KEGG   ORTHOLOGY: K06645Help
Entry
K06645                      KO                                     

Name
CDC25A
Definition
M-phase inducer phosphatase 1 [EC:3.1.3.48]
Pathway
Cell cycle
Cellular senescence
Progesterone-mediated oocyte maturation
MicroRNAs in cancer
Module
M00691  
DNA damage-induced cell cycle checkpoints
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K06645  CDC25A; M-phase inducer phosphatase 1
   04218 Cellular senescence
    K06645  CDC25A; M-phase inducer phosphatase 1
 Organismal Systems
  Endocrine system
   04914 Progesterone-mediated oocyte maturation
    K06645  CDC25A; M-phase inducer phosphatase 1
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    K06645  CDC25A; M-phase inducer phosphatase 1
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00691  DNA damage-induced cell cycle checkpoints
     K06645  CDC25A; M-phase inducer phosphatase 1
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     K06645  CDC25A; M-phase inducer phosphatase 1
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Tyrosine phosphatases (PTPs)
  Class III PTPs
   CDC25s
    K06645  CDC25A; M-phase inducer phosphatase 1
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  Check point factors
   Other check point factors
    K06645  CDC25A; M-phase inducer phosphatase 1
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
993(CDC25A)
PTR: 
460341(CDC25A)
PPS: 
100985899(CDC25A)
GGO: 
101142222(CDC25A)
PON: 
100460228(CDC25A)
NLE: 
100588003(CDC25A)
MCC: 
710858(CDC25A)
MCF: 
102137696(CDC25A)
CSAB: 
103228635(CDC25A)
RRO: 
104671299(CDC25A)
RBB: 
108517663(CDC25A)
CJC: 
100408832(CDC25A)
SBQ: 
101041208(CDC25A)
MMU: 
12530(Cdc25a)
RNO: 
171102(Cdc25a)
CGE: 
100767961(Cdc25a)
NGI: 
103750230(Cdc25a)
HGL: 
101699133(Cdc25a)
CCAN: 
109699005(Cdc25a)
OCU: 
100354280(CDC25A)
TUP: 
102482369(CDC25A)
CFA: 
484780(CDC25A)
AML: 
100477247(CDC25A)
UMR: 
103675112(CDC25A)
FCA: 
101098445(CDC25A)
PTG: 
102957057(CDC25A)
AJU: 
106979176(CDC25A)
BTA: 
520188(CDC25A)
BOM: 
102285046(CDC25A)
BIU: 
109576463(CDC25A)
PHD: 
102326574(CDC25A)
CHX: 
102181731(CDC25A)
OAS: 
101113178(CDC25A)
SSC: 
100737380(CDC25A)
CFR: 
102509600(CDC25A)
CDK: 
105103857(CDC25A)
BACU: 
103016547(CDC25A)
LVE: 
103085456(CDC25A)
ECB: 
100064223(CDC25A)
EPZ: 
103567910(CDC25A)
EAI: 
106821782(CDC25A)
MYB: 
MYD: 
102760761(CDC25A)
HAI: 
109375294(CDC25A)
RSS: 
109443501(CDC25A)
PALE: 
102897196(CDC25A)
LAV: 
100659991(CDC25A)
MDO: 
100018150(CDC25A)
SHR: 
100924467(CDC25A)
OAA: 
100085311(CDC25A)
GGA: 
420375(CDC25A)
MGP: 
100546502(CDC25A)
CJO: 
107308656(CDC25A)
APLA: 
101800901(CDC25A)
ACYG: 
106046801(CDC25A)
TGU: 
100231363(CDC25A)
GFR: 
102040683(CDC25A)
FAB: 
101816817(CDC25A)
PHI: 
102104005(CDC25A)
PMAJ: 
107201060(CDC25A)
CCW: 
104686374(CDC25A)
FPG: 
101911899(CDC25A)
FCH: 
102054923(CDC25A)
CLV: 
102084553(CDC25A)
AAM: 
ASN: 
102384816(CDC25A)
AMJ: 
102569214(CDC25A)
PSS: 
102458852(CDC25A)
CMY: 
102931776(CDC25A)
CPIC: 
101944298(CDC25A)
ACS: 
PVT: 
110082540(CDC25A)
PBI: 
103059140(CDC25A)
GJA: 
107124887(CDC25A)
XLA: 
398141 734734(cdc25a.S)
XTR: 
733851(cdc25a)
NPR: 
SGH: 
SFM: 
CIN: 
LGI: 
OBI: 
NVE: 
HMG: 
TAD: 
ACAN: 
GTT: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Karlsson-Rosenthal C, Millar JB
  Title
Cdc25: mechanisms of checkpoint inhibition and recovery.
  Journal
Trends Cell Biol 16:285-92 (2006)
DOI:10.1016/j.tcb.2006.04.002
Reference
  Authors
Hong HY, Choi J, Cho YW, Kim BC
  Title
Cdc25A promotes cell survival by stimulating NF-kappaB activity through IkappaB-alpha phosphorylation and destabilization.
  Journal
Biochem Biophys Res Commun 420:293-6 (2012)
DOI:10.1016/j.bbrc.2012.02.152
  Sequence
[hsa:993]

KEGG   ORTHOLOGY: K05866Help
Entry
K05866                      KO                                     

Name
CDC25B
Definition
M-phase inducer phosphatase 2 [EC:3.1.3.48]
Pathway
MAPK signaling pathway
Cell cycle
Progesterone-mediated oocyte maturation
MicroRNAs in cancer
Module
M00691  
DNA damage-induced cell cycle checkpoints
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K05866  CDC25B; M-phase inducer phosphatase 2
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K05866  CDC25B; M-phase inducer phosphatase 2
 Organismal Systems
  Endocrine system
   04914 Progesterone-mediated oocyte maturation
    K05866  CDC25B; M-phase inducer phosphatase 2
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    K05866  CDC25B; M-phase inducer phosphatase 2
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00691  DNA damage-induced cell cycle checkpoints
     K05866  CDC25B; M-phase inducer phosphatase 2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     K05866  CDC25B; M-phase inducer phosphatase 2
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Tyrosine phosphatases (PTPs)
  Class III PTPs
   CDC25s
    K05866  CDC25B; M-phase inducer phosphatase 2
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  Check point factors
   Other check point factors
    K05866  CDC25B; M-phase inducer phosphatase 2
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
994(CDC25B)
PTR: 
458064(CDC25B)
PPS: 
100978502(CDC25B)
GGO: 
101127265(CDC25B)
PON: 
100434256(CDC25B)
NLE: 
MCC: 
717573(CDC25B)
MCF: 
102135274(CDC25B)
CSAB: 
103247543(CDC25B)
RRO: 
104674594(CDC25B)
RBB: 
108533547(CDC25B)
CJC: 
100395201(CDC25B)
SBQ: 
101033653(CDC25B)
MMU: 
12531(Cdc25b)
RNO: 
171103(Cdc25b)
CGE: 
100765509(Cdc25b)
NGI: 
103743120(Cdc25b)
HGL: 
101701077(Cdc25b)
CCAN: 
109691288(Cdc25b)
OCU: 
103348219(CDC25B)
TUP: 
102474077(CDC25B)
CFA: 
485790(CDC25B)
AML: 
100483177(CDC25B)
UMR: 
103674532(CDC25B)
FCA: 
101092757(CDC25B)
PTG: 
102962278(CDC25B)
AJU: 
106980182(CDC25B)
BTA: 
505847(CDC25B)
BOM: 
102276738(CDC25B)
BIU: 
109567187(CDC25B)
PHD: 
102315199(CDC25B)
CHX: 
102179213(CDC25B)
OAS: 
SSC: 
100329127(CDC25B)
CFR: 
102521503(CDC25B)
CDK: 
105096018(CDC25B)
BACU: 
103012203(CDC25B)
LVE: 
103081717(CDC25B)
ECB: 
100052425(CDC25B)
EPZ: 
103559812(CDC25B)
EAI: 
106847689(CDC25B)
MYB: 
102244544(CDC25B)
MYD: 
HAI: 
109383851(CDC25B)
RSS: 
109448468(CDC25B)
PALE: 
102893112(CDC25B)
LAV: 
100664658(CDC25B)
SHR: 
100927310(CDC25B)
OAA: 
100075940(CDC25B)
GGA: 
MGP: 
100548933(CDC25B)
CJO: 
107306857(CDC25B)
TGU: 
FAB: 
PHI: 
CCW: 
FPG: 
101922961(CDC25B)
FCH: 
102053620(CDC25B)
CLV: 
102087487(CDC25B)
AAM: 
ASN: 
102369674(CDC25B)
AMJ: 
102576728(CDC25B)
CMY: 
102929649(CDC25B)
CPIC: 
101951508(CDC25B)
ACS: 
100568149(cdc25b)
PVT: 
110079809(CDC25B)
PBI: 
103054614(CDC25B)
GJA: 
107108364(CDC25B)
XLA: 
100158454(cdc25b.L) 100158455(cdc25b.S)
XTR: 
100036608(cdc25b)
NPR: 
108797984(CDC25B)
DRE: 
57925(cdc25b)
SRX: 
SANH: 
SGH: 
IPU: 
108263583(cdc25b)
AMEX: 
103034961(cdc25b)
TRU: 
101069500(cdc25b)
LCO: 
104937992(cdc25b)
MZE: 
101482927(cdc25b)
OLA: 
101168663(cdc25b)
XMA: 
CSEM: 
103383293(cdc25b)
LCF: 
108876631(cdc25b)
HCQ: 
109528197(cdc25b)
BPEC: 
110157348(cdc25b)
SASA: 
ELS: 
105015857(cdc25b)
SFM: 
108920196(cdc25b)
LCM: 
102366036(CDC25B)
CMK: 
SPU: 
APLC: 
SKO: 
CRG: 
LAK: 
ACAN: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Karlsson-Rosenthal C, Millar JB
  Title
Cdc25: mechanisms of checkpoint inhibition and recovery.
  Journal
Trends Cell Biol 16:285-92 (2006)
DOI:10.1016/j.tcb.2006.04.002
Reference
  Authors
Schmitt E, Boutros R, Froment C, Monsarrat B, Ducommun B, Dozier C
  Title
CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage.
  Journal
J Cell Sci 119:4269-75 (2006)
DOI:10.1242/jcs.03200
  Sequence
[hsa:994]

KEGG   ORTHOLOGY: K05867Help
Entry
K05867                      KO                                     

Name
CDC25C
Definition
M-phase inducer phosphatase 3 [EC:3.1.3.48]
Pathway
Cell cycle
Oocyte meiosis
Progesterone-mediated oocyte maturation
MicroRNAs in cancer
Module
M00691  
DNA damage-induced cell cycle checkpoints
M00693  
Cell cycle - G2/M transition
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K05867  CDC25C; M-phase inducer phosphatase 3
   04114 Oocyte meiosis
    K05867  CDC25C; M-phase inducer phosphatase 3
 Organismal Systems
  Endocrine system
   04914 Progesterone-mediated oocyte maturation
    K05867  CDC25C; M-phase inducer phosphatase 3
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    K05867  CDC25C; M-phase inducer phosphatase 3
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00691  DNA damage-induced cell cycle checkpoints
     K05867  CDC25C; M-phase inducer phosphatase 3
    M00693  Cell cycle - G2/M transition
     K05867  CDC25C; M-phase inducer phosphatase 3
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     K05867  CDC25C; M-phase inducer phosphatase 3
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K05867  CDC25C; M-phase inducer phosphatase 3
 Protein Tyrosine phosphatases (PTPs)
  Class III PTPs
   CDC25s
    K05867  CDC25C; M-phase inducer phosphatase 3
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  Check point factors
   Other check point factors
    K05867  CDC25C; M-phase inducer phosphatase 3
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
995(CDC25C)
PTR: 
746151(CDC25C)
PPS: 
100990018(CDC25C)
GGO: 
101150213(CDC25C)
PON: 
100451443(CDC25C)
NLE: 
100588617(CDC25C)
MCC: 
714115(CDC25C)
MCF: 
101866661(CDC25C)
CSAB: 
103244613(CDC25C)
RRO: 
104681726(CDC25C)
RBB: 
108541696(CDC25C)
CJC: 
SBQ: 
101041558(CDC25C)
MMU: 
12532(Cdc25c)
RNO: 
307511(Cdc25c)
CGE: 
100773417(Cdc25c)
NGI: 
103735158(Cdc25c)
HGL: 
101712931(Cdc25c)
CCAN: 
109700186(Cdc25c)
OCU: 
100343637(CDC25C)
TUP: 
102499060(CDC25C)
CFA: 
610456(CDC25C)
AML: 
100482691(CDC25C)
UMR: 
FCA: 
101086942(CDC25C)
PTG: 
102968740(CDC25C)
AJU: 
106967966(CDC25C)
BTA: 
507731(CDC25C)
BOM: 
102287313(CDC25C)
BIU: 
109562060(CDC25C)
PHD: 
102321967(CDC25C)
CHX: 
102187214(CDC25C)
OAS: 
101110327(CDC25C)
SSC: 
100144474(CDC25C)
CFR: 
102516690(CDC25C)
CDK: 
105090655(CDC25C)
BACU: 
103014243(CDC25C)
LVE: 
103088476(CDC25C)
ECB: 
100062352(CDC25C)
EPZ: 
103551352(CDC25C)
EAI: 
106839210(CDC25C)
MYB: 
102262547(CDC25C)
MYD: 
102761242(CDC25C)
HAI: 
109392993(CDC25C)
RSS: 
109451823(CDC25C)
PALE: 
102894193(CDC25C)
LAV: 
100670954(CDC25C)
MDO: 
100025023(CDC25C)
SHR: 
100924438(CDC25C)
AAM: 
106487224(CDC25C)
ASN: 
102384314(CDC25C)
AMJ: 
102572255(CDC25C)
PSS: 
102456953(CDC25C)
CMY: 
CPIC: 
101952003(CDC25C)
ACS: 
100565034(cdc25c)
PVT: 
110077149(CDC25C)
PBI: 
103051692(CDC25C)
GJA: 
XLA: 
100337563(cdc25c1) 397737(cdc25c.L) 398119(cdc25c.S)
XTR: 
100124300(cdc25c)
NPR: 
108797600(CDC25C)
SASA: 
ELS: 
105010884(cdc25c)
SFM: 
108934112(cdc25c)
LCM: 
102356985(CDC25C)
CMK: 
ISC: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Karlsson-Rosenthal C, Millar JB
  Title
Cdc25: mechanisms of checkpoint inhibition and recovery.
  Journal
Trends Cell Biol 16:285-92 (2006)
DOI:10.1016/j.tcb.2006.04.002
Reference
PMID:8119945
  Authors
Strausfeld U, Fernandez A, Capony JP, Girard F, Lautredou N, Derancourt J, Labbe JC, Lamb NJ
  Title
Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis.
  Journal
J Biol Chem 269:5989-6000 (1994)
  Sequence
[hsa:995]

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