KEGG   ORTHOLOGY: K07201Help
Entry
K07201                      KO                                     

Name
FOXO1
Definition
forkhead box protein O1
Pathway
ko04068  FoxO signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04218  Cellular senescence
ko04910  Insulin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko04922  Glucagon signaling pathway
ko04931  Insulin resistance
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05215  Prostate cancer
Module
M00676  PI3K-Akt signaling
Disease
H00037  Alveolar rhabdomyosarcoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    K07201  FOXO1; forkhead box protein O1
   04152 AMPK signaling pathway
    K07201  FOXO1; forkhead box protein O1
 Cellular Processes
  Cell growth and death
   04218 Cellular senescence
    K07201  FOXO1; forkhead box protein O1
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K07201  FOXO1; forkhead box protein O1
   04922 Glucagon signaling pathway
    K07201  FOXO1; forkhead box protein O1
   04919 Thyroid hormone signaling pathway
    K07201  FOXO1; forkhead box protein O1
  Aging
   04211 Longevity regulating pathway - mammal
    K07201  FOXO1; forkhead box protein O1
   04213 Longevity regulating pathway - multiple species
    K07201  FOXO1; forkhead box protein O1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K07201  FOXO1; forkhead box protein O1
   05202 Transcriptional misregulation in cancers
    K07201  FOXO1; forkhead box protein O1
   05215 Prostate cancer
    K07201  FOXO1; forkhead box protein O1
  Endocrine and metabolic diseases
   04931 Insulin resistance
    K07201  FOXO1; forkhead box protein O1
   04933 AGE-RAGE signaling pathway in diabetic complications
    K07201  FOXO1; forkhead box protein O1
  Infectious diseases
   05165 Human papillomavirus infection
    K07201  FOXO1; forkhead box protein O1
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00676  PI3K-Akt signaling
     K07201  FOXO1; forkhead box protein O1
Transcription factors [BR:ko03000]
 Eukaryotic Type
  Helix-turn-helix
   Fork head/winged helix other regulators
    K07201  FOXO1; forkhead box protein O1
BRITE hierarchy
Genes
HSA: 2308(FOXO1)
PTR: 467352(FOXO1)
PPS: 100996020(FOXO1)
GGO: 101151399(FOXO1)
PON: 100460676(FOXO1)
NLE: 100594615(FOXO1)
MCC: 700030(FOXO1)
MCF: 102116712(FOXO1) 102139030
CSAB: 103214322(FOXO1)
RRO: 104671116(FOXO1) 104679162
RBB: 108514115(FOXO1)
CJC: 100397393(FOXO1)
SBQ: 101053657(FOXO1)
MMU: 56458(Foxo1)
RNO: 84482(Foxo1)
CGE: 100768647(Foxo1)
NGI: 103747066(Foxo1)
HGL: 101707441(Foxo1)
CCAN: 109688921(Foxo1)
OCU: 100358471(FOXO1)
TUP: 102489658(FOXO1)
CFA: 477295(FOXO1)
AML: 100471182(FOXO1)
UMR: 103677704(FOXO1)
ORO: 101373912(FOXO1)
FCA: 101096628(FOXO1)
PTG: 102969147(FOXO1)
AJU: 106972644(FOXO1)
BTA: 506618(FOXO1)
BOM: 102284612(FOXO1)
BIU: 109566997(FOXO1)
PHD: 102339130(FOXO1)
CHX: 102184915(FOXO1)
OAS: 101107877(FOXO1)
SSC: 397077(FOXO1)
CFR: 102511562(FOXO1)
CDK: 105091004(FOXO1)
BACU: 103020667(FOXO1)
LVE: 103086905(FOXO1)
OOR: 101285637(FOXO1)
ECB: 100050481(FOXO1)
EPZ: 103552024(FOXO1)
EAI: 106848479(FOXO1)
MYB: 102253962(FOXO1)
MYD: 102766094(FOXO1)
HAI: 109387667(FOXO1)
RSS: 109456920(FOXO1)
PALE: 102892244(FOXO1)
LAV: 100655740(FOXO1)
TMU: 101340503
MDO: 100021587(FOXO1)
SHR: 100928882(FOXO1)
OAA: 100082288(FOXO1)
GGA: 374231(FOXO1)
MGP: 100540055(FOXO1)
CJO: 107308196(FOXO1)
APLA: 101795447(FOXO1)
ACYG: 106035078(FOXO1)
TGU: 100217629(FOXO1)
GFR: 102039410(FOXO1)
FAB: 101809090(FOXO1)
PHI: 102099738(FOXO1)
PMAJ: 107210372(FOXO1)
CCW: 104689938(FOXO1)
FPG: 101915696(FOXO1)
FCH: 102057600(FOXO1)
CLV: 102086772(FOXO1)
EGZ: 104129682(FOXO1)
AAM: 106489240(FOXO1)
ASN: 102388853(FOXO1)
AMJ: 102576430(FOXO1)
PSS: 102449767(FOXO1)
CMY: 102939461(FOXO1)
CPIC: 101940772(FOXO1)
ACS: 100557662(foxo1)
PVT: 110076126(FOXO1)
PBI: 103062993(FOXO1)
GJA: 107110257(FOXO1)
XLA: 108709932(foxo1.S) 444991(foxo1.L)
XTR: 493378(foxo1)
NPR: 108787037(FOXO1)
DRE: 567969(foxo1b) 768121(foxo1a)
IPU: 108277356 108277791(foxo1)
AMEX: 103032706(foxo1) 103046520
TRU: 101072628(foxo1) 101073915
MZE: 101468133 101469585(foxo1)
OLA: 100301620(foxo1) 101164740
XMA: 102236896(foxo1) 102237615
PRET: 103475003 103475797(foxo1)
NFU: 107380205(foxo1) 107386483
CSEM: 103378152(foxo1) 103395707
BPEC: 110158469 110164373(foxo1)
SFM: 108921676(foxo1) 108941767
LCM: 102347273(FOXO1)
CMK: 103177236(foxo1)
SPU: 585334(FoxO)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Bois PR, Izeradjene K, Houghton PJ, Cleveland JL, Houghton JA, Grosveld GC
  Title
FOXO1a acts as a selective tumor suppressor in alveolar rhabdomyosarcoma.
  Journal
J Cell Biol 170:903-12 (2005)
DOI:10.1083/jcb.200501040
Reference
  Authors
Zhang X, Gan L, Pan H, Guo S, He X, Olson ST, Mesecar A, Adam S, Unterman TG
  Title
Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding.
  Journal
J Biol Chem 277:45276-84 (2002)
DOI:10.1074/jbc.M208063200
  Sequence
[hsa:2308]
Reference
PMID:9479491
  Authors
Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC
  Title
Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.
  Journal
Genomics 47:187-99 (1998)
DOI:10.1006/geno.1997.5122
  Sequence
[hsa:2308]

DBGET integrated database retrieval system