KEGG   ORTHOLOGY: K06480Help
Entry
K06480                      KO                                     

Name
ITGA1, CD49a
Definition
integrin alpha 1
Pathway
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Hematopoietic cell lineage
Regulation of actin cytoskeleton
Human papillomavirus infection
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy (DCM)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06480  ITGA1, CD49a; integrin alpha 1
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06480  ITGA1, CD49a; integrin alpha 1
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06480  ITGA1, CD49a; integrin alpha 1
  Cell motility
   04810 Regulation of actin cytoskeleton
    K06480  ITGA1, CD49a; integrin alpha 1
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K06480  ITGA1, CD49a; integrin alpha 1
 Human Diseases
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K06480  ITGA1, CD49a; integrin alpha 1
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K06480  ITGA1, CD49a; integrin alpha 1
   05414 Dilated cardiomyopathy (DCM)
    K06480  ITGA1, CD49a; integrin alpha 1
  Infectious diseases
   05165 Human papillomavirus infection
    K06480  ITGA1, CD49a; integrin alpha 1
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K06480  ITGA1, CD49a; integrin alpha 1
CD molecules [BR:ko04090]
 Proteins
  K06480  CD49a, ITGA1; integrin, alpha 1
BRITE hierarchy
Genes
HSA: 
3672(ITGA1)
PTR: 
461880(ITGA1)
PPS: 
100978092(ITGA1)
GGO: 
101128466(ITGA1)
PON: 
100439453(ITGA1)
NLE: 
100587675(ITGA1)
MCC: 
703456(ITGA1)
MCF: 
102132675(ITGA1)
CSAB: 
103221277(ITGA1)
RRO: 
104680210(ITGA1)
RBB: 
108522901(ITGA1)
CJC: 
100404358(ITGA1)
SBQ: 
101041823(ITGA1)
MMU: 
109700(Itga1)
RNO: 
25118(Itga1)
CGE: 
100750393(Itga1)
NGI: 
103734043(Itga1)
HGL: 
101703242(Itga1)
CCAN: 
109695513(Itga1)
OCU: 
100342711(ITGA1)
TUP: 
102476855(ITGA1)
CFA: 
489210(ITGA1)
AML: 
100476147(ITGA1)
UMR: 
103664837(ITGA1)
ORO: 
101375017(ITGA1)
FCA: 
101089743(ITGA1)
PTG: 
102959454(ITGA1)
AJU: 
106976294(ITGA1)
BTA: 
535951(ITGA1)
BOM: 
102281967(ITGA1)
BIU: 
109574799(ITGA1)
PHD: 
102317389(ITGA1)
CHX: 
102172761(ITGA1)
OAS: 
101114307(ITGA1)
SSC: 
100512142(ITGA1)
CFR: 
102522660(ITGA1)
CDK: 
105084260(ITGA1)
BACU: 
103016121(ITGA1)
LVE: 
103086550(ITGA1)
ECB: 
100063434(ITGA1)
EPZ: 
103558069(ITGA1)
EAI: 
106843329(ITGA1)
MYB: 
102244635(ITGA1)
MYD: 
102759756(ITGA1)
HAI: 
109382143(ITGA1)
RSS: 
109449693(ITGA1)
PALE: 
102884999(ITGA1)
LAV: 
100674420(ITGA1)
TMU: 
MDO: 
100031492(ITGA1)
SHR: 
GGA: 
395951(ITGA1)
MGP: 
CJO: 
107305976(ITGA1)
APLA: 
101802326(ITGA1)
ACYG: 
106035623(ITGA1)
TGU: 
100224251(ITGA1)
GFR: 
102032334(ITGA1)
FAB: 
PHI: 
102104969(ITGA1)
PMAJ: 
107216171(ITGA1)
CCW: 
104686656(ITGA1)
FPG: 
101916108(ITGA1)
FCH: 
102056851(ITGA1)
CLV: 
102091068(ITGA1)
EGZ: 
104131630(ITGA1)
AAM: 
ASN: 
102378753(ITGA1)
AMJ: 
102575277(ITGA1)
PSS: 
102452547(ITGA1)
CMY: 
102938729(ITGA1)
CPIC: 
101948817(ITGA1)
ACS: 
PVT: 
110073900(ITGA1)
PBI: 
GJA: 
107116961(ITGA1)
XLA: 
XTR: 
100492880(itga1)
NPR: 
DRE: 
570868(itga1)
SRX: 
107713335(itga1)
SANH: 
SGH: 
CCAR: 
IPU: 
108276985(itga1)
AMEX: 
103023700(itga1)
TRU: 
TNG: 
LCO: 
104932737(itga1)
NCC: 
MZE: 
101472231(itga1)
OLA: 
101159685(itga1)
XMA: 
102222514(itga1)
PRET: 
103473468(itga1)
NFU: 
107374734(itga1)
CSEM: 
103390416(itga1)
LCF: 
108874021(itga1)
HCQ: 
109527962(itga1)
BPEC: 
110157451(itga1)
SASA: 
ELS: 
105026687(itga1)
SFM: 
108925102(itga1)
LCM: 
102365285(ITGA1)
CMK: 
103177841(itga1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Mattila E, Pellinen T, Nevo J, Vuoriluoto K, Arjonen A, Ivaska J
  Title
Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP.
  Journal
Nat Cell Biol 7:78-85 (2005)
DOI:10.1038/ncb1209
  Sequence
[hsa:3672]
Reference
PMID:8428973
  Authors
Briesewitz R, Epstein MR, Marcantonio EE
  Title
Expression of native and truncated forms of the human integrin alpha 1 subunit.
  Journal
J Biol Chem 268:2989-96 (1993)
  Sequence
[hsa:3672]

KEGG   ORTHOLOGY: K06481Help
Entry
K06481                      KO                                     

Name
ITGA2, CD49b
Definition
integrin alpha 2
Pathway
Phagosome
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Platelet activation
Hematopoietic cell lineage
Regulation of actin cytoskeleton
Human papillomavirus infection
Pathways in cancer
Proteoglycans in cancer
Small cell lung cancer
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy (DCM)
Disease
H01235  
Bleeding disorder platelet-type
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06481  ITGA2, CD49b; integrin alpha 2
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06481  ITGA2, CD49b; integrin alpha 2
 Cellular Processes
  Transport and catabolism
   04145 Phagosome
    K06481  ITGA2, CD49b; integrin alpha 2
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06481  ITGA2, CD49b; integrin alpha 2
  Cell motility
   04810 Regulation of actin cytoskeleton
    K06481  ITGA2, CD49b; integrin alpha 2
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K06481  ITGA2, CD49b; integrin alpha 2
   04611 Platelet activation
    K06481  ITGA2, CD49b; integrin alpha 2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06481  ITGA2, CD49b; integrin alpha 2
   05205 Proteoglycans in cancer
    K06481  ITGA2, CD49b; integrin alpha 2
   05222 Small cell lung cancer
    K06481  ITGA2, CD49b; integrin alpha 2
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K06481  ITGA2, CD49b; integrin alpha 2
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K06481  ITGA2, CD49b; integrin alpha 2
   05414 Dilated cardiomyopathy (DCM)
    K06481  ITGA2, CD49b; integrin alpha 2
  Infectious diseases
   05165 Human papillomavirus infection
    K06481  ITGA2, CD49b; integrin alpha 2
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   K06481  ITGA2, CD49b; integrin alpha 2
  Exosomal proteins of bladder cancer cells
   K06481  ITGA2, CD49b; integrin alpha 2
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta1 integrins
   VLA-3
    ITGB1; integrin beta 1
     VLA-2
      K06481 ITGA2, CD49b; integrin alpha 2
 5. Cadherin Family
  Classic Cadherins
   Vertebrate Type I classic cadherins
    CDHE, CDH1; cadherin 1, type 1, E-cadherin
     VLA-2
      K06481 ITGA2, CD49b; integrin alpha 2
CD molecules [BR:ko04090]
 Proteins
  K06481  CD49b, ITGA2; integrin, alpha 2
BRITE hierarchy
Genes
HSA: 
3673(ITGA2)
PTR: 
471550(ITGA2)
PPS: 
100978441(ITGA2)
GGO: 
101127372(ITGA2)
NLE: 
100588661(ITGA2)
MCC: 
703572(ITGA2)
MCF: 
102133302(ITGA2)
CSAB: 
103221285(ITGA2)
RRO: 
104672477(ITGA2)
RBB: 
108522903(ITGA2)
CJC: 
100403636(ITGA2)
SBQ: 
101041311(ITGA2)
MMU: 
16398(Itga2)
RNO: 
170921(Itga2)
CGE: 
100774579(Itga2)
NGI: 
103734059(Itga2)
HGL: 
101702532(Itga2)
CCAN: 
109696854(Itga2)
OCU: 
100101621(ITGA2)
TUP: 
102476022(ITGA2)
CFA: 
489208(ITGA2)
AML: 
100476403(ITGA2)
UMR: 
103664633(ITGA2)
ORO: 
101375601(ITGA2)
FCA: 
101090237(ITGA2)
PTG: 
102958888(ITGA2)
AJU: 
106976293(ITGA2)
BTA: 
281872(ITGA2)
BOM: 
102281399(ITGA2)
BIU: 
109574862(ITGA2)
PHD: 
102317742(ITGA2)
CHX: 
102172198(ITGA2)
OAS: 
101119848(ITGA2)
SSC: 
397483(ITGA2)
CFR: 
102522915(ITGA2)
CDK: 
105084263(ITGA2)
BACU: 
103016586(ITGA2)
LVE: 
103085988(ITGA2)
ECB: 
100063367(ITGA2)
EPZ: 
103558080(ITGA2)
EAI: 
106843345(ITGA2)
MYB: 
102244336(ITGA2)
MYD: 
102760052(ITGA2)
HAI: 
109382125(ITGA2)
RSS: 
109449706(ITGA2)
PALE: 
102897185(ITGA2)
LAV: 
100674705(ITGA2)
TMU: 
MDO: 
100031498(ITGA2)
SHR: 
105749727(ITGA2)
GGA: 
100857227(ITGA2)
CJO: 
107305978(ITGA2)
APLA: 
101802508(ITGA2)
ACYG: 
106035652(ITGA2)
TGU: 
100221336(ITGA2)
GFR: 
102038455(ITGA2)
FAB: 
101818939(ITGA2)
PHI: 
102108289(ITGA2)
PMAJ: 
107216191(ITGA2)
CCW: 
104686657(ITGA2)
FPG: 
101915932(ITGA2)
FCH: 
102056680(ITGA2)
CLV: 
102091733(ITGA2)
EGZ: 
104131629(ITGA2)
AAM: 
ASN: 
102382534(ITGA2)
AMJ: 
102562789(ITGA2)
PSS: 
102452981(ITGA2)
CMY: 
102938513(ITGA2)
CPIC: 
101948248(ITGA2)
ACS: 
100564306(itga2)
PVT: 
110073896(ITGA2)
PBI: 
103048386(ITGA2)
GJA: 
107116970(ITGA2)
XLA: 
373743(itga2.L)
XTR: 
100492714(itga2)
NPR: 
108799979(ITGA2)
DRE: 
100536533(itga2.2)
SRX: 
SANH: 
SGH: 
CCAR: 
IPU: 
108276854(itga2)
AMEX: 
103040237(itga2)
TRU: 
101065018(itga2)
TNG: 
LCO: 
104922975(itga2)
NCC: 
104961568(itga2)
MZE: 
101463902(itga2)
OLA: 
101174027(itga2)
XMA: 
102225347(itga2)
PRET: 
103469997(itga2)
NFU: 
107394288(itga2)
CSEM: 
103397740(itga2)
LCF: 
108896084(itga2)
HCQ: 
109526498(itga2)
BPEC: 
110172107(itga2)
SASA: 
ELS: 
105014941(itga2)
SFM: 
108925115(itga2)
LCM: 
102355132(ITGA2)
CMK: 
103177840(itga2)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2545729
  Authors
Takada Y, Hemler ME
  Title
The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain.
  Journal
J Cell Biol 109:397-407 (1989)
DOI:10.1083/jcb.109.1.397
  Sequence
[hsa:3673]
Reference
  Authors
Graham KL, Halasz P, Tan Y, Hewish MJ, Takada Y, Mackow ER, Robinson MK, Coulson BS
  Title
Integrin-using rotaviruses bind alpha2beta1 integrin alpha2 I domain via VP4 DGE sequence and recognize alphaXbeta2 and alphaVbeta3 by using VP7 during cell entry.
  Journal
J Virol 77:9969-78 (2003)
DOI:10.1128/JVI.77.18.9969-9978.2003

KEGG   ORTHOLOGY: K06476Help
Entry
K06476                      KO                                     

Name
ITGA2B, CD41
Definition
integrin alpha 2B
Pathway
Rap1 signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Platelet activation
Hematopoietic cell lineage
Regulation of actin cytoskeleton
Human papillomavirus infection
Pathways in cancer
Small cell lung cancer
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy (DCM)
Fluid shear stress and atherosclerosis
Disease
H00226  
Glanzmann thrombasthenia
H01740  
Macrothrombocytopenia
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K06476  ITGA2B, CD41; integrin alpha 2B
   04151 PI3K-Akt signaling pathway
    K06476  ITGA2B, CD41; integrin alpha 2B
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06476  ITGA2B, CD41; integrin alpha 2B
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06476  ITGA2B, CD41; integrin alpha 2B
  Cell motility
   04810 Regulation of actin cytoskeleton
    K06476  ITGA2B, CD41; integrin alpha 2B
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K06476  ITGA2B, CD41; integrin alpha 2B
   04611 Platelet activation
    K06476  ITGA2B, CD41; integrin alpha 2B
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06476  ITGA2B, CD41; integrin alpha 2B
   05222 Small cell lung cancer
    K06476  ITGA2B, CD41; integrin alpha 2B
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K06476  ITGA2B, CD41; integrin alpha 2B
   05410 Hypertrophic cardiomyopathy (HCM)
    K06476  ITGA2B, CD41; integrin alpha 2B
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K06476  ITGA2B, CD41; integrin alpha 2B
   05414 Dilated cardiomyopathy (DCM)
    K06476  ITGA2B, CD41; integrin alpha 2B
  Infectious diseases
   05165 Human papillomavirus infection
    K06476  ITGA2B, CD41; integrin alpha 2B
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K06476  ITGA2B, CD41; integrin alpha 2B
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06476  ITGA2B, CD41; integrin alpha 2B
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Others
   ICAM4; intercellular adhesion molecule 4
    alpha IIb beta 3
     K06476 ITGA2B, CD41; integrin alpha 2B
 5. Cadherin Family
  Classic Cadherins
   Vertebrate Type II classic cadherins
    CDH6; cadherin 6, type 2, K-cadherin
     alpha IIb  beta 3
      K06476 ITGA2B, CD41; integrin alpha 2B
 7. Others
  TNFSF5, CD40L; tumor necrosis factor (ligand) superfamily, member 5
   alpha IIb beta 3
    K06476 ITGA2B, CD41; integrin alpha 2B
CD molecules [BR:ko04090]
 Proteins
  K06476  CD41, ITGA2B; integrin, alpha 2b
BRITE hierarchy
Genes
HSA: 
3674(ITGA2B)
PTR: 
454730(ITGA2B)
PPS: 
100991197(ITGA2B)
GGO: 
101136113(ITGA2B)
PON: 
100452800(ITGA2B)
NLE: 
100601385(ITGA2B)
MCC: 
714955(ITGA2B)
MCF: 
102119413(ITGA2B)
CSAB: 
103243322(ITGA2B)
RRO: 
104654717(ITGA2B)
RBB: 
108532191(ITGA2B)
CJC: 
100408748(ITGA2B)
SBQ: 
101031876(ITGA2B)
MMU: 
16399(Itga2b)
RNO: 
685269(Itga2b)
CGE: 
100762814(Itga2b)
NGI: 
103738294(Itga2b)
HGL: 
101714332(Itga2b)
CCAN: 
109686433(Itga2b)
OCU: 
100008734(ITGA2B)
TUP: 
102493954(ITGA2B)
CFA: 
403789(ITGA2B)
AML: 
100484185(ITGA2B)
UMR: 
103665592(ITGA2B)
ORO: 
101369639(ITGA2B)
FCA: 
101100930(ITGA2B)
PTG: 
102951724(ITGA2B)
AJU: 
106974321(ITGA2B)
BTA: 
515011(ITGA2B)
BOM: 
102275560(ITGA2B)
BIU: 
109573568(ITGA2B)
PHD: 
102319110(ITGA2B)
CHX: 
102183451(ITGA2B)
OAS: 
101115719(ITGA2B)
SSC: 
397059(ITGA2B)
CFR: 
102521427(ITGA2B)
CDK: 
105094425(ITGA2B)
BACU: 
102999724(ITGA2B)
LVE: 
103075356(ITGA2B)
ECB: 
100009697(ITGA2B)
EPZ: 
103551206(ITGA2B)
EAI: 
106836459(ITGA2B)
MYB: 
102252761(ITGA2B)
MYD: 
102767172(ITGA2B)
HAI: 
109394948(ITGA2B)
RSS: 
109458526(ITGA2B)
PALE: 
102883900(ITGA2B)
LAV: 
100654429(ITGA2B)
TMU: 
MDO: 
100023354(ITGA2B)
SHR: 
100932021(ITGA2B)
MGP: 
APLA: 
101792319(ITGA2B)
ACYG: 
106046909(ITGA2B)
GFR: 
106632013(ITGA2B)
FAB: 
101814120(ITGA2B)
PHI: 
102101807(ITGA2B)
PMAJ: 
107215044(ITGA2B)
FPG: 
101913845(ITGA2B)
FCH: 
102046031(ITGA2B)
EGZ: 
ASN: 
102372475(ITGA2B)
AMJ: 
102570562(ITGA2B)
CMY: 
102942431(ITGA2B)
CPIC: 
101947159(ITGA2B)
ACS: 
100557235(itga2b)
PVT: 
110081352(ITGA2B)
PBI: 
103054796(ITGA2B)
GJA: 
XLA: 
100191022(itga2b.1.S) 495051(itga2b.2.L)
XTR: 
100158580(itga2b.1) 100495138(itga2b.2)
NPR: 
DRE: 
445380(itga2b)
SRX: 
SANH: 
SGH: 
IPU: 
108258137(itga2b)
AMEX: 
LCO: 
104938137(itga2b)
XMA: 
102221313(itga2b)
PRET: 
LCF: 
108873242(itga2b)
SASA: 
ELS: 
SFM: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2439501
  Authors
Poncz M, Eisman R, Heidenreich R, Silver SM, Vilaire G, Surrey S, Schwartz E, Bennett JS
  Title
Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors.
  Journal
J Biol Chem 262:8476-82 (1987)
  Sequence
[hsa:3674]
Reference
  Authors
Ye F, Petrich BG, Anekal P, Lefort CT, Kasirer-Friede A, Shattil SJ, Ruppert R, Moser M, Fassler R, Ginsberg MH
  Title
The mechanism of kindlin-mediated activation of integrin alphaIIbbeta3.
  Journal
Curr Biol 23:2288-95 (2013)
DOI:10.1016/j.cub.2013.09.050

KEGG   ORTHOLOGY: K06482Help
Entry
K06482                      KO                                     

Name
ITGA3, CD49c
Definition
integrin alpha 3
Pathway
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Hematopoietic cell lineage
Regulation of actin cytoskeleton
Human papillomavirus infection
Pathways in cancer
Small cell lung cancer
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy (DCM)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06482  ITGA3, CD49c; integrin alpha 3
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06482  ITGA3, CD49c; integrin alpha 3
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06482  ITGA3, CD49c; integrin alpha 3
  Cell motility
   04810 Regulation of actin cytoskeleton
    K06482  ITGA3, CD49c; integrin alpha 3
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K06482  ITGA3, CD49c; integrin alpha 3
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06482  ITGA3, CD49c; integrin alpha 3
   05222 Small cell lung cancer
    K06482  ITGA3, CD49c; integrin alpha 3
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K06482  ITGA3, CD49c; integrin alpha 3
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K06482  ITGA3, CD49c; integrin alpha 3
   05414 Dilated cardiomyopathy (DCM)
    K06482  ITGA3, CD49c; integrin alpha 3
  Infectious diseases
   05165 Human papillomavirus infection
    K06482  ITGA3, CD49c; integrin alpha 3
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06482  ITGA3, CD49c; integrin alpha 3
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta1 integrins
   VLA-2
    ITGB1; integrin beta 1
     VLA-3
      K06482 ITGA3, CD49c; integrin alpha 3
   VLA-3
    ITGB1; integrin beta 1
     VLA-3
      K06482 ITGA3, CD49c; integrin alpha 3
CD molecules [BR:ko04090]
 Proteins
  K06482  CD49c, ITGA3; integrin, alpha 3
BRITE hierarchy
Genes
HSA: 
3675(ITGA3)
PTR: 
455111(ITGA3)
PPS: 
100993709(ITGA3)
GGO: 
101147579(ITGA3)
PON: 
100459915(ITGA3)
NLE: 
100596503(ITGA3)
MCC: 
700962(ITGA3)
MCF: 
102123329(ITGA3)
CSAB: 
103242953(ITGA3)
RRO: 
104680261(ITGA3)
RBB: 
108516444(ITGA3)
CJC: 
100386753(ITGA3)
SBQ: 
101050876(ITGA3)
MMU: 
16400(Itga3)
RNO: 
360606(Itga3)
CGE: 
100758471(Itga3)
NGI: 
103738376(Itga3)
HGL: 
101699399(Itga3)
CCAN: 
109691414(Itga3)
OCU: 
100348594(ITGA3)
TUP: 
102476747(ITGA3)
CFA: 
491074(ITGA3)
AML: 
100479748(ITGA3)
UMR: 
103660962(ITGA3)
ORO: 
101366550(ITGA3)
FCA: 
101093156(ITGA3)
PTG: 
102966946(ITGA3)
AJU: 
106985164(ITGA3)
BTA: 
508490(ITGA3)
BOM: 
102266712(ITGA3)
BIU: 
109574210(ITGA3)
PHD: 
102330470(ITGA3)
CHX: 
102185499(ITGA3)
OAS: 
101118038(ITGA3)
SSC: 
100517053(ITGA3)
CFR: 
102508309(ITGA3)
CDK: 
105104827(ITGA3)
BACU: 
103017998(ITGA3)
LVE: 
103073252(ITGA3)
ECB: 
100056202(ITGA3)
EPZ: 
103551055(ITGA3)
EAI: 
106826435(ITGA3)
MYB: 
102245715(ITGA3)
MYD: 
102751287(ITGA3)
HAI: 
109380829(ITGA3)
RSS: 
109451998(ITGA3)
PALE: 
102884713(ITGA3)
LAV: 
100671578(ITGA3)
TMU: 
MDO: 
100022489(ITGA3)
SHR: 
100928379(ITGA3)
OAA: 
100080433(ITGA3)
GGA: 
373946(ITGA3)
CJO: 
107325069(ITGA3)
APLA: 
ACYG: 
GFR: 
102036678(ITGA3)
FAB: 
101812468(ITGA3)
PHI: 
102105462(ITGA3)
PMAJ: 
107198661(ITGA3)
FPG: 
101915907(ITGA3)
FCH: 
102055031(ITGA3)
CLV: 
102092573(ITGA3)
AAM: 
106492755(ITGA3)
ASN: 
102379676(ITGA3)
AMJ: 
106736741(ITGA3)
PSS: 
102454368(ITGA3)
CMY: 
102938482(ITGA3)
CPIC: 
101948058(ITGA3)
ACS: 
PVT: 
110079172(ITGA3)
PBI: 
103048286(ITGA3)
GJA: 
107112527(ITGA3)
XLA: 
108702534 373657(itga3.L)
XTR: 
100494331(itga3)
NPR: 
108784022(ITGA3)
DRE: 
100331874(itga3b) 407685(itga3a)
SRX: 
SANH: 
SGH: 
CCAR: 
IPU: 
AMEX: 
TRU: 
101077013(itga3)
TNG: 
LCO: 
NCC: 
104966408(itga3)
MZE: 
OLA: 
XMA: 
PRET: 
NFU: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
108928278(itga3)
LCM: 
102347243(ITGA3)
CMK: 
103183847(itga3)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1655803
  Authors
Takada Y, Murphy E, Pil P, Chen C, Ginsberg MH, Hemler ME
  Title
Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen.
  Journal
J Cell Biol 115:257-66 (1991)
DOI:10.1083/jcb.115.1.257
  Sequence
[hsa:3675]
Reference
  Authors
Mueller SC, Ghersi G, Akiyama SK, Sang QX, Howard L, Pineiro-Sanchez M, Nakahara H, Yeh Y, Chen WT
  Title
A novel protease-docking function of integrin at invadopodia.
  Journal
J Biol Chem 274:24947-52 (1999)
DOI:10.1074/jbc.274.35.24947

KEGG   ORTHOLOGY: K06483Help
Entry
K06483                      KO                                     

Name
ITGA4, CD49d
Definition
integrin alpha 4
Pathway
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Cell adhesion molecules (CAMs)
Hematopoietic cell lineage
Leukocyte transendothelial migration
Intestinal immune network for IgA production
Regulation of actin cytoskeleton
Leishmaniasis
Human papillomavirus infection
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy (DCM)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06483  ITGA4, CD49d; integrin alpha 4
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06483  ITGA4, CD49d; integrin alpha 4
   04514 Cell adhesion molecules (CAMs)
    K06483  ITGA4, CD49d; integrin alpha 4
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06483  ITGA4, CD49d; integrin alpha 4
  Cell motility
   04810 Regulation of actin cytoskeleton
    K06483  ITGA4, CD49d; integrin alpha 4
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K06483  ITGA4, CD49d; integrin alpha 4
   04670 Leukocyte transendothelial migration
    K06483  ITGA4, CD49d; integrin alpha 4
   04672 Intestinal immune network for IgA production
    K06483  ITGA4, CD49d; integrin alpha 4
 Human Diseases
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K06483  ITGA4, CD49d; integrin alpha 4
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K06483  ITGA4, CD49d; integrin alpha 4
   05414 Dilated cardiomyopathy (DCM)
    K06483  ITGA4, CD49d; integrin alpha 4
  Infectious diseases
   05165 Human papillomavirus infection
    K06483  ITGA4, CD49d; integrin alpha 4
   05140 Leishmaniasis
    K06483  ITGA4, CD49d; integrin alpha 4
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06483  ITGA4, CD49d; integrin alpha 4
  Exosomal proteins of other cancer cells
   K06483  ITGA4, CD49d; integrin alpha 4
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Neural system
   6/5 subfamily
    NRCAM; neuronal cell adhesion molecule
     VLA-4
      K06483 ITGA4, CD49d; integrin alpha 4
  Others
   VCAM1; vascular cell adhesion molecule 1
    VLA-4
     K06483 ITGA4, CD49d; integrin alpha 4
    alpha 4 beta7
     K06483 ITGA4, CD49d; integrin alpha 4
   MADCAM1; mucosal vascular addressin cell adhesion molecule 1
    alpha 4 beta7
     K06483 ITGA4, CD49d; integrin alpha 4
   LU; Lutheran blood group glycoprotein
    VLA-4
     K06483 ITGA4, CD49d; integrin alpha 4
   JAM2; junctional adhesion molecule 2
    VLA-4
     K06483 ITGA4, CD49d; integrin alpha 4
CD molecules [BR:ko04090]
 Proteins
  K06483  CD49d, ITGA4; integrin, alpha 4
BRITE hierarchy
Genes
HSA: 
3676(ITGA4)
PTR: 
470596(ITGA4)
PPS: 
100983460(ITGA4)
GGO: 
101139877(ITGA4)
PON: 
100441139(ITGA4)
NLE: 
100602993(ITGA4)
MCC: 
704745(ITGA4)
MCF: 
102128433(ITGA4)
CSAB: 
103217451(ITGA4)
RRO: 
104666588(ITGA4)
RBB: 
CJC: 
SBQ: 
101048275(ITGA4)
MMU: 
16401(Itga4)
RNO: 
311144(Itga4)
CGE: 
100762323(Itga4)
NGI: 
103729874(Itga4)
HGL: 
101709723(Itga4)
CCAN: 
109698815(Itga4)
OCU: 
100346103(ITGA4)
TUP: 
102492567(ITGA4)
CFA: 
488429(ITGA4)
AML: 
100464670(ITGA4)
UMR: 
103659636(ITGA4)
ORO: 
101363662(ITGA4)
FCA: 
101081745(ITGA4)
PTG: 
102966166(ITGA4)
AJU: 
106988793(ITGA4)
BTA: 
282882(ITGA4)
BOM: 
102277811(ITGA4)
BIU: 
109565881(ITGA4)
PHD: 
102338796(ITGA4)
CHX: 
102183190(ITGA4)
OAS: 
443499(ITGA4)
SSC: 
100521477(ITGA4)
CFR: 
102520363(ITGA4)
CDK: 
105098747(ITGA4)
BACU: 
103010335(ITGA4)
LVE: 
103077106(ITGA4)
ECB: 
100067886(ITGA4)
EPZ: 
EAI: 
106826601(ITGA4)
MYB: 
102259547(ITGA4)
MYD: 
102765676(ITGA4)
HAI: 
109392600(ITGA4)
RSS: 
109458850(ITGA4)
PALE: 
102896887(ITGA4)
LAV: 
100674409(ITGA4)
TMU: 
MDO: 
100027449(ITGA4)
SHR: 
100923854(ITGA4)
OAA: 
100085588(ITGA4)
GGA: 
424121(ITGA4)
MGP: 
100545328(ITGA4)
CJO: 
107316604(ITGA4)
APLA: 
101799485(ITGA4)
ACYG: 
106030050(ITGA4)
TGU: 
100219853(ITGA4)
GFR: 
102045380(ITGA4)
FAB: 
101819955(ITGA4)
PHI: 
102111437(ITGA4)
PMAJ: 
107207539(ITGA4)
CCW: 
104694156(ITGA4)
FPG: 
101915570(ITGA4)
FCH: 
102056732(ITGA4)
CLV: 
102097249(ITGA4)
EGZ: 
104132712(ITGA4)
AAM: 
106499121(ITGA4)
ASN: 
AMJ: 
102564142(ITGA4)
PSS: 
102452735(ITGA4)
CMY: 
102929730(ITGA4)
CPIC: 
101938123(ITGA4)
ACS: 
100552809(itga4)
PVT: 
110086963(ITGA4)
PBI: 
103059886(ITGA4)
GJA: 
107106004(ITGA4)
XLA: 
108701397(itga4.L) 397839(itga4.S)
XTR: 
100487924(itga4)
NPR: 
108789472(ITGA4)
DRE: 
100331333(itga4)
SRX: 
SANH: 
SGH: 
CCAR: 
109096075(itga4)
IPU: 
108266204(itga4)
AMEX: 
103022753(itga4)
TRU: 
101067986(itga4)
TNG: 
LCO: 
104932944(itga4)
NCC: 
104962655(itga4)
MZE: 
101467543(itga4)
OLA: 
101166094(itga4)
XMA: 
102235568(itga4)
PRET: 
103480518(itga4)
NFU: 
107389696(itga4)
CSEM: 
103391801(itga4)
LCF: 
108901275(itga4)
HCQ: 
109517042(itga4)
BPEC: 
110164214(itga4)
SASA: 
ELS: 
SFM: 
LCM: 
102348836(ITGA4)
CMK: 
103176505(itga4)
DPL: 
PRAP: 
ZNE: 
TUT: 
CRG: 
OBI: 
LAK: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2788572
  Authors
Takada Y, Elices MJ, Crouse C, Hemler ME
  Title
The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function.
  Journal
EMBO J 8:1361-8 (1989)
  Sequence
[hsa:3676]
Reference
  Authors
Luissint AC, Lutz PG, Calderwood DA, Couraud PO, Bourdoulous S
  Title
JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation.
  Journal
J Cell Biol 183:1159-73 (2008)
DOI:10.1083/jcb.200805061

KEGG   ORTHOLOGY: K06484Help
Entry
K06484                      KO                                     

Name
ITGA5, CD49e
Definition
integrin alpha 5
Pathway
Phagosome
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Hematopoietic cell lineage
Regulation of actin cytoskeleton
Bacterial invasion of epithelial cells
Shigellosis
Pertussis
Human papillomavirus infection
Proteoglycans in cancer
MicroRNAs in cancer
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy (DCM)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06484  ITGA5, CD49e; integrin alpha 5
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06484  ITGA5, CD49e; integrin alpha 5
 Cellular Processes
  Transport and catabolism
   04145 Phagosome
    K06484  ITGA5, CD49e; integrin alpha 5
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06484  ITGA5, CD49e; integrin alpha 5
  Cell motility
   04810 Regulation of actin cytoskeleton
    K06484  ITGA5, CD49e; integrin alpha 5
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K06484  ITGA5, CD49e; integrin alpha 5
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    K06484  ITGA5, CD49e; integrin alpha 5
   05205 Proteoglycans in cancer
    K06484  ITGA5, CD49e; integrin alpha 5
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K06484  ITGA5, CD49e; integrin alpha 5
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K06484  ITGA5, CD49e; integrin alpha 5
   05414 Dilated cardiomyopathy (DCM)
    K06484  ITGA5, CD49e; integrin alpha 5
  Infectious diseases
   05131 Shigellosis
    K06484  ITGA5, CD49e; integrin alpha 5
   05133 Pertussis
    K06484  ITGA5, CD49e; integrin alpha 5
   05100 Bacterial invasion of epithelial cells
    K06484  ITGA5, CD49e; integrin alpha 5
   05165 Human papillomavirus infection
    K06484  ITGA5, CD49e; integrin alpha 5
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06484  ITGA5, CD49e; integrin alpha 5
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Neural system
   6/5 subfamily
    L1CAM; L1 cell adhesion molecule
     VLA-5
      K06484 ITGA5, CD49e; integrin alpha 5
 5. Cadherin Family
  Clustered protocadherin
   PCDHA; protocadherin alpha
    VLA-5
     K06484 ITGA5, CD49e; integrin alpha 5
 7. Others
  TNFSF5, CD40L; tumor necrosis factor (ligand) superfamily, member 5
   VLA-5
    K06484 ITGA5, CD49e; integrin alpha 5
  SDC1; syndecan 1
   VLA-5
    K06484 ITGA5, CD49e; integrin alpha 5
  SDC4; syndecan 4
   VLA-5
    K06484 ITGA5, CD49e; integrin alpha 5
CD molecules [BR:ko04090]
 Proteins
  K06484  CD49e, ITGA5; integrin, alpha 5
BRITE hierarchy
Genes
HSA: 
3678(ITGA5)
PTR: 
451958(ITGA5)
PPS: 
100968295(ITGA5)
GGO: 
101134285(ITGA5)
PON: 
100453984(ITGA5)
NLE: 
100606925(ITGA5)
MCC: 
574315(ITGA5)
MCF: 
102114969(ITGA5)
CSAB: 
103238438(ITGA5)
RRO: 
104670562(ITGA5)
RBB: 
108514611(ITGA5)
CJC: 
100386674(ITGA5)
SBQ: 
101043820(ITGA5)
MMU: 
16402(Itga5)
RNO: 
315346(Itga5)
CGE: 
100768174(Itga5)
NGI: 
103738966(Itga5)
HGL: 
101714885(Itga5)
CCAN: 
109686653(Itga5)
OCU: 
100009172(ITGA5)
TUP: 
102467775(ITGA5)
CFA: 
486493(ITGA5)
AML: 
100479433(ITGA5)
UMR: 
103675680(ITGA5)
ORO: 
101380023(ITGA5)
FCA: 
101093870(ITGA5)
PTG: 
102959936(ITGA5)
AJU: 
106989320(ITGA5)
BTA: 
281873(ITGA5)
BOM: 
102276200(ITGA5)
BIU: 
109558343(ITGA5)
PHD: 
102337753(ITGA5)
CHX: 
102176587(ITGA5)
OAS: 
443140(ITGA5)
SSC: 
100155091(ITGA5)
CFR: 
102507691(ITGA5)
CDK: 
105101003(ITGA5)
BACU: 
103011640(ITGA5)
LVE: 
103074553(ITGA5)
ECB: 
100064655(ITGA5)
EPZ: 
103563237(ITGA5)
EAI: 
106828260(ITGA5)
MYB: 
102255900(ITGA5)
MYD: 
HAI: 
109391860(ITGA5)
RSS: 
109443711(ITGA5)
PALE: 
102889111(ITGA5)
LAV: 
100676951(ITGA5)
TMU: 
SHR: 
100923187(ITGA5)
PHI: 
102111964(ITGA5)
FPG: 
101923738(ITGA5)
FCH: 
102047845(ITGA5)
ASN: 
102382434(ITGA5)
AMJ: 
102563393(ITGA5)
PSS: 
102445917(ITGA5)
CMY: 
102942186(ITGA5)
CPIC: 
101936839(ITGA5)
ACS: 
100566243(itga5)
PVT: 
110071758(ITGA5)
PBI: 
103062319(ITGA5)
GJA: 
107119049(ITGA5)
XLA: 
394366(itga5.L) 397842(itga5.S)
XTR: 
100492002(itga5)
NPR: 
108797346(ITGA5)
DRE: 
386787(itga5)
SRX: 
SANH: 
SGH: 
CCAR: 
IPU: 
108275658(itga5)
AMEX: 
103025198(itga5)
TRU: 
TNG: 
LCO: 
MZE: 
OLA: 
XMA: 
PRET: 
NFU: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
BFO: 
LAK: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2958481
  Authors
Argraves WS, Suzuki S, Arai H, Thompson K, Pierschbacher MD, Ruoslahti E
  Title
Amino acid sequence of the human fibronectin receptor.
  Journal
J Cell Biol 105:1183-90 (1987)
DOI:10.1083/jcb.105.3.1183
  Sequence
[hsa:3678]
Reference
  Authors
Weigel-Kelley KA, Yoder MC, Srivastava A
  Title
Alpha5beta1 integrin as a cellular coreceptor for human parvovirus B19: requirement of functional activation of beta1 integrin for viral entry.
  Journal
Blood 102:3927-33 (2003)
DOI:10.1182/blood-2003-05-1522

KEGG   ORTHOLOGY: K06485Help
Entry
K06485                      KO                                     

Name
ITGA6, CD49f
Definition
integrin alpha 6
Pathway
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Cell adhesion molecules (CAMs)
Hematopoietic cell lineage
Regulation of actin cytoskeleton
Toxoplasmosis
Human papillomavirus infection
Pathways in cancer
Small cell lung cancer
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy (DCM)
Disease
H00586  
Epidermolysis bullosa, junctional
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06485  ITGA6, CD49f; integrin alpha 6
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06485  ITGA6, CD49f; integrin alpha 6
   04514 Cell adhesion molecules (CAMs)
    K06485  ITGA6, CD49f; integrin alpha 6
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06485  ITGA6, CD49f; integrin alpha 6
  Cell motility
   04810 Regulation of actin cytoskeleton
    K06485  ITGA6, CD49f; integrin alpha 6
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K06485  ITGA6, CD49f; integrin alpha 6
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06485  ITGA6, CD49f; integrin alpha 6
   05222 Small cell lung cancer
    K06485  ITGA6, CD49f; integrin alpha 6
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K06485  ITGA6, CD49f; integrin alpha 6
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K06485  ITGA6, CD49f; integrin alpha 6
   05414 Dilated cardiomyopathy (DCM)
    K06485  ITGA6, CD49f; integrin alpha 6
  Infectious diseases
   05165 Human papillomavirus infection
    K06485  ITGA6, CD49f; integrin alpha 6
   05145 Toxoplasmosis
    K06485  ITGA6, CD49f; integrin alpha 6
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06485  ITGA6, CD49f; integrin alpha 6
  Exosomal proteins of breast milk
   K06485  ITGA6, CD49f; integrin alpha 6
Cell adhesion molecules and their ligands [BR:ko04516]
 7. Others
  SDC1; syndecan 1
   alpha 6 beta 4
    K06485 ITGA6, CD49f; integrin alpha 6
  SDC4; syndecan 4
   alpha 6 beta 4
    K06485 ITGA6, CD49f; integrin alpha 6
CD molecules [BR:ko04090]
 Proteins
  K06485  CD49f, ITGA6; integrin, alpha 6
BRITE hierarchy
Genes
HSA: 
3655(ITGA6)
PTR: 
459742(ITGA6)
PPS: 
100967602(ITGA6)
GGO: 
101146479(ITGA6)
PON: 
100442478(ITGA6)
NLE: 
100600735(ITGA6)
MCC: 
697643(ITGA6)
MCF: 
101925271(ITGA6)
CSAB: 
103217327(ITGA6)
RRO: 
104673514(ITGA6)
RBB: 
108522273(ITGA6)
CJC: 
100403557(ITGA6)
SBQ: 
101045102(ITGA6)
MMU: 
16403(Itga6)
RNO: 
114517(Itga6)
CGE: 
100769534(Itga6)
NGI: 
103751741(Itga6)
HGL: 
101705215(Itga6)
CCAN: 
109700950(Itga6)
OCU: 
100008642(ITGA6)
TUP: 
102500081(ITGA6)
CFA: 
100856563(ITGA6)
AML: 
100474079(ITGA6)
UMR: 
103659892(ITGA6)
ORO: 
101383404(ITGA6)
FCA: 
101092454(ITGA6)
PTG: 
102963994(ITGA6)
AJU: 
106987915(ITGA6)
BTA: 
535043(ITGA6)
BOM: 
102265941(ITGA6)
BIU: 
109566462(ITGA6)
PHD: 
102338717(ITGA6)
CHX: 
102186530(ITGA6)
OAS: 
101113656(ITGA6)
SSC: 
100158200(ITGA6)
CFR: 
102518543(ITGA6)
CDK: 
105091094(ITGA6)
BACU: 
103017654(ITGA6)
LVE: 
103078101(ITGA6)
ECB: 
100064056(ITGA6)
EPZ: 
103553123(ITGA6)
EAI: 
106834716(ITGA6)
MYB: 
102261916(ITGA6)
MYD: 
102771141(ITGA6)
HAI: 
109390397(ITGA6)
RSS: 
109445224(ITGA6)
PALE: 
102883425(ITGA6)
LAV: 
100661035(ITGA6)
TMU: 
MDO: 
100018376(ITGA6)
SHR: 
100929219(ITGA6)
OAA: 
100084141(ITGA6)
GGA: 
396226(ITGA6)
MGP: 
100538428(ITGA6)
CJO: 
107316693(ITGA6)
APLA: 
101791104(ITGA6)
ACYG: 
106029997(ITGA6)
TGU: 
100221694(ITGA6)
GFR: 
102042715(ITGA6)
FAB: 
101812515(ITGA6)
PHI: 
102101887(ITGA6)
PMAJ: 
107207401(ITGA6)
CCW: 
104693875(ITGA6)
FPG: 
101924838(ITGA6)
FCH: 
102050643(ITGA6)
CLV: 
102098455(ITGA6)
EGZ: 
104128056(ITGA6)
AAM: 
106499243(ITGA6)
ASN: 
102384271(ITGA6)
AMJ: 
102565962(ITGA6)
PSS: 
102463367(ITGA6)
CMY: 
102942520(ITGA6)
CPIC: 
101938096(ITGA6)
ACS: 
100555687(itga6)
PVT: 
110086019(ITGA6)
PBI: 
103053454(ITGA6)
GJA: 
107107039(ITGA6)
XLA: 
108702994(itga6.S) 397985(itga6.L)
XTR: 
100497992(itga6)
NPR: 
108800541(ITGA6)
DRE: 
503893(itga6a) 541320(itga6b)
SRX: 
SANH: 
SGH: 
CCAR: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
PRET: 
NFU: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
102345625(ITGA6)
CMK: 
BFO: 
CIN: 
TCA: 
DPA: 
TUT: 
HRO: 
CRG: 
OBI: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1976638
  Authors
Tamura RN, Rozzo C, Starr L, Chambers J, Reichardt LF, Cooper HM, Quaranta V
  Title
Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4.
  Journal
J Cell Biol 111:1593-604 (1990)
DOI:10.1083/jcb.111.4.1593
  Sequence
[hsa:3655]
Reference
  Authors
Pawar SC, Demetriou MC, Nagle RB, Bowden GT, Cress AE
  Title
Integrin alpha6 cleavage: a novel modification to modulate cell migration.
  Journal
Exp Cell Res 313:1080-9 (2007)
DOI:10.1016/j.yexcr.2007.01.006

KEGG   ORTHOLOGY: K06583Help
Entry
K06583                      KO                                     

Name
ITGA7
Definition
integrin alpha 7
Pathway
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Regulation of actin cytoskeleton
Human papillomavirus infection
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy (DCM)
Disease
H00590  
Congenital muscular dystrophies (CMD/MDC)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06583  ITGA7; integrin alpha 7
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06583  ITGA7; integrin alpha 7
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06583  ITGA7; integrin alpha 7
  Cell motility
   04810 Regulation of actin cytoskeleton
    K06583  ITGA7; integrin alpha 7
 Human Diseases
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K06583  ITGA7; integrin alpha 7
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K06583  ITGA7; integrin alpha 7
   05414 Dilated cardiomyopathy (DCM)
    K06583  ITGA7; integrin alpha 7
  Infectious diseases
   05165 Human papillomavirus infection
    K06583  ITGA7; integrin alpha 7
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06583  ITGA7; integrin alpha 7
BRITE hierarchy
Genes
HSA: 
3679(ITGA7)
PTR: 
451967(ITGA7)
PPS: 
100986603(ITGA7)
GGO: 
101154143(ITGA7)
PON: 
100439761(ITGA7)
NLE: 
100589979(ITGA7)
MCC: 
707279(ITGA7)
MCF: 
102130741(ITGA7)
CSAB: 
RRO: 
104673715(ITGA7)
RBB: 
108516025(ITGA7)
CJC: 
100401654(ITGA7)
SBQ: 
101050387(ITGA7)
MMU: 
16404(Itga7)
RNO: 
81008(Itga7)
CGE: 
100773038(Itga7)
NGI: 
103738830(Itga7)
HGL: 
101702836(Itga7)
CCAN: 
109696206(Itga7)
OCU: 
100346005(ITGA7)
TUP: 
102491576(ITGA7)
CFA: 
481097(ITGA7)
AML: 
100475280(ITGA7)
UMR: 
103656923(ITGA7)
ORO: 
101378058(ITGA7)
FCA: 
101089783(ITGA7)
PTG: 
102954733(ITGA7)
AJU: 
106986862(ITGA7)
BTA: 
506953(ITGA7)
BOM: 
102282217(ITGA7)
BIU: 
109559400(ITGA7)
PHD: 
102330157(ITGA7)
CHX: 
102169839(ITGA7)
OAS: 
101115445(ITGA7)
SSC: 
110260578(ITGA7)
CFR: 
102524098(ITGA7)
CDK: 
BACU: 
103006781(ITGA7)
LVE: 
103071252(ITGA7)
ECB: 
100058756(ITGA7)
EPZ: 
103560209(ITGA7)
EAI: 
106841313(ITGA7)
MYB: 
102249761(ITGA7)
MYD: 
102773890(ITGA7)
HAI: 
109396843(ITGA7)
RSS: 
109452998(ITGA7)
PALE: 
102890305(ITGA7)
LAV: 
100665471(ITGA7)
TMU: 
SHR: 
100927189(ITGA7)
OAA: 
100087799(ITGA7)
GGA: 
101749098(ITGA7)
MGP: 
100550013(ITGA7)
CJO: 
107325796(ITGA7)
PHI: 
CLV: 
102088100(ITGA7)
ASN: 
102374848(ITGA7)
AMJ: 
PSS: 
102452166(ITGA7)
CMY: 
CPIC: 
101952718(ITGA7)
ACS: 
100552402(itga7)
PVT: 
110073732(ITGA7)
PBI: 
103064537(ITGA7)
GJA: 
107105864(ITGA7)
XLA: 
108708560(itga7.L) 108708991(itga7.S)
XTR: 
100494050(itga7)
NPR: 
108796489(ITGA7)
DRE: 
100006255(itga7)
SRX: 
SANH: 
SGH: 
107567937(itga7)
CCAR: 
IPU: 
AMEX: 
103028643(itga7)
TRU: 
101063602(itga7)
TNG: 
LCO: 
104939938(itga7)
NCC: 
104954764(itga7)
MZE: 
101483649(itga7)
OLA: 
101161550(itga7)
XMA: 
PRET: 
103464425(itga7)
NFU: 
107385306(itga7)
CSEM: 
103386373(itga7)
LCF: 
108891051(itga7)
HCQ: 
109522173(itga7)
BPEC: 
110168424(itga7)
SASA: 
ELS: 
105006268(itga7)
SFM: 
108928434(itga7)
LCM: 
102365385(ITGA7)
CMK: 
BFO: 
APLC: 
PRAP: 
PXY: 
ZNE: 
DPX: 
TUT: 
HRO: 
MYI: 
LAK: 
OVI: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9473524
  Authors
Leung E, Lim SP, Berg R, Yang Y, Ni J, Wang SX, Krissansen GW
  Title
A novel extracellular domain variant of the human integrin alpha 7 subunit generated by alternative intron splicing.
  Journal
Biochem Biophys Res Commun 243:317-25 (1998)
DOI:10.1006/bbrc.1998.8092
  Sequence
[hsa:3679]

KEGG   ORTHOLOGY: K06584Help
Entry
K06584                      KO                                     

Name
ITGA8
Definition
integrin alpha 8
Pathway
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Cell adhesion molecules (CAMs)
Regulation of actin cytoskeleton
Human papillomavirus infection
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy (DCM)
Disease
H01728  
Potter syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06584  ITGA8; integrin alpha 8
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06584  ITGA8; integrin alpha 8
   04514 Cell adhesion molecules (CAMs)
    K06584  ITGA8; integrin alpha 8
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06584  ITGA8; integrin alpha 8
  Cell motility
   04810 Regulation of actin cytoskeleton
    K06584  ITGA8; integrin alpha 8
 Human Diseases
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K06584  ITGA8; integrin alpha 8
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K06584  ITGA8; integrin alpha 8
   05414 Dilated cardiomyopathy (DCM)
    K06584  ITGA8; integrin alpha 8
  Infectious diseases
   05165 Human papillomavirus infection
    K06584  ITGA8; integrin alpha 8
BRITE hierarchy
Genes
HSA: 
8516(ITGA8)
PTR: 
450323(ITGA8)
PPS: 
100967547(ITGA8)
GGO: 
101134255(ITGA8)
PON: 
100442074(ITGA8)
NLE: 
100603717(ITGA8)
MCC: 
698888(ITGA8)
MCF: 
102115695(ITGA8)
CSAB: 
103237941(ITGA8)
RRO: 
104664159(ITGA8)
RBB: 
108530933(ITGA8)
CJC: 
100404891(ITGA8)
SBQ: 
101043234(ITGA8)
MMU: 
241226(Itga8)
RNO: 
364786(Itga8)
CGE: 
100769007(Itga8)
NGI: 
103734817(Itga8)
HGL: 
101724376(Itga8)
CCAN: 
109691367(Itga8)
OCU: 
100351181(ITGA8)
TUP: 
102484826(ITGA8)
CFA: 
487119(ITGA8)
AML: 
100478512(ITGA8)
UMR: 
103664242(ITGA8)
ORO: 
101377347(ITGA8)
FCA: 
101100222(ITGA8)
PTG: 
102963555(ITGA8)
AJU: 
106970995(ITGA8)
BTA: 
511976(ITGA8)
BOM: 
102273105(ITGA8)
BIU: 
109567974(ITGA8)
PHD: 
102318928(ITGA8)
CHX: 
102181695(ITGA8)
OAS: 
101117689(ITGA8)
SSC: 
100512676(ITGA8)
CFR: 
CDK: 
BACU: 
103020775(ITGA8)
LVE: 
103090157(ITGA8)
ECB: 
100056217(ITGA8)
EPZ: 
EAI: 
MYB: 
102253526(ITGA8)
MYD: 
102760985(ITGA8)
HAI: 
109374603(ITGA8)
RSS: 
PALE: 
102878211(ITGA8)
LAV: 
100674808(ITGA8)
TMU: 
MDO: 
100027090(ITGA8)
SHR: 
100913539(ITGA8)
OAA: 
100077343(ITGA8)
GGA: 
396225(ITGA8)
MGP: 
CJO: 
107309024(ITGA8)
APLA: 
101796164(ITGA8)
ACYG: 
106039679(ITGA8)
TGU: 
100232593(ITGA8)
GFR: 
102032097(ITGA8)
FAB: 
101815379(ITGA8)
PHI: 
102109520(ITGA8)
PMAJ: 
107200937(ITGA8)
CCW: 
104689346(ITGA8)
FPG: 
101922157(ITGA8)
FCH: 
102058984(ITGA8)
CLV: 
102085272(ITGA8)
EGZ: 
104128416(ITGA8)
AAM: 
106483498(ITGA8)
ASN: 
102385374(ITGA8)
AMJ: 
102574925(ITGA8)
PSS: 
102455225(ITGA8)
CMY: 
102942160(ITGA8)
CPIC: 
101945414(ITGA8)
ACS: 
100554689(itga8)
PVT: 
110085993(ITGA8)
PBI: 
GJA: 
107120962(ITGA8)
XLA: 
108718824(itga8.L) 108719885(itga8.S)
XTR: 
100487624(itga8)
NPR: 
108795077(ITGA8)
DRE: 
100141346(itga8)
SRX: 
SANH: 
SGH: 
CCAR: 
IPU: 
108256655(itga8)
AMEX: 
103045927(itga8)
TRU: 
101074931(itga8)
TNG: 
LCO: 
NCC: 
104968270(itga8)
MZE: 
101468620(itga8)
OLA: 
101164748(itga8)
XMA: 
102217862(itga8)
PRET: 
103478622(itga8)
NFU: 
CSEM: 
103388400(itga8)
LCF: 
108892053(itga8)
HCQ: 
109518014(itga8)
BPEC: 
110171606(itga8)
SASA: 
ELS: 
105028485(itga8)
SFM: 
108940685(itga8)
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
APLC: 
SKO: 
DPX: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
MYI: 
OBI: 
LAK: 
SMM: 
SHX: 
OVI: 
HMG: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7768999
  Authors
Schnapp LM, Breuss JM, Ramos DM, Sheppard D, Pytela R
  Title
Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells.
  Journal
J Cell Sci 108 ( Pt 2):537-44 (1995)
  Sequence
[hsa:8516]
Reference
  Authors
Lu M, Munger JS, Steadele M, Busald C, Tellier M, Schnapp LM
  Title
Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1.
  Journal
J Cell Sci 115:4641-8 (2002)
DOI:10.1242/jcs.00145

KEGG   ORTHOLOGY: K06585Help
Entry
K06585                      KO                                     

Name
ITGA9
Definition
integrin alpha 9
Pathway
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Cell adhesion molecules (CAMs)
Regulation of actin cytoskeleton
Human papillomavirus infection
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy (DCM)
Disease
H00590  
Congenital muscular dystrophies (CMD/MDC)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06585  ITGA9; integrin alpha 9
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06585  ITGA9; integrin alpha 9
   04514 Cell adhesion molecules (CAMs)
    K06585  ITGA9; integrin alpha 9
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06585  ITGA9; integrin alpha 9
  Cell motility
   04810 Regulation of actin cytoskeleton
    K06585  ITGA9; integrin alpha 9
 Human Diseases
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K06585  ITGA9; integrin alpha 9
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K06585  ITGA9; integrin alpha 9
   05414 Dilated cardiomyopathy (DCM)
    K06585  ITGA9; integrin alpha 9
  Infectious diseases
   05165 Human papillomavirus infection
    K06585  ITGA9; integrin alpha 9
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Others
   VCAM1; vascular cell adhesion molecule 1
    VLA-9
     K06585 ITGA9; integrin alpha 9
BRITE hierarchy
Genes
HSA: 
3680(ITGA9)
PTR: 
470789(ITGA9)
PPS: 
100994889(ITGA9)
GGO: 
101138424(ITGA9)
PON: 
NLE: 
100595679(ITGA9)
MCC: 
MCF: 
102140731(ITGA9)
CSAB: 
103221076(ITGA9)
RRO: 
RBB: 
CJC: 
100399269(ITGA9)
SBQ: 
101038034(ITGA9)
MMU: 
104099(Itga9)
RNO: 
685004(Itga9)
CGE: 
100754465(Itga9)
NGI: 
103752249(Itga9)
HGL: 
101717104(Itga9)
CCAN: 
OCU: 
TUP: 
CFA: 
477021(ITGA9)
AML: 
100480310(ITGA9)
UMR: 
103680775(ITGA9)
ORO: 
101365247(ITGA9)
FCA: 
101090796(ITGA9)
PTG: 
102953513(ITGA9)
AJU: 
106966687(ITGA9)
BTA: 
532127(ITGA9)
BOM: 
BIU: 
109576217(ITGA9)
PHD: 
102335756(ITGA9)
CHX: 
102174073(ITGA9)
OAS: 
101109832(ITGA9)
SSC: 
100626707(ITGA9)
CFR: 
CDK: 
105090729(ITGA9)
BACU: 
103013408(ITGA9)
LVE: 
103089640(ITGA9)
ECB: 
100054374(ITGA9)
EPZ: 
103553903(ITGA9)
EAI: 
106834287(ITGA9)
MYB: 
MYD: 
102760930(ITGA9)
HAI: 
109385214(ITGA9)
RSS: 
109445345(ITGA9)
PALE: 
102878201(ITGA9)
LAV: 
100660884(ITGA9)
TMU: 
MDO: 
100019816(ITGA9)
SHR: 
100924632(ITGA9)
OAA: 
100086578(ITGA9)
GGA: 
420757(ITGA9)
MGP: 
100538631(ITGA9)
CJO: 
APLA: 
101791579(ITGA9)
ACYG: 
106045504(ITGA9)
TGU: 
100222922(ITGA9)
GFR: 
102032026(ITGA9)
FAB: 
PHI: 
102104601(ITGA9)
PMAJ: 
107200799(ITGA9)
CCW: 
104689248(ITGA9)
FPG: 
101919942(ITGA9)
FCH: 
102046730(ITGA9)
CLV: 
102091471(ITGA9)
EGZ: 
104129626(ITGA9)
AAM: 
106489001(ITGA9)
ASN: 
102380208(ITGA9)
AMJ: 
102575161(ITGA9)
PSS: 
102445814(ITGA9)
CMY: 
102947219(ITGA9)
CPIC: 
101947043(ITGA9)
ACS: 
100556197(itga9)
PVT: 
110084229(ITGA9)
PBI: 
GJA: 
107105731(ITGA9)
XLA: 
108719000(itga9.L)
XTR: 
100494771(itga9)
NPR: 
DRE: 
394012(itga9)
SRX: 
SANH: 
SGH: 
CCAR: 
IPU: 
108263163(itga9)
AMEX: 
103039452(itga9)
TRU: 
101080188(itga9)
TNG: 
LCO: 
104918624(itga9)
NCC: 
104967819(itga9)
MZE: 
101471488(itga9)
OLA: 
101161001(itga9)
XMA: 
102232636(itga9)
PRET: 
103477052(itga9)
NFU: 
107375756(itga9)
CSEM: 
103387563(itga9)
LCF: 
108894382(itga9)
HCQ: 
109516126(itga9)
BPEC: 
110157152(itga9)
SASA: 
ELS: 
105029045(itga9)
SFM: 
108923686(itga9)
LCM: 
102349376(ITGA9)
CMK: 
103185506(itga9)
SPU: 
APLC: 
SKO: 
TUT: 
HRO: 
CRG: 
MYI: 
OBI: 
EPA: 
ADF: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8290272
  Authors
Hibi K, Yamakawa K, Ueda R, Horio Y, Murata Y, Tamari M, Uchida K, Takahashi T, Nakamura Y, Takahashi T
  Title
Aberrant upregulation of a novel integrin alpha subunit gene at 3p21.3 in small cell lung cancer.
  Journal
Oncogene 9:611-9 (1994)
  Sequence
[hsa:3680]
Reference
  Authors
Schreiber TD, Steinl C, Essl M, Abele H, Geiger K, Muller CA, Aicher WK, Klein G
  Title
The integrin alpha9beta1 on hematopoietic stem and progenitor cells: involvement in cell adhesion, proliferation and differentiation.
  Journal
Haematologica 94:1493-501 (2009)
DOI:10.3324/haematol.2009.006072

KEGG   ORTHOLOGY: K06586Help
Entry
K06586                      KO                                     

Name
ITGA10
Definition
integrin alpha 10
Pathway
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Regulation of actin cytoskeleton
Human papillomavirus infection
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy (DCM)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06586  ITGA10; integrin alpha 10
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06586  ITGA10; integrin alpha 10
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06586  ITGA10; integrin alpha 10
  Cell motility
   04810 Regulation of actin cytoskeleton
    K06586  ITGA10; integrin alpha 10
 Human Diseases
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K06586  ITGA10; integrin alpha 10
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K06586  ITGA10; integrin alpha 10
   05414 Dilated cardiomyopathy (DCM)
    K06586  ITGA10; integrin alpha 10
  Infectious diseases
   05165 Human papillomavirus infection
    K06586  ITGA10; integrin alpha 10
BRITE hierarchy
Genes
HSA: 
8515(ITGA10)
PTR: 
457982(ITGA10)
PPS: 
100967359(ITGA10)
GGO: 
101134042(ITGA10)
PON: 
100461052(ITGA10)
NLE: 
100590974(ITGA10)
MCC: 
100428484(ITGA10)
MCF: 
102143042(ITGA10)
CSAB: 
103224063(ITGA10)
RRO: 
104671046(ITGA10)
RBB: 
108531442(ITGA10)
CJC: 
100400720(ITGA10)
SBQ: 
101040453(ITGA10)
MMU: 
213119(Itga10)
RNO: 
310683(Itga10)
CGE: 
100754198(Itga10)
NGI: 
103729511(Itga10)
HGL: 
101701994(Itga10)
CCAN: 
OCU: 
100340248(ITGA10)
TUP: 
102499937(ITGA10)
CFA: 
608287(ITGA10)
AML: 
100483953(ITGA10)
UMR: 
103678405(ITGA10)
ORO: 
101379997(ITGA10)
FCA: 
101097997(ITGA10)
PTG: 
102962579(ITGA10)
AJU: 
106986064(ITGA10)
BTA: 
506526(ITGA10)
BOM: 
102287332(ITGA10)
BIU: 
109555827(ITGA10)
PHD: 
102326345(ITGA10)
CHX: 
102185415(ITGA10)
OAS: 
101117377(ITGA10)
SSC: 
100511507(ITGA10)
CFR: 
102519178(ITGA10)
CDK: 
105105882(ITGA10)
BACU: 
103004608(ITGA10)
LVE: 
103068454(ITGA10)
ECB: 
100065205(ITGA10)
EPZ: 
103556229(ITGA10)
EAI: 
106847657(ITGA10)
MYB: 
102260193(ITGA10)
MYD: 
102772965(ITGA10)
HAI: 
109373692(ITGA10)
RSS: 
109451534(ITGA10)
PALE: 
102896303(ITGA10)
LAV: 
100667832(ITGA10)
TMU: 
MDO: 
100014893(ITGA10)
SHR: 
100925712(ITGA10)
CJO: 
107324318(ITGA10)
PHI: 
102107747(ITGA10)
PMAJ: 
107214606(ITGA10)
CCW: 
104683642(ITGA10)
FPG: 
101918997(ITGA10)
FCH: 
102050353(ITGA10)
EGZ: 
104133359(ITGA10)
AAM: 
106486157(ITGA10)
ASN: 
102383820(ITGA10)
AMJ: 
PSS: 
102445307(ITGA10)
CMY: 
CPIC: 
101939007(ITGA10)
ACS: 
PVT: 
110088133(ITGA10)
PBI: 
103049358(ITGA10)
GJA: 
107110085(ITGA10)
XLA: 
108699602(itga10.L)
XTR: 
101734246(itga10)
NPR: 
108798333(ITGA10)
DRE: 
572348(itga10)
SRX: 
SANH: 
SGH: 
CCAR: 
IPU: 
108267060(itga10)
AMEX: 
TRU: 
101064178(itga10)
TNG: 
LCO: 
104934675(itga10)
MZE: 
101466767(itga10)
OLA: 
101157085(itga10)
XMA: 
102234214(itga10)
PRET: 
103478737(itga10)
NFU: 
107379587(itga10)
CSEM: 
103388244(itga10)
LCF: 
108885918(itga10)
HCQ: 
109522796(itga10)
BPEC: 
110163030(itga10)
SASA: 
ELS: 
105018979(itga10)
SFM: 
108925716(itga10)
LCM: 
102352016(ITGA10)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9685391
  Authors
Camper L, Hellman U, Lundgren-Akerlund E
  Title
Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes.
  Journal
J Biol Chem 273:20383-9 (1998)
DOI:10.1074/jbc.273.32.20383
  Sequence
[hsa:8515]
Reference
  Authors
Bengtsson T, Aszodi A, Nicolae C, Hunziker EB, Lundgren-Akerlund E, Fassler R
  Title
Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes.
  Journal
J Cell Sci 118:929-36 (2005)
DOI:10.1242/jcs.01678

KEGG   ORTHOLOGY: K06587Help
Entry
K06587                      KO                                     

Name
ITGA11
Definition
integrin alpha 11
Pathway
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Regulation of actin cytoskeleton
Human papillomavirus infection
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy (DCM)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06587  ITGA11; integrin alpha 11
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06587  ITGA11; integrin alpha 11
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06587  ITGA11; integrin alpha 11
  Cell motility
   04810 Regulation of actin cytoskeleton
    K06587  ITGA11; integrin alpha 11
 Human Diseases
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K06587  ITGA11; integrin alpha 11
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K06587  ITGA11; integrin alpha 11
   05414 Dilated cardiomyopathy (DCM)
    K06587  ITGA11; integrin alpha 11
  Infectious diseases
   05165 Human papillomavirus infection
    K06587  ITGA11; integrin alpha 11
BRITE hierarchy
Genes
HSA: 
22801(ITGA11)
PTR: 
453537(ITGA11)
PPS: 
100993366(ITGA11)
GGO: 
101143568(ITGA11)
PON: 
100454617(ITGA11)
NLE: 
100589734(ITGA11)
MCC: 
694090(ITGA11)
MCF: 
102124633(ITGA11)
CSAB: 
103245421(ITGA11)
RRO: 
104662593(ITGA11)
RBB: 
108514729(ITGA11)
CJC: 
100397792(ITGA11)
SBQ: 
101035789(ITGA11)
MMU: 
319480(Itga11)
RNO: 
315744(Itga11)
CGE: 
100761554(Itga11)
NGI: 
103736909(Itga11)
HGL: 
101710116(Itga11)
CCAN: 
109688214(Itga11)
OCU: 
100344251(ITGA11)
TUP: 
102482967(ITGA11)
CFA: 
478353(ITGA11)
AML: 
100479237(ITGA11)
UMR: 
103679149(ITGA11)
ORO: 
101385440(ITGA11)
FCA: 
101093524(ITGA11)
PTG: 
102964245(ITGA11)
AJU: 
106980726(ITGA11)
BTA: 
523755(ITGA11)
BOM: 
102285426(ITGA11)
BIU: 
109564717(ITGA11)
PHD: 
102336321(ITGA11)
CHX: 
102171074(ITGA11)
OAS: 
101105162(ITGA11)
SSC: 
100520350(ITGA11)
CFR: 
102518637(ITGA11)
CDK: 
105087311(ITGA11)
BACU: 
103015659(ITGA11)
LVE: 
103071141(ITGA11)
ECB: 
100065211(ITGA11)
EPZ: 
103554819(ITGA11)
EAI: 
106835653(ITGA11)
MYB: 
102242832(ITGA11)
MYD: 
HAI: 
109385221(ITGA11)
RSS: 
109444328(ITGA11)
PALE: 
102890264(ITGA11)
LAV: 
100670461(ITGA11)
TMU: 
MDO: 
100025947(ITGA11)
SHR: 
100929099(ITGA11)
OAA: 
100085786(ITGA11)
GGA: 
415560(ITGA11)
MGP: 
100547226(ITGA11)
CJO: 
107318934(ITGA11)
APLA: 
101805216(ITGA11)
ACYG: 
106043639(ITGA11)
TGU: 
100221278(ITGA11)
GFR: 
102033726(ITGA11)
FAB: 
101817027(ITGA11)
PHI: 
102111928(ITGA11)
PMAJ: 
107209138(ITGA11)
CCW: 
104683868(ITGA11)
FPG: 
101911569(ITGA11)
FCH: 
102056115(ITGA11)
CLV: 
102094194(ITGA11)
EGZ: 
104128391(ITGA11)
AAM: 
ASN: 
102379146(ITGA11)
AMJ: 
106736974(ITGA11)
PSS: 
102459585(ITGA11)
CMY: 
102947891(ITGA11)
CPIC: 
101947313(ITGA11)
ACS: 
PVT: 
110086892(ITGA11)
PBI: 
103060809(ITGA11)
GJA: 
107113280(ITGA11)
XLA: 
108711510 378559(itga11.L)
XTR: 
100489152(itga11)
NPR: 
108784111(ITGA11)
DRE: 
541475(itga11a)
SRX: 
SANH: 
SGH: 
CCAR: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
104955853(itga11)
MZE: 
OLA: 
XMA: 
PRET: 
NFU: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
102358961(ITGA11)
CMK: 
103189577(itga11)
CIN: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Lehnert K, Ni J, Leung E, Gough SM, Weaver A, Yao WP, Liu D, Wang SX, Morris CM, Krissansen GW
  Title
Cloning, sequence analysis, and chromosomal localization of the novel human integrin alpha11 subunit (ITGA11).
  Journal
Genomics 60:179-87 (1999)
DOI:10.1006/geno.1999.5909
  Sequence
[hsa:22801]
Reference
  Authors
Lu N, Carracedo S, Ranta J, Heuchel R, Soininen R, Gullberg D
  Title
The human alpha11 integrin promoter drives fibroblast-restricted expression in vivo and is regulated by TGF-beta1 in a Smad- and Sp1-dependent manner.
  Journal
Matrix Biol 29:166-76 (2010)
DOI:10.1016/j.matbio.2009.11.003

KEGG   ORTHOLOGY: K06487Help
Entry
K06487                      KO                                     

Name
ITGAV, CD51
Definition
integrin alpha V
Pathway
Phagosome
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Cell adhesion molecules (CAMs)
Regulation of actin cytoskeleton
Thyroid hormone signaling pathway
Human papillomavirus infection
Pathways in cancer
Proteoglycans in cancer
Small cell lung cancer
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy (DCM)
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06487  ITGAV, CD51; integrin alpha V
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06487  ITGAV, CD51; integrin alpha V
   04514 Cell adhesion molecules (CAMs)
    K06487  ITGAV, CD51; integrin alpha V
 Cellular Processes
  Transport and catabolism
   04145 Phagosome
    K06487  ITGAV, CD51; integrin alpha V
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06487  ITGAV, CD51; integrin alpha V
  Cell motility
   04810 Regulation of actin cytoskeleton
    K06487  ITGAV, CD51; integrin alpha V
 Organismal Systems
  Endocrine system
   04919 Thyroid hormone signaling pathway
    K06487  ITGAV, CD51; integrin alpha V
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06487  ITGAV, CD51; integrin alpha V
   05205 Proteoglycans in cancer
    K06487  ITGAV, CD51; integrin alpha V
   05222 Small cell lung cancer
    K06487  ITGAV, CD51; integrin alpha V
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K06487  ITGAV, CD51; integrin alpha V
   05410 Hypertrophic cardiomyopathy (HCM)
    K06487  ITGAV, CD51; integrin alpha V
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K06487  ITGAV, CD51; integrin alpha V
   05414 Dilated cardiomyopathy (DCM)
    K06487  ITGAV, CD51; integrin alpha V
  Infectious diseases
   05165 Human papillomavirus infection
    K06487  ITGAV, CD51; integrin alpha V
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Integrins (complement receptors)
    K06487  ITGAV, CD51; integrin alpha V
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06487  ITGAV, CD51; integrin alpha V
  Exosomal proteins of epithelial cells
   K06487  ITGAV, CD51; integrin alpha V
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Neural system
   6/5 subfamily
    L1CAM; L1 cell adhesion molecule
     VNR
      K06487 ITGAV, CD51; integrin alpha V
   N/0 subfamily
    THY1, CD90; Thy-1 cell surface antigen
     VNR
      K06487 ITGAV, CD51; integrin alpha V
  Others
   PECAM1, CD31; platelet/endothelial cell adhesion molecule
    VNR
     K06487 ITGAV, CD51; integrin alpha V
   ICAM4; intercellular adhesion molecule 4
    VNR
     K06487 ITGAV, CD51; integrin alpha V
    alpha V beta 1
     K06487 ITGAV, CD51; integrin alpha V
    alpha V beta 5
     K06487 ITGAV, CD51; integrin alpha V
 7. Others
  SDC1; syndecan 1
   VNR
    K06487 ITGAV, CD51; integrin alpha V
   alpha V beta 5
    K06487 ITGAV, CD51; integrin alpha V
CD molecules [BR:ko04090]
 Proteins
  K06487  CD51, ITGAV; integrin, alpha V
BRITE hierarchy
Genes
HSA: 
3685(ITGAV)
PTR: 
459807(ITGAV)
PPS: 
100975589(ITGAV)
GGO: 
101148851(ITGAV)
PON: 
100451792(ITGAV)
NLE: 
100604485(ITGAV)
MCC: 
707756(ITGAV)
MCF: 
102116249(ITGAV)
CSAB: 
103217487(ITGAV)
RRO: 
104667754(ITGAV)
RBB: 
108535417(ITGAV)
CJC: 
100389906(ITGAV)
SBQ: 
101032614(ITGAV)
MMU: 
16410(Itgav)
RNO: 
296456(Itgav)
CGE: 
100752313(Itgav)
NGI: 
103728788(Itgav)
HGL: 
101717672(Itgav)
CCAN: 
109686646(Itgav)
OCU: 
100008956(ITGAV)
TUP: 
102469850(ITGAV)
CFA: 
488437(ITGAV)
AML: 
UMR: 
103659655(ITGAV)
ORO: 
101368762(ITGAV)
FCA: 
PTG: 
102972745(ITGAV)
AJU: 
106976526(ITGAV)
BTA: 
281875(ITGAV)
BOM: 
102281111(ITGAV)
BIU: 
109565743(ITGAV)
PHD: 
102342772(ITGAV)
CHX: 
102187813(ITGAV)
OAS: 
443143(ITGAV)
SSC: 
397285(ITGAV)
CFR: 
102508062(ITGAV)
CDK: 
105098976(ITGAV)
BACU: 
103000411(ITGAV)
LVE: 
103087072(ITGAV)
ECB: 
100068706(ITGAV)
EPZ: 
103557856(ITGAV)
EAI: 
106827445(ITGAV)
MYB: 
102260401(ITGAV)
MYD: 
102763517(ITGAV)
HAI: 
109372713(ITGAV)
RSS: 
109459749(ITGAV)
PALE: 
102895440(ITGAV)
LAV: 
100671252(ITGAV)
TMU: 
MDO: 
100028127(ITGAV)
SHR: 
100929053(ITGAV)
OAA: 
100085661(ITGAV)
GGA: 
396420(ITGAV)
MGP: 
100541922(ITGAV)
CJO: 
107316434(ITGAV)
APLA: 
101803022(ITGAV)
ACYG: 
106034465(ITGAV)
TGU: 
100228982(ITGAV)
GFR: 
102036333(ITGAV)
FAB: 
101808349(ITGAV)
PHI: 
102112204(ITGAV)
PMAJ: 
107207631(ITGAV)
CCW: 
104693720(ITGAV)
FPG: 
101920061(ITGAV)
FCH: 
102060179(ITGAV)
CLV: 
102097696(ITGAV)
EGZ: 
104130500(ITGAV)
AAM: 
106499128(ITGAV)
ASN: 
102388058(ITGAV)
AMJ: 
102569658(ITGAV)
PSS: 
102458254(ITGAV)
CMY: 
102941818(ITGAV)
CPIC: 
101943422(ITGAV)
ACS: 
100567819(itgav)
PVT: 
110089997(ITGAV)
PBI: 
103060270(ITGAV)
GJA: 
107121779(ITGAV)
XLA: 
397997(itgav.L)
XTR: 
100144691(itgav)
NPR: 
108794469(ITGAV)
DRE: 
100151255(itgav)
SRX: 
SANH: 
SGH: 
CCAR: 
IPU: 
108266447(itgav)
AMEX: 
103023542(itgav)
TRU: 
101079631(itgav)
TNG: 
LCO: 
104935588(itgav)
MZE: 
101477896(itgav)
OLA: 
101174307(itgav)
XMA: 
PRET: 
103460203(itgav)
NFU: 
CSEM: 
103392367(itgav)
LCF: 
HCQ: 
109531168(itgav)
BPEC: 
110162930(itgav)
SASA: 
ELS: 
105027294(itgav)
SFM: 
LCM: 
CMK: 
103176518(itgav)
CRG: 
NVE: 
EPA: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2443500
  Authors
Suzuki S, Argraves WS, Arai H, Languino LR, Pierschbacher MD, Ruoslahti E
  Title
Amino acid sequence of the vitronectin receptor alpha subunit and comparative expression of adhesion receptor mRNAs.
  Journal
J Biol Chem 262:14080-5 (1987)
  Sequence
[hsa:3685]
Reference
  Authors
Lyle C, McCormick F
  Title
Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells.
  Journal
Virol J 7:148 (2010)
DOI:10.1186/1743-422X-7-148

DBGET integrated database retrieval system