KEGG   ORTHOLOGY: K07198Help
Entry
K07198                      KO                                     

Name
PRKAA, AMPK
Definition
5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
Pathway
ko04068  FoxO signaling pathway
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04371  Apelin signaling pathway
ko04530  Tight junction
ko04710  Circadian rhythm
ko04714  Thermogenesis
ko04910  Insulin signaling pathway
ko04920  Adipocytokine signaling pathway
ko04921  Oxytocin signaling pathway
ko04922  Glucagon signaling pathway
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko05410  Hypertrophic cardiomyopathy (HCM)
ko05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04371 Apelin signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04068 FoxO signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04151 PI3K-Akt signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04152 AMPK signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04150 mTOR signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  Cellular community - eukaryotes
   04530 Tight junction
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04922 Glucagon signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04920 Adipocytokine signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04921 Oxytocin signaling pathway
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  Aging
   04211 Longevity regulating pathway - mammal
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04213 Longevity regulating pathway - multiple species
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  Environmental adaptation
   04710 Circadian rhythm
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04714 Thermogenesis
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
 Human Diseases
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   05410 Hypertrophic cardiomyopathy (HCM)
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
   04931 Insulin resistance
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.11  cAMP-dependent protein kinase
     K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CAMK group
  CAMKL family
   K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
Membrane trafficking [BR:ko04131]
 Autophagy
  Other autophagy associated proteins
   Others
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
  Mitophagy factors
   Other mitophagy factors
    K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit
BRITE hierarchy
Genes
HSA: 5562(PRKAA1) 5563(PRKAA2)
PTR: 471564(PRKAA1) 741802(PRKAA2)
PPS: 100975618(PRKAA1) 100991417(PRKAA2)
GGO: 101137882(PRKAA2) 101152987(PRKAA1)
PON: 100172060(PRKAA2) 100174304(PRKAA1)
NLE: 100582042(PRKAA2) 100595096(PRKAA1)
MCC: 695558(PRKAA1) 717703(PRKAA2)
MCF: 102143726(PRKAA2) 102144683(PRKAA1)
CSAB: 103215177(PRKAA1) 103224740(PRKAA2)
RRO: 104664292(PRKAA2) 104676941(PRKAA1)
RBB: 108532936(PRKAA2) 108544746(PRKAA1)
CJC: 100385413(PRKAA1) 100396565(PRKAA2)
SBQ: 101030830(PRKAA1) 101033212(PRKAA2)
MMU: 105787(Prkaa1) 108079(Prkaa2)
RNO: 65248(Prkaa1) 78975(Prkaa2)
CGE: 100767909(Prkaa2) 100769574(Prkaa1)
NGI: 103734094(Prkaa2) 103741338(Prkaa1)
HGL: 101698482(Prkaa2) 101722998(Prkaa1)
CCAN: 109687258(Prkaa2) 109695664(Prkaa1)
OCU: 100340670(PRKAA2) 100358166(PRKAA1)
TUP: 102491119(PRKAA2) 106735707(PRKAA1)
CFA: 479351(PRKAA1) 489571(PRKAA2)
AML: 100470115(PRKAA1) 100481376(PRKAA2)
UMR: 103664677(PRKAA1) 103670673(PRKAA2)
ORO: 101372712(PRKAA1) 101379000(PRKAA2)
FCA: 101095885(PRKAA1) 101096000(PRKAA2)
PTG: 102956343(PRKAA1) 102970831(PRKAA2)
AJU: 106970910(PRKAA1) 106974988(PRKAA2)
BTA: 538954(PRKAA2) 540404(PRKAA1)
BOM: 102265959(PRKAA1) 102270414(PRKAA2)
PHD: 102316046(PRKAA1) 102325193(PRKAA2)
CHX: 102171295(PRKAA2) 102181338(PRKAA1)
OAS: 100127210(PRKAA2) 101103425(PRKAA1)
SSC: 100145903(PRKAA1) 397504(PRKAA2)
CFR: 102510276(PRKAA1) 102523424(PRKAA2)
CDK: 105092817(PRKAA2) 105106940(PRKAA1)
BACU: 103018222(PRKAA2) 103019090(PRKAA1)
LVE: 103069202(PRKAA2) 103074848(PRKAA1)
OOR: 101287451(PRKAA1) 101290391(PRKAA2)
ECB: 100009710(PRKAA1) 100034159(PRKAA2)
EAI: 106824750(PRKAA1) 106833475(PRKAA2)
MYB: 102241697(PRKAA2) 102248668(PRKAA1)
MYD: 102759339(PRKAA1) 102774877(PRKAA2)
HAI: 109374016(PRKAA2) 109376169(PRKAA1)
RSS: 109440607 109441921 109450192(PRKAA1) 109453062(PRKAA2)
PALE: 102884524(PRKAA2) 102886520(PRKAA1)
LAV: 100659413(PRKAA1) 100671280(PRKAA2)
MDO: 100013711(PRKAA1) 100019066(PRKAA2)
SHR: 100926139(PRKAA2) 100928944(PRKAA1)
OAA: 100075352(PRKAA1)
GGA: 427185(PRKAA1) 429110(PRKAA2)
MGP: 100034740(PRKAA1) 780945(PRKAA2)
CJO: 107305860(PRKAA1) 107317703(PRKAA2)
APLA: 101799561(PRKAA2) 101801595(PRKAA1)
ACYG: 106033088(PRKAA2) 106036363(PRKAA1)
TGU: 100217569(PRKAA1) 100224153(PRKAA2)
GFR: 102031783(PRKAA2) 102038682(PRKAA1) 102044941
FAB: 101809698(PRKAA1) 101811154(PRKAA2)
PHI: 102111333(PRKAA2) 102111653(PRKAA1)
PMAJ: 107208272(PRKAA2) 107216196(PRKAA1)
CCW: 104686759(PRKAA1) 104695510(PRKAA2)
FPG: 101913786(PRKAA1) 101919295(PRKAA2)
FCH: 102049360(PRKAA2) 102050598(PRKAA1)
CLV: 102087954(PRKAA1) 102088108(PRKAA2)
EGZ: 104123889(PRKAA2) 104133929(PRKAA1)
AAM: 106498958(PRKAA2) 106499548(PRKAA1) 106499832
ASN: 102374152(PRKAA2) 102375567(PRKAA1)
AMJ: 102570371(PRKAA1) 102576605(PRKAA2)
PSS: 102444277(PRKAA1) 102459596(PRKAA2)
CMY: 102940952(PRKAA2) 102944011(PRKAA1)
CPIC: 101941141(PRKAA1) 101948919(PRKAA2)
ACS: 100551935(prkaa2) 100567445(prkaa1)
PVT: 110073913(PRKAA1) 110077130(PRKAA2)
PBI: 103057294(PRKAA1) 103064935(PRKAA2)
GJA: 107108814(PRKAA1) 107118038(PRKAA2)
XLA: 108714249 108715541 399172(prkaa2.S) 495290(prkaa1.L)
XTR: 100145520(prkaa1) 100216099(prkaa2)
NPR: 108788157(PRKAA2) 108790816(PRKAA1)
DRE: 100001198(prkaa1) 572074(prkaa2)
IPU: 108258037(prkaa2) 108260283
AMEX: 103022500(prkaa1) 103028619(prkaa2)
TRU: 101065197(prkaa1) 101076074(prkaa2)
LCO: 104919125(prkaa2) 104924922(prkaa1)
NCC: 104959371(prkaa1) 104959556(prkaa2)
MZE: 101471464(prkaa1) 101487955(prkaa2)
OLA: 101162057(prkaa1) 101173851(prkaa2)
XMA: 102231393(prkaa2) 102237231(prkaa1)
PRET: 103463785(prkaa2) 103473399(prkaa1)
NFU: 107374929(prkaa1) 107393439(prkaa2)
CSEM: 103376655(prkaa2) 103390073(prkaa1)
LCF: 108874097(prkaa1) 108879064(prkaa2)
HCQ: 109517709(prkaa1) 109532068(prkaa2)
BPEC: 110154939(prkaa2) 110157325(prkaa1)
SASA: 106560227 106562970(prkaa1) 106568674 106584208(prkaa2)
ELS: 105011784(prkaa2) 105015246(prkaa1)
SFM: 108923517(prkaa2) 108924948(prkaa1)
LCM: 102349521(PRKAA1) 102365637(PRKAA2)
CMK: 103172450(prkaa1) 103185288(prkaa2)
CIN: 100184788
SPU: 100888004
APLC: 110977481
SKO: 100313552(Prkaa2)
DME: Dmel_CG3051(AMPKalpha)
DSI: Dsimw501_GD16554(Dsim_GD16554)
MDE: 101899168
AAG: 5568845
AME: 409577(SNF1A)
BIM: 100744469
BTER: 100643177
SOC: 105201163
AEC: 105146359
ACEP: 105627819
PBAR: 105426255
HST: 105190214
CFO: 105252990
LHU: 105671278
PGC: 109855776
NVI: 100120450
TCA: 663357(Snf1a)
DPA: 109545112
NVL: 108557505
BMOR: 100101222
PMAC: 106711118
PRAP: 110991484
PXY: 105386201
API: 103309639
DNX: 107165577
ZNE: 110828230
CEL: CELE_PAR2.3(aak-1) CELE_T01C8.1(aak-2)
CBR: CBG06916(Cbr-aak-1) CBG16249(Cbr-aak-2)
BMY: Bm1_50100
CRG: 105341321
MYI: 110449031
OBI: 106875312
EPA: 110241483
ADF: 107338938
HMG: 101238049(prkaa2)
AQU: 100642122
ATH: AT3G01090(KIN10) AT3G29160(KIN11) AT5G39440(SnRK1.3)
LJA: Lj0g3v0072749.1(Lj0g3v0072749.1) Lj0g3v0093489.2(Lj0g3v0093489.2) Lj0g3v0267379.1(Lj0g3v0267379.1) Lj0g3v0267379.2(Lj0g3v0267379.2) Lj0g3v0278259.1(Lj0g3v0278259.1) Lj1g3v2449150.1(Lj1g3v2449150.1) Lj2g3v1068760.1(Lj2g3v1068760.1) Lj3g3v1411750.1(Lj3g3v1411750.1) Lj3g3v2118210.1(Lj3g3v2118210.1) Lj4g3v2249030.1(Lj4g3v2249030.1) Lj4g3v2249030.2(Lj4g3v2249030.2) Lj5g3v1813880.1(Lj5g3v1813880.1) Lj5g3v1813880.2(Lj5g3v1813880.2) Lj5g3v1813880.3(Lj5g3v1813880.3) Lj6g3v1984590.1(Lj6g3v1984590.1)
MDM: 103404469 103408873 103408874(CIPK14) 103413365 103416244(CIPK30) 103423097(CIPK23) 103429042 103433741(CIPK10) 103434891 103437872(CIPK01) 103441969(CIPK03) 103442725 103446313(CIPK20) 103452612(CIPK26) 103452734(CIPK27)
VVI: 100241678(CIPK13) 100243154 100244972(CIPK11) 100254223 100255067 100258329(CIPK16) 100259621(CIPK19)
DOSA: Os01t0292200-01(Os01g0292200) Os01t0824600-01(Os01g0824600) Os02t0178000-01(Os02g0178000) Os03t0289100-01(Os03g0289100) Os05t0136200-01(Os05g0136200) Os05t0332300-01(Os05g0332300) Os05t0476350-00(Os05g0476350) Os05t0476466-00(Os05g0476466) Os05t0530500-01(Os05g0530500) Os06t0543400-01(Os06g0543400) Os07t0637000-01(Os07g0637000) Os07t0687000-00(Os07g0687000) Os08t0484600-01(Os08g0484600) Os11t0113700-01(Os11g0113700) Os12t0113500-01(Os12g0113500)
ATS: 109735301(LOC109735301) 109735326(LOC109735326) 109740446(LOC109740446) 109753963(LOC109753963) 109763841(LOC109763841) 109768849(LOC109768849) 109768972(LOC109768972) 109770353(LOC109770353) 109772576(LOC109772576) 109776637(LOC109776637) 109777741(LOC109777741) 109778022(LOC109778022) 109781333(LOC109781333) 109786308(LOC109786308) 109786686(LOC109786686)
MIS: MICPUN_60554(SNF1-like) MICPUN_68014
DDI: DDB_G0277905(snfA)
DFA: DFA_01354(snfA)
TAN: TA09820
TPV: TP04_0818
BBO: BBOV_III009120(17.m07797)
SMIN: v1.2.001779.t1(symbB.v1.2.001779.t1) v1.2.012456.t2(symbB.v1.2.012456.t2) v1.2.020616.t1(symbB.v1.2.020616.t1) v1.2.020700.t1(symbB.v1.2.020700.t1)
PTI: PHATRDRAFT_8773(MARK3)
TPS: THAPSDRAFT_26536(SNF1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y, Birnbaum MJ, Thompson CB
  Title
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.
  Journal
Mol Cell 18:283-93 (2005)
DOI:10.1016/j.molcel.2005.03.027
Reference
PMID:8557660
  Authors
Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE
  Title
Mammalian AMP-activated protein kinase subfamily.
  Journal
J Biol Chem 271:611-4 (1996)
DOI:10.1074/jbc.271.2.611
  Sequence
[hsa:5562]

KEGG   ORTHOLOGY: K07199Help
Entry
K07199                      KO                                     

Name
PRKAB
Definition
5'-AMP-activated protein kinase, regulatory beta subunit
Pathway
ko04068  FoxO signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04371  Apelin signaling pathway
ko04530  Tight junction
ko04710  Circadian rhythm
ko04714  Thermogenesis
ko04910  Insulin signaling pathway
ko04920  Adipocytokine signaling pathway
ko04921  Oxytocin signaling pathway
ko04922  Glucagon signaling pathway
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko05410  Hypertrophic cardiomyopathy (HCM)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04371 Apelin signaling pathway
    K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
   04068 FoxO signaling pathway
    K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
   04152 AMPK signaling pathway
    K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
 Cellular Processes
  Cellular community - eukaryotes
   04530 Tight junction
    K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
   04922 Glucagon signaling pathway
    K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
   04920 Adipocytokine signaling pathway
    K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
   04921 Oxytocin signaling pathway
    K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
  Aging
   04211 Longevity regulating pathway - mammal
    K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
   04213 Longevity regulating pathway - multiple species
    K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
  Environmental adaptation
   04710 Circadian rhythm
    K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
   04714 Thermogenesis
    K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
 Human Diseases
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
   04931 Insulin resistance
    K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
BRITE hierarchy
Genes
HSA: 5564(PRKAB1) 5565(PRKAB2)
PTR: 452297(PRKAB1) 457245(PRKAB2)
PPS: 100972311(PRKAB2) 100975205(PRKAB1)
GGO: 101126241(PRKAB1) 101151966(PRKAB2)
PON: 100173201(PRKAB1)
NLE: 100597131(PRKAB2) 100600676(PRKAB1)
MCC: 695737(PRKAB1) 699806(PRKAB2)
MCF: 101925338(PRKAB2) 102133927(PRKAB1)
CSAB: 103239238(PRKAB1) 103247234(PRKAB2)
RRO: 104666241(PRKAB1) 104678672(PRKAB2)
RBB: 108517082(PRKAB2) 108534006(PRKAB1)
CJC: 100406673(PRKAB2) 100409760(PRKAB1)
SBQ: 101029046(PRKAB1) 101051388(PRKAB2)
MMU: 108097(Prkab2) 19079(Prkab1)
RNO: 64562(Prkab2) 83803(Prkab1)
CGE: 100755226(Prkab1) 100772359(Prkab2)
NGI: 103726789(Prkab1) 103731998(Prkab2)
HGL: 101705863(Prkab1) 101720100(Prkab2)
CCAN: 109696161(Prkab1) 109696888(Prkab2)
OCU: 100340412(PRKAB2) 100348780(PRKAB1)
TUP: 102471560(PRKAB1) 102477154(PRKAB2)
CFA: 100856379(PRKAB2) 486295(PRKAB1)
AML: 100463656(PRKAB1) 100475764(PRKAB2)
UMR: 103678332(PRKAB1) 103678391(PRKAB2)
ORO: 101372153(PRKAB1) 101383756(PRKAB2)
FCA: 101092284(PRKAB2) 101094051(PRKAB1)
PTG: 102952112(PRKAB1) 102972403(PRKAB2)
AJU: 106971697(PRKAB1) 106985832(PRKAB2)
BTA: 512665(PRKAB2) 534107(PRKAB1)
BOM: 102275377(PRKAB2) 102278235(PRKAB1)
BIU: 109555847(PRKAB2) 109571380(PRKAB1)
PHD: 102321375(PRKAB1) 102341101(PRKAB2)
CHX: 102169928(PRKAB2) 102181705(PRKAB1)
OAS: 101107899(PRKAB1) 101113114(PRKAB2)
SSC: 100156537(PRKAB1) 100157793(PRKAB2)
CFR: 102510343(PRKAB1) 102516135(PRKAB2)
CDK: 105089467(PRKAB2) 105104898(PRKAB1)
BACU: 103015065(PRKAB1) 103019135(PRKAB2)
LVE: 103085288(PRKAB1) 103089470(PRKAB2)
OOR: 101270605(PRKAB2) 101289338(PRKAB1)
ECB: 100034094(PRKAB1) 100034095(PRKAB2)
EPZ: 103540717(PRKAB1) 103542394(PRKAB2)
EAI: 106844778(PRKAB1) 106847656(PRKAB2)
MYB: 102242848(PRKAB1) 102250933(PRKAB2)
MYD: 102766305(PRKAB2) 102768765(PRKAB1)
HAI: 109386179(PRKAB1) 109389886(PRKAB2)
RSS: 109436016(PRKAB2) 109459470(PRKAB1)
PALE: 102886980(PRKAB1) 102887949(PRKAB2)
LAV: 100665273(PRKAB2) 100676546(PRKAB1)
MDO: 100013848(PRKAB2) 100014200(PRKAB1)
SHR: 100919221(PRKAB1) 105750525(PRKAB2)
OAA: 100083731
GGA: 416986(PRKAB1) 427017(PRKAB2)
MGP: 100543948(PRKAB1) 100551469(PRKAB2)
CJO: 107317110(PRKAB2) 107321393(PRKAB1)
APLA: 101803934(PRKAB2) 101805480(PRKAB1)
ACYG: 106031361(PRKAB1) 106041622(PRKAB2)
TGU: 100218045(PRKAB2) 100220812(PRKAB1)
GFR: 102039548(PRKAB2) 102045511(PRKAB1)
FAB: 101807095(PRKAB1) 101807509(PRKAB2)
PHI: 102108217(PRKAB1) 102110041(PRKAB2)
PMAJ: 107208034(PRKAB2) 107211650(PRKAB1)
CCW: 104688531(PRKAB1) 104695440(PRKAB2)
FPG: 101918959(PRKAB1) 101922375(PRKAB2)
FCH: 102054722(PRKAB2) 102057661(PRKAB1)
CLV: 102096409(PRKAB2) 102096945(PRKAB1)
EGZ: 104129861(PRKAB1) 104132070(PRKAB2)
AAM: 106486336(PRKAB1) 106499653(PRKAB2)
ASN: 102382402(PRKAB1) 102383969(PRKAB2)
AMJ: 102560973(PRKAB2) 102568469(PRKAB1)
PSS: 102458779(PRKAB2) 102462692(PRKAB1)
CMY: 102931879(PRKAB1) 102938628
CPIC: 101941080(PRKAB2) 101943824(PRKAB1)
ACS: 100553465(prkab1) 100554551(prkab2)
PVT: 110088958(PRKAB1) 110089841(PRKAB2)
PBI: 103053428(PRKAB2) 103056425(PRKAB1)
GJA: 107119945(PRKAB2) 107122271(PRKAB1)
XLA: 108715739(prkab2.S) 108715919 380372(prkab2.L) 443998(prkab1.S)
XTR: 100127782(prkab2) 100380160(prkab1)
NPR: 108800403(PRKAB1)
DRE: 100170795(prkab2) 335232(prkab1b) 436905(prkab1a)
IPU: 100528577(aakb1) 108277360(prkab1) 108280523
TRU: 101075190(prkab2) 101077063 101077896(prkab1)
LCM: 102345693(PRKAB2) 102350587(PRKAB1)
CMK: 103179976 103189858(prkab1)
CIN: 100184659
SPU: 592944
APLC: 110975207
SKO: 100371289
DME: Dmel_CG8057(alc)
DSI: Dsimw501_GD10101(Dsim_GD10101)
MDE: 101897466
AAG: 5573949
AME: 409662(alc)
BIM: 100740818
BTER: 100649644
SOC: 105200212
AEC: 105153371
ACEP: 105619482
PBAR: 105434289
HST: 105184528
LHU: 105671840
PGC: 109858397
NVI: 100120670(alc)
TCA: 659775
NVL: 108567643
BMOR: 100126177
PMAC: 106714859
PRAP: 110993995
API: 100166968
DNX: 107170076
ZNE: 110834362
FCD: 110859296
TUT: 107364490
CEL: CELE_F55F3.1(aakb-1) CELE_Y47D3A.15(aakb-2)
CBR: CBG07378(Cbr-aakb-1) CBG13217(Cbr-aakb-2)
BMY: Bm1_18185
TSP: Tsp_05912
CRG: 105344372
MYI: 110452686
OBI: 106872364
EPA: 110235926
HMG: 100212092
AQU: 100634103
ATH: AT4G16360 AT5G21170(AKINBETA1)
LJA: Lj0g3v0233389.1(Lj0g3v0233389.1) Lj6g3v1721620.1(Lj6g3v1721620.1)
SLY: 101055581 101055582 543678(Sip1) 543876(GAL83)
DOSA: Os03t0319100-01(Os03g0319100) Os05t0491200-01(Os05g0491200) Os07t0687300-01(Os07g0687300)
ATS: 109750595(LOC109750595) 109768115(LOC109768115) 109770856(LOC109770856)
APRO: F751_6239
SPO: SPCC1919.03c(amk2)
SMIN: v1.2.030067.t1(symbB.v1.2.030067.t1)
SPAR: SPRG_15880
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8663446
  Authors
Dyck JR, Gao G, Widmer J, Stapleton D, Fernandez CS, Kemp BE, Witters LA
  Title
Regulation of 5'-AMP-activated protein kinase activity by the noncatalytic beta and gamma subunits.
  Journal
J Biol Chem 271:17798-803 (1996)
DOI:10.1074/jbc.271.30.17798
Reference
PMID:9224708
  Authors
Stapleton D, Woollatt E, Mitchelhill KI, Nicholl JK, Fernandez CS, Michell BJ, Witters LA, Power DA, Sutherland GR, Kemp BE
  Title
AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location.
  Journal
FEBS Lett 409:452-6 (1997)
DOI:10.1016/S0014-5793(97)00569-3
  Sequence
[hsa:5564]

KEGG   ORTHOLOGY: K07200Help
Entry
K07200                      KO                                     

Name
PRKAG
Definition
5'-AMP-activated protein kinase, regulatory gamma subunit
Pathway
ko04068  FoxO signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04371  Apelin signaling pathway
ko04530  Tight junction
ko04710  Circadian rhythm
ko04714  Thermogenesis
ko04910  Insulin signaling pathway
ko04920  Adipocytokine signaling pathway
ko04921  Oxytocin signaling pathway
ko04922  Glucagon signaling pathway
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko05410  Hypertrophic cardiomyopathy (HCM)
Disease
H00069  Glycogen storage diseases (GSD)
H00292  Hypertrophic cardiomyopathy (HCM)
H01154  Wolff-Parkinson-White (WPW) syndrome
H01956  Glycogen storage disease of heart
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04371 Apelin signaling pathway
    K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
   04068 FoxO signaling pathway
    K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
   04152 AMPK signaling pathway
    K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
 Cellular Processes
  Cellular community - eukaryotes
   04530 Tight junction
    K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
   04922 Glucagon signaling pathway
    K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
   04920 Adipocytokine signaling pathway
    K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
   04921 Oxytocin signaling pathway
    K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
  Aging
   04211 Longevity regulating pathway - mammal
    K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
   04213 Longevity regulating pathway - multiple species
    K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
  Environmental adaptation
   04710 Circadian rhythm
    K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
   04714 Thermogenesis
    K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
 Human Diseases
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
   04931 Insulin resistance
    K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
BRITE hierarchy
Other DBs
COG: COG0517
Genes
HSA: 51422(PRKAG2) 53632(PRKAG3) 5571(PRKAG1)
PTR: 451872(PRKAG1) 463879(PRKAG2) 470648(PRKAG3)
PPS: 100987544(PRKAG2) 100989947(PRKAG3) 100996156(PRKAG1)
GGO: 101130530(PRKAG2) 101132134(PRKAG3) 101143913(PRKAG1)
PON: 100173926(PRKAG2) 100440280(PRKAG3) 100442951(PRKAG1)
NLE: 100598921(PRKAG2) 100606474(PRKAG3) 100607037(PRKAG1)
MCC: 100425255(PRKAG2) 702782(PRKAG3) 709298(PRKAG1)
MCF: 101865279(PRKAG1) 102128414(PRKAG2) 102130217(PRKAG3)
CSAB: 103217881(PRKAG3) 103227261(PRKAG2) 103238254(PRKAG1)
RRO: 104660035(PRKAG3) 104678710(PRKAG2) 104679727(PRKAG1)
RBB: 108518487(PRKAG3) 108523111(PRKAG2) 108543920(PRKAG1)
CJC: 100386781(PRKAG2) 100390042(PRKAG1) 100394141(PRKAG3)
SBQ: 101028682(PRKAG3) 101042380(PRKAG2) 101044457(PRKAG1)
MMU: 108099(Prkag2) 19082(Prkag1) 241113(Prkag3)
RNO: 25520(Prkag1) 301518(Prkag3) 373545(Prkag2)
CGE: 100758649(Prkag2) 100765754(Prkag1) 100770459(Prkag3)
NGI: 103727728(Prkag3) 103745323(Prkag2) 103750569(Prkag1)
HGL: 101699641(Prkag2) 101699667(Prkag3) 101721085(Prkag1)
CCAN: 109680387(Prkag3) 109685265(Prkag2) 109694818(Prkag1)
OCU: 100352581(PRKAG3) 100353180(PRKAG2) 100356542(PRKAG1)
TUP: 102471857(PRKAG3) 102478146 102498498(PRKAG1) 102502947(PRKAG2)
CFA: 475546(PRKAG2) 486559(PRKAG1) 488526(PRKAG3)
AML: 100468143(PRKAG3) 100474747(PRKAG1) 100480315(PRKAG2)
UMR: 103660987(PRKAG2) 103662753(PRKAG3) 103675453(PRKAG1)
ORO: 101364224(PRKAG2) 101369816(PRKAG1) 101374600(PRKAG3)
FCA: 101092204(PRKAG3) 101094684(PRKAG1) 101100119(PRKAG2)
PTG: 102951896(PRKAG1) 102959115(PRKAG3) 102960269(PRKAG2) 102960547
AJU: 106969288(PRKAG1) 106969553(PRKAG2) 106970101(PRKAG3)
BTA: 104972294 282324(PRKAG1) 504219(PRKAG2) 511961(PRKAG3)
BOM: 102268424(PRKAG1) 102276048(PRKAG3) 102277941(PRKAG2)
BIU: 109557811(PRKAG2) 109559147(PRKAG1) 109570727(PRKAG3)
PHD: 102318850(PRKAG3) 102323146(PRKAG2) 102336994(PRKAG1)
CHX: 100861301(PRKAG3) 102179737(PRKAG1) 102180727(PRKAG2)
OAS: 100142674(PRKAG3) 101103143(PRKAG1) 101104483(PRKAG2) 105615140
SSC: 100515868(PRKAG2) 397149(PRKAG3) 414426(PRKAG1)
CFR: 102504447(PRKAG2) 102508228 102517958(PRKAG3) 102522019(PRKAG1)
CDK: 105096091(PRKAG3) 105098685(PRKAG2) 105103784(PRKAG1)
BACU: 102999310(PRKAG3) 103000853(PRKAG2) 103017735(PRKAG1)
LVE: 103079195(PRKAG1) 103079471(PRKAG2) 103079524(PRKAG3)
OOR: 101269890(PRKAG1) 101286740(PRKAG2) 101288264(PRKAG3)
ECB: 100034096(PRKAG1) 100034098(PRKAG2) 100034099(PRKAG3)
EPZ: 103552223(PRKAG1) 103553142 103560519 103567915(PRKAG3)
EAI: 106823337(PRKAG2) 106836814(PRKAG1) 106838460(PRKAG3)
MYB: 102245261(PRKAG1) 102250591(PRKAG2) 102256066(PRKAG3)
MYD: 102759115 102759388(PRKAG2) 102761682(PRKAG3) 102762694(PRKAG1)
HAI: 109380528(PRKAG3) 109389657(PRKAG2) 109393222(PRKAG1)
RSS: 109435162(PRKAG2) 109443834(PRKAG1) 109452672(PRKAG3)
PALE: 102882613(PRKAG3) 102887347(PRKAG1) 102898038(PRKAG2)
LAV: 100669727(PRKAG1) 100672035(PRKAG2) 100675348(PRKAG3)
MDO: 100011008(PRKAG3) 100018968(PRKAG2) 100032744(PRKAG1)
SHR: 100918024(PRKAG3) 100919530 100927282(PRKAG1) 111721143
OAA: 100082459(PRKAG2)
GGA: 107055408(PRKAG1) 420435(PRKAG2) 424208(PRKAG3) 429688(PRKAG1)
MGP: 100540283(PRKAG3) 100544714(PRKAG2)
CJO: 107308766(PRKAG2) 107317021(PRKAG3) 107325757(PRKAG1)
APLA: 101803710(PRKAG2)
ACYG: 106036828(PRKAG2) 106039315(PRKAG3) 106047717(PRKAG1)
TGU: 100218551(PRKAG2) 100219826(PRKAG3)
GFR: 102033868(PRKAG1) 102035320(PRKAG3) 102042687(PRKAG2)
FAB: 101811942(PRKAG1) 101819371(PRKAG3) 101821783(PRKAG2)
PHI: 102100656(PRKAG3) 102103273(PRKAG1) 102105447(PRKAG2)
PMAJ: 107198595(PRKAG1) 107207521(PRKAG3) 107216388(PRKAG2)
CCW: 104686512(PRKAG2) 104693965(PRKAG3)
FPG: 101915063(PRKAG1) 101917527(PRKAG2) 101921211(PRKAG3)
FCH: 102047539(PRKAG2) 102049283(PRKAG1) 102054583(PRKAG3)
CLV: 102084443(PRKAG3) 102098319(PRKAG2) 102098499
EGZ: 104130997(PRKAG2) 104132405(PRKAG3)
AAM: 106490284(PRKAG2) 106497509(PRKAG1) 106499071 106499072(PRKAG3)
ASN: 102377007(PRKAG3) 102381631(PRKAG2) 102383827(PRKAG1) 106722024
PSS: 102462081(PRKAG2)
CMY: 102929680(PRKAG2) 102936816(PRKAG3) 102943724(PRKAG1)
CPIC: 101934012(PRKAG1) 101938821 101943694(PRKAG3) 101951703(PRKAG2)
ACS: 100553577(prkag2) 100562137(prkag1) 100564629(prkag3)
PVT: 110071918(PRKAG2) 110074862(PRKAG1) 110078204(PRKAG3)
PBI: 103053289(PRKAG1) 103053647(PRKAG3) 103062096(PRKAG2)
GJA: 107120891(PRKAG1) 107122113 107123157(PRKAG2)
XLA: 100127310(prkag3.S) 108718729 380124(prkag3-b) 398958(prkag1.S) 444397(prkag2.L)
XTR: 100125135(prkag2) 100158499(prkag1) 779860(prkag3)
NPR: 108784340(PRKAG2) 108785778(PRKAG3) 108791397(PRKAG1)
DRE: 406440(prkag1) 553319(prkag3a) 568316(prkag2b) 570761(prkag2a) 678619(prkag3b)
TRU: 101064981 101070084(prkag1) 101074638(prkag2) 105416222(prkag3)
SFM: 108918427(prkag1) 108931742 108937712 108942228(prkag3)
LCM: 102345950(PRKAG2) 102348610(PRKAG1) 102366003(PRKAG3)
CMK: 103173476 103187036(prkag2) 103189258(prkag1)
CIN: 100177756
SPU: 756927
APLC: 110984227
SKO: 100373594
DME: Dmel_CG17299(SNF4Agamma)
DSI: Dsimw501_GD19405(Dsim_GD19405)
MDE: 101890250
AME: 724442(GB12579)
BIM: 100750102
BTER: 100643749
AEC: 105152280
ACEP: 105621246
PBAR: 105428348
HST: 105187708
CFO: 105252883
LHU: 105676688
PGC: 109853146
TCA: 661973
DPA: 109539842
NVL: 108563529
BMOR: 100145904(Snf4agamma) 101744333
API: 100169066
DNX: 107164757
ZNE: 110831051
FCD: 110852443
TUT: 107360918
CEL: CELE_Y111B2A.8(aakg-1)
CBR: CBG11682
BMY: Bm1_41170
CRG: 105348277
OBI: 106869147
LAK: 106170538
EPA: 110245169
ADF: 107353147
HMG: 100205593
AQU: 100639517
GRA: 105800758
EGR: 104424186
GMX: 100815681
CAM: 101497124
LJA: Lj0g3v0307699.1(Lj0g3v0307699.1) Lj4g3v2367350.1(Lj4g3v2367350.1) Lj4g3v2367350.2(Lj4g3v2367350.2)
CMAX: 111493020
JRE: 109009738
CANN: 107862099
NTO: 104099526
OEU: 111382131
DCR: 108194091
NNU: 104586115
APRO: F751_4978
SCE: YGL115W(SNF4)
ERC: Ecym_2281
KMX: KLMA_20225(SNF4)
NCS: NCAS_0D03340(NCAS0D03340)
NDI: NDAI_0I01510(NDAI0I01510)
TPF: TPHA_0J01900(TPHA0J01900)
TBL: TBLA_0A01530(TBLA0A01530)
TDL: TDEL_0A01720(TDEL0A01720)
KAF: KAFR_0A04540(KAFR0A04540)
PIC: PICST_43920(SNF4)
CAL: CAALFM_C603920WA(SNF4)
CAUR: QG37_04881
SLB: AWJ20_2789(SNF4)
NCR: NCU01471
NTE: NEUTE1DRAFT127373(NEUTE1DRAFT_127373)
MGR: MGG_04005
MAW: MAC_08736
MAJ: MAA_01336
CMT: CCM_09417
MBE: MBM_02797
ANI: AN6851.2
ANG: ANI_1_1580124(An14g06220)
ABE: ARB_03369
TVE: TRV_02884
PTE: PTT_11754
ZTR: MYCGRDRAFT_68009(MgSNF4)
SPO: SPAC1556.08c(cbs2)
CNE: CNA03430
CNB: CNBA3300
ABP: AGABI1DRAFT66832(AGABI1DRAFT_66832)
ABV: AGABI2DRAFT197431(AGABI2DRAFT_197431)
MGL: MGL_2034
SMIN: v1.2.020901.t1(symbB.v1.2.020901.t1)
SPAR: SPRG_14738
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8663446
  Authors
Dyck JR, Gao G, Widmer J, Stapleton D, Fernandez CS, Kemp BE, Witters LA
  Title
Regulation of 5'-AMP-activated protein kinase activity by the noncatalytic beta and gamma subunits.
  Journal
J Biol Chem 271:17798-803 (1996)
DOI:10.1074/jbc.271.30.17798
Reference
PMID:8621499
  Authors
Gao G, Fernandez CS, Stapleton D, Auster AS, Widmer J, Dyck JR, Kemp BE, Witters LA
  Title
Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase.
  Journal
J Biol Chem 271:8675-81 (1996)
DOI:10.1074/jbc.271.15.8675
  Sequence
[hsa:5571]

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