KEGG   ORTHOLOGY: K06276Help
Entry
K06276                      KO                                     

Name
PDPK1
Definition
3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
Pathway
Platinum drug resistance
PPAR signaling pathway
MAPK signaling pathway - yeast
FoxO signaling pathway
Sphingolipid signaling pathway
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Focal adhesion
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Thyroid hormone signaling pathway
Insulin resistance
Aldosterone-regulated sodium reabsorption
Toxoplasmosis
Hepatitis C
Proteoglycans in cancer
Endometrial cancer
Prostate cancer
Non-small cell lung cancer
Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04011 MAPK signaling pathway - yeast
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   04068 FoxO signaling pathway
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   04071 Sphingolipid signaling pathway
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   04151 PI3K-Akt signaling pathway
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   04152 AMPK signaling pathway
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   04150 mTOR signaling pathway
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
  Cell growth and death
   04210 Apoptosis
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
 Organismal Systems
  Immune system
   04660 T cell receptor signaling pathway
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   04664 Fc epsilon RI signaling pathway
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
  Endocrine system
   04910 Insulin signaling pathway
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   03320 PPAR signaling pathway
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   04919 Thyroid hormone signaling pathway
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
  Nervous system
   04722 Neurotrophin signaling pathway
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
 Human Diseases
  Cancers
   05231 Choline metabolism in cancer
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   05205 Proteoglycans in cancer
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   05215 Prostate cancer
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   05213 Endometrial cancer
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   05223 Non-small cell lung cancer
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
  Endocrine and metabolic diseases
   04931 Insulin resistance
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
  Infectious diseases
   05160 Hepatitis C
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
   05145 Toxoplasmosis
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
  Drug resistance
   01524 Platinum drug resistance
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: AGC group
  PDK1 family
   K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Acrosomal exocytosis proteins
    K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1
BRITE hierarchy
Other DBs
COG: 
GO: 
Genes
HSA: 
5170(PDPK1)
PTR: 
467875(PDPK1)
PPS: 
GGO: 
PON: 
100452403(PDPK1)
NLE: 
MCC: 
697523(PDPK1)
MCF: 
101866379(PDPK1)
CSAB: 
103247598(PDPK1)
RRO: 
RBB: 
108514085(PDPK1)
CJC: 
100389944(PDPK1)
SBQ: 
101032521(PDPK1)
MMU: 
18607(Pdpk1)
RNO: 
81745(Pdpk1)
CGE: 
100772477(Pdpk1)
NGI: 
103743959(Pdpk1)
HGL: 
101709940(Pdpk1)
CCAN: 
OCU: 
100347954(PDPK1)
TUP: 
102497633(PDPK1)
CFA: 
479875(PDPK1)
AML: 
100473305(PDPK1)
UMR: 
103668498(PDPK1)
FCA: 
101101686(PDPK1)
PTG: 
102960424(PDPK1)
AJU: 
106978772(PDPK1)
BTA: 
100138102(PDPK1)
BOM: 
102264327(PDPK1)
BIU: 
109578066(PDPK1)
PHD: 
102343964(PDPK1)
CHX: 
102184966(PDPK1)
OAS: 
101117211(PDPK1)
SSC: 
100192445(PDPK1)
CFR: 
102504617(PDPK1)
CDK: 
105099701(PDPK1)
BACU: 
103010966(PDPK1)
LVE: 
103081765(PDPK1)
ECB: 
100630736(PDPK1)
EPZ: 
103551639(PDPK1)
EAI: 
106826000(PDPK1)
MYB: 
102262391(PDPK1)
MYD: 
102756818(PDPK1)
HAI: 
109385875(PDPK1)
RSS: 
109439417(PDPK1)
PALE: 
102896950(PDPK1)
LAV: 
100660030(PDPK1)
MDO: 
100018830(PDPK1)
SHR: 
100917568(PDPK1)
OAA: 
100089083(PDPK1)
GGA: 
416588(PDPK1)
MGP: 
100541724(PDPK1)
CJO: 
107320588(PDPK1)
APLA: 
101798010(PDPK1)
ACYG: 
106046039(PDPK1)
TGU: 
100227045(PDPK1)
GFR: 
102032960(PDPK1)
FAB: 
101813442(PDPK1)
PHI: 
102107665(PDPK1)
PMAJ: 
107211032(PDPK1)
CCW: 
104684909(PDPK1)
FPG: 
101919837(PDPK1)
FCH: 
102054066(PDPK1)
CLV: 
102092469(PDPK1)
AAM: 
106486128(PDPK1)
ASN: 
102383992(PDPK1)
AMJ: 
102575851(PDPK1)
PSS: 
102460679(PDPK1)
CMY: 
102946336(PDPK1)
CPIC: 
101943277(PDPK1)
ACS: 
100559955(pdpk1)
PVT: 
110085010(PDPK1)
PBI: 
103067411(PDPK1)
GJA: 
107106228(PDPK1)
XLA: 
108703133(pdpk1.S) 444529(pdpk1.L)
XTR: 
779524(pdpk1)
NPR: 
108794718(PDPK1)
DRE: 
403000(pdpk1b)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
101076701(pdpk1)
TNG: 
LCO: 
104923215(pdpk1)
NCC: 
104946334(pdpk1)
MZE: 
101463568(pdpk1)
OLA: 
101164682(pdpk1)
XMA: 
102230385(pdpk1)
CSEM: 
103381714(pdpk1)
LCF: 
108886759(pdpk1)
HCQ: 
109530196(pdpk1)
BPEC: 
110159640(pdpk1)
SASA: 
ELS: 
105021296(pdpk1)
SFM: 
108923949(pdpk1)
LCM: 
102346160(PDPK1)
CMK: 
103186641(pdpk1)
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD13545(Dsim_GD13545)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
DPA: 
NVL: 
BMOR: 
DPL: 
PXY: 
API: 
DNX: 
PHU: 
DPX: 
ISC: 
TUT: 
CEL: 
CBR: 
CBG08059(Cbr-pdk-1)
NAI: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
LAK: 
SMM: 
SHX: 
OVI: 
NVE: 
ADF: 
HMG: 
TAD: 
AQU: 
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
BOE: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
GHI: 
EGR: 
GMX: 
PVU: 
VRA: 
VAR: 
CCAJ: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj5g3v1701510.1(Lj5g3v1701510.1) Lj5g3v1701510.2(Lj5g3v1701510.2)
LANG: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
ZJU: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
VVI: 
SLY: 
SPEN: 
SOT: 
CANN: 
NTA: 
INI: 
SIND: 
BVG: 
NNU: 
OSA: 
DOSA: 
Os01t0872800-01(Os01g0872800)
OBR: 
BDI: 
ATS: 
SBI: 
ZMA: 
SITA: 
PDA: 
EGU: 
MUS: 
DCT: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
MNG: 
OLU: 
OTA: 
BPG: 
MIS: 
CSL: 
CVR: 
APRO: 
GSL: 
SCE: 
YDR466W(PKH3) YDR490C(PKH1) YOL100W(PKH2)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A07990(NCAS0A07990) NCAS_0C04940(NCAS0C04940)
NDI: 
NDAI_0G04290(NDAI0G04290) NDAI_0H01020(NDAI0H01020)
TPF: 
TPHA_0D02740(TPHA0D02740) TPHA_0P01050(TPHA0P01050)
TBL: 
TBLA_0B02310(TBLA0B02310) TBLA_0B08250(TBLA0B08250) TBLA_0E02790(TBLA0E02790)
TDL: 
TDEL_0A04580(TDEL0A04580) TDEL_0D05320(TDEL0D05320)
KAF: 
KAFR_0C01440(KAFR0C01440) KAFR_0K02490(KAFR0K02490)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
CAUR: 
NCR: 
NCU03571(stk-23)
NTE: 
NEUTE1DRAFT130853(NEUTE1DRAFT_130853)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
FGR: 
FPU: 
FVR: 
FOX: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
PLJ: 
VAL: 
VDA: 
CFJ: 
ELA: 
PFY: 
SSL: 
BFU: 
MBE: 
PSCO: 
GLZ: 
ANI: 
AFM: 
AOR: 
AOR_1_1502194(AO090012000858)
ANG: 
ANI_1_1236024(An02g08630)
AFV: 
ACT: 
NFI: 
PCS: 
PDP: 
CIM: 
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
SNOG_06367(SNOG_06366)
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
TMS: 
PPL: 
TVS: 
DSQ: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT36927(AGABI1DRAFT_36927)
ABV: 
AGABI2DRAFT68901(AGABI2DRAFT_68901)
CPUT: 
WSE: 
WIC: 
PFP: 
MGL: 
PGR: 
MLR: 
MBR: 
SRE: 
DDI: 
DPP: 
DFA: 
DFA_05743(pdkB) DFA_09142(pdkA)
EIV: 
ACAN: 
TET: 
PTM: 
SMIN: 
v1.2.010039.t1(symbB.v1.2.010039.t1)
AAF: 
PIF: 
PSOJ: 
SPAR: 
EHX: 
GTT: 
NGR: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9094314
  Authors
Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P
  Title
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.
  Journal
Curr Biol 7:261-9 (1997)
DOI:10.1016/S0960-9822(06)00122-9
  Sequence
[hsa:5170]
Reference
PMID:9445476
  Authors
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G.
  Title
Phosphorylation and activation of p70s6k by PDK1.
  Journal
Science 279:707-10 (1998)
DOI:10.1126/science.279.5351.707
  Sequence
[hsa:5170]
Reference
  Authors
Casamayor A, Torrance PD, Kobayashi T, Thorner J, Alessi DR
  Title
Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast.
  Journal
Curr Biol 9:186-97 (1999)
DOI:10.1016/S0960-9822(99)80088-8
  Sequence
Reference
  Authors
Inagaki M, Schmelzle T, Yamaguchi K, Irie K, Hall MN, Matsumoto K
  Title
PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast.
  Journal
Mol Cell Biol 19:8344-52 (1999)
DOI:10.1128/MCB.19.12.8344
  Sequence

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