743(COL1A2) 107211448
CCW: 104689333(COL1A2)
FPG: 101921645(COL1A2) 101924780(COL1A1)
FCH: 102046312(COL1A1) 102047033(COL1A2)
CLV: 102090396(COL1A2) 102092022(COL1A1)
EGZ: 104129008(COL1A2) 104131410
ASN: 102372309(COL1A2) 102376361(COL1A1)
AMJ: 102565404(COL1A1) 102568819(COL1A2)
PSS: 102445411(COL1A1) 102457083(COL1A2) 106732816
CPIC: 101942871(COL1A2) 101946870 101949941(COL1A1)
ACS: 100559991(col1a2) 100565711(col1a1)
PVT: 110074712(COL1A2) 110079135(COL1A1)
PBI: 103053762(COL1A2) 103055359(COL1A1)
GJA: 107112523(COL1A1) 107118003(COL1A2) 107125148
XLA: 108700840(col1a1.L) 108719903(col1a2.S) 380419(col1a2.L) 380515(col1a1.S)
XTR: 496414(col1a1) 780175(col1a2)
NPR: 108784001(COL1A1) 108786596 108790501(COL1A2)
DRE: 325675(col1a1b) 336471(col1a2) 337158(col1a1a)
MZE: 101475669 101476419(col1a1) 101486099(col1a2)
OLA: 100144368(col1) 101162163 105355091(col1a2)
XMA: 102219489(col1a2) 102229978 102232000(col1a1)
LCM: 102345189(COL1A2) 102349893(COL1A1)
CMK: 103190072
API: 100168286
DNX: 107169478
CRG: 105325221
AQU: 100638905
ZMA: 107181290
ABP: AGABI1DRAFT114760(AGABI1DRAFT_114760)
SALS: SLNWT_4907
STRE: GZL_07344
SLX: SLAV_20100(bag)
PSEE: FRP1_19170
AFS: AFR_26810
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2394758
  Authors
Weil D, D'Alessio M, Ramirez F, Eyre DR
  Title
Structural and functional characterization of a splicing mutation in the pro-alpha 2(I) collagen gene of an Ehlers-Danlos type VII patient.
  Journal
J Biol Chem 265:16007-11 (1990)
  Sequence
[hsa:1278]

KEGG   ORTHOLOGY: K06237Help
Entry
K06237                      KO                                     

Name
COL4A
Definition
collagen, type IV, alpha
Pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04974  Protein digestion and absorption
ko05146  Amoebiasis
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05222  Small cell lung cancer
Disease
H00579  Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC)
H00581  Alport syndrome
H00582  Benign familial hematuria
H00839  Porencephaly
H00877  Brain small vessel disease with hemorrhage
H01640  Uterine leiomyoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06237  COL4A; collagen, type IV, alpha
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06237  COL4A; collagen, type IV, alpha
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06237  COL4A; collagen, type IV, alpha
 Organismal Systems
  Endocrine system
   04926 Relaxin signaling pathway
    K06237  COL4A; collagen, type IV, alpha
  Digestive system
   04974 Protein digestion and absorption
    K06237  COL4A; collagen, type IV, alpha
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06237  COL4A; collagen, type IV, alpha
   05222 Small cell lung cancer
    K06237  COL4A; collagen, type IV, alpha
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K06237  COL4A; collagen, type IV, alpha
  Infectious diseases
   05165 Human papillomavirus infection
    K06237  COL4A; collagen, type IV, alpha
   05146 Amoebiasis
    K06237  COL4A; collagen, type IV, alpha
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other cancer cells
   K06237  COL4A; collagen, type IV, alpha
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta1 integrins
   VLA-1
    ITGB1; integrin beta 1
     K06237 COL4A; collagen, type IV, alpha
   VLA-2
    ITGB1; integrin beta 1
     K06237 COL4A; collagen, type IV, alpha
   VLA-3
    ITGB1; integrin beta 1
     K06237 COL4A; collagen, type IV, alpha
   alpha 10 beta 1
    ITGB1; integrin beta 1
     K06237 COL4A; collagen, type IV, alpha
   alpha 11 beta 1
    ITGB1; integrin beta 1
     K06237 COL4A; collagen, type IV, alpha
  Beta8 integrins
   alpha V beta 8
    ITGB8; integrin beta 8
     K06237 COL4A; collagen, type IV, alpha
 4. Link Protein Family
  CD44; CD44 antigen
   K06237 COL4A; collagen, type IV, alpha
 7. Others
  APP; amyloid beta A4 protein
   K06237 COL4A; collagen, type IV, alpha
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Extracellular matrix molecules
   K06237  COL4A; collagen, type IV, alpha
BRITE hierarchy
Genes
HSA: 1282(COL4A1) 1284(COL4A2) 1285(COL4A3) 1286(COL4A4) 1287(COL4A5) 1288(COL4A6)
PTR: 452659(COL4A1) 452661(COL4A2) 459986(COL4A4) 459988(COL4A3) 465804(COL4A6) 465805(COL4A5)
PPS: 100972511(COL4A4) 100972868(COL4A3) 100976901(COL4A1) 100977235(COL4A2) 100983653(COL4A6) 100984686(COL4A5)
GGO: 101128311(COL4A1) 101130790(COL4A6) 101133910(COL4A5) 101136942(COL4A4) 101137308(COL4A3) 101149355(COL4A2)
PON: 100443710(COL4A4) 100444077(COL4A3) 100444160(COL4A1) 100444523(COL4A2) 100457450(COL4A6) 100457807(COL4A5)
NLE: 100584285(COL4A2) 100587255(COL4A6) 100588259(COL4A5) 100598507(COL4A4) 100598848(COL4A3) 100603791(COL4A1) 105739830
MCC: 100429807(COL4A2) 700281(COL4A1) 703707(COL4A6) 703814(COL4A5) 708287(COL4A4) 712444(COL4A3)
MCF: 102118598(COL4A4) 102122146(COL4A3) 102122606(COL4A1) 102125366(COL4A6) 102127262(COL4A5) 102131342(COL4A2)
CSAB: 103214793(COL4A2) 103214795(COL4A1) 103217991(COL4A3) 103217992(COL4A4) 103232468(COL4A5) 103232470(COL4A6)
RRO: 104658850(COL4A6) 104665145 104671965(COL4A3) 104671966(COL4A4) 104676252 104679242(COL4A1) 104679243(COL4A2) 104681889(COL4A5)
RBB: 108522717 108527057(COL4A1) 108527058(COL4A2) 108534853 108538728(COL4A3) 108538749(COL4A4) 108541576(COL4A5) 108544815
CJC: 100388461(COL4A4) 100388823(COL4A3) 100394953(COL4A6) 100400812(COL4A1) 100405184(COL4A2) 100409842(COL4A5)
SBQ: 101034927(COL4A3) 101035241(COL4A4) 101035708(COL4A5) 101038957(COL4A1) 101044518(COL4A2) 101051846(COL4A6)
MMU: 12826(Col4a1) 12827(Col4a2) 12828(Col4a3) 12829(Col4a4) 12830(Col4a5) 94216(Col4a6)
RNO: 102557498 290905(Col4a1) 306628(Col4a2) 363265(Col4a3) 363457(Col4a5) 363458(Col4a6)
CGE: 100756006 100757740(Col4a1) 100766914 100772575 100772869(Col4a6) 103158667(Col4a3) 107976999(Col4a2)
NGI: 103727826(Col4a4) 103727827(Col4a3) 103735559 103736928 103750029(Col4a6) 103750063(Col4a5) 103751683(Col4a2) 103751684(Col4a1)
HGL: 101709004(Col4a3) 101709338(Col4a5) 101709839(Col4a4) 101710396(Col4a6) 101718501(Col4a1) 101721657(Col4a2)
OCU: 100338437(COL4A6) 100357427(COL4A5) 100357900(COL4A4) 100358256(COL4A1) 100358522(COL4A2) 108176892(COL4A3)
TUP: 102478229(COL4A3) 102479923(COL4A1) 102480773(COL4A2) 102486100(COL4A5) 102489000(COL4A6) 102494131(COL4A4)
CFA: 403466(COL4A5) 403496(COL4A1) 403840(COL4A6) 403841(COL4A4) 403842(COL4A3) 403843(COL4A2)
AML: 100478660(COL4A3) 100478752(COL4A1) 100478914(COL4A4) 100479004(COL4A2) 100479688(COL4A6) 100480195(COL4A5)
UMR: 103657624(COL4A2) 103657625(COL4A1) 103662858(COL4A3) 103662859(COL4A4) 103668926(COL4A5) 103668927(COL4A6) 103679771
ORO: 101366517(COL4A3) 101367094(COL4A4) 101373537(COL4A5) 101373882(COL4A6) 101378777(COL4A1) 101381103(COL4A2)
FCA: 101087512(COL4A3) 101089498(COL4A6) 101091469(COL4A4) 101093002(COL4A5) 101096030(COL4A1) 101096282(COL4A2)
PTG: 102951304(COL4A6) 102951890(COL4A5) 102962233(COL4A4) 102965883(COL4A3) 102965922(COL4A2) 102966202(COL4A1)
AJU: 106967336(COL4A6) 106967337(COL4A5) 106972295(COL4A3) 106972327(COL4A4) 106973151 106986354(COL4A2) 106986355(COL4A1)
BTA: 282191(COL4A1) 317711(COL4A3) 407107(COL4A4) 508632(COL4A2) 511602(COL4A5) 523526(COL4A6)
BOM: 102265778(COL4A4) 102271607(COL4A5) 102272072(COL4A6) 102282491(COL4A2) 102282767(COL4A1) 102285223(COL4A3)
BIU: 109555197(COL4A6) 109555345(COL4A5) 109566959(COL4A1) 109567101(COL4A2) 109571374(COL4A3) 109575895(COL4A4)
PHD: 102315075(COL4A5) 102342203(COL4A1) 102342560(COL4A2) 102343336(COL4A3) 102343687(COL4A4) 102344964(COL4A6)
CHX: 102171079(COL4A1) 102171347(COL4A2) 102176677(COL4A6) 102176947(COL4A5) 102190083(COL4A4) 102190364(COL4A3) 108633195
OAS: 101102790(COL4A3) 101112706(COL4A5) 101113128(COL4A6) 101115552(COL4A1) 101115805 101118172(COL4A4)
SSC: 100153454(COL4A2) 100515336(COL4A1) 100620724(COL4A6) 100621403(COL4A4) 100621504(COL4A3) 100737091(COL4A5)
CFR: 102508830(COL4A2) 102509068(COL4A1) 102520494(COL4A6) 102521464(COL4A5) 102524319(COL4A3) 102524585(COL4A4)
CDK: 105088289(COL4A4) 105088300(COL4A3) 105094076(COL4A2) 105094077 105094080(COL4A1) 105095427(COL4A6) 105099555(COL4A5) 105099557
BACU: 103009501(COL4A5) 103009884(COL4A1) 103009983(COL4A6) 103010470(COL4A2) 103010606(COL4A4) 103020723(COL4A3)
LVE: 103070575(COL4A6) 103074830(COL4A3) 103078804(COL4A4) 103088369(COL4A1) 103089438(COL4A2) 103091674(COL4A5)
OOR: 101270978(COL4A3) 101276186(COL4A2) 101278113(COL4A4) 101280233(COL4A1) 101289595(COL4A6) 101289846(COL4A5)
ECB: 100037402(COL4A3) 100054545(COL4A5) 100060112(COL4A6) 100062160(COL4A4) 100066148(COL4A1) 100066264(COL4A2)
EPZ: 103540115 103542545 103544685 103547138(COL4A3) 103547140(COL4A4) 103556641(COL4A2) 103556643(COL4A1) 103559208(COL4A5)
EAI: 106827857(COL4A4) 106827859(COL4A3) 106838202(COL4A2) 106838209(COL4A1) 106839712(COL4A5) 106839714(COL4A6)
MYB: 102242641(COL4A6) 102243536(COL4A2) 102248314(COL4A3) 102249405(COL4A4) 102249508(COL4A1) 102256779(COL4A5)
MYD: 102752490(COL4A2) 102752777(COL4A1) 102764359(COL4A4) 102764638(COL4A3) 102768696(COL4A5) 102774545(COL4A6)
HAI: 109383910(COL4A1) 109383936(COL4A2) 109390501(COL4A3) 109393347(COL4A6) 109393353(COL4A5) 109396325(COL4A4)
RSS: 109438324(COL4A5) 109438331(COL4A6) 109447073(COL4A2) 109447074(COL4A1) 109449897(COL4A4) 109450262(COL4A3)
PALE: 102879139(COL4A3) 102879385(COL4A4) 102891781(COL4A5) 102895248(COL4A6) 102898083(COL4A2) 102898331(COL4A1)
LAV: 100664111(COL4A3) 100664398(COL4A4) 100667607(COL4A5) 100667893 100677472(COL4A1) 100677754(COL4A2)
MDO: 100021663(COL4A3) 100021728(COL4A4) 100023678(COL4A2) 100023705(COL4A1) 100025514
SHR: 100917328(COL4A3) 100917586(COL4A4) 100923249(COL4A2) 100923506(COL4A1) 100931618(COL4A5)
OAA: 100073948(COL4A4) 100078067(COL4A5) 100084401(COL4A1) 100084415(COL4A2)
GGA: 395530(COL4A1) 418752(COL4A2) 422348(COL4A5) 422350(COL4A6) 424797(COL4A3) 424799(COL4A4)
MGP: 100539562(COL4A4) 100539715(COL4A3) 100540855(COL4A5) 100541005(COL4A6) 100548601(COL4A2) 100550138(COL4A1)
CJO: 107307933(COL4A2) 107307934(COL4A1) 107307945 107312780(COL4A5) 107312782(COL4A6) 107318047(COL4A4) 107318048(COL4A3)
APLA: 101797440(COL4A4) 101797613(COL4A3) 101799662(COL4A5) 101800228(COL4A6) 101803874(COL4A2) 101804910(COL4A1)
ACYG: 106036183(COL4A3) 106036184(COL4A4) 106038545(COL4A6) 106038546(COL4A5) 106044442(COL4A1) 106044448(COL4A2)
TGU: 100218909(COL4A2) 100221489(COL4A3) 100224679(COL4A1) 100226545(COL4A5) 100227313(COL4A4) 105759150
GFR: 102034561(COL4A1) 102041212(COL4A6) 102041386(COL4A5) 102044225(COL4A2) 102044746(COL4A4) 102044913(COL4A3)
FAB: 101807691(COL4A5) 101807885(COL4A6) 101810620(COL4A4) 101810814(COL4A3) 101814446(COL4A1) 101814637(COL4A2)
PHI: 102100218(COL4A1) 102101909(COL4A4) 102102271(COL4A3) 102106135(COL4A6) 102106323(COL4A5) 102111682(COL4A2)
PMAJ: 107201901(COL4A2) 107201911(COL4A1) 107203714(COL4A6) 107203715(COL4A5) 107208754(COL4A4) 107208755(COL4A3)
CCW: 104686326(COL4A2) 104686327(COL4A1) 104693432(COL4A4) 104693493(COL4A3) 104694452(COL4A5) 104694483(COL4A6)
FPG: 101918166(COL4A6) 101918345(COL4A5) 101922424(COL4A4) 101922604(COL4A3) 101924055(COL4A2) 101924227(COL4A1)
FCH: 102046549(COL4A2) 102046717(COL4A1) 102051664(COL4A3) 102051835(COL4A4) 102052258(COL4A5) 102052429(COL4A6)
CLV: 102083797(COL4A4) 102083978 102085871(COL4A6) 102088881(COL4A1) 102089261(COL4A2) 102090256(COL4A5)
EGZ: 104127064(COL4A4) 104127065(COL4A3) 104132467(COL4A2) 104132468(COL4A1) 104133137(COL4A6) 104133297(COL4A5)
AAM: 106482661(COL4A5) 106482670 106485842(COL4A3) 106485911(COL4A4) 106493997(COL4A1) 106493998(COL4A2)
ASN: 102371381(COL4A3) 102375031(COL4A1) 102375357(COL4A4) 102380122(COL4A5) 102380767(COL4A6) 102388567(COL4A2)
AMJ: 102558085(COL4A6) 102558315(COL4A5) 102558707(COL4A1) 102559838(COL4A4) 102577197(COL4A3) 106736939(COL4A2)
PSS: 102443377(COL4A6) 102445225(COL4A3) 102445487(COL4A4) 102455715(COL4A1) 102455954(COL4A2) 102458094(COL4A5) 106731762
CMY: 102933966(COL4A2) 102934197(COL4A1) 102942604(COL4A6) 102942829(COL4A5) 102946071(COL4A4) 102946297(COL4A3)
CPIC: 101933552(COL4A3) 101944666(COL4A1) 101944934(COL4A2) 101945224(COL4A4) 101951592(COL4A5) 101952404(COL4A6) 103305925
ACS: 100551853(col4a1) 100552050(col4a2) 100554629(col4a6) 100554823(col4a5) 100564708(col4a3) 100564906(col4a4)
PVT: 110074283(COL4A6) 110074284 110074350 110074351 110078449(COL4A3) 110078450(COL4A4) 110080661(COL4A2) 110090761(COL4A1)
PBI: 103050392(COL4A1) 103051663 103053883(COL4A2) 103056355(COL4A3) 103056584(COL4A4) 103056708(COL4A6) 103057504(COL4A5) 103062845
GJA: 107109155 107112116 107113382(COL4A2) 107114009(COL4A5) 107115995(COL4A3) 107115996(COL4A4) 107120742
XLA: 108698394 108698395(col4a5.L) 108700098(col4a5.S) 108700099 108709738(col4a2.S) 108709739 108709740 373763(col4a2.L) 373764(col4a1.L)
XTR: 100124870(col4a1) 100486079(col4a2) 100492984(col4a5) 100493153(col4a6)
NPR: 108787443(COL4A1) 108787444(COL4A2) 108788810(COL4A6) 108788813(COL4A5)
DRE: 323561(col4a5) 553355(col4a2) 554268(col4a6) 554269(col4a1)
BPEC: 110158306(col4a5) 110158307 110173190(col4a2) 110173192(col4a1) 110173582
LCM: 102346118(COL4A5) 102346381(COL4A6) 102348817(COL4A3) 102349091 102349357 102351071(COL4A2) 102351330(COL4A1) 106702950
CMK: 103175983(col4a3) 103175991(col4a4) 103177556(col4a1) 103177608(col4a2) 103179092(col4a5) 103179614 103182601 103182603
CIN: 100185145(col4a1) 100186775
SPU: 373182(COLP3alpha)
DME: Dmel_CG16858(vkg) Dmel_CG4145(Col4a1)
DSI: Dsimw501_GD11984(Dsim_GD11984) Dsimw501_GD23318(Dsim_GD23318)
NVI: 100119790 100119830(Cg25c)
BMOR: 101736620 692625(Let-2) 693056(CPR146)
CEL: CELE_F01G12.5(let-2)
CBR: CBG16372(Cbr-let-2)
BMY: Bm1_16850
VRA: 106767539
SOT: 107059481
PNO: SNOG_10073(SNOG_10072)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Colorado PC, Torre A, Kamphaus G, Maeshima Y, Hopfer H, Takahashi K, Volk R, Zamborsky ED, Herman S, Sarkar PK, Ericksen MB, Dhanabal M, Simons M, Post M, Kufe DW, Weichselbaum RR, Sukhatme VP, Kalluri R
  Title
Anti-angiogenic cues from vascular basement membrane collagen.
  Journal
Cancer Res 60:2520-6 (2000)
  Sequence
[hsa:1282]
Reference
PMID:3311751
  Authors
Brazel D, Oberbaumer I, Dieringer H, Babel W, Glanville RW, Deutzmann R, Kuhn K
  Title
Completion of the amino acid sequence of the alpha 1 chain of human basement membrane collagen (type IV) reveals 21 non-triplet interruptions located within the collagenous domain.
  Journal
Eur J Biochem 168:529-36 (1987)
DOI:10.1111/j.1432-1033.1987.tb13450.x
  Sequence
[hsa:1282]

KEGG   ORTHOLOGY: K06238Help
Entry
K06238                      KO                                     

Name
COL6A
Definition
collagen, type VI, alpha
Pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko04974  Protein digestion and absorption
ko05165  Human papillomavirus infection
Disease
H00431  Ossification of the posterior longitudinal ligament of spine (OPLL)
H00590  Congenital muscular dystrophies (CMD/MDC)
H00831  Primary dystonia
H01338  Myosclerosis
H01340  Bethlem myopathy
H01341  Collagen VI myopathy
H01358  Atopic dermatitis
H01778  Ullrich disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06238  COL6A; collagen, type VI, alpha
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06238  COL6A; collagen, type VI, alpha
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06238  COL6A; collagen, type VI, alpha
 Organismal Systems
  Digestive system
   04974 Protein digestion and absorption
    K06238  COL6A; collagen, type VI, alpha
 Human Diseases
  Infectious diseases
   05165 Human papillomavirus infection
    K06238  COL6A; collagen, type VI, alpha
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K06238  COL6A; collagen, type VI, alpha
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta1 integrins
   alpha 10 beta 1
    ITGB1; integrin beta 1
     K06238 COL6A; collagen, type VI, alpha
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Extracellular matrix molecules
   K06238  COL6A; collagen, type VI, alpha
 Hyaluronan
  Extracellular matrix or blood plasma proteins
   K06238  COL6A; collagen, type VI, alpha
BRITE hierarchy
Genes
HSA: 1291(COL6A1) 1292(COL6A2) 1293(COL6A3) 131873(COL6A6) 256076(COL6A5)
PTR: 450204(COL6A1) 460045(COL6A3) 470923(COL6A5) 474056(COL6A2) 742913(COL6A6) 749971
PPS: 100967866(COL6A5) 100968217(COL6A6) 100976833(COL6A2) 100978062(COL6A1) 100978109(COL6A3) 100980925
GGO: 101129379(COL6A3) 101142723(COL6A5) 101152234(COL6A6) 101153020(COL6A1) 101153620(COL6A2)
PON: 100431604(COL6A5) 100434628(COL6A6) 100459849(COL6A3) 100460129(COL6A1) 100461602(COL6A2)
NLE: 100583380 100585837 100590247 100598572(COL6A5) 100600267(COL6A6) 100602363(COL6A1) 100602701(COL6A2) 105737523(COL6A3)
MCC: 693357 694701(COL6A3) 709493(COL6A2) 719319(COL6A6) 719331(COL6A5) 721855(COL6A1)
MCF: 102120608(COL6A3) 102137568 102137961(COL6A2) 102138836(COL6A1) 102138933(COL6A5) 102140059(COL6A6)
CSAB: 103218151(COL6A3) 103220301(COL6A2) 103221158(COL6A1) 103241696(COL6A6) 103241698(COL6A5) 103241700
RRO: 104656442 104658033(COL6A3) 104667404 104667602(COL6A2) 104667603(COL6A1) 104675733(COL6A6) 104675744(COL6A5)
RBB: 108522239(COL6A5) 108522246(COL6A6) 108537207 108539763(COL6A2) 108539779(COL6A1) 108540980(COL6A3)
CJC: 100404862(COL6A2) 100407319(COL6A3) 100407758(COL6A6) 100408376(COL6A1) 100408489 100413876(COL6A5)
MMU: 12833(Col6a1) 12834(Col6a2) 12835(Col6a3) 245026(Col6a6) 665033(Col6a5) 68553(Col6a4)
RNO: 294337(Col6a1) 315979(Col6a6) 315981(Col6a4) 361821(Col6a2) 367313(Col6a3) 501047(Col6a5)
CGE: 100754390(Col6a2) 100755078(Col6a1) 100769833(Col6a6) 100770126(Col6a5) 100770413(Col6a4) 100771857(Col6a3) 103164567 107977038
NGI: 103726199(Col6a3) 103727287(Col6a6) 103727289(Col6a5) 103729582 103739958(Col6a1) 103739960(Col6a2) 103740338 103747174 103747522
HGL: 101710889(Col6a1) 101711621(Col6a2) 101715830(Col6a6) 101717072(Col6a3)
CCAN: 109678219 109679488(Col6a5) 109695884(Col6a2) 109695885(Col6a1) 109702133(Col6a3)
OCU: 100339915(COL6A6) 100340417(COL6A5) 100343947(COL6A1) 100356474(COL6A2) 103345754(COL6A3)
TUP: 102469950 102471230(COL6A2) 102473520(COL6A1) 102474421 102477630(COL6A6) 102478065(COL6A5) 102494068(COL6A3)
CFA: 100856491(COL6A2) 403582(COL6A3) 403668(COL6A1) 485659(COL6A5) 610614 610649(COL6A6)
AML: 100463941(COL6A6) 100464071(COL6A1) 100465530(COL6A3) 100483347(COL6A2) 100484892(COL6A5) 105235913
UMR: 103662830(COL6A3) 103679288(COL6A5) 103679853 103680680(COL6A2) 103680734(COL6A1) 103681822(COL6A6) 103681833
ORO: 101371920(COL6A3) 101376308(COL6A2) 101381689(COL6A1) 101383410(COL6A5) 101384542 101386561(COL6A6)
FCA: 101081156(COL6A1) 101081323(COL6A3) 101092138(COL6A5) 101095676(COL6A6) 101096163 101100658(COL6A2)
PTG: 102949405(COL6A3) 102950795 102954671(COL6A5) 102955253(COL6A6) 102965155(COL6A1) 102965452(COL6A2)
AJU: 106968414(COL6A3) 106971585(COL6A6) 106971586(COL6A5) 106971588 106987515(COL6A1) 106987516(COL6A2)
BTA: 282194(COL6A2) 511422(COL6A1) 530102(COL6A6) 530657(COL6A3) 785805(COL6A5)
BOM: 102268113 102271535(COL6A5) 102272379(COL6A6) 102278458(COL6A2) 102280323(COL6A1) 102283468
BIU: 109556565(COL6A3) 109561193(COL6A1) 109561279(COL6A2) 109561676(COL6A5) 109563454 109563465
PHD: 102318058(COL6A2) 102322035(COL6A6) 102326367(COL6A5) 102329057(COL6A3) 102342317(COL6A1)
CHX: 102169643(COL6A3) 102178401(COL6A6) 102178669(COL6A5) 102191085(COL6A1) 102191378(COL6A2)
OAS: 101106490(COL6A2) 101111424(COL6A6) 101111927(COL6A1) 101118494(COL6A5) 443051(COL6A3)
SSC: 100101551(COL6A3) 100101552(COL6A2) 100515967(COL6A5) 100516642(COL6A6) 100623720
CFR: 102510339(COL6A6) 102517560(COL6A2) 102517804(COL6A1) 102518086(COL6A5) 102518337 102518573 102522202(COL6A3)
CDK: 105088769 105088770(COL6A5) 105088773 105090586(COL6A1) 105090598(COL6A2) 105102875(COL6A3)
BACU: 103000682(COL6A6) 103000952(COL6A5) 103005784(COL6A2) 103006351(COL6A1) 103009925(COL6A3)
LVE: 103070306(COL6A6) 103070853(COL6A5) 103071281(COL6A3) 103077986(COL6A2) 103084946(COL6A1) 103088616 103088885
OOR: 101273414(COL6A3) 101282272(COL6A5) 101283292(COL6A6) 101287775(COL6A1) 101288202(COL6A2)
ECB: 100050035(COL6A1) 100055332(COL6A2) 100064145 100064173(COL6A5) 100064285(COL6A6) 100066356(COL6A3)
EPZ: 103550795 103550797(COL6A5) 103550800 103557612(COL6A3) 103558411(COL6A1) 103558413(COL6A2)
EAI: 106832180(COL6A3) 106842751 106842753(COL6A5) 106842755 106842982(COL6A1) 106842984(COL6A2)
MYB: 102245872(COL6A2) 102251267(COL6A1) 102254080(COL6A6) 102255770(COL6A5) 102256069 102257789(COL6A3)
MYD: 102756186(COL6A2) 102758253(COL6A3) 102761570(COL6A1) 102761905 102768549(COL6A5) 102768839(COL6A6)
HAI: 109373828(COL6A1) 109373829(COL6A2) 109374373(COL6A6) 109374954(COL6A3) 109378932 109395820
RSS: 109438023(COL6A2) 109438028(COL6A1) 109444510(COL6A6) 109444512 109444550(COL6A5) 109452166(COL6A3)
PALE: 102881112(COL6A3) 102881673(COL6A2) 102883628(COL6A6) 102883890 102892412(COL6A5) 102896988(COL6A1)
LAV: 100655197(COL6A3) 100662988(COL6A2) 100663273(COL6A1) 100664786 100665075 100665360(COL6A6)
MDO: 100017951(COL6A3) 100026420(COL6A2) 100030389(COL6A6) 100030416(COL6A5) 100030437 100617956(COL6A1)
SHR: 100920576(COL6A6) 100920836(COL6A5) 100922222 100922223(COL6A1) 100929764 100933417(COL6A2) 111721184
OAA: 100076164(COL6A3) 100083653(COL6A2) 100083849(COL6A6) 100083893(COL6A5) 100083924 100093454(COL6A1)
GGA: 396000(COL6A1) 396292(COL6A2) 396548(COL6A3) 428448(COL6A6)
MGP: 100544967(COL6A1) 100546041(COL6A2) 100549061(COL6A3) 100551157(COL6A6)
CJO: 107309331(COL6A6) 107316360(COL6A2) 107316361(COL6A1) 107316506(COL6A3)
APLA: 101789974(COL6A2) 101790433(COL6A1) 101794158(COL6A3) 101802198(COL6A6)
ACYG: 106034517(COL6A3) 106046646(COL6A6) 106049609(COL6A1) 106049611(COL6A2)
TGU: 100224039(COL6A2) 100225004(COL6A3) 100226931(COL6A1)
GFR: 102031525(COL6A1) 102031692(COL6A2) 102037459(COL6A3) 102038575(COL6A6)
FAB: 101810477(COL6A3) 101818502(COL6A6) 101819820(COL6A1) 101820018(COL6A2)
PHI: 102104058(COL6A3) 102111047(COL6A2) 102111230(COL6A1)
PMAJ: 107207216(COL6A2) 107207261(COL6A1) 107207729(COL6A3)
CCW: 104689285(COL6A6) 104694557(COL6A3) 104694583(COL6A2) 104694607(COL6A1)
FPG: 101918577(COL6A1) 101918752(COL6A2) 101920384(COL6A6) 101922851(COL6A3)
FCH: 102048076(COL6A3) 102048570(COL6A6) 102051119(COL6A2) 102051465(COL6A1)
CLV: 102087195(COL6A1) 102087375(COL6A2) 102089916(COL6A3) 102093355(COL6A6) 110356609
EGZ: 104122533(COL6A1) 104122541(COL6A2) 104123243(COL6A3) 104127526 104127527
AAM: 106482282(COL6A1) 106482286(COL6A2) 106484387(COL6A3) 106491159
CMY: 102929645 102943888(COL6A3) 102945351(COL6A1) 102945574(COL6A2) 102946934(COL6A6)
ACS: 100556168(col6a2) 100558915(col6a1) 100559509(col6a3) 100561835(col6a6) 100562030 103279150
PVT: 110083710(COL6A3) 110086129(COL6A6) 110086130 110091155(COL6A2) 110091157(COL6A1)
GJA: 107112804(COL6A3) 107114270(COL6A2) 107120736(COL6A1) 107123435
XLA: 108702277 108702278 108703023(col6a1.S) 108703024(col6a2.S) 108718494 108718495(col6a6.L) 108719692(col6a6.S) 380129(col6a1.L) 398368 734275(col6a2.L)
XTR: 100145523(col6a2) 100486063 100487679(col6a6) 100488707(col6a3) 100490352(col6a1)
NPR: 108788853(COL6A1) 108789838(COL6A3) 108792064 108795802(COL6A6) 108801821(COL6A2)
DRE: 100535278 556874(col6a3) 564005(col6a4a) 567771(col6a2) 569755(col6a1)
TRU: 101062524 101064693(col6a6) 101075798 101079628(col6a2) 101079860(col6a1) 105417804(col6a3) 105418959
XMA: 102219605 102221880(col6a6) 102227077 102227835(col6a3) 102234225(col6a1) 102234476(col6a2)
CSEM: 103388122(col6a6) 103392061 103392341 103392369 103396226(col6a2) 103396256(col6a1)
HCQ: 109506874 109512175(col6a6) 109512791(col6a1) 109512816(col6a2) 109517120(col6a3) 109517639 109523290
BPEC: 110153401 110158189(col6a3) 110160762 110166521 110170466(col6a2) 110170467(col6a1)
AQU: 100640739
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9107679
  Authors
Trikka D, Davis T, Lapenta V, Brahe C, Kessling AM
  Title
Human COL6A1: genomic characterization of the globular domains, structural and evolutionary comparison with COL6A2.
  Journal
Mamm Genome 8:342-5 (1997)
DOI:10.1007/s003359900436
  Sequence
[hsa:1291]

KEGG   ORTHOLOGY: K05637Help
Entry
K05637                      KO                                     

Name
LAMA1_2
Definition
laminin, alpha 1/2
Pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko05145  Toxoplasmosis
ko05146  Amoebiasis
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05222  Small cell lung cancer
Disease
H00590  Congenital muscular dystrophies (CMD/MDC)
H01958  Merosin-deficient congenital muscular dystrophy
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K05637  LAMA1_2; laminin, alpha 1/2
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K05637  LAMA1_2; laminin, alpha 1/2
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05637  LAMA1_2; laminin, alpha 1/2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05637  LAMA1_2; laminin, alpha 1/2
   05222 Small cell lung cancer
    K05637  LAMA1_2; laminin, alpha 1/2
  Infectious diseases
   05165 Human papillomavirus infection
    K05637  LAMA1_2; laminin, alpha 1/2
   05146 Amoebiasis
    K05637  LAMA1_2; laminin, alpha 1/2
   05145 Toxoplasmosis
    K05637  LAMA1_2; laminin, alpha 1/2
BRITE hierarchy
Genes
HSA: 284217(LAMA1) 3908(LAMA2)
PTR: 455302(LAMA1) 472122(LAMA2)
PPS: 100990839(LAMA1) 100995714(LAMA2)
GGO: 101141143(LAMA2) 101143230(LAMA1)
PON: 100438698(LAMA1) 100458901(LAMA2)
NLE: 100583654(LAMA2) 100591959(LAMA1)
MCC: 715394(LAMA2) 722472(LAMA1)
MCF: 102145776(LAMA2) 102146003(LAMA1)
CSAB: 103222731(LAMA1) 103240395(LAMA2)
RRO: 104655298(LAMA2) 104670221(LAMA1)
RBB: 108523928(LAMA1) 108534366(LAMA2)
CJC: 100403734(LAMA1) 100405831(LAMA2)
SBQ: 101032961(LAMA2) 101041079(LAMA1)
MMU: 16772(Lama1) 16773(Lama2)
RNO: 309368(Lama2) 316758(Lama1)
CGE: 100765555(Lama1) 100771923(Lama2)
NGI: 103729744(Lama2) 103735414(Lama1) 103740954
HGL: 101717328(Lama1) 101725515(Lama2)
CCAN: 109695361(Lama2) 109700511 109703355 109703366(Lama1)
OCU: 100350500(LAMA2) 100357482(LAMA1)
TUP: 102481486(LAMA2) 102488646(LAMA1)
CFA: 100683420(LAMA2) 102156629(LAMA1)
AML: 100465830(LAMA1) 100484712(LAMA2)
UMR: 103663512(LAMA2) 103664656(LAMA1)
ORO: 101364310(LAMA1) 101383157(LAMA2)
FCA: 101083299(LAMA1) 101092612(LAMA2)
PTG: 102950444(LAMA2) 102969465(LAMA1)
AJU: 106975487(LAMA2) 106984540(LAMA1)
BTA: 100138434(LAMA2) 506387(LAMA1)
BOM: 102275509(LAMA1) 102282697 102287620(LAMA2)
BIU: 109563534(LAMA2) 109577666(LAMA1)
PHD: 102332506(LAMA2) 102333233(LAMA1)
CHX: 102176003(LAMA1) 102187050(LAMA2)
OAS: 101102692(LAMA1) 101117424(LAMA2)
SSC: 100154420(LAMA2) 100625589(LAMA1)
CFR: 102504667 102505642(LAMA1) 102521730(LAMA2)
CDK: 105096330(LAMA2) 105099434(LAMA1)
BACU: 102998029(LAMA2) 103011922(LAMA1)
LVE: 103078532(LAMA2) 103081594(LAMA1)
OOR: 101282490(LAMA1) 101290006(LAMA2)
ECB: 100059860(LAMA1) 100073067(LAMA2)
EPZ: 103552993(LAMA2) 103564595(LAMA1)
EAI: 106835371(LAMA2) 106838023(LAMA1)
MYB: 102249932 102256202(LAMA1) 102261526(LAMA2)
MYD: 102770077(LAMA2) 102773720(LAMA1)
HAI: 109375466 109377451(LAMA1)
RSS: 109446236(LAMA2) 109460414(LAMA1)
PALE: 102884860(LAMA1) 102894718(LAMA2)
LAV: 100672596(LAMA1) 100677404(LAMA2)
MDO: 100015923(LAMA1) 100030895(LAMA2)
SHR: 100924495(LAMA2) 100925578(LAMA1)
OAA: 100078011(LAMA2) 100079917(LAMA1)
GGA: 374016(LAMA1) 421709(LAMA2)
MGP: 100545053(LAMA2) 100550433(LAMA1)
CJO: 107310030(LAMA1) 107311739(LAMA2)
APLA: 101790960(LAMA2) 101791570(LAMA1)
ACYG: 106032489(LAMA2) 106034951(LAMA1)
TGU: 100222025(LAMA1) 100226618(LAMA2)
GFR: 102031966(LAMA1) 102040597(LAMA2)
FAB: 101806802(LAMA2) 101809243(LAMA1)
PHI: 102100894(LAMA2) 102105406(LAMA1)
PMAJ: 107200340(LAMA1) 107202118(LAMA2)
CCW: 104687288(LAMA1) 104690723(LAMA2)
FPG: 101918838(LAMA2) 101920298(LAMA1)
FCH: 102056264(LAMA1) 102059098(LAMA2)
CLV: 102087859(LAMA1) 102091939(LAMA2)
EGZ: 104127771(LAMA1) 104131156(LAMA2)
AAM: 106484524(LAMA1) 106497996(LAMA2)
ASN: 102377125(LAMA2) 102380091(LAMA1)
AMJ: 102565892(LAMA2) 106736709(LAMA1)
PSS: 102452116(LAMA1) 102462585(LAMA2)
CMY: 102940671(LAMA1) 102943418(LAMA2)
CPIC: 101943517(LAMA2) 101950807(LAMA1)
ACS: 100563687(lama1) 100565785(lama2)
PVT: 110077555(LAMA2) 110078890(LAMA1)
PBI: 103050826 103051723(LAMA2) 103061662(LAMA1)
GJA: 107112746(LAMA1) 107115141(LAMA2)
XTR: 100488009(lama1) 100497008(lama2)
NPR: 108784886(LAMA1) 108786894(LAMA2)
DRE: 100049705(lama2) 569971(lama1)
IPU: 108272667(lama1) 108275333(lama2)
AMEX: 103025806(lama1) 103046019(lama2) 111189576
TRU: 101061431(lama2) 101079183
LCO: 104929878(lama2) 104934322(lama1)
MZE: 101477084(lama1) 101477553(lama2)
OLA: 101172376(lama2)
XMA: 102223911(lama2) 102228775(lama1)
PRET: 103457642(lama2) 103460170(lama1)
NFU: 107377827(lama2)
CSEM: 103381240(lama2) 103392033(lama1)
HCQ: 109520396(lama2) 109526303
BPEC: 110156398(lama2) 110175641(lama1)
ELS: 105017913(lama2) 105025738(lama1) 109614882
LCM: 102353402(LAMA2) 102365183 102367012(LAMA1)
CMK: 103181058(lama1) 103182330(lama2)
CIN: 100182119
SPU: 587274
APLC: 110979495
SKO: 100369691
DME: Dmel_CG42677(wb)
DSI: Dsimw501_GD23957(Dsim_GD23957)
MDE: 101892460
AAG: 5570897
AME: 410775
BIM: 100748549
BTER: 100649561
SOC: 105193731
AEC: 105149529
ACEP: 105622440
PBAR: 105429888
NVI: 100118105
TCA: 658046
BMOR: 101746347
PRAP: 111004471
API: 100162936
DNX: 107169281
ZNE: 110827145
CEL: CELE_T22A3.8(lam-3)
CBR: CBG24338(Cbr-lam-3)
BMY: Bm1_24440
CRG: 105339670
MYI: 110463298
AQU: 100638010
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1714537
  Authors
Haaparanta T, Uitto J, Ruoslahti E, Engvall E
  Title
Molecular cloning of the cDNA encoding human laminin A chain.
  Journal
Matrix 11:151-60 (1991)
Reference
  Authors
Miner JH, Yurchenco PD
  Title
Laminin functions in tissue morphogenesis.
  Journal
Annu Rev Cell Dev Biol 20:255-84 (2004)
DOI:10.1146/annurev.cellbio.20.010403.094555
Reference
PMID:8294519
  Authors
Vuolteenaho R, Nissinen M, Sainio K, Byers M, Eddy R, Hirvonen H, Shows TB, Sariola H, Engvall E, Tryggvason K
  Title
Human laminin M chain (merosin): complete primary structure, chromosomal assignment, and expression of the M and A chain in human fetal tissues.
  Journal
J Cell Biol 124:381-94 (1994)
DOI:10.1083/jcb.124.3.381
  Sequence
[hsa:3908]

KEGG   ORTHOLOGY: K06240Help
Entry
K06240                      KO                                     

Name
LAMA3_5
Definition
laminin, alpha 3/5
Pathway
ko01100  Metabolic pathways
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko05145  Toxoplasmosis
ko05146  Amoebiasis
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05222  Small cell lung cancer
Disease
H00586  Epidermolysis bullosa, junctional
H00813  Laryngo onycho cutaneous syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06240  LAMA3_5; laminin, alpha 3/5
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06240  LAMA3_5; laminin, alpha 3/5
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06240  LAMA3_5; laminin, alpha 3/5
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06240  LAMA3_5; laminin, alpha 3/5
   05222 Small cell lung cancer
    K06240  LAMA3_5; laminin, alpha 3/5
  Infectious diseases
   05165 Human papillomavirus infection
    K06240  LAMA3_5; laminin, alpha 3/5
   05146 Amoebiasis
    K06240  LAMA3_5; laminin, alpha 3/5
   05145 Toxoplasmosis
    K06240  LAMA3_5; laminin, alpha 3/5
BRITE hierarchy
Genes
HSA: 3909(LAMA3) 3911(LAMA5)
PTR: 455339(LAMA3) 458387(LAMA5)
PPS: 100971419(LAMA5) 100977893(LAMA3)
GGO: 101124609(LAMA5) 101132916(LAMA3) 101137951 109025539
PON: 100439539(LAMA3) 100456580
NLE: 100581144(LAMA5) 100601935(LAMA3)
MCC: 100430603(LAMA5) 701313(LAMA3)
MCF: 102120952(LAMA3) 102128796(LAMA5)
CSAB: 103222632(LAMA3) 103243076(LAMA5)
RRO: 104663822(LAMA5) 104678039(LAMA3)
RBB: 108531795 108535245(LAMA5) 108536899(LAMA3)
CJC: 100401798(LAMA3) 103792989(LAMA5) 108588071
SBQ: 101042136(LAMA3) 101046958(LAMA5) 104650868
MMU: 16774(Lama3) 16776(Lama5)
RNO: 140433(Lama5) 307582(Lama3)
CGE: 100755004(Lama3) 100755091(Lama5)
NGI: 103742237(Lama5) 103745694(Lama3)
CCAN: 109674257(Lama3) 109674258 109675263 109689091(Lama5)
OCU: 100346886(LAMA3) 103347398(LAMA5)
TUP: 102471895(LAMA5) 102496463(LAMA3)
CFA: 442954(LAMA5) 480173(LAMA3)
AML: 100482780(LAMA5) 100484669(LAMA3) 105236402
UMR: 103660581(LAMA5) 103664853(LAMA3)
ORO: 101370639(LAMA5) 101386047(LAMA3)
FCA: 101083923(LAMA5) 101100161(LAMA3)
PTG: 102956725(LAMA3) 102960452(LAMA5)
AJU: 106969907(LAMA5) 106978465(LAMA3)
BTA: 100336873(LAMA3) 104968606 506751(LAMA5)
BOM: 102266736(LAMA5) 102287154(LAMA3)
PHD: 102340730(LAMA3) 102344954(LAMA5)
CHX: 102171801(LAMA5) 102190835(LAMA3) 108637403
OAS: 101120460(LAMA3) 101121444(LAMA5)
SSC: 100511642(LAMA3) 110257482(LAMA5)
CFR: 102503954(LAMA5) 102507092 102510013(LAMA3)
BACU: 103004795 103010510(LAMA5) 103012309(LAMA3)
LVE: 103073424(LAMA5) 103084753(LAMA3)
OOR: 101274600(LAMA3) 101284962(LAMA5)
ECB: 100058057(LAMA5) 791238(LAMA3)
EPZ: 103550984(LAMA5) 103565717 103566148(LAMA3)
EAI: 106822923(LAMA3) 106836404(LAMA5)
HAI: 109380081(LAMA5) 109390099 109390109(LAMA3)
RSS: 109452372(LAMA3) 109459151(LAMA5)
PALE: 102892706(LAMA5) 102897225(LAMA3) 107196266
LAV: 100661521 100676944(LAMA5) 104845537(LAMA3)
MDO: 100011544(LAMA3) 100026192(LAMA5)
SHR: 100924531(LAMA5) 100934145(LAMA3)
OAA: 100074317(LAMA3) 100074506(LAMA5)
GGA: 428148(LAMA5) 428524(LAMA3)
MGP: 100540219(LAMA3) 100545291(LAMA5)
CJO: 107310092(LAMA3) 107322934(LAMA5)
APLA: 101799829(LAMA3) 101801954(LAMA5) 106015339
TGU: 100223855(LAMA5) 100225002(LAMA3)
GFR: 102039057(LAMA3) 102040047(LAMA5) 106631846
FAB: 101821218(LAMA5) 101821788(LAMA3) 107603345
PHI: 102107936(LAMA3) 102108636(LAMA5)
PMAJ: 107213297(LAMA5) 107216062(LAMA3)
CCW: 104687364(LAMA3) 104687815(LAMA5)
FPG: 101915356(LAMA3) 101920966(LAMA5)
FCH: 102058399(LAMA5) 102059161(LAMA3)
CLV: 102092628(LAMA5) 102096169(LAMA3) 110358475
EGZ: 104130661(LAMA5) 104134156(LAMA3)
AAM: 106484867(LAMA3) 106492782(LAMA5)
ASN: 102382736(LAMA5) 102386555(LAMA3) 106722691
AMJ: 102563156(LAMA3) 102566563(LAMA5)
PSS: 102445876(LAMA3) 102458379(LAMA5)
CMY: 102935975(LAMA5) 102938310(LAMA3)
CPIC: 101939396(LAMA3) 101950903(LAMA5)
ACS: 100552852(lama5) 100561436(lama3)
PVT: 110074919(LAMA3) 110086875(LAMA5)
GJA: 107118414(LAMA3) 107122549(LAMA5)
XLA: 108700926(lama5.L) 108702189 108718553(lama3.L)
XTR: 100145762(lama5) 100496680(lama3)
NPR: 108789987(LAMA5) 108795478(LAMA3)
DRE: 321243(lama5) 567640(si:ch211-241e1.3)
IPU: 108267308(lama3) 108270685 108275926(lama5)
LCO: 104918308(lama3) 104934349(lama5) 109142832
MZE: 101464839(lama5) 101467834(lama3) 101479911
OLA: 101162509(lama5) 101163522(lama3)
XMA: 102223356(lama3) 102237100(lama5) 111609763
PRET: 103461181 103461923(lama5) 103463811(lama3) 103479641
NFU: 107383938(lama3) 107390549(lama5)
CSEM: 103385170(lama5) 103396180(lama3)
LCF: 108879160 108883438(lama3) 108887436(lama5)
BPEC: 110157494(lama3) 110161114(lama5)
ELS: 105018940(lama3) 105027950(lama5)
SFM: 108925624(lama5) 108937590(lama3)
LCM: 102355038(LAMA5) 102366759(LAMA3) 106702630
CMK: 103179715(lama3) 103181033 103186251(lama5)
CIN: 100176802(lama5)
SPU: 578626
APLC: 110978598
DME: Dmel_CG10236(LanA)
DSI: Dsimw501_GD13136(Dsim_GD13136)
MDE: 101897673
AAG: 5571044
AME: 412663(LamA)
BIM: 100746728
BTER: 100645678
SOC: 105204864
AEC: 105150546
ACEP: 105623902
PBAR: 105426527
HST: 105187360
CFO: 105257775
LHU: 105672030
PGC: 109858972
NVI: 100119934
TCA: 661583(LanA)
DPA: 109541736
NVL: 108564488
PMAC: 106717210
PRAP: 110999452
PXY: 105392052
API: 100169395
DNX: 107173414
FCD: 110842377
CEL: CELE_K08C7.3(epi-1)
CBR: CBG04423(Cbr-epi-1)
BMY: Bm1_38590
CRG: 105335256
MYI: 110448329
HMG: 100200618
AQU: 109582339
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
McLean WH, Irvine AD, Hamill KJ, Whittock NV, Coleman-Campbell CM, Mellerio JE, Ashton GS, Dopping-Hepenstal PJ, Eady RA, Jamil T, Phillips R, Shabbir SG, Haroon TS, Khurshid K, Moore JE, Page B, Darling J, Atherton DJ, Van Steensel MA, Munro CS, Smith FJ, McGrath JA
  Title
An unusual N-terminal deletion of the laminin alpha3a isoform leads to the chronic granulation tissue disorder laryngo-onycho-cutaneous syndrome.
  Journal
Hum Mol Genet 12:2395-409 (2003)
DOI:10.1093/hmg/ddg234
  Sequence
[hsa:3909]
Reference
  Authors
Miner JH, Yurchenco PD
  Title
Laminin functions in tissue morphogenesis.
  Journal
Annu Rev Cell Dev Biol 20:255-84 (2004)
DOI:10.1146/annurev.cellbio.20.010403.094555

KEGG   ORTHOLOGY: K06241Help
Entry
K06241                      KO                                     

Name
LAMA4
Definition
laminin, alpha 4
Pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko05143  African trypanosomiasis
ko05145  Toxoplasmosis
ko05146  Amoebiasis
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05222  Small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06241  LAMA4; laminin, alpha 4
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06241  LAMA4; laminin, alpha 4
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06241  LAMA4; laminin, alpha 4
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06241  LAMA4; laminin, alpha 4
   05222 Small cell lung cancer
    K06241  LAMA4; laminin, alpha 4
  Infectious diseases
   05165 Human papillomavirus infection
    K06241  LAMA4; laminin, alpha 4
   05146 Amoebiasis
    K06241  LAMA4; laminin, alpha 4
   05145 Toxoplasmosis
    K06241  LAMA4; laminin, alpha 4
   05143 African trypanosomiasis
    K06241  LAMA4; laminin, alpha 4
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Others
   LU; Lutheran blood group glycoprotein
    Laminin-14
     K06241 LAMA4; laminin, alpha 4
   MCAM, CD146; melanoma cell adhesion molecule
    Laminin-8
     K06241 LAMA4; laminin, alpha 4
 2. Integrin Family
  Beta1 integrins
   VLA-6
    ITGB1; integrin beta 1
     Laminin-8
      K06241 LAMA4; laminin, alpha 4
BRITE hierarchy
Genes
HSA: 3910(LAMA4)
PTR: 462946(LAMA4)
PPS: 100973904(LAMA4)
GGO: 101146642(LAMA4)
NLE: 100587786(LAMA4)
MCC: 696685(LAMA4)
MCF: 102132640(LAMA4)
CSAB: 103240557(LAMA4)
RRO: 104659760(LAMA4)
RBB: 108512065(LAMA4)
CJC: 100396274(LAMA4)
SBQ: 101054093(LAMA4)
MMU: 16775(Lama4)
RNO: 309816(Lama4)
CGE: 100757321(Lama4)
NGI: 103749527(Lama4)
HGL: 101702455 101716530(Lama4)
CCAN: 109681101 109699573(Lama4)
OCU: 108177458(LAMA4)
CFA: 475034(LAMA4)
AML: 100472419(LAMA4)
UMR: 103676980(LAMA4)
FCA: 101086907(LAMA4)
PTG: 102953957(LAMA4)
AJU: 106968914(LAMA4)
BTA: 529670(LAMA4)
BOM: 102282139(LAMA4)
BIU: 109563807(LAMA4)
PHD: 102326172(LAMA4)
CHX: 102177440(LAMA4)
OAS: 101107969(LAMA4)
SSC: 100154581(LAMA4)
CFR: 102505297(LAMA4)
CDK: 105099215(LAMA4)
BACU: 103014236(LAMA4)
LVE: 103070825(LAMA4)
OOR: 101278374(LAMA4)
ECB: 100066875(LAMA4)
EPZ: 103547537(LAMA4)
EAI: 106847044(LAMA4)
MYB: 102244301(LAMA4)
MYD: 102773988(LAMA4)
HAI: 109384762(LAMA4)
RSS: 109449124(LAMA4)
PALE: 102877962(LAMA4)
LAV: 100662531(LAMA4)
TMU: 101352772
MDO: 100029499(LAMA4)
SHR: 100926054(LAMA4)
OAA: 100074197(LAMA4)
GGA: 421749(LAMA4)
MGP: 100541748(LAMA4)
CJO: 107311854(LAMA4)
APLA: 101800985(LAMA4)
ACYG: 106032574(LAMA4)
TGU: 100228260(LAMA4)
GFR: 102038317(LAMA4)
FAB: 101808787(LAMA4)
PHI: 102104140(LAMA4)
PMAJ: 107201853(LAMA4)
CCW: 104691288(LAMA4)
FPG: 101924138(LAMA4)
FCH: 102057374(LAMA4)
CLV: 102095906(LAMA4)
EGZ: 104131982(LAMA4)
AAM: 106489675(LAMA4)
ASN: 102384015(LAMA4)
AMJ: 102564492(LAMA4)
PSS: 102444833(LAMA4)
CMY: 102935888(LAMA4)
CPIC: 101949188(LAMA4)
ACS: 100556625 100565882(lama4)
PVT: 110085314(LAMA4)
PBI: 103058868(LAMA4)
GJA: 107111673(LAMA4)
XLA: 108716825(lama4.L) 108717424
XTR: 100489161(lama4)
NPR: 108790079(LAMA4) 108797114
DRE: 566796(lama4)
SRX: 107715692(lama4)
SANH: 107670252(lama4)
SGH: 107565453(lama4)
IPU: 108275439(lama4)
AMEX: 103026767(lama4)
TRU: 101072818(lama4)
LCO: 104922932(lama4)
NCC: 104943210
MZE: 101466004(lama4)
OLA: 101163050(lama4)
XMA: 102221061(lama4)
PRET: 103458006(lama4)
NFU: 107384793(lama4)
CSEM: 103380641(lama4)
LCF: 108899321(lama4)
HCQ: 109509329(lama4)
BPEC: 110153303(lama4)
ELS: 105017888(lama4)
SFM: 108929407(lama4)
LCM: 102359744(LAMA4)
CMK: 103182579(lama4)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8706685
  Authors
Richards A, Al-Imara L, Pope FM
  Title
The complete cDNA sequence of laminin alpha 4 and its relationship to the other human laminin alpha chains.
  Journal
Eur J Biochem 238:813-21 (1996)
DOI:10.1111/j.1432-1033.1996.0813w.x
  Sequence
[hsa:3910]
Reference
PMID:7781776
  Authors
Iivanainen A, Sainio K, Sariola H, Tryggvason K
  Title
Primary structure and expression of a novel human laminin alpha 4 chain.
  Journal
FEBS Lett 365:183-8 (1995)
DOI:10.1016/0014-5793(95)00462-I
  Sequence
[hsa:3910]

KEGG   ORTHOLOGY: K05636Help
Entry
K05636                      KO                                     

Name
LAMB1
Definition
laminin, beta 1
Pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko05145  Toxoplasmosis
ko05146  Amoebiasis
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05222  Small cell lung cancer
Disease
H00268  Lissencephaly (LIS)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K05636  LAMB1; laminin, beta 1
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K05636  LAMB1; laminin, beta 1
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05636  LAMB1; laminin, beta 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05636  LAMB1; laminin, beta 1
   05222 Small cell lung cancer
    K05636  LAMB1; laminin, beta 1
  Infectious diseases
   05165 Human papillomavirus infection
    K05636  LAMB1; laminin, beta 1
   05146 Amoebiasis
    K05636  LAMB1; laminin, beta 1
   05145 Toxoplasmosis
    K05636  LAMB1; laminin, beta 1
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Neural system
   Enzymatic CD
    PTPRF, LAR; receptor-type tyrosine-protein phosphatase F
     Laminin-1
      K05636 LAMB1; laminin, beta 1
  Others
   LU; Lutheran blood group glycoprotein
    Laminin-10
     K05636 LAMB1; laminin, beta 1
   MCAM, CD146; melanoma cell adhesion molecule
    Laminin-8
     K05636 LAMB1; laminin, beta 1
   CXADR, CAR; coxsackievirus and adenovirus receptor
    Laminin-1
     K05636 LAMB1; laminin, beta 1
 2. Integrin Family
  Beta1 integrins
   VLA-1
    ITGB1; integrin beta 1
     Laminin-1
      K05636 LAMB1; laminin, beta 1
     Laminin-2
      K05636 LAMB1; laminin, beta 1
   VLA-2
    ITGB1; integrin beta 1
     Laminin-1
      K05636 LAMB1; laminin, beta 1
     Laminin-2
      K05636 LAMB1; laminin, beta 1
   VLA-3
    ITGB1; integrin beta 1
     Laminin-2
      K05636 LAMB1; laminin, beta 1
     Laminin-10
      K05636 LAMB1; laminin, beta 1
   VLA-6
    ITGB1; integrin beta 1
     Laminin-1
      K05636 LAMB1; laminin, beta 1
     Laminin-2
      K05636 LAMB1; laminin, beta 1
     Laminin-8
      K05636 LAMB1; laminin, beta 1
     Laminin-10
      K05636 LAMB1; laminin, beta 1
   VLA-7
    ITGB1; integrin beta 1
     Laminin-1
      K05636 LAMB1; laminin, beta 1
     Laminin-2
      K05636 LAMB1; laminin, beta 1
  Beta4 integrins
   alpha 6 beta 4
    ITGB4; integrin beta 4
     Laminin-1
      K05636 LAMB1; laminin, beta 1
     Laminin-2
      K05636 LAMB1; laminin, beta 1
 7. Others
  DAG1; dystroglycan 1
   Laminin-1
    K05636 LAMB1; laminin, beta 1
   Laminin-2
    K05636 LAMB1; laminin, beta 1
  APP; amyloid beta A4 protein
   Laminin-1
    K05636 LAMB1; laminin, beta 1
BRITE hierarchy
Genes
HSA: 3912(LAMB1)
PTR: 463656(LAMB1)
PPS: 100994583(LAMB1)
GGO: 101134136(LAMB1)
PON: 100458670(LAMB1)
NLE: 100581721(LAMB1)
MCC: 702111(LAMB1)
MCF: 102126233(LAMB1)
CSAB: 103226726(LAMB1)
RRO: 104677415(LAMB1)
RBB: 108540465(LAMB1)
CJC: 100400907(LAMB1)
SBQ: 101045731(LAMB1)
MMU: 16777(Lamb1)
RNO: 298941(Lamb1)
CGE: 100757343(Lamb1)
NGI: 103732168(Lamb1)
HGL: 101700233(Lamb1)
CCAN: 109690109(Lamb1) 109690112
OCU: 100358679(LAMB1)
TUP: 102469659(LAMB1)
CFA: 475882(LAMB1)
AML: 100472572(LAMB1)
UMR: 103674704(LAMB1) 103675101
ORO: 101382657(LAMB1)
FCA: 101080367(LAMB1)
PTG: 102954545 102962439(LAMB1)
AJU: 106980652(LAMB1)
BTA: 520030(LAMB1)
BOM: 102278503(LAMB1)
BIU: 109557393(LAMB1)
PHD: 102337582(LAMB1)
CHX: 102176661(LAMB1)
OAS: 101105743(LAMB1)
SSC: 396707(LAMB1)
CFR: 102521906(LAMB1)
CDK: 105093058(LAMB1)
BACU: 102997450(LAMB1)
LVE: 103071744(LAMB1)
OOR: 101278853(LAMB1)
ECB: 100060360(LAMB1)
EPZ: 103567994(LAMB1)
EAI: 106825193(LAMB1)
MYB: 102250973(LAMB1) 102263034
MYD: 102774918(LAMB1)
HAI: 109372668(LAMB1)
RSS: 109454582(LAMB1)
PALE: 102881611(LAMB1)
LAV: 100675837(LAMB1)
TMU: 101351432
MDO: 100010605(LAMB1)
SHR: 100929086(LAMB1)
GGA: 396478(LAMB1)
MGP: 100548782(LAMB1)
CJO: 107307972(LAMB1)
APLA: 101801494(LAMB1)
ACYG: 106042002(LAMB1)
TGU: 100222516(LAMB1)
GFR: 102035516(LAMB1)
FAB: 101809033(LAMB1)
PHI: 102104811(LAMB1)
PMAJ: 107204235(LAMB1)
CCW: 104686917(LAMB1)
FPG: 101913281(LAMB1)
FCH: 102053954(LAMB1)
CLV: 102091353(LAMB1)
EGZ: 104123792(LAMB1)
AAM: 106487735(LAMB1)
ASN: 102384699(LAMB1)
AMJ: 102568782(LAMB1)
PSS: 102458826(LAMB1)
CMY: 102929487(LAMB1)
CPIC: 101942545(LAMB1)
ACS: 100555341(lamb1)
PVT: 110070347(LAMB1)
PBI: 103059637(LAMB1)
GJA: 107119904(LAMB1)
XLA: 108711179(lamb1.L) 108713081(lamb1.S)
XTR: 100495516(lamb1)
NPR: 108802662(LAMB1)
DRE: 286830(lamb1a)
IPU: 108275309(lamb1) 108276201(lamb2) 108279853
TRU: 101062763(lamb1) 101075179
LCO: 104929904 104933728(lamb1)
NCC: 104941784(lamb1)
OLA: 101165682 101167953(lamb1)
XMA: 102229311(lamb1) 102232124
NFU: 107387385 107389091(lamb1)
CSEM: 103379635(lamb1) 103382600
BPEC: 110161568 110163781(lamb1)
ELS: 105007961 105018083(lamb1)
LCM: 102357660(LAMB1) 102358482
CIN: 100179911(lamb1)
SPU: 582206(lamb1)
DME: Dmel_CG7123(LanB1)
DSI: Dsimw501_GD23490(Dsim_GD23490)
MDE: 101887411
AAG: 5578743
AME: 726736(LanB1)
BIM: 100746803
BTER: 100642555
SOC: 105197652
AEC: 105152359
ACEP: 105626418
HST: 105180834
CFO: 105250996
LHU: 105667788
NVI: 100123956
TCA: 661297
DPA: 109537961
BMOR: 100862837(LanB1-w) 692392
PMAC: 106708834
PRAP: 110992852
API: 100159769
ZNE: 110833184
FCD: 110856721
CEL: CELE_W03F8.5(lam-1)
CBR: CBG20003(Cbr-lam-1)
BMY: Bm1_01080
TSP: Tsp_02564
OBI: 106877208
SHX: MS3_08997
EPA: 110253703
HMG: 100197276(lamb1)
AQU: 105314164
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3611077
  Authors
Pikkarainen T, Eddy R, Fukushima Y, Byers M, Shows T, Pihlajaniemi T, Saraste M, Tryggvason K
  Title
Human laminin B1 chain. A multidomain protein with gene (LAMB1) locus in the q22 region of chromosome 7.
  Journal
J Biol Chem 262:10454-62 (1987)
  Sequence
[hsa:3912]
Reference
  Authors
Durbeej M
  Title
Laminins.
  Journal
Cell Tissue Res 339:259-68 (2010)
DOI:10.1007/s00441-009-0838-2

KEGG   ORTHOLOGY: K06243Help
Entry
K06243                      KO                                     

Name
LAMB2
Definition
laminin, beta 2
Pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko05145  Toxoplasmosis
ko05146  Amoebiasis
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05222  Small cell lung cancer
Disease
H00576  Pierson syndrome
H01657  Nephrotic syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06243  LAMB2; laminin, beta 2
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06243  LAMB2; laminin, beta 2
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06243  LAMB2; laminin, beta 2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06243  LAMB2; laminin, beta 2
   05222 Small cell lung cancer
    K06243  LAMB2; laminin, beta 2
  Infectious diseases
   05165 Human papillomavirus infection
    K06243  LAMB2; laminin, beta 2
   05146 Amoebiasis
    K06243  LAMB2; laminin, beta 2
   05145 Toxoplasmosis
    K06243  LAMB2; laminin, beta 2
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Others
   LU; Lutheran blood group glycoprotein
    Laminin-11
     K06243 LAMB2; laminin, beta 2
    Laminin-14
     K06243 LAMB2; laminin, beta 2
 2. Integrin Family
  Beta1 integrins
   VLA-3
    ITGB1; integrin beta 1
     Laminin-11
      K06243 LAMB2; laminin, beta 2
   VLA-6
    ITGB1; integrin beta 1
     Laminin-11
      K06243 LAMB2; laminin, beta 2
BRITE hierarchy
Genes
HSA: 3913(LAMB2)
PTR: 460365(LAMB2)
PPS: 100969648(LAMB2)
GGO: 101131073(LAMB2)
PON: 100441641(LAMB2)
NLE: 100591482(LAMB2)
MCC: 707892(LAMB2)
MCF: 102135628(LAMB2)
CSAB: 103227619(LAMB2)
RRO: 104667469(LAMB2)
RBB: 108527002(LAMB2)
CJC: 100389118(LAMB2)
SBQ: 101027384(LAMB2)
MMU: 16779(Lamb2)
RNO: 25473(Lamb2)
CGE: 100762566(Lamb2)
NGI: 103750198(Lamb2)
HGL: 101706277(Lamb2)
CCAN: 109691976(Lamb2)
OCU: 100009388(LAMB2)
TUP: 102484646(LAMB2)
CFA: 476626(LAMB2)
AML: 100477974(LAMB2)
UMR: 103675103(LAMB2)
ORO: 101380776(LAMB2)
FCA: 101082047(LAMB2)
PTG: 102950017(LAMB2)
AJU: 106979235(LAMB2)
BTA: 520167(LAMB2) 530599
BOM: 102278118(LAMB2) 102282698
PHD: 102338562 102339027(LAMB2)
CHX: 102179246 102183372(LAMB2)
OAS: 101106719(LAMB2) 101117707
SSC: 101101688(LAMB2)
CFR: 102510254(LAMB2)
CDK: 105087776(LAMB2) 105088203
BACU: 102999125(LAMB2)
LVE: 103071970(LAMB2)
OOR: 101271226(LAMB2)
ECB: 100053539(LAMB2)
EPZ: 103553398(LAMB2)
EAI: 106830680(LAMB2)
MYB: 102258809(LAMB2) 102259106
MYD: 102765623(LAMB2)
PALE: 102889392(LAMB2)
LAV: 100655070(LAMB2)
MDO: 100027514(LAMB2) 100619627
OAA: 100075055(LAMB2)
GGA: 101748153 373980(LAMB2)
MGP: 100543991(LAMB2)
APLA: 101791187(LAMB2)
ACYG: 106044086(LAMB2)
TGU: 100222711(LAMB2)
GFR: 102039808(LAMB2) 102039977
FAB: 101807978(LAMB2) 101815023
PHI: 102105000 102108687(LAMB2)
CCW: 104683487
FPG: 101924374(LAMB2) 101924542
EGZ: 104134764(LAMB2)
AAM: 106489385
ASN: 102383684
CPIC: 101935096(LAMB2) 101948213
ACS: 100562869(lamb2)
GJA: 107119588(LAMB2)
XLA: 108715891(lamb2.S) 494988(lamb2.L)
XTR: 100170549 100485566(lamb2)
NPR: 108804387(LAMB2)
DRE: 337767(lamb2)
IPU: 108275997
AMEX: 103045854(lamb2)
TRU: 101074108(lamb2)
LCO: 104931246
MZE: 101470464
OLA: 101158524(lamb2)
PRET: 103466896(lamb2)
NFU: 107391424
CSEM: 103384674(lamb2)
LCF: 108884707(lamb2)
HCQ: 109511755(lamb2)
BPEC: 110172200(lamb2)
ELS: 105027768(lamb2)
SFM: 108925623
LCM: 102357973(LAMB2)
CMK: 103176694(lamb2)
SKO: 100371750
ADF: 107344906
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7698745
  Authors
Wewer UM, Gerecke DR, Durkin ME, Kurtz KS, Mattei MG, Champliaud MF, Burgeson RE, Albrechtsen R
  Title
Human beta 2 chain of laminin (formerly S chain): cDNA cloning, chromosomal localization, and expression in carcinomas.
  Journal
Genomics 24:243-52 (1994)
DOI:10.1006/geno.1994.1612
  Sequence
[hsa:3913]
Reference
  Authors
Durbeej M
  Title
Laminins.
  Journal
Cell Tissue Res 339:259-68 (2010)
DOI:10.1007/s00441-009-0838-2

KEGG   ORTHOLOGY: K06244Help
Entry
K06244                      KO                                     

Name
LAMB3
Definition
laminin, beta 3
Pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko05145  Toxoplasmosis
ko05146  Amoebiasis
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05222  Small cell lung cancer
Disease
H00586  Epidermolysis bullosa, junctional
H00615  Amelogenesis imperfecta
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06244  LAMB3; laminin, beta 3
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06244  LAMB3; laminin, beta 3
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06244  LAMB3; laminin, beta 3
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06244  LAMB3; laminin, beta 3
   05222 Small cell lung cancer
    K06244  LAMB3; laminin, beta 3
  Infectious diseases
   05165 Human papillomavirus infection
    K06244  LAMB3; laminin, beta 3
   05146 Amoebiasis
    K06244  LAMB3; laminin, beta 3
   05145 Toxoplasmosis
    K06244  LAMB3; laminin, beta 3
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta1 integrins
   VLA-3
    ITGB1; integrin beta 1
     Laminin-5
      K06244 LAMB3; laminin, beta 3
   VLA-6
    ITGB1; integrin beta 1
     Laminin-5
      K06244 LAMB3; laminin, beta 3
  Beta4 integrins
   alpha 6 beta 4
    ITGB4; integrin beta 4
     Laminin-5
      K06244 LAMB3; laminin, beta 3
BRITE hierarchy
Genes
HSA: 3914(LAMB3)
PTR: 469668(LAMB3)
PPS: 100980738(LAMB3)
GGO: 101147168(LAMB3)
PON: 100434204(LAMB3)
NLE: 100593136(LAMB3)
MCC: 720945(LAMB3)
MCF: 102116149(LAMB3) 102116810
CSAB: 103230157(LAMB3)
RRO: 104664167(LAMB3)
RBB: 108539549(LAMB3)
CJC: 100400492(LAMB3)
SBQ: 101041547(LAMB3)
MMU: 16780(Lamb3)
RNO: 305078(Lamb3)
CGE: 100763082(Lamb3)
NGI: 103727074(Lamb3)
HGL: 101713053(Lamb3)
CCAN: 109697854(Lamb3)
OCU: 100342905(LAMB3)
TUP: 102500921(LAMB3)
CFA: 442953(LAMB3)
AML: 100465597(LAMB3)
UMR: 103672489(LAMB3)
ORO: 101368738(LAMB3)
FCA: 101088641(LAMB3)
PTG: 102966519(LAMB3)
AJU: 106981781(LAMB3)
BTA: 529939(LAMB3)
BOM: 102274964(LAMB3)
BIU: 109570638(LAMB3)
PHD: 102318363(LAMB3)
CHX: 102168376(LAMB3)
OAS: 101105176(LAMB3)
SSC: 100736655(LAMB3)
CFR: 102503746(LAMB3)
CDK: 105099347(LAMB3)
BACU: 103003030(LAMB3)
LVE: 103087166(LAMB3)
OOR: 101284932(LAMB3)
ECB: 100056564(LAMB3)
EPZ: 103548659(LAMB3)
EAI: 106827171(LAMB3)
MYB: 102258165(LAMB3)
MYD: 102772410(LAMB3)
HAI: 109396115(LAMB3)
RSS: 109436137(LAMB3)
PALE: 102896504(LAMB3)
LAV: 100666736(LAMB3)
TMU: 101340544
MDO: 100021649(LAMB3)
SHR: 100922990(LAMB3)
OAA: 100079022(LAMB3)
GGA: 428268(LAMB3)
MGP: 100550212(LAMB3)
CJO: 107324774(LAMB3)
APLA: 101803829(LAMB3)
ACYG: 106041273(LAMB3)
TGU: 100219268(LAMB3)
GFR: 102045655(LAMB3)
FAB: 101812663(LAMB3)
PHI: 102114134(LAMB3)
PMAJ: 107214830(LAMB3)
CCW: 104692501(LAMB3)
FPG: 101910502(LAMB3)
FCH: 102053143(LAMB3)
CLV: 102086173(LAMB3)
EGZ: 104126830(LAMB3)
AAM: 106490981(LAMB3)
ASN: 102384455(LAMB3)
AMJ: 102568796(LAMB3)
PSS: 102458677(LAMB3)
CMY: 102934621(LAMB3)
CPIC: 101933356(LAMB3)
ACS: 100558673(lamb3)
PVT: 110072367(LAMB3)
PBI: 103057230 103060496(LAMB3)
GJA: 107108297(LAMB3)
XLA: 108709379(lamb3.S)
XTR: 100125073(lamb3)
NPR: 108792087(LAMB3)
DRE: 101885031
SRX: 107710800(lamb3)
SANH: 107667625(lamb3)
SGH: 107574763(lamb3)
IPU: 108281073(lamb3)
AMEX: 103034394(lamb3)
TRU: 101072355(lamb3)
LCO: 104922486(lamb3)
NCC: 104944693(lamb3)
MZE: 101474838(lamb3)
OLA: 101160896(lamb3)
XMA: 102232579(lamb3)
PRET: 103465466(lamb3)
CSEM: 103386619
LCF: 108873528(lamb3)
HCQ: 109514514(lamb3)
SASA: 106565121 106583477(lamb3)
ELS: 105016836(lamb3)
SFM: 108933774(lamb3)
LCM: 102358013(LAMB3)
CMK: 103182508(lamb3)
EPA: 110237345
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7512558
  Authors
Gerecke DR, Wagman DW, Champliaud MF, Burgeson RE
  Title
The complete primary structure for a novel laminin chain, the laminin B1k chain.
  Journal
J Biol Chem 269:11073-80 (1994)
  Sequence
[hsa:3914]
Reference
  Authors
Durbeej M
  Title
Laminins.
  Journal
Cell Tissue Res 339:259-68 (2010)
DOI:10.1007/s00441-009-0838-2

KEGG   ORTHOLOGY: K06245Help
Entry
K06245                      KO                                     

Name
LAMB4
Definition
laminin, beta 4
Pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko05145  Toxoplasmosis
ko05146  Amoebiasis
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05222  Small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06245  LAMB4; laminin, beta 4
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06245  LAMB4; laminin, beta 4
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06245  LAMB4; laminin, beta 4
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06245  LAMB4; laminin, beta 4
   05222 Small cell lung cancer
    K06245  LAMB4; laminin, beta 4
  Infectious diseases
   05165 Human papillomavirus infection
    K06245  LAMB4; laminin, beta 4
   05146 Amoebiasis
    K06245  LAMB4; laminin, beta 4
   05145 Toxoplasmosis
    K06245  LAMB4; laminin, beta 4
BRITE hierarchy
Genes
HSA: 22798(LAMB4)
PTR: 463657(LAMB4)
PPS: 100995715(LAMB4)
GGO: 101134487(LAMB4)
PON: 100461994(LAMB4)
NLE: 100581377(LAMB4)
MCC: 702225(LAMB4)
MCF: 102126627(LAMB4)
CSAB: 103226727(LAMB4)
RRO: 104661900 104672365(LAMB4)
RBB: 108540493
CJC: 100401649(LAMB4)
SBQ: 101050272(LAMB4)
NGI: 103732167(Lamb4)
HGL: 101699161(Lamb4)
TUP: 102469239(LAMB4)
CFA: 483260(LAMB4)
AML: 100477380(LAMB4)
UMR: 103674619(LAMB4)
ORO: 101382364(LAMB4)
FCA: 101101552(LAMB4)
PTG: 102953694(LAMB4)
AJU: 106980651(LAMB4)
BOM: 102281573(LAMB4)
PHD: 102324351(LAMB4)
CHX: 102174902(LAMB4)
OAS: 101106520(LAMB4)
SSC: 100623759(LAMB4)
CFR: 102521665(LAMB4)
CDK: 105093059(LAMB4)
BACU: 103006714(LAMB4)
LVE: 103071469(LAMB4)
ECB: 100060434(LAMB4)
EPZ: 103552450
EAI: 106825243(LAMB4)
MYB: 102251547(LAMB4)
MYD: 102774343(LAMB4)
HAI: 109372664(LAMB4)
RSS: 109454569(LAMB4)
PALE: 102896150(LAMB4)
LAV: 100658659(LAMB4)
TMU: 101360165
MDO: 100010505(LAMB4)
SHR: 100930114(LAMB4)
GGA: 396076(LAMB4)
CJO: 107307135(LAMB4)
APLA: 101801687(LAMB4)
ACYG: 106042016(LAMB4)
TGU: 100232151(LAMB4)
FAB: 101808835(LAMB4)
PHI: 102112414(LAMB4)
PMAJ: 107204229(LAMB4)
CCW: 104686860(LAMB4)
FPG: 101913112(LAMB4)
FCH: 102053780(LAMB4)
CLV: 102091528(LAMB4)
AAM: 106487734(LAMB4)
ASN: 102384443(LAMB4)
AMJ: 106736754(LAMB4)
PSS: 106731798(LAMB4)
CMY: 102931548(LAMB4)
CPIC: 101951512(LAMB4)
ACS: 100555540(lamb4)
PVT: 110080786(LAMB4)
PBI: 103061084(LAMB4)
XLA: 108711178(lamb4.L)
XTR: 100485623(lamb4)
DRE: 286831(lamb4)
SRX: 107712510
SANH: 107703192
SGH: 107589316
IPU: 108275290(lamb4)
AMEX: 103026700
TRU: 101062982(lamb4)
LCO: 104933731(lamb4)
MZE: 101468799
XMA: 102229570
PRET: 103466312
NFU: 107389093
CSEM: 103379636
LCF: 108891731
BPEC: 110163793
SASA: 106573244(lamb4)
ELS: 105018082
SFM: 108931438
LCM: 102356245(LAMB4)
CMK: 103190193(lamb4)
 » show all
TaxonomyKoalaUniProt

KEGG   ORTHOLOGY: K05635Help
Entry
K05635                      KO                                     

Name
LAMC1
Definition
laminin, gamma 1
Pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko05020  Prion diseases
ko05145  Toxoplasmosis
ko05146  Amoebiasis
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05222  Small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K05635  LAMC1; laminin, gamma 1
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K05635  LAMC1; laminin, gamma 1
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05635  LAMC1; laminin, gamma 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05635  LAMC1; laminin, gamma 1
   05222 Small cell lung cancer
    K05635  LAMC1; laminin, gamma 1
  Neurodegenerative diseases
   05020 Prion diseases
    K05635  LAMC1; laminin, gamma 1
  Infectious diseases
   05165 Human papillomavirus infection
    K05635  LAMC1; laminin, gamma 1
   05146 Amoebiasis
    K05635  LAMC1; laminin, gamma 1
   05145 Toxoplasmosis
    K05635  LAMC1; laminin, gamma 1
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Neural system
   Enzymatic CD
    PTPRF, LAR; receptor-type tyrosine-protein phosphatase F
     Laminin-1
      K05635 LAMC1; laminin, gamma 1
  Others
   LU; Lutheran blood group glycoprotein
    Laminin-10
     K05635 LAMC1; laminin, gamma 1
    Laminin-11
     K05635 LAMC1; laminin, gamma 1
   MCAM, CD146; melanoma cell adhesion molecule
    Laminin-8
     K05635 LAMC1; laminin, gamma 1
   CXADR, CAR; coxsackievirus and adenovirus receptor
    Laminin-1
     K05635 LAMC1; laminin, gamma 1
 2. Integrin Family
  Beta1 integrins
   VLA-1
    ITGB1; integrin beta 1
     Laminin-1
      K05635 LAMC1; laminin, gamma 1
     Laminin-2
      K05635 LAMC1; laminin, gamma 1
   VLA-2
    ITGB1; integrin beta 1
     Laminin-1
      K05635 LAMC1; laminin, gamma 1
     Laminin-2
      K05635 LAMC1; laminin, gamma 1
   VLA-3
    ITGB1; integrin beta 1
     Laminin-2
      K05635 LAMC1; laminin, gamma 1
     Laminin-10
      K05635 LAMC1; laminin, gamma 1
     Laminin-11
      K05635 LAMC1; laminin, gamma 1
   VLA-6
    ITGB1; integrin beta 1
     Laminin-1
      K05635 LAMC1; laminin, gamma 1
     Laminin-2
      K05635 LAMC1; laminin, gamma 1
     Laminin-8
      K05635 LAMC1; laminin, gamma 1
     Laminin-10
      K05635 LAMC1; laminin, gamma 1
     Laminin-11
      K05635 LAMC1; laminin, gamma 1
   VLA-7
    ITGB1; integrin beta 1
     Laminin-1
      K05635 LAMC1; laminin, gamma 1
     Laminin-2
      K05635 LAMC1; laminin, gamma 1
  Beta4 integrins
   alpha 6 beta 4
    ITGB4; integrin beta 4
     Laminin-1
      K05635 LAMC1; laminin, gamma 1
     Laminin-2
      K05635 LAMC1; laminin, gamma 1
 7. Others
  DAG1; dystroglycan 1
   Laminin-1
    K05635 LAMC1; laminin, gamma 1
   Laminin-2
    K05635 LAMC1; laminin, gamma 1
  APP; amyloid beta A4 protein
   Laminin-1
    K05635 LAMC1; laminin, gamma 1
BRITE hierarchy
Genes
HSA: 3915(LAMC1)
PTR: 457570(LAMC1)
PPS: 100968935(LAMC1)
GGO: 101132251(LAMC1)
PON: 100446999(LAMC1)
NLE: 100607126(LAMC1)
MCC: 715265(LAMC1)
MCF: 102116045(LAMC1)
CSAB: 103230459(LAMC1)
RRO: 104666795(LAMC1)
RBB: 108512695(LAMC1)
CJC: 100401710(LAMC1)
SBQ: 101037029(LAMC1)
MMU: 226519(Lamc1)
RNO: 117036(Lamc1)
CGE: 100761564(Lamc1)
NGI: 103726706(Lamc1)
HGL: 101720256(Lamc1)
CCAN: 109690242(Lamc1)
OCU: 100351387 103346447(LAMC1)
TUP: 102490693(LAMC1)
CFA: 480034(LAMC1)
AML: 100476326(LAMC1)
UMR: 103672511(LAMC1)
ORO: 101384210(LAMC1)
FCA: 101090321(LAMC1)
PTG: 102970302(LAMC1)
AJU: 106966784(LAMC1)
BTA: 532572(LAMC1)
BOM: 102268051(LAMC1)
BIU: 109570361(LAMC1)
PHD: 102317704(LAMC1)
CHX: 102170256(LAMC1)
OAS: 101105588(LAMC1)
SSC: 100514785(LAMC1)
CFR: 102509312(LAMC1)
CDK: 105096228(LAMC1)
BACU: 102999353(LAMC1)
LVE: 103090009(LAMC1)
OOR: 101282409(LAMC1)
ECB: 100055269(LAMC1)
EPZ: 103552121(LAMC1)
EAI: 106837014(LAMC1)
MYB: 102240493(LAMC1)
MYD: 102757457(LAMC1)
HAI: 109379100
RSS: 109445649(LAMC1)
PALE: 102885413(LAMC1)
LAV: 100671561(LAMC1)
TMU: 101360306
MDO: 100023945(LAMC1)
SHR: 100921255(LAMC1)
OAA: 100085738(LAMC1)
GGA: 424442(LAMC1)
MGP: 100541563(LAMC1)
CJO: 107317202(LAMC1)
APLA: 101802078(LAMC1)
ACYG: 106042469(LAMC1)
TGU: 100220035
GFR: 102044070(LAMC1)
FAB: 101810616(LAMC1)
PHI: 102105582(LAMC1)
PMAJ: 107207916(LAMC1)
CCW: 104693655(LAMC1)
FPG: 101917671(LAMC1)
FCH: 102056333(LAMC1)
CLV: 102094157(LAMC1)
EGZ: 104129720(LAMC1)
AAM: 106495749(LAMC1)
ASN: 102386182(LAMC1)
AMJ: 102561098(LAMC1)
PSS: 102462364(LAMC1)
CMY: 102940960(LAMC1)
CPIC: 101936526(LAMC1)
ACS: 100557963(lamc1)
PVT: 110091308(LAMC1)
PBI: 103051961(LAMC1)
GJA: 107121047(LAMC1)
XLA: 108714357(lamc1.L) 108715634(lamc1.S)
XTR: 100036631(lamc1)
NPR: 108803355(LAMC1)
DRE: 286832(lamc1)
IPU: 108267334(lamc1)
AMEX: 103023755(lamc1)
LCO: 104937399(lamc1)
MZE: 101478201(lamc1)
OLA: 100529197(lamc1)
XMA: 102226864(lamc1)
PRET: 103479953(lamc1)
NFU: 107383677(lamc1)
CSEM: 103398751
LCF: 108884872(lamc1)
HCQ: 109518828(lamc1)
BPEC: 110175115(lamc1)
ELS: 105018127(lamc1)
SFM: 108935127(lamc1)
LCM: 102359639(LAMC1)
CMK: 103179989(lamc2) 103180069(lamc1) 103183090
CIN: 100185266
SPU: 587252
APLC: 110987370
DME: Dmel_CG3322(LanB2)
DER: Dere_GG15392(Dere_LanB2)
DSE: Dsec_GM25166(Dsec_LanB2)
DSI: Dsimw501_GD14197(Dsim_LanB2)
DYA: Dyak_GE20856(Dyak_LanB2)
MDE: 101890619
AGA: AgaP_AGAP007629(LANB2)
AAG: 5566123
AME: 409474(LanB2)
BIM: 100743720
BTER: 100651805
SOC: 105193337
AEC: 105152770
ACEP: 105626050
PBAR: 105427491
HST: 105184920
CFO: 105254284
LHU: 105669218
PGC: 109861005
NVI: 100120968
TCA: 657051
BMOR: 101746961
PMAC: 106717211
PRAP: 110999917
PXY: 105392046
API: 100160481
ZNE: 110830676
FCD: 110845551
CEL: CELE_C54D1.5(lam-2)
CBR: CBG10982(Cbr-lam-2)
BMY: Bm1_27925
MYI: 110466528
OBI: 106882600
SHX: MS3_03032
ADF: 107353270
HMG: 100207691(lamc1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3360804
  Authors
Pikkarainen T, Kallunki T, Tryggvason K
  Title
Human laminin B2 chain. Comparison of the complete amino acid sequence with the B1 chain reveals variability in sequence homology between different structural domains.
  Journal
J Biol Chem 263:6751-8 (1988)
  Sequence
[hsa:3915]
Reference
  Authors
Durbeej M
  Title
Laminins.
  Journal
Cell Tissue Res 339:259-68 (2010)
DOI:10.1007/s00441-009-0838-2

KEGG   ORTHOLOGY: K06246Help
Entry
K06246                      KO                                     

Name
LAMC2
Definition
laminin, gamma 2
Pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko05145  Toxoplasmosis
ko05146  Amoebiasis
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05222  Small cell lung cancer
Disease
H00586  Epidermolysis bullosa, junctional
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06246  LAMC2; laminin, gamma 2
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06246  LAMC2; laminin, gamma 2
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06246  LAMC2; laminin, gamma 2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06246  LAMC2; laminin, gamma 2
   05222 Small cell lung cancer
    K06246  LAMC2; laminin, gamma 2
  Infectious diseases
   05165 Human papillomavirus infection
    K06246  LAMC2; laminin, gamma 2
   05146 Amoebiasis
    K06246  LAMC2; laminin, gamma 2
   05145 Toxoplasmosis
    K06246  LAMC2; laminin, gamma 2
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta1 integrins
   VLA-3
    ITGB1; integrin beta 1
     Laminin-5
      K06246 LAMC2; laminin, gamma 2
   VLA-6
    ITGB1; integrin beta 1
     Laminin-5
      K06246 LAMC2; laminin, gamma 2
  Beta4 integrins
   alpha 6 beta 4
    ITGB4; integrin beta 4
     Laminin-5
      K06246 LAMC2; laminin, gamma 2
BRITE hierarchy
Genes
HSA: 3918(LAMC2)
PTR: 457571(LAMC2)
PPS: 100967996(LAMC2)
GGO: 101132608(LAMC2)
PON: 100446634(LAMC2)
NLE: 100581925(LAMC2)
MCC: 715212(LAMC2)
MCF: 102116676(LAMC2)
CSAB: 103230458(LAMC2)
RRO: 104666798(LAMC2)
RBB: 108512736(LAMC2)
CJC: 100401336(LAMC2)
SBQ: 101035864(LAMC2)
MMU: 16782(Lamc2)
RNO: 192362(Lamc2)
CGE: 100765048(Lamc2)
NGI: 103726677(Lamc2)
HGL: 101719910(Lamc2)
CCAN: 109690249(Lamc2)
OCU: 103346853
TUP: 102480923(LAMC2)
CFA: 442939(LAMC2)
AML: 100475077(LAMC2)
UMR: 103672510(LAMC2)
ORO: 101384487(LAMC2)
FCA: 101089571(LAMC2)
PTG: 102966330(LAMC2)
BTA: 511043(LAMC2)
BOM: 102268327(LAMC2)
BIU: 109570495(LAMC2)
PHD: 102338881(LAMC2)
CHX: 102170540(LAMC2)
OAS: 100216328(LAMC2)
SSC: 100624264(LAMC2)
CFR: 102509067(LAMC2)
CDK: 105096227(LAMC2)
BACU: 103005240(LAMC2)
LVE: 103090274(LAMC2)
OOR: 101282661(LAMC2)
ECB: 791245(LAMC2)
EPZ: 103552000(LAMC2)
EAI: 106836991(LAMC2)
MYB: 102256358(LAMC2)
MYD: 102756895(LAMC2)
HAI: 109379101(LAMC2)
RSS: 109450425(LAMC2)
PALE: 102892078(LAMC2)
LAV: 100661346(LAMC2)
TMU: 101360565
MDO: 100023967(LAMC2)
SHR: 100921523(LAMC2)
OAA: 100085748(LAMC2)
GGA: 408043(LAMC2)
MGP: 104912357(LAMC2)
CJO: 107317204(LAMC2)
APLA: 101801618(LAMC2)
ACYG: 106042525(LAMC2)
TGU: 100230527(LAMC2)
GFR: 102044238(LAMC2)
FAB: 101810811(LAMC2)
PHI: 102101982(LAMC2)
PMAJ: 107207920(LAMC2)
CCW: 104693621(LAMC2)
FPG: 101915775(LAMC2)
FCH: 102056164(LAMC2)
CLV: 102093606(LAMC2)
EGZ: 104129707(LAMC2)
AAM: 106495750(LAMC2)
ASN: 102367869(LAMC2)
AMJ: 102577248(LAMC2)
PSS: 102462123(LAMC2)
CMY: 102940747(LAMC2)
CPIC: 101946386(LAMC2)
ACS: 100557765(lamc2)
PVT: 110091307(LAMC2)
PBI: 103051722(LAMC2)
GJA: 107112886 107121025(LAMC2)
XLA: 108714355(lamc2.L)
XTR: 100489162(lamc2)
NPR: 108803366(LAMC2)
SGH: 107563561
IPU: 108267337
AMEX: 103023426(lamc2)
TRU: 101079112
LCO: 104937404
NCC: 104963776
MZE: 101477641(lamc2)
OLA: 101156437
XMA: 102221687
PRET: 103479955
NFU: 107383682
CSEM: 103398757
LCF: 108884874(lamc2)
HCQ: 109518824(lamc2)
BPEC: 110165981(lamc2)
SASA: 106569065 106599435(lamc2)
ELS: 105018120(lamc2)
SFM: 108935172
LCM: 102359091(LAMC2)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1383240
  Authors
Kallunki P, Sainio K, Eddy R, Byers M, Kallunki T, Sariola H, Beck K, Hirvonen H, Shows TB, Tryggvason K
  Title
A truncated laminin chain homologous to the B2 chain: structure, spatial expression, and chromosomal assignment.
  Journal
J Cell Biol 119:679-93 (1992)
DOI:10.1083/jcb.119.3.679
  Sequence
[hsa:3918]
Reference
  Authors
Durbeej M
  Title
Laminins.
  Journal
Cell Tissue Res 339:259-68 (2010)
DOI:10.1007/s00441-009-0838-2

KEGG   ORTHOLOGY: K06247Help
Entry
K06247                      KO                                     

Name
LAMC3
Definition
laminin, gamma 3
Pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko05145  Toxoplasmosis
ko05146  Amoebiasis
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05222  Small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06247  LAMC3; laminin, gamma 3
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06247  LAMC3; laminin, gamma 3
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06247  LAMC3; laminin, gamma 3
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06247  LAMC3; laminin, gamma 3
   05222 Small cell lung cancer
    K06247  LAMC3; laminin, gamma 3
  Infectious diseases
   05165 Human papillomavirus infection
    K06247  LAMC3; laminin, gamma 3
   05146 Amoebiasis
    K06247  LAMC3; laminin, gamma 3
   05145 Toxoplasmosis
    K06247  LAMC3; laminin, gamma 3
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Others
   LU; Lutheran blood group glycoprotein
    Laminin-14
     K06247 LAMC3; laminin, gamma 3
BRITE hierarchy
Genes
HSA: 10319(LAMC3)
PTR: 464805(LAMC3)
PPS: 100995906(LAMC3)
GGO: 101128153(LAMC3)
PON: 100441462(LAMC3)
NLE: 100602023(LAMC3)
MCC: 722430(LAMC3)
MCF: 101925473 102147194(LAMC3)
CSAB: 103239930(LAMC3)
RRO: 104660568(LAMC3)
RBB: 108513926(LAMC3)
CJC: 100403136(LAMC3)
SBQ: 101054103(LAMC3)
MMU: 23928(Lamc3)
RNO: 102554659 311862(Lamc3)
CGE: 100751974(Lamc3)
NGI: 103727706(Lamc3)
HGL: 101697108(Lamc3)
CCAN: 109687632(Lamc3)
OCU: 103345292(LAMC3) 103346304
TUP: 102470123(LAMC3)
CFA: 491290(LAMC3)
AML: 100477198(LAMC3)
UMR: 103670411(LAMC3)
ORO: 101369468(LAMC3)
FCA: 101098499(LAMC3)
PTG: 102961184(LAMC3)
AJU: 106985338(LAMC3)
BTA: 518914(LAMC3)
BOM: 102265732(LAMC3)
BIU: 109566555(LAMC3)
PHD: 102345037(LAMC3)
CHX: 102184914(LAMC3)
OAS: 101122429(LAMC3)
SSC: 100157958(LAMC3)
CFR: 102519796(LAMC3)
CDK: 105085161(LAMC3)
BACU: 103006188(LAMC3)
LVE: 103071106(LAMC3)
OOR: 101280646(LAMC3)
ECB: 100069663(LAMC3)
EPZ: 103561038(LAMC3)
EAI: 106845299(LAMC3)
MYB: 102256058(LAMC3)
MYD: 102762957(LAMC3)
HAI: 109380683(LAMC3)
RSS: 109445946(LAMC3)
PALE: 102881476(LAMC3)
LAV: 100670126(LAMC3)
TMU: 101342240
MDO: 100015877(LAMC3)
SHR: 100935179(LAMC3)
OAA: 100075439(LAMC3)
GGA: 417180(LAMC3)
MGP: 100541837(LAMC3)
CJO: 107321813(LAMC3)
APLA: 101790325(LAMC3)
ACYG: 106044073(LAMC3)
TGU: 100219625(LAMC3)
GFR: 102031774(LAMC3)
FAB: 101821419(LAMC3)
PHI: 102100010(LAMC3)
PMAJ: 107212226(LAMC3)
CCW: 104688476(LAMC3)
FPG: 101922120(LAMC3)
FCH: 102058848(LAMC3)
CLV: 102091335(LAMC3)
EGZ: 104129836(LAMC3)
AAM: 106490315(LAMC3)
ASN: 102368946(LAMC3)
AMJ: 102568295(LAMC3)
PSS: 102461806(LAMC3)
CMY: 102938542(LAMC3)
CPIC: 101934606(LAMC3)
PVT: 110079604(LAMC3)
PBI: 103065626(LAMC3)
GJA: 107108926(LAMC3)
DRE: 558958(lamc3)
IPU: 108260275(lamc3)
AMEX: 103026870
TRU: 101061410(lamc3)
LCO: 104924923(lamc3)
NCC: 104947943
MZE: 101472039
OLA: 105355198(lamc3)
XMA: 102228440
PRET: 103473396
NFU: 107374931
CSEM: 103390070(lamc3)
LCF: 108874095
HCQ: 109517711
BPEC: 110157350
ELS: 105015244(lamc3)
SFM: 108927253(lamc3)
LCM: 102355446(LAMC3)
CMK: 103183102(lamc3)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Koch M, Olson PF, Albus A, Jin W, Hunter DD, Brunken WJ, Burgeson RE, Champliaud MF
  Title
Characterization and expression of the laminin gamma3 chain: a novel, non-basement membrane-associated, laminin chain.
  Journal
J Cell Biol 145:605-18 (1999)
DOI:10.1083/jcb.145.3.605
  Sequence
[hsa:10319]
Reference
  Authors
Durbeej M
  Title
Laminins.
  Journal
Cell Tissue Res 339:259-68 (2010)
DOI:10.1007/s00441-009-0838-2

KEGG   ORTHOLOGY: K06248Help
Entry
K06248                      KO                                     

Name
CHAD
Definition
chondroadherin
Pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko05165  Human papillomavirus infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06248  CHAD; chondroadherin
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06248  CHAD; chondroadherin
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06248  CHAD; chondroadherin
 Human Diseases
  Infectious diseases
   05165 Human papillomavirus infection
    K06248  CHAD; chondroadherin
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta1 integrins
   VLA-2
    ITGB1; integrin beta 1
     K06248 CHAD; chondroadherin
Proteoglycans [BR:ko00535]
 Extracellular matrix (ECM) proteoglycans
  Small leucine-rich proteoglycan (SLRP) family
   class IV
    K06248  CHAD; chondroadherin
BRITE hierarchy
Genes
HSA: 1101(CHAD)
PTR: 747194(CHAD)
PPS: 100987217(CHAD)
GGO: 101135402(CHAD)
PON: 100456207(CHAD)
NLE: 100579593 100580028(CHAD)
MCC: 702601(CHAD)
MCF: 102135245(CHAD)
CSAB: 103242933(CHAD)
RRO: 104680276(CHAD)
RBB: 108516431(CHAD)
CJC: 100384970(CHAD)
SBQ: 101027984(CHAD)
MMU: 12643(Chad)
RNO: 29195(Chad)
CGE: 100758456(Chad)
NGI: 103738388(Chad)
HGL: 101705837(Chad)
CCAN: 109681506(Chad)
OCU: 100347341(CHAD)
TUP: 102474235(CHAD)
CFA: 609296(CHAD)
AML: 100474986(CHAD)
ORO: 101370869(CHAD)
FCA: 111557728(CHAD)
PTG: 107180075(CHAD)
AJU: 106985152(CHAD)
BTA: 281069(CHAD)
BOM: 102286624(CHAD)
BIU: 109574171(CHAD)
PHD: 102325230(CHAD)
CHX: 102176727(CHAD)
OAS: 105608408(CHAD)
SSC: 100624069(CHAD)
CFR: 102521285(CHAD)
CDK: 105097742(CHAD)
BACU: 102998876(CHAD)
LVE: 103069406(CHAD)
OOR: 101276724(CHAD)
ECB: 100147607(CHAD)
EPZ: 103549559(CHAD)
EAI: 106826351(CHAD)
MYB: 102241550(CHAD)
MYD: 102768490(CHAD)
HAI: 109380758(CHAD)
RSS: 109447020(CHAD)
PALE: 102887721(CHAD)
LAV: 100669678(CHAD)
TMU: 101353058
MDO: 100617168(CHAD)
SHR: 100919960(CHAD)
GGA: 769665(CHAD)
MGP: 100550465(CHAD)
CJO: 107322307(CHAD)
APLA: 101796802(CHAD)
ACYG: 106034661(CHAD)
TGU: 100219841(CHAD)
GFR: 102041008(CHAD)
FAB: 101819253(CHAD)
PHI: 102111719(CHAD)
PMAJ: 107212427(CHAD)
CCW: 104694290(CHAD)
FPG: 101917256(CHAD)
FCH: 102054080(CHAD)
CLV: 102087447(CHAD)
EGZ: 104125414(CHAD)
AAM: 106500045(CHAD)
ASN: 102370704(CHAD)
AMJ: 102573229(CHAD)
PSS: 102446841(CHAD)
CMY: 102936694(CHAD)
CPIC: 101946500(CHAD)
ACS: 103277842(chad)
PVT: 110091203(CHAD)
PBI: 103062184(CHAD)
GJA: 107110029(CHAD)
XLA: 108701097(chad.L) 108702793(chad.S)
XTR: 101732210(chad)
NPR: 108796401(CHAD)
DRE: 394038(chad)
IPU: 108273870(chad)
AMEX: 103037341(chad)
TRU: 105417299(chad)
LCO: 109142191(chad)
NCC: 104944426(chad)
MZE: 101484009(chad)
OLA: 105356591(chad)
XMA: 102222628(chad)
PRET: 103481744(chad)
NFU: 107387471(chad)
CSEM: 103381900(chad)
LCF: 108892015(chad)
HCQ: 109518560(chad)
BPEC: 110154230(chad)
ELS: 105006984(chad)
SFM: 108930283(chad)
LCM: 102361099(CHAD)
CMK: 103175646(chad)
MYI: 110465019
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Mansson B, Wenglen C, Morgelin M, Saxne T, Heinegard D
  Title
Association of chondroadherin with collagen type II.
  Journal
J Biol Chem 276:32883-8 (2001)
DOI:10.1074/jbc.M101680200
  Sequence
[hsa:1101]
Reference
PMID:9461555
  Authors
Shen Z, Gantcheva S, Mansson B, Heinegard D, Sommarin Y
  Title
Chondroadherin expression changes in skeletal development.
  Journal
Biochem J 330 ( Pt 1):549-57 (1998)
DOI:10.1042/bj3300549
  Sequence
[rno:29195]

KEGG   ORTHOLOGY: K06249Help
Entry
K06249                      KO                                     

Name
RELN
Definition
reelin [EC:3.4.21.-]
Pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko05165  Human papillomavirus infection
Disease
H00268  Lissencephaly (LIS)
H00809  Familial epilepsy temporal lobe (ETL)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06249  RELN; reelin
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06249  RELN; reelin
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06249  RELN; reelin
 Human Diseases
  Infectious diseases
   05165 Human papillomavirus infection
    K06249  RELN; reelin
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.-  
     K06249  RELN; reelin
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta1 integrins
   VLA-3
    ITGB1; integrin beta 1
     K06249 RELN; reelin
BRITE hierarchy
Genes
HSA: 5649(RELN)
PTR: 463635(RELN)
PPS: 100987617(RELN)
GGO: 101141160(RELN)
PON: 100447813(RELN)
NLE: 100593340(RELN)
MCC: 696372(RELN)
MCF: 102129690(RELN)
CSAB: 103226686(RELN)
RRO: 104663444 104673554
RBB: 108515151(RELN)
CJC: 100403212(RELN)
SBQ: 101049210(RELN)
MMU: 19699(Reln)
RNO: 24718(Reln)
CGE: 100758172(Reln)
NGI: 103732198(Reln)
HGL: 101719888(Reln)
OCU: 100341603(RELN)
TUP: 102501166(RELN)
CFA: 483273(RELN)
AML: 100480458(RELN)
UMR: 103674717(RELN)
ORO: 101384714(RELN)
FCA: 101085703(RELN)
PTG: 102959297(RELN)
AJU: 106972717(RELN)
BTA: 281450(RELN)
BOM: 102265040(RELN)
PHD: 102318736(RELN)
CHX: 102172966(RELN)
OAS: 101120658(RELN)
SSC: 100627126(RELN)
CFR: 102514061(RELN)
CDK: 105093049(RELN)
BACU: 102999363(RELN)
LVE: 103086689(RELN)
OOR: 101286755(RELN)
ECB: 100058621(RELN)
EPZ: 103560052 103566810(RELN)
EAI: 106825228(RELN)
MYB: 102252569(RELN)
MYD: 102775302(RELN)
HAI: 109389504(RELN)
RSS: 109454145(RELN)
PALE: 102898395(RELN)
LAV: 100655250(RELN)
TMU: 101361669
MDO: 100013879(RELN)
SHR: 100921360(RELN)
OAA: 100076682(RELN)
GGA: 427850(RELN)
MGP: 100545091
CJO: 107324286(RELN)
APLA: 101791094(RELN)
ACYG: 106035515(RELN)
TGU: 100231258(RELN)
GFR: 102037725(RELN)
FAB: 101809778(RELN)
PHI: 102108705(RELN)
PMAJ: 107204750(RELN)
CCW: 104686928(RELN)
FPG: 101912180(RELN)
FCH: 102053889(RELN)
CLV: 102093832(RELN)
EGZ: 104128581(RELN)
AAM: 106485255(RELN)
ASN: 102374091(RELN)
AMJ: 102576118(RELN)
PSS: 102453313(RELN)
CMY: 102931247(RELN)
CPIC: 101941140(RELN)
ACS: 100552788(reln)
PVT: 110077192(RELN)
PBI: 103057030(RELN)
GJA: 107113702(RELN)
XLA: 398547(reln.L)
XTR: 100192371(reln)
NPR: 108790212(RELN) 108795226
DRE: 260303(reln)
SRX: 107711363(reln) 107728186
SGH: 107567483(reln) 107599772
IPU: 108264645(reln)
AMEX: 103047667(reln)
TRU: 101074793(reln)
LCO: 104940675(reln)
NCC: 104950072(reln)
MZE: 101485598(reln)
OLA: 100049232(reln)
XMA: 102226043(reln)
PRET: 103466397(reln)
NFU: 107388505(reln)
CSEM: 103380435(reln)
LCF: 108876668(reln)
HCQ: 109507627(reln)
BPEC: 110169442(reln)
ELS: 105018330(reln)
SFM: 108918695 108931568(reln)
LCM: 102348401(RELN)
CMK: 103176978(reln)
CIN: 100184419
SPU: 579060(reln)
APLC: 110982067
SKO: 100377292
CRG: 105317553
MYI: 110455393
OBI: 106875197
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7715726
  Authors
D'Arcangelo G, Miao GG, Chen SC, Soares HD, Morgan JI, Curran T
  Title
A protein related to extracellular matrix proteins deleted in the mouse mutant reeler.
  Journal
Nature 374:719-23 (1995)
DOI:10.1038/374719a0
  Sequence
[mmu:19699]
Reference
  Authors
Yip JW, Yip YP, Nakajima K, Capriotti C
  Title
Reelin controls position of autonomic neurons in the spinal cord.
  Journal
Proc Natl Acad Sci U S A 97:8612-6 (2000)
DOI:10.1073/pnas.150040497

KEGG   ORTHOLOGY: K04659Help
Entry
K04659                      KO                                     

Name
THBS2S
Definition
thrombospondin 2/3/4/5
Pathway
ko04145  Phagosome
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko05144  Malaria
ko05165  Human papillomavirus infection
Disease
H00476  Multiple epiphyseal dysplasia (MED)
H00477  Pseudoachondroplasia (PSACH)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K04659  THBS2S; thrombospondin 2/3/4/5
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K04659  THBS2S; thrombospondin 2/3/4/5
 Cellular Processes
  Transport and catabolism
   04145 Phagosome
    K04659  THBS2S; thrombospondin 2/3/4/5
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04659  THBS2S; thrombospondin 2/3/4/5
 Human Diseases
  Infectious diseases
   05165 Human papillomavirus infection
    K04659  THBS2S; thrombospondin 2/3/4/5
   05144 Malaria
    K04659  THBS2S; thrombospondin 2/3/4/5
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Opsonins
    K04659  THBS2S; thrombospondin 2/3/4/5
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K04659  THBS2S; thrombospondin 2/3/4/5
  Exosomal proteins of colorectal cancer cells
   K04659  THBS2S; thrombospondin 2/3/4/5
  Exosomal proteins of bladder cancer cells
   K04659  THBS2S; thrombospondin 2/3/4/5
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta1 integrins
   VLA-3
    ITGB1; integrin beta 1
     K04659 THBS2S; thrombospondin 2/3/4/5
  Beta3 integrins
   alpha IIb  beta 3
    ITGB3; integrin beta 3
     K04659 THBS2S; thrombospondin 2/3/4/5
   VNR
    ITGB3; integrin beta 3
     K04659 THBS2S; thrombospondin 2/3/4/5
 7. Others
  SDC4; syndecan 4
   K04659 THBS2S; thrombospondin 2/3/4/5
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Extracellular matrix molecules
   K04659  THBS2S; thrombospondin 2/3/4/5
BRITE hierarchy
Genes
HSA: 1311(COMP) 7058(THBS2) 7059(THBS3) 7060(THBS4)
PTR: 450172(THBS4) 457359(THBS3) 463138(THBS2) 469068(COMP)
PPS: 100967906(COMP) 100978289(THBS4) 100985431(THBS3) 100991072(THBS2)
GGO: 101128581(THBS4) 101149083(THBS3) 101150111(THBS2) 101152032(COMP)
PON: 100443331(THBS3) 100447159(COMP) 100461836(THBS4)
NLE: 100580032(THBS2) 100582320(COMP) 100588927(THBS4) 100593174(THBS3)
MCC: 574276(THBS4) 708165(THBS2) 717572(THBS3) 720286(COMP)
MCF: 101867220(COMP) 102120028(THBS3) 102125342(THBS2) 102129227(THBS4)
CSAB: 103223769(THBS4) 103223887(THBS3) 103234192(COMP) 103240966(THBS2)
RRO: 104659600(THBS3) 104680172(THBS4) 104680632(COMP) 104681915(THBS2)
RBB: 108515625(COMP) 108525204 108526834(THBS3) 108528909(THBS4) 108542407(THBS2)
CJC: 100391538(THBS4) 100391690 100397101(THBS3) 100401976(THBS2)
SBQ: 101039744(THBS3) 101040437(COMP) 101043743(THBS2) 101046556(THBS4)
MMU: 12845(Comp) 21826(Thbs2) 21827(Thbs3) 21828(Thbs4)
RNO: 25304(Comp) 29220(Thbs4) 292406(Thbs2) 681309(Thbs3)
CGE: 100752022(Thbs2) 100756924(Thbs3) 100762358(Thbs4) 100766091(Comp)
NGI: 103726858(Comp) 103742336(Thbs2) 103750279(Thbs4) 103750946(Thbs3)
HGL: 101696497(Thbs2) 101703996(Comp) 101704466(Thbs3) 101726773(Thbs4)
CCAN: 109680095(Thbs4) 109687973(Thbs3) 109688824 109694649(Comp) 109700790(Thbs2)
OCU: 100343910(THBS3) 100357137(THBS4) 100357972(THBS2)
TUP: 102476294(COMP) 102485527(THBS4) 102489246(Mucin-1) 102502758(THBS2)
CFA: 476665(COMP) 484087(THBS2) 488930(THBS4) 610359(THBS3)
AML: 100471588(THBS4) 100475917(THBS3) 100479895(COMP) 100481026(THBS2)
UMR: 103660792(THBS2) 103668378(THBS3) 103674931(COMP) 103681497(THBS4)
ORO: 101367458(THBS3) 101379053(THBS4) 101379820(COMP) 101381226(THBS2)
FCA: 101087199(THBS4) 101088820(COMP) 101093580(THBS3) 101100567(THBS2)
PTG: 102961939(THBS4) 102970054(THBS2) 102970726(THBS3) 102971808(COMP)
AJU: 106969137(COMP) 106972141(THBS4) 106978641(THBS2) 106981523(THBS3)
BTA: 281088(COMP) 338092(THBS2) 504323(THBS3) 541281(THBS4)
BOM: 102267028(COMP) 102271065(THBS3) 102277745 102284714(THBS4) 106701188(THBS2)
BIU: 109553708(THBS3) 109561393(COMP) 109564125(THBS2) 109564670(THBS4)
PHD: 102321875(THBS3) 102325197(THBS4) 102331784(THBS2) 102337395(COMP)
CHX: 102179674(THBS2) 102179675(THBS4) 102190117(COMP) 102190652(THBS3)
OAS: 101107864(COMP) 101115211(THBS4) 101116784(THBS3) 101116840(THBS2) 105606081
SSC: 100153940(THBS2) 100155108(THBS3) 100513005(THBS4) 396554(COMP)
CFR: 102511726(COMP) 102513826(THBS2) 102520625(THBS3) 102524625(THBS4)
CDK: 105084831(THBS4) 105088884(THBS3) 105091818(THBS2) 105101885(COMP)
BACU: 102998613(THBS4) 102999752(THBS2) 103007252(COMP) 103007962(THBS3)
LVE: 103068905(THBS3) 103083668(THBS4) 103086398(THBS2) 103090939(COMP)
OOR: 101271822(THBS3) 101272205(THBS2) 101274051(COMP) 101284998(THBS4)
ECB: 100033911(COMP) 100050044(THBS2) 100063449(THBS3) 100073261(THBS4)
EPZ: 103546470(THBS2) 103552847(THBS3) 103556665(THBS4) 103565076(COMP)
EAI: 106828497(THBS3) 106841151(THBS4) 106846480(COMP) 106846766(THBS2)
MYB: 102242389(THBS2) 102248184(THBS4) 102249845(COMP) 102250634(THBS3)
MYD: 102752804(THBS4) 102759156(THBS3) 102759906(THBS2) 102770367(COMP)
HAI: 109381904(THBS4) 109382454(COMP) 109391677(THBS2) 109393407(THBS3)
RSS: 109434678(THBS3) 109438035(THBS2) 109445657(THBS4) 109449974(COMP)
PALE: 102880862(THBS2) 102885384(COMP) 102890277(THBS3) 102898345(THBS4)
LAV: 100657841(THBS3) 100667600(COMP) 100673862(THBS4) 100677407(THBS2)
MDO: 100016186(COMP) 100022025(THBS3) 100032579(THBS4) 100032659(THBS2)
SHR: 100913793(THBS2) 100926884(THBS4) 100928896(THBS3) 100934583(COMP)
OAA: 100082089(THBS2)
GGA: 396306(THBS4) 414837(THBS2) 420120(COMP)
MGP: 100545155(THBS2) 100548314(COMP)
CJO: 107305921(THBS4) 107311485(THBS2) 107325349(COMP)
APLA: 101797309(THBS3) 101797964(THBS2) 101801619(THBS4) 101803344(COMP)
ACYG: 106042117(THBS4) 106044590(THBS2) 106047968(COMP) 106048533(THBS3)
TGU: 100217632(THBS3) 100221289(THBS2) 100223523(THBS4)
GFR: 102035426(COMP) 102041416(THBS3) 102042662(THBS2) 102043756(THBS4)
FAB: 101807800(COMP) 101812668(THBS4) 101813407(THBS2) 101822081(THBS3)
PHI: 102105229(THBS2) 102107320(COMP) 102111962(THBS3) 102113828(THBS4)
PMAJ: 107201101(THBS2) 107214594(THBS3) 107215384(COMP) 107216117(THBS4)
CCW: 104683533 104684330(THBS2) 104695692(THBS4) 104697387(COMP)
FPG: 101920098(THBS4) 101921164(THBS3) 101923157(THBS2) 101923991(COMP)
FCH: 102046521(THBS3) 102049450(THBS4) 102058509(COMP) 102059472(THBS2)
CLV: 102088266(THBS2) 102095550(THBS3) 102097761(THBS4) 102098894(COMP)
EGZ: 104124903(THBS4) 104128875(THBS2) 104129782(COMP) 104134863(THBS3)
AAM: 106487359(THBS2) 106494326(THBS3) 106496803(COMP) 106497564 106499036
ASN: 102368490(THBS2) 102376216(COMP) 102384190(THBS4) 102388282(THBS3)
AMJ: 102565816(THBS3) 102573791(THBS4) 102576627(THBS2) 106737012(COMP) 106737441
PSS: 102447492(THBS4) 102453824 102459232(THBS2) 102462619(COMP)
CMY: 102939257(COMP) 102941449(THBS2) 102942106(THBS3) 102946626(THBS4)
CPIC: 101930762(THBS2) 101934649(THBS4) 101937108(THBS3) 101937854(COMP)
ACS: 100559567(thbs3) 100563584(thbs2) 100563715(thbs4) 100564230(comp)
PVT: 110072531(COMP) 110073932(THBS4) 110080993(THBS3) 110083084(THBS2)
PBI: 103049428(THBS3) 103057878(THBS4) 103065576(THBS2) 103067390(COMP)
GJA: 107106668(THBS2) 107115485(THBS4) 107117080(THBS3) 107125775(COMP)
XLA: 108695262 108700446(thbs3.S) 108706910 108716699 108717845 380339(thbs3.L) 397943(thbs4) 446985(thbs4.S)
XTR: 100494714(comp) 100494997(thbs2) 496875(thbs3) 780130(thbs4)
NPR: 108789855(THBS2) 108794774(THBS3) 108796348 108797516(THBS4)
DRE: 100318854(comp) 100535241(thbs2a) 252849(thbs3a) 252850(thbs4b) 563429(thbs4a)
TRU: 101070052 101071532(comp) 101075106(thbs4) 101077022(thbs2) 101079662(thbs3)
LCO: 104920415(comp) 104921293(thbs4) 104922466 104934561 104937267(thbs3) 104940043(thbs2)
PRET: 103463136(comp) 103470407(thbs4) 103473457 103477036(thbs2) 103477525(thbs3) 103481557
CSEM: 103381578 103387278(thbs2) 103388114(thbs3) 103390445 103395640(comp) 103398290(thbs4)
LCM: 102345222(THBS4) 102349677(THBS3) 102360244(COMP) 102363612(THBS2)
CMK: 103174435 103174809(thbs2) 103177771(thbs4) 103182059(comp)
CIN: 100169670(thbsb) 100169671(thbsbi)
SPU: 576669(thbs3) 585488
DME: Dmel_CG11326(Tsp)
DSI: Dsimw501_GD22550(Dsim_GD22550) Dsimw501_GD27031(Dsim_GD27031)
MDE: 101901673
AAG: 5569974
AME: 413782(Tsp)
BIM: 100750023
BTER: 100650650
SOC: 105205371
AEC: 105153996
ACEP: 105618023
HST: 105181268
CFO: 105250842
LHU: 105675000
NVI: 100114667
TCA: 655453
NVL: 108568621
BMOR: 101743002
PMAC: 106716790
PRAP: 111002663
API: 100168802
DNX: 107166897
ZNE: 110838833
FCD: 110863343
TUT: 107360433
OBI: 106872747
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1559694
  Authors
LaBell TL, Milewicz DJ, Disteche CM, Byers PH
  Title
Thrombospondin II: partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans.
  Journal
Genomics 12:421-9 (1992)
DOI:10.1016/0888-7543(92)90430-Z
  Sequence
[hsa:7058]
Reference
  Authors
Christopherson KS, Ullian EM, Stokes CC, Mullowney CE, Hell JW, Agah A, Lawler J, Mosher DF, Bornstein P, Barres BA
  Title
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis.
  Journal
Cell 120:421-33 (2005)
DOI:10.1016/j.cell.2004.12.020

KEGG   ORTHOLOGY: K05717Help
Entry
K05717                      KO                                     

Name
FN1
Definition
fibronectin 1
Pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko04810  Regulation of actin cytoskeleton
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05100  Bacterial invasion of epithelial cells
ko05146  Amoebiasis
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05222  Small cell lung cancer
Disease
H01260  Glomerulopathy with fibronectin deposits (GFND)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K05717  FN1; fibronectin 1
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K05717  FN1; fibronectin 1
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05717  FN1; fibronectin 1
  Cell motility
   04810 Regulation of actin cytoskeleton
    K05717  FN1; fibronectin 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05717  FN1; fibronectin 1
   05205 Proteoglycans in cancer
    K05717  FN1; fibronectin 1
   05222 Small cell lung cancer
    K05717  FN1; fibronectin 1
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05717  FN1; fibronectin 1
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    K05717  FN1; fibronectin 1
   05165 Human papillomavirus infection
    K05717  FN1; fibronectin 1
   05146 Amoebiasis
    K05717  FN1; fibronectin 1
Membrane trafficking [BR:ko04131]
 Endoplasmic reticulum (ER) - Golgi transport
  Forward pathways
   ER-Golgi intermediate compartment (ERGIC) proteins
    K05717  FN1; fibronectin 1
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of bladder cancer cells
   K05717  FN1; fibronectin 1
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Others
   CXADR, CAR; coxsackievirus and adenovirus receptor
    K05717 FN1; fibronectin 1
 2. Integrin Family
  Beta1 integrins
   VLA-4
    ITGB1; integrin beta 1
     K05717 FN1; fibronectin 1
   VLA-5
    ITGB1; integrin beta 1
     K05717 FN1; fibronectin 1
   VLA-8
    ITGB1; integrin beta 1
     K05717 FN1; fibronectin 1
   alpha V beta 1
    ITGB1; integrin beta 1
     K05717 FN1; fibronectin 1
  Beta3 integrins
   alpha IIb  beta 3
    ITGB3; integrin beta 3
     K05717 FN1; fibronectin 1
   VNR
    ITGB3; integrin beta 3
     K05717 FN1; fibronectin 1
  Beta6 integrins
   alpha V beta 6
    ITGB6; integrin beta 6
     K05717 FN1; fibronectin 1
  Beta7 integrins
   alpha 4 beta 7
    ITGB7; integrin beta 7
     K05717 FN1; fibronectin 1
  Beta8 integrins
   alpha V beta 8
    ITGB8; integrin beta 8
     K05717 FN1; fibronectin 1
 4. Link Protein Family
  CD44; CD44 antigen
   K05717 FN1; fibronectin 1
 7. Others
  SDC1; syndecan 1
   K05717 FN1; fibronectin 1
  SDC4; syndecan 4
   K05717 FN1; fibronectin 1
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Extracellular matrix molecules
   K05717  FN1; fibronectin 1
BRITE hierarchy
Genes
HSA: 2335(FN1)
PTR: 459926(FN1)
PPS: 100992555(FN1)
GGO: 101138168(FN1)
PON: 100449704(FN1)
NLE: 100601303(FN1)
MCC: 613269(FN1)
MCF: 102119232(FN1)
CSAB: 103217800(FN1)
RRO: 104669238(FN1)
RBB: 108543178(FN1)
CJC: 100405983(FN1)
SBQ: 101045340(FN1)
MMU: 14268(Fn1)
RNO: 25661(Fn1)
CGE: 100751189(Fn1)
NGI: 103727691(Fn1)
HGL: 101718570(Fn1)
CCAN: 109697804(Fn1) 109702876
OCU: 100328589(FN1)
TUP: 102490245(FN1) 102499269
CFA: 403845(FN1)
AML: 100464134(FN1)
UMR: 103662788(FN1)
ORO: 101365197(FN1)
FCA: 101081746(FN1)
PTG: 102970250(FN1)
AJU: 106970125(FN1)
BTA: 280794(FN1)
BOM: 102280180(FN1)
PHD: 102336627(FN1)
CHX: 102182645(FN1)
OAS: 100216462(FN1)
SSC: 397620(FN1)
CFR: 102518759(FN1)
CDK: 105086605(FN1)
BACU: 103018975(FN1)
LVE: 103084224(FN1)
OOR: 101275475(FN1)
ECB: 100034189(FN1)
EPZ: 103563053(FN1)
EAI: 106832715(FN1)
MYB: 102244892(FN1)
MYD: 102753951(FN1)
HAI: 109380590(FN1)
RSS: 109445065(FN1)
PALE: 102891509(FN1)
LAV: 100667853(FN1)
TMU: 101361092
MDO: 100014118(FN1)
SHR: 100927509(FN1)
OAA: 100078116(FN1)
GGA: 396133(FN1)
MGP: 100551213(FN1)
CJO: 107316471(FN1)
APLA: 101800175(FN1)
ACYG: 106034457(FN1)
TGU: 100231676(FN1)
GFR: 102039500(FN1)
FAB: 101807963(FN1)
PHI: 102104961(FN1)
PMAJ: 107207628(FN1)
CCW: 104694587(FN1)
FPG: 101911302(FN1)
FCH: 102054264(FN1)
CLV: 102090641(FN1)
EGZ: 104124152(FN1)
AAM: 106492397(FN1)
ASN: 102381879(FN1)
AMJ: 102569824(FN1)
PSS: 102450093(FN1)
CMY: 102932170(FN1)
CPIC: 101942436 101948945(FN1)
ACS: 100563512(fn1)
PVT: 110081893(FN1)
PBI: 103048603(FN1)
GJA: 107121182(FN1)
XLA: 397744(fn1.S)
XTR: 595087(fn1)
NPR: 108789839(FN1)
DRE: 100005469(fn1a)
TRU: 101061998 101071818(fn1)
LCO: 104918250(fn1) 104919608
MZE: 101472390 101472884(fn1)
OLA: 100529198(fn1) 101159085
PRET: 103460487 103462008(fn1)
NFU: 107381665(fn1) 107390187
LCM: 102360478 102367537(FN1)
CMK: 103176556(fn1)
LAK: 106165850
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kay RA, Ellis IR, Jones SJ, Perrier S, Florence MM, Schor AM, Schor SL
  Title
The expression of migration stimulating factor, a potent oncofetal cytokine, is uniquely controlled by 3'-untranslated region-dependent nuclear sequestration of its precursor messenger RNA.
  Journal
Cancer Res 65:10742-9 (2005)
DOI:10.1158/0008-5472.CAN-05-2038
  Sequence
[hsa:2335]
Reference
  Authors
Yi M, Ruoslahti E
  Title
A fibronectin fragment inhibits tumor growth, angiogenesis, and metastasis.
  Journal
Proc Natl Acad Sci U S A 98:620-4 (2001)
DOI:10.1073/pnas.98.2.620
Reference
PMID:3031656
  Authors
Dean DC, Bowlus CL, Bourgeois S
  Title
Cloning and analysis of the promotor region of the human fibronectin gene.
  Journal
Proc Natl Acad Sci U S A 84:1876-80 (1987)
DOI:10.1073/pnas.84.7.1876
  Sequence
[hsa:2335]

KEGG   ORTHOLOGY: K06250Help
Entry
K06250                      KO                                     

Name
SPP1, BNSP, OPN
Definition
secreted phosphoprotein 1
Pathway
ko04151  PI3K-Akt signaling pathway
ko04371  Apelin signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko04620  Toll-like receptor signaling pathway
ko05165  Human papillomavirus infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04371 Apelin signaling pathway
    K06250  SPP1, BNSP, OPN; secreted phosphoprotein 1
   04151 PI3K-Akt signaling pathway
    K06250  SPP1, BNSP, OPN; secreted phosphoprotein 1
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06250  SPP1, BNSP, OPN; secreted phosphoprotein 1
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06250  SPP1, BNSP, OPN; secreted phosphoprotein 1
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K06250  SPP1, BNSP, OPN; secreted phosphoprotein 1
 Human Diseases
  Infectious diseases
   05165 Human papillomavirus infection
    K06250  SPP1, BNSP, OPN; secreted phosphoprotein 1
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta1 integrins
   VLA-4
    ITGB1; integrin beta 1
     K06250 SPP1, BNSP, OPN; secreted phosphoprotein 1
   VLA-8
    ITGB1; integrin beta 1
     K06250 SPP1, BNSP, OPN; secreted phosphoprotein 1
   VLA-9
    ITGB1; integrin beta 1
     K06250 SPP1, BNSP, OPN; secreted phosphoprotein 1
  Beta3 integrins
   VNR
    ITGB3; integrin beta 3
     K06250 SPP1, BNSP, OPN; secreted phosphoprotein 1
BRITE hierarchy
Genes
HSA: 6696(SPP1)
PTR: 461366(SPP1)
PPS: 100994106(SPP1)
GGO: 101139661(SPP1)
PON: 100189638(SPP1)
NLE: 100594369(SPP1)
MCC: 704930(SPP1)
MCF: 102137879(SPP1)
CSAB: 103235944(SPP1)
RRO: 104664613(SPP1)
RBB: 108544702(SPP1)
CJC: 100412217(SPP1)
SBQ: 101054347(SPP1)
MMU: 20750(Spp1)
RNO: 25353(Spp1)
CGE: 100769547(Spp1)
NGI: 103731750(Spp1)
HGL: 101726269(Spp1)
CCAN: 109679386(Spp1)
OCU: 100008982(SPP1)
TUP: 102486669(SPP1)
CFA: 478471(SPP1)
AML: 100475539(SPP1)
UMR: 103677885(SPP1)
ORO: 101386416(SPP1)
FCA: 101094264(SPP1)
PTG: 102951907(SPP1)
AJU: 106976213(SPP1)
BTA: 281499(SPP1)
BOM: 102274580(SPP1)
BIU: 109560352(SPP1)
PHD: 102342012(SPP1)
CHX: 100860805(SPP1)
OAS: 443058(SPP1)
SSC: 397087(SPP1)
CFR: 102524305(SPP1)
CDK: 105091573(SPP1)
BACU: 103005187(SPP1)
LVE: 103078728(SPP1)
OOR: 101270190(SPP1)
ECB: 100053029(SPP1)
EPZ: 103553211(SPP1)
EAI: 106831951(SPP1)
MYB: 102245794(SPP1)
MYD: 102762154(SPP1)
HAI: 109396331(SPP1)
RSS: 109439127(SPP1)
PALE: 102890230(SPP1)
LAV: 100670250(SPP1)
TMU: 101343228
MDO: 100016723(SPP1)
SHR: 100924158(SPP1)
OAA: 100085686(SPP1)
GGA: 395210(SPP1)
MGP: 100541448(SPP1)
CJO: 107313466(SPP1)
APLA: 101792362(SPP1)
ACYG: 106041870(SPP1)
TGU: 100231638(SPP1)
GFR: 102040595(SPP1)
FAB: 101815587(SPP1)
PHI: 102103014(SPP1)
PMAJ: 107202628(SPP1)
CCW: 104697257(SPP1)
FPG: 101911265(SPP1)
FCH: 102054986(SPP1)
CLV: 102083765(SPP1)
EGZ: 104127329(SPP1)
AAM: 106496659(SPP1)
ASN: 102379819(SPP1)
AMJ: 102569137(SPP1)
PSS: 102454425(SPP1)
CMY: 102934797(SPP1)
CPIC: 101931292(SPP1)
ACS: 100562360(spp1)
PVT: 110080523(SPP1)
PBI: 103051467(SPP1)
GJA: 107110534(SPP1)
LCM: 102353922(SPP1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2726470
  Authors
Kiefer MC, Bauer DM, Barr PJ
  Title
The cDNA and derived amino acid sequence for human osteopontin.
  Journal
Nucleic Acids Res 17:3306 (1989)
DOI:10.1093/nar/17.8.3306
  Sequence
[hsa:6696]
Reference
  Authors
Wai PY, Kuo PC
  Title
The role of Osteopontin in tumor metastasis.
  Journal
J Surg Res 121:228-41 (2004)
DOI:10.1016/j.jss.2004.03.028

KEGG   ORTHOLOGY: K06251Help
Entry
K06251                      KO                                     

Name
VTN
Definition
vitronectin
Pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko04610  Complement and coagulation cascades
ko05165  Human papillomavirus infection
ko05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06251  VTN; vitronectin
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06251  VTN; vitronectin
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06251  VTN; vitronectin
 Organismal Systems
  Immune system
   04610 Complement and coagulation cascades
    K06251  VTN; vitronectin
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    K06251  VTN; vitronectin
  Infectious diseases
   05165 Human papillomavirus infection
    K06251  VTN; vitronectin
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K06251  VTN; vitronectin
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta1 integrins
   VLA-8
    ITGB1; integrin beta 1
     K06251 VTN; vitronectin
   alpha V beta 1
    ITGB1; integrin beta 1
     K06251 VTN; vitronectin
  Beta3 integrins
   alpha IIb  beta 3
    ITGB3; integrin beta 3
     K06251 VTN; vitronectin
   VNR
    ITGB3; integrin beta 3
     K06251 VTN; vitronectin
  Beta5 integrins
   alpha V beta 5
    ITGB5; integrin beta 5
     K06251 VTN; vitronectin
  Beta8 integrins
   alpha V beta 8
    ITGB8; integrin beta 8
     K06251 VTN; vitronectin
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Extracellular matrix molecules
   K06251  VTN; vitronectin
BRITE hierarchy
Genes
HSA: 7448(VTN)
PTR: 738261(VTN)
PPS: 100980616(VTN)
GGO: 101154561(VTN)
PON: 100174092(VTN)
NLE: 100592274(VTN)
MCC: 708499(VTN)
MCF: 102130928(VTN)
CSAB: 103242610(VTN)
RRO: 104669368(VTN)
RBB: 108539950(VTN)
CJC: 100401491(VTN)
SBQ: 101045891(VTN)
MMU: 22370(Vtn)
RNO: 29169(Vtn)
CGE: 100767624(Vtn)
NGI: 103724488(Vtn)
HGL: 101705708(Vtn)
CCAN: 109698358(Vtn)
OCU: 100009128(VTN)
TUP: 102487110(VTN)
CFA: 480621(VTN)
AML: 100480900(VTN)
UMR: 103667232(VTN)
ORO: 101384418(VTN)
FCA: 101100765(VTN)
PTG: 102951541(VTN)
AJU: 106983254(VTN)
BTA: 507525(VTN)
BOM: 102275472(VTN)
BIU: 109574379(VTN)
PHD: 102321705(VTN)
CHX: 100861216(VTN)
OAS: 101119231(VTN)
SSC: 397192(VTN)
CFR: 102520038(VTN)
CDK: 105088189(VTN)
BACU: 103000100(VTN)
LVE: 103076801(VTN)
OOR: 101278304(VTN)
ECB: 100059034(VTN)
EPZ: 103555940(VTN)
EAI: 106844588(VTN)
MYB: 102244665(VTN)
MYD: 102762559(VTN)
HAI: 109385176(VTN)
RSS: 109447282(VTN)
PALE: 102878956(VTN)
LAV: 100653772(VTN)
TMU: 101356068
MDO: 100024550(VTN)
SHR: 100925192(VTN)
OAA: 100086729(VTN)
GGA: 395935(VTN)
MGP: 100540405(VTN)
CJO: 107322472(VTN)
APLA: 101797180(VTN)
ACYG: 106049173(VTN)
TGU: 100228142(VTN)
GFR: 102041817(VTN)
FAB: 101820369(VTN)
PHI: 102114367(VTN)
PMAJ: 107212769(VTN)
CCW: 104691062(VTN)
FPG: 101916608(VTN)
FCH: 102051485(VTN)
CLV: 102094351(VTN)
EGZ: 104131937(VTN)
AAM: 106484310(VTN)
ASN: 102369166(VTN)
AMJ: 102576642(VTN)
PSS: 102452123(VTN)
CMY: 102943267(VTN)
CPIC: 101950598(VTN)
ACS: 100565334(vtn)
PVT: 110084310(VTN)
PBI: 103059864(VTN)
GJA: 107119426(VTN)
XLA: 445877(vtn.L)
XTR: 548363(vtn)
NPR: 108787538(VTN)
DRE: 403026(vtnb) 553699(vtna)
SRX: 107731971
IPU: 108277704(VTN) 108279116(vtn)
AMEX: 103043894 103044206(vtn)
TRU: 101063214(vtn) 101063812
NCC: 104958838 104966720(vtn)
MZE: 101478828(vtn) 101478950
XMA: 102219010 102230980(vtn)
PRET: 103474541(vtn) 103475650
CSEM: 103378071(vtn) 103395458
HCQ: 109525425(vtn) 109532034
BPEC: 110154106(vtn) 110155896
LCM: 102362370(VTN)
CMK: 103180586(vtn) 103180587
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2414098
  Authors
Suzuki S, Oldberg A, Hayman EG, Pierschbacher MD, Ruoslahti E
  Title
Complete amino acid sequence of human vitronectin deduced from cDNA. Similarity of cell attachment sites in vitronectin and fibronectin.
  Journal
EMBO J 4:2519-24 (1985)
  Sequence
[hsa:7448]
Reference
  Authors
Madsen CD, Sidenius N
  Title
The interaction between urokinase receptor and vitronectin in cell adhesion and signalling.
  Journal
Eur J Cell Biol 87:617-29 (2008)
DOI:10.1016/j.ejcb.2008.02.003

KEGG   ORTHOLOGY: K06252Help
Entry
K06252                      KO                                     

Name
TN
Definition
tenascin
Pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko05165  Human papillomavirus infection
ko05206  MicroRNAs in cancer
Disease
H00802  Ehlers-Danlos syndrome (EDS)
H01037  Vesicoureteral reflux
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06252  TN; tenascin
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06252  TN; tenascin
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06252  TN; tenascin
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    K06252  TN; tenascin
  Infectious diseases
   05165 Human papillomavirus infection
    K06252  TN; tenascin
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Neural system
   6/5 subfamily
    L1CAM; L1 cell adhesion molecule
     K06252 TN; tenascin
  Others
   CXADR, CAR; coxsackievirus and adenovirus receptor
    K06252 TN; tenascin
 2. Integrin Family
  Beta1 integrins
   VLA-2
    ITGB1; integrin beta 1
     K06252 TN; tenascin
   VLA-8
    ITGB1; integrin beta 1
     K06252 TN; tenascin
   VLA-9
    ITGB1; integrin beta 1
     K06252 TN; tenascin
  Beta3 integrins
   VNR
    ITGB3; integrin beta 3
     K06252 TN; tenascin
  Beta6 integrins
   alpha V beta 6
    ITGB6; integrin beta 6
     K06252 TN; tenascin
 7. Others
  SDC1; syndecan 1
   K06252 TN; tenascin
  SDC4; syndecan 4
   K06252 TN; tenascin
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Extracellular matrix molecules
   K06252  TN; tenascin
BRITE hierarchy
Genes
HSA: 3371(TNC) 63923(TNN) 7143(TNR) 7148(TNXB)
PTR: 462578 469593(TNN) 469594(TNR) 742736(TNC)
PPS: 100977568(TNC) 100980229(TNN) 100981352(TNR) 100992963(TNXB)
GGO: 101144256(TNC) 101147118 101148303 101150034(TNN) 101152209(TNR)
PON: 100443502(TNXB) 100451868(TNC) 100452638(TNR) 100453010(TNN)
NLE: 100580126(TNN) 100581667(TNR) 100597679(TNXB) 100598677(TNC)
MCC: 702720(TNC) 708587(TNN) 708707(TNR) 716998(TNXB)
MCF: 102125644(TNN) 102131497(TNXB) 102133064(TNR) 102141221(TNC)
CSAB: 103218953(TNC) 103221720(TNXA) 103221729(TNXB) 103230545(TNR) 103230548(TNN)
RRO: 104665530(TNN) 104665533(TNR) 104674099(TNXB) 104679259(TNC) 104680681
CJC: 100395051(TNR) 100395776(TNN) 100396269(TNXB) 100414580(TNC)
SBQ: 101027727(TNR) 101035776(TNXB) 101047122(TNC) 101050844(TNN)
MMU: 21923(Tnc) 21960(Tnr) 329278(Tnn) 81877(Tnxb)
RNO: 116640(Tnc) 25567(Tnr) 304913(Tnn)
NGI: 103724414(Tnxb) 103727986(Tnn) 103727988(Tnr) 103734553(Tnc)
HGL: 101712839(Tnxb) 101716740(Tnr) 101718352(Tnn) 101718559(Tnc)
OCU: 100301551(TNC) 100347324(TNR) 100356305(TNN) 100357231(TNXB)
TUP: 102480847(TNN) 102491753(TNXB) 102495875(TNR) 102496046(TNC)
CFA: 100682877(TNXB) 481689(TNC) 490334(TNR) 490335(TNN)
AML: 100468841(TNR) 100471963(TNN) 100473350(TNC) 100478371(TNXB)
UMR: 103669282(TNN) 103669293(TNR) 103670500(TNC) 103682333(TNXB)
ORO: 101364666(TNN) 101365272(TNR) 101386461(TNC) 101386939(TNXB)
FCA: 101083629(TNC) 101096629(TNR) 101097863(TNN) 101101563(TNXB)
AJU: 106968310(TNR) 106968316(TNN) 106978587(TNC) 106983475(TNXB)
BTA: 282654(TNXB) 517433(TNN) 526409(TNR) 540664(TNC)
BOM: 102268167(TNXB) 102283502(TNC) 102283906(TNR) 102287019(TNN)
BIU: 109563393(TNC) 109570783(TNR) 109570804(TNN) 109576847(TNXB)
PHD: 102316906(TNN) 102317369(TNXB) 102317841(TNR) 102326118(TNC)
CHX: 102174446(TNXB) 102179198(TNC) 102181229(TNN) 102181525(TNR)
OAS: 100820740(TNXB) 101116748(TNN) 101117435(TNR) 101118337(TNC)
SSC: 100520686(TNR) 102163961(TNN) 397460(TNC) 445520(TNXB)
CFR: 102504776(TNC) 102506793(TNXB) 102520208(TNR) 102523008(TNN)
CDK: 105087513 105090860(TNXB) 105099963(TNR) 105099990(TNN) 105103745(TNC)
BACU: 103007093(TNR) 103011265(TNN) 103014899(TNXB) 103017087(TNC)
LVE: 103077329(TNC) 103087655(TNXB) 103088802(TNR) 103089331(TNN)
OOR: 101277758(TNN) 101278474(TNR) 101278708(TNXB) 101284395(TNC)
ECB: 100049835(TNC) 100059315(TNXB) 100061556(TNN) 100061691(TNR)
EPZ: 103552178(TNN) 103552228(TNR) 103561782(TNC) 103563303(TNXB)
EAI: 106824209(TNC) 106831007(TNXB) 106833952(TNR) 106833955(TNN)
MYB: 102245416(TNR) 102252550(TNC) 102253855(TNXB) 102261192(TNN) 102261482
MYD: 102751272(TNXB) 102754571(TNC) 102766266(TNR) 102770687(TNN)
HAI: 109373091(TNXB) 109385116(TNN) 109385122(TNR) 109390423(TNC)
RSS: 109436781(TNXB) 109445088(TNR) 109447148(TNC) 109448672(TNN)
PALE: 102879390(TNR) 102889033(TNXB) 102890398(TNN) 102898698(TNC)
LAV: 100655345(TNC) 100656584(TNR) 100657780(TNXB) 100667593(TNN)
MDO: 100013925(TNC) 100021303(TNN) 100021328(TNR) 100025581(TNXB)
SHR: 100916411 100925562(TNC) 100930095(TNN) 100930353(TNR) 100932708(TNXB)
OAA: 100076692(TNC) 100084768(TNXB) 100084954(TNN) 100084981(TNR) 100089817
GGA: 396106(TNX) 396213(TNR) 396440(TNC) 424435(TNN)
MGP: 100539559(TNR) 100540402(TNC) 100542328(TNN) 104913619(TNXB)
CJO: 107317195(TNN) 107317287(TNR) 107321567(TNXB) 107321653(TNC)
APLA: 101794275(TNXB) 101796235(TNN) 101799180(TNR) 101804896(TNC)
ACYG: 106037106(TNC) 106042473(TNR) 106042485(TNN) 106049852(TNXB)
TGU: 100219574(TNC) 100221864(TNR)
GFR: 102036993(TNC) 102042767(TNXB) 102045268(TNR)
FAB: 101809708 101817866(TNR) 101821680(TNC)
PHI: 102100617(TNC) 102104056(TNR) 102109273(TNXB) 102112443(TNN)
CCW: 104688240(TNC) 104693643(TNR) 104693645(TNN)
FPG: 101914380(TNR) 101916970(TNN) 101917023(TNC) 106112526
FCH: 102052293 102054173(TNR) 102056280(TNC) 102057018(TNN)
CLV: 102096667(TNR) 102097682(TNC)
EGZ: 104122734(TNC) 104129715(TNN) 104129724(TNR)
ASN: 102377691(TNXB) 102379949(TNC) 102383421(TNR) 102384165(TNN)
AMJ: 102563388(TNXB) 102573675(TNN) 106736616(TNR) 106736863(TNC)
PSS: 102450849(TNR) 102451335(TNN) 102455609(TNC) 102459430(TNXB)
CMY: 102932192 102940814(TNC) 102945412(TNR) 102945641(TNN)
CPIC: 101937376(TNN) 101948811(TNR) 101950415(TNC) 101950626(TNXB)
GJA: 107107308(TNXB) 107115942(TNR) 107115943(TNN) 107122469(TNC)
XLA: 108698936(tnxb.L) 108700035 108700569(tnxb.S) 108713537 108714346(tnn.L) 108715624 398332(tnc.L)
XTR: 100135076(tnr) 100489649(tnxb) 100491528(tnn) 100494697(tnc)
DRE: 100149028(zmp:0000000846) 30037(tnc) 30234(tnn) 369191(tnr)
LCO: 104929192(tnr) 104930582 104930867 104930937(Tenascin) 104936863(tnn)
LCM: 102345859(TNXB) 102351342(TNN) 102357582 102366423(TNR) 102366554(TNC)
CMK: 103180421(tnc) 103184805(tnr)
CIN: 100178031
SPU: 576745
LAK: 106171939
SMIN: v1.2.002114.t1(symbB.v1.2.002114.t1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1707164
  Authors
Siri A, Carnemolla B, Saginati M, Leprini A, Casari G, Baralle F, Zardi L
  Title
Human tenascin: primary structure, pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies.
  Journal
Nucleic Acids Res 19:525-31 (1991)
DOI:10.1093/nar/19.3.525
  Sequence
[hsa:3371]
Reference
  Authors
Joester A, Faissner A
  Title
The structure and function of tenascins in the nervous system.
  Journal
Matrix Biol 20:13-22 (2001)
DOI:10.1016/S0945-053X(00)00136-0

KEGG   ORTHOLOGY: K03900Help
Entry
K03900                      KO                                     

Name
VWF
Definition
von Willebrand factor
Pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko04610  Complement and coagulation cascades
ko04611  Platelet activation
ko05165  Human papillomavirus infection
Disease
H00219  Hemophilia
H01740  Macrothrombocytopenia
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K03900  VWF; von Willebrand factor
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K03900  VWF; von Willebrand factor
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K03900  VWF; von Willebrand factor
 Organismal Systems
  Immune system
   04610 Complement and coagulation cascades
    K03900  VWF; von Willebrand factor
   04611 Platelet activation
    K03900  VWF; von Willebrand factor
 Human Diseases
  Infectious diseases
   05165 Human papillomavirus infection
    K03900  VWF; von Willebrand factor
Chaperones and folding catalysts [BR:ko03110]
 Intramolecular chaperones
  Others
   K03900  VWF; von Willebrand factor
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K03900  VWF; von Willebrand factor
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta1 integrins
   VLA-4
    ITGB1; integrin beta 1
     K03900 VWF; von Willebrand factor
   VLA-9
    ITGB1; integrin beta 1
     K03900 VWF; von Willebrand factor
  Beta3 integrins
   alpha IIb  beta 3
    ITGB3; integrin beta 3
     K03900 VWF; von Willebrand factor
   VNR
    ITGB3; integrin beta 3
     K03900 VWF; von Willebrand factor
BRITE hierarchy
Genes
HSA: 7450(VWF)
PTR: 451773(VWF)
PPS: 100985238(VWF)
GGO: 101135657 101142333(VWF) 109025016
PON: 100434817(VWF)
NLE: 100580759(VWF)
MCC: 722019(VWF)
MCF: 102132631(VWF)
CSAB: 103218442(VWF)
RRO: 104680130(VWF)
RBB: 108536508(VWF)
CJC: 100396684(VWF)
SBQ: 101044155(VWF)
MMU: 22371(Vwf)
RNO: 116669(Vwf)
CGE: 100750531(Vwf)
NGI: 103727534(Vwf)
HGL: 101696988(Vwf)
CCAN: 109682788(Vwf)
OCU: 100009165(VWF)
TUP: 102483687(VWF)
CFA: 399544(VWF)
AML: 100468710(VWF)
UMR: 103656237(VWF)
ORO: 101385961(VWF)
FCA: 493760(VWF)
PTG: 102965421(VWF)
AJU: 106965451(VWF)
BTA: 280958(VWF)
BOM: 102282731(VWF)
BIU: 109558606(VWF)
PHD: 102339185(VWF)
CHX: 102191119(VWF)
OAS: 101110931(VWF)
SSC: 399543(VWF)
CFR: 102505067(VWF)
CDK: 105098230(VWF)
BACU: 103021101(VWF)
LVE: 103073004(VWF)
OOR: 101277710(VWF)
ECB: 100059472(VWF)
EPZ: 103546989(VWF)
EAI: