KEGG ORTHOLOGY: K06451

ORTHOLOGY: K06451

Entry

K06451                      KO

Symbol

CD3E

Name

T-cell surface glycoprotein CD3 epsilon chain

Pathway

map04640

Hematopoietic cell lineage

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map04660

T cell receptor signaling pathway

map05142

Chagas disease

map05162

Measles

map05166

Human T-cell leukemia virus 1 infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05340

Primary immunodeficiency

Disease

H00091

T-B+Severe combined immunodeficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   04660 T cell receptor signaling pathway
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   04658 Th1 and Th2 cell differentiation
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   04659 Th17 cell differentiation
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   05170 Human immunodeficiency virus 1 infection
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   05162 Measles
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   05169 Epstein-Barr virus infection
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
  09163 Immune disease
   05340 Primary immunodeficiency
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
CD molecules [BR:ko04090]
Proteins
  K06451  CD3e; CD3E antigen, epsilon polypeptide (TiT3 complex)

Genes

HSA:

916(CD3E)

PTR:	742330(CD3E)

PPS:	100978919(CD3E)

GGO:	101149676(CD3E)

PON:	100440004(CD3E)

NLE:	100582516(CD3E)

HMH:

116477006

MCC:	699467(CD3E)

MCF:	102133065(CD3E)

MTHB:

126936068

MNI:	105476414(CD3E)

CSAB:

103248584(CD3E)

CATY:

105582468(CD3E)

PANU:

101017085(CD3E)

TGE:	112606383(CD3E)

MLEU:

105528216(CD3E)

RRO:	104665572(CD3E)

RBB:	108536387(CD3E)

TFN:	117080881(CD3E)

PTEH:

111540204(CD3E)

CANG:

105501091(CD3E)

CJC:	100403944(CD3E)

SBQ:	101030803(CD3E)

CIMI:

108300594(CD3E)

CSYR:

103252367(CD3E)

MMUR:

105876056(CD3E)

LCAT:

123641521(CD3E)

PCOQ:

105819243(CD3E)

OGA:	100966596(CD3E)

MMU:	12501(Cd3e)

MCAL:

110302127(Cd3e)

MPAH:

110328560(Cd3e)

RNO:	315609(Cd3e)

MCOC:

116073337(Cd3e)

ANU:	117699427(Cd3e)

MUN:

110549111

CGE:	100757488(Cd3e)

MAUA:

101836794(Cd3e)

PROB:

127231638

PLEU:

114691295(Cd3e)

MORG:

121438262(Cd3e)

MFOT:

126510033

AAMP:

119810074(Cd3e)

NGI:	103728619(Cd3e)

HGL:	101711464(Cd3e)

CPOC:

100727781(Cd3e)

CCAN:

109684407(Cd3e)

DORD:

105980885(Cd3e)

DSP:	122110413(Cd3e)

PLOP:

125347803

NCAR:

124959811

MMMA:

107145811

OCU:	100008616(CD3E) 100339529

OPI:	101521312(CD3E)

TUP:	102499022(CD3E)

GVR:	103592268(CD3E)

CFA:	442981(CD3E)

CLUD:

112671249

VVP:	112920227(CD3E)

VLG:	121499400(CD3E)

NPO:

129497000

AML:	100482462(CD3E)

UMR:	103662338(CD3E)

UAH:	113260003(CD3E)

UAR:	123792617(CD3E)

ELK:

111153962

LLV:

125079621

MPUF:

101676091(CD3E)

MNP:

132027477

MLK:

131836598

NVS:	122912333(CD3E)

ORO:	101385667(CD3E)

EJU:	114211298(CD3E)

ZCA:	113913757(CD3E)

MLX:	118013285(CD3E)

NSU:	110586253(CD3E)

LWW:	102729553(CD3E)

FCA:	493936(CD3E)

PYU:	121035463(CD3E)

PCOO:

112865851(CD3E)

PBG:	122483024(CD3E)

PVIV:

125176523

LRUF:

124504771

PTG:	102969557(CD3E)

PPAD:

109278561(CD3E)

PUC:

125909427

AJU:

106966166

HHV:	120229941(CD3E)

BTA:	281054(CD3E)

BOM:	102272861(CD3E)

BIU:	109569940(CD3E)

BBUB:

102390460(CD3E)

BBIS:

104981364(CD3E)

CHX:	102190711(CD3E)

OAS:	443437(CD3E)

BTAX:

128060834

ODA:	120876318(CD3E)

CCAD:

122450228(CD3E)

MBEZ:

129553777

SSC:	397455(CD3E)

CFR:	102518964(CD3E)

CBAI:

105067821(CD3E)

CDK:	105090174(CD3E)

VPC:	102542709(CD3E)

BACU:

103003476(CD3E)

BMUS:

118899674(CD3E)

LVE:	103070290(CD3E)

OOR:

101279986

DLE:	111166898(CD3E)

PCAD:

102979279

PSIU:

116758072(CD3E)

NASI:

112404002(CD3E)

ECB:	100629532(CD3E)

EPZ:	103546676(CD3E)

EAI:	106840276(CD3E)

MYB:	102240865(CD3E)

MYD:	102753033(CD3E)

MMYO:

118664241(CD3E)

MLF:	102438976(CD3E)

PKL:	118710580(CD3E)

EFUS:

103293819

MNA:	107530780(CD3E)

DRO:	112314382(CD3E)

SHON:

118994765(CD3E)

AJM:	119050802(CD3E)

PDIC:

114499775(CD3E)

PHAS:

123818673(CD3E)

MMF:	118628023(CD3E)

PPAM:

129086043

HAI:	109385284(CD3E)

RFQ:	117030447(CD3E)

PALE:

102894744(CD3E)

PGIG:

120622048(CD3E)

PVP:	105309263(CD3E)

RAY:	107516045(CD3E)

MJV:	108385087(CD3E)

TOD:

119239887

SARA:

101545393(CD3E)

SETR:

126015614

LAV:	100654724(CD3E)

TMU:

101359660

ETF:	101656529(CD3E)

DNM:	101421796(CD3E)

MDO:	100031478(CD3E)

GAS:	123239093(CD3E)

SHR:	100919058(CD3E)

PCW:	110207187(CD3E)

OAA:	103164647(CD3E)

GGA:	396062(CD3E)

PCOC:

116233174(CD3E)

MGP:	100542967(CD3E)

CJO:	107324151(CD3E)

TPAI:

128087673

LMUT:

125703730

NMEL:

110387607(CD3E)

APLA:

101792798(CD3E)

ACYG:

106039831

CATA:

118252428

AFUL:

116497933(CD3E)

TGU:	115498349(CD3E)

LSR:	110470447(CD3E)

SCAN:

103822978(CD3E)

PMOA:

120508488(CD3E)

OTC:	121340848(CD3E)

PRUF:

121348513(CD3E)

GFR:	102033069(CD3E)

FAB:	101805814(CD3E)

OMA:

130262469

PHI:	102100748(CD3E)

PMAJ:

107214303(CD3E)

CCAE:

111939275(CD3E)

CCW:	104692070(CD3E)

CBRC:

103618515(CD3E)

ETL:	114056274(CD3E)

ZAB:	102074438(CD3E)

ACHL:

103806925(CD3E)

SVG:	106858160(CD3E)

MMEA:

130583274

HRT:

120762480

FPG:	101916374(CD3E)

FCH:	102052256(CD3E)

CLV:	102092091(CD3E)

EGZ:	104124563(CD3E)

NNI:	104019038(CD3E)

PCRI:

104037965(CD3E)

PLET:

104623865(CD3E)

EHS:	104508131(CD3E)

PCAO:

104041594(CD3E)

ACUN:

113488553(CD3E)

TALA:

104362678(CD3E)

PADL:

103921537(CD3E)

AFOR:

103894944(CD3E)

ACHC:

115344580(CD3E)

HALD:

104312091(CD3E)

HLE:	104836396(CD3E)

AGEN:

126038199

GCL:

127025857

CCRI:

104156647(CD3E)

CSTI:

104551755(CD3E)

CMAC:

104485275(CD3E)

MUI:	104535368(CD3E)

BREG:

104631275(CD3E)

FGA:	104073433(CD3E)

GSTE:

104260226(CD3E)

LDI:	104354386(CD3E)

MNB:	103774582(CD3E)

OHA:	104331957(CD3E)

NNT:	104408028(CD3E)

SHAB:

115616384(CD3E)

DPUB:

104299250(CD3E)

PGUU:

104462627(CD3E)

ACAR:

104521636(CD3E)

AVIT:

104270070(CD3E)

CVF:	104295025(CD3E)

RTD:

128918573

CUCA:

104068840(CD3E)

TEO:	104373114(CD3E)

BRHI:

104497095(CD3E)

AAM:	106491550(CD3E)

AROW:

112962095(CD3E)

NPD:	112948116(CD3E)

TGT:	104569302(CD3E)

DNE:	112991722(CD3E)

SCAM:

104151775(CD3E)

ASN:	102385481(CD3E)

AMJ:	102572715(CD3E)

CPOO:

109315402(CD3E)

GGN:	109293882(CD3E)

PSS:	102444605(CD3E)

CMY:	102940609(CD3E)

CCAY:

125625460

DCC:	119846657(CD3E)

CPIC:

101932898(CD3E)

TST:	117868714(CD3E)

CABI:

116822955(CD3E)

MRV:	120375881(CD3E)

ACS:	103281392(cd3e)

ASAO:

132782469

PVT:	110079214(CD3E)

PBI:	103063950(CD3E)

PMUR:

107284819(CD3E)

CTIG:

120307253(CD3E)

TSR:	106540658(CD3E)

PGUT:

117670185(CD3E)

APRI:

131203942

PTEX:

113441828(CD3E)

NSS:	113420881(CD3E)

VKO:	123020252(CD3E)

PMUA:

114585624(CD3E)

PRAF:

128402758

ZVI:	118097107(CD3E)

HCG:

128333839

STOW:

125442238

XLA:	108696460(cd3e.L) 108697598(cd3e.S)

XTR:	100101735(cd3e)

NPR:	108792155(CD3E)

RTEM:

120916071(CD3E)

BBUF:

120996018(CD3E)

BGAR:

122926772(CD3E)

MUO:	115481598(CD3E)

GSH:	117347846(CD3E)

SRX:	107710512(cd3e) 107757322

SANH:

107677251 107678881 107696790(cd3e)

SGH:	107557646(cd3e) 107575792

CCAR:

109113691(cd3e)

CAUA:

113058827 113058859 113114680

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

TROS:

TDW:

MANU:

IPU:

IFU:

PHYP:

113544469(cd3e)

SMEO:

TFD:

TVC:

AMEX:

EEE:	113581196(cd3e)

CHAR:

105911012

TRU:	654301(cd3e)

TFS:

130535526

NCC:	104958452(cd3e)

TBEN:

117470090

CGOB:

115017714(cd3e)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116679175(cd3e)

PFLV:

114552596(cd3e)

GAT:

PPUG:

AFB:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:	101473479(cd3e)

ONL:	100699580(cd3e)

OAU:

116328965

OML:	112136422 112149932

CSAI:

133442496

XMA:	111612026(cd3e)

XCO:	114162006(cd3e)

XHE:	116707969(cd3e)

PRET:

108166815(cd3e)

PFOR:

103154612 107833469(cd3e)

PLAI:

106942052

PMEI:

106914150 106914157(cd3e)

GAF:	122832286 122832288

PPRL:

129358861

CVG:	107080969 107102557(cd3e)

GMU:	124883953 124883954

NFU:	107372865(cd3e)

KMR:	108244419 108244420

ALIM:

106514964 106514970

NWH:	119411564 119411565

AOCE:

111574529(cd3e)

CSEM:

103377690

POV:	109634477(cd3e)

SSEN:

HHIP:

HSP:

SMAU:

LCF:

SDU:	111232876(cd3e)

SLAL:

111650651(cd3e)

XGL:

120792561

HCQ:	109529377(cd3e)

SBIA:

133504737

PEE:

133405554

PTAO:

133482344

MALB:

109951826(cd3e)

BSPL:

114868718

SJO:

128360868

SASA:

100136516(cd3e)

STRU:

115163129(cd3e)

OTW:

112265197

OMY:	100499597(cd3e)

OGO:

123992953

ONE:	115136973 115142145

OKI:	109905520(cd3e)

OKE:	118384684 118397259

SALP:

111957664 111982584

SNH:

120018799

ELS:	105011076 105011093

SFM:	108932125(cd3e) 108932308

PKI:	111854926 111854957

AANG:

LOC:

PSPA:

ARUT:

LCM:	102349686(CD3E)

RTP:

CPLA:

LERI:

Reference

PMID:3012357

Authors

Gold DP, Puck JM, Pettey CL, Cho M, Coligan J, Woody JN, Terhorst C

Title

Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex.

Journal

Nature 321:431-4 (1986)
DOI:10.1038/321431a0

Sequence

[hsa:916]

Reference

PMID:15546002

Authors

de Saint Basile G, Geissmann F, Flori E, Uring-Lambert B, Soudais C, Cavazzana-Calvo M, Durandy A, Jabado N, Fischer A, Le Deist F

Title

Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3.

Journal

J Clin Invest 114:1512-7 (2004)
DOI:10.1172/JCI22588

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (22)   
   KEGG PATHWAY (22)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (31)   
   KEGG DRUG (31)   
Gene (395)   
   KEGG GENES (391)   
   KEGG MGENES (3)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (453)   

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