KEGG   ORTHOLOGY: K07203Help
Entry
K07203                      KO                                     

Name
MTOR, FRAP, TOR
Definition
serine/threonine-protein kinase mTOR [EC:2.7.11.1]
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
ErbB signaling pathway
HIF-1 signaling pathway
Phospholipase D signaling pathway
Autophagy - other
Autophagy - yeast
Mitophagy - yeast
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - worm
Longevity regulating pathway - multiple species
Cellular senescence
Apelin signaling pathway
Jak-STAT signaling pathway
Th17 cell differentiation
Insulin signaling pathway
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Insulin resistance
Human papillomavirus infection
Kaposi's sarcoma-associated herpesvirus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Pancreatic cancer
Glioma
Prostate cancer
Acute myeloid leukemia
Breast cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04371 Apelin signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04630 Jak-STAT signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04066 HIF-1 signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04072 Phospholipase D signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04151 PI3K-Akt signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04152 AMPK signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04150 mTOR signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04138 Autophagy - yeast
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04136 Autophagy - other eukaryotes
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04139 Mitophagy - yeast
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  Cell growth and death
   04218 Cellular senescence
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
 Organismal Systems
  Immune system
   04659 Th17 cell differentiation
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  Endocrine system
   04910 Insulin signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04920 Adipocytokine signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04919 Thyroid hormone signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  Aging
   04211 Longevity regulating pathway - mammal
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04212 Longevity regulating pathway - worm
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04213 Longevity regulating pathway - multiple species
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05230 Central carbon metabolism in cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05231 Choline metabolism in cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05206 MicroRNAs in cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05205 Proteoglycans in cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05212 Pancreatic cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05214 Glioma
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05221 Acute myeloid leukemia
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05215 Prostate cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05224 Breast cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04931 Insulin resistance
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  Infectious diseases
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05165 Human papillomavirus infection
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   01522 Endocrine resistance
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: Atypical group
  PIKK family [OT]
   K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
BRITE hierarchy
Other DBs
COG: 
Genes
HSA: 
2475(MTOR)
PTR: 
457945(MTOR)
PPS: 
100980204(MTOR)
GGO: 
PON: 
100456786(MTOR)
NLE: 
100594291(MTOR)
MCC: 
106992736(MTOR)
MCF: 
102128371(MTOR)
CSAB: 
103225615(MTOR)
RRO: 
104654362(MTOR)
RBB: 
108539366(MTOR)
CJC: 
100406608(MTOR)
SBQ: 
101047083(MTOR)
MMU: 
56717(Mtor)
RNO: 
56718(Mtor)
CGE: 
100755421(Mtor)
NGI: 
103732897(Mtor)
HGL: 
101725626(Mtor)
CCAN: 
OCU: 
100356164(MTOR)
TUP: 
102485262(MTOR)
CFA: 
478232(MTOR)
AML: 
100471122(MTOR)
UMR: 
103666660(MTOR)
FCA: 
101098152(MTOR)
PTG: 
102967196(MTOR)
AJU: 
106984907(MTOR)
BTA: 
100139219(MTOR)
BOM: 
102281727(MTOR)
BIU: 
109570401(MTOR)
PHD: 
102332614(MTOR)
CHX: 
100860902(MTOR)
OAS: 
100271659(MTOR)
SSC: 
100127359(MTOR)
CFR: 
102510836(MTOR)
CDK: 
105107024(MTOR)
BACU: 
103004460(MTOR)
LVE: 
103083889(MTOR)
ECB: 
100051341(MTOR)
EPZ: 
103552237(MTOR)
EAI: 
106836676(MTOR)
MYB: 
102241670(MTOR)
MYD: 
102766933(MTOR)
HAI: 
109381262(MTOR)
RSS: 
109455267(MTOR)
PALE: 
102885092(MTOR)
LAV: 
100660112(MTOR)
MDO: 
100619675(MTOR)
SHR: 
100931480(MTOR)
OAA: 
100079751(MTOR)
GGA: 
419455(MTOR)
MGP: 
100547037(MTOR)
CJO: 
107323407(MTOR)
APLA: 
101802486(MTOR)
ACYG: 
106040228(MTOR)
TGU: 
100219695(MTOR)
GFR: 
102034190(MTOR)
FAB: 
101820693(MTOR)
PHI: 
102108233(MTOR)
PMAJ: 
107213730(MTOR)
CCW: 
104693234(MTOR)
FPG: 
101919512(MTOR)
FCH: 
102051979(MTOR)
CLV: 
102093827(MTOR)
AAM: 
106482444(MTOR)
ASN: 
102372197(MTOR)
AMJ: 
102574334(MTOR)
PSS: 
102451030(MTOR)
CMY: 
CPIC: 
101949839(MTOR)
ACS: 
100565267(mtor)
PVT: 
110073225(MTOR)
PBI: 
103053332(MTOR)
GJA: 
107108920(MTOR)
XLA: 
XTR: 
100491970(mtor)
NPR: 
DRE: 
324254(mtor)
SRX: 
SANH: 
SGH: 
IPU: 
108265039(mtor)
TRU: 
101074470(mtor)
TNG: 
LCO: 
104919512(mtor)
NCC: 
MZE: 
101471360(mtor)
OLA: 
101156248(mtor)
XMA: 
102220301(mtor)
CSEM: 
103384900(mtor)
LCF: 
108882623(mtor)
HCQ: 
109511770(mtor)
BPEC: 
110157966(mtor)
SASA: 
100380849(mtor)
ELS: 
105013925(mtor)
SFM: 
108931071(mtor)
LCM: 
102360124(MTOR)
CMK: 
103181362(mtor)
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSI: 
Dsimw501_GD23862(Dsim_GD23862)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
409393(Tor)
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
DPA: 
NVL: 
BMOR: 
100431180(TOR2)
DPL: 
PXY: 
API: 
DNX: 
PHU: 
DPX: 
TUT: 
CEL: 
CELE_B0261.2(let-363)
CBR: 
CBG12850(Cbr-let-363)
NAI: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
LAK: 
SMM: 
SHX: 
OVI: 
NVE: 
ADF: 
HMG: 
TAD: 
AQU: 
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
BOE: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
GHI: 
EGR: 
GMX: 
PVU: 
VRA: 
VAR: 
CCAJ: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj1g3v0052210.1(Lj1g3v0052210.1) Lj1g3v0052210.2(Lj1g3v0052210.2) Lj1g3v0052210.3(Lj1g3v0052210.3) Lj6g3v1900300.1(Lj6g3v1900300.1) Lj6g3v1900300.2(Lj6g3v1900300.2) Lj6g3v1900300.3(Lj6g3v1900300.3)
LANG: 
FVE: 
PPER: 
PMUM: 
PXB: 
ZJU: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0001s29620g(POPTRDRAFT_1069777) POPTR_0009s08790g(POPTRDRAFT_1087408)
VVI: 
SLY: 
SPEN: 
SOT: 
CANN: 
NTA: 
INI: 
SIND: 
BVG: 
NNU: 
OSA: 
4338174(OsTOR)
DOSA: 
Os05t0235300-01(Os05g0235300)
OBR: 
BDI: 
ATS: 
SBI: 
ZMA: 
542211(cl3114_1(600))
SITA: 
PDA: 
EGU: 
MUS: 
DCT: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
APRO: 
CME: 
GSL: 
CCP: 
SCE: 
YJR066W(TOR1) YKL203C(TOR2)
AGO: 
ERC: 
KLA: 
LTH: 
ZRO: 
CGR: 
NCS: 
NCAS_0G03440(NCAS0G03440)
NDI: 
NDAI_0D01470(NDAI0D01470)
TPF: 
TPHA_0F03570(TPHA0F03570)
TBL: 
TBLA_0D03670(TBLA0D03670)
TDL: 
TDEL_0F00460(TDEL0F00460)
KAF: 
KAFR_0A08100(KAFR0A08100) KAFR_0E00310(KAFR0E00310)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
CAUR: 
NCR: 
NTE: 
NEUTE1DRAFT148627(NEUTE1DRAFT_148627)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
FVR: 
FOX: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
PLJ: 
VAL: 
VDA: 
CFJ: 
ELA: 
PFY: 
SSL: 
BFU: 
MBE: 
PSCO: 
GLZ: 
ANI: 
AFM: 
AOR: 
AOR_1_1042054(AO090011000608)
ANG: 
ANI_1_672144(An16g04720)
AFV: 
ACT: 
NFI: 
PCS: 
PDP: 
CIM: 
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
SNOG_08246(SNOG_08245)
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
TVS: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT126075(AGABI1DRAFT_126075) AGABI1DRAFT35543(AGABI1DRAFT_35543)
ABV: 
AGABI2DRAFT151451(AGABI2DRAFT_151451) AGABI2DRAFT151460(AGABI2DRAFT_151460)
CPUT: 
SLA: 
WSE: 
WIC: 
UMA: 
PFP: 
MGL: 
PGR: 
MLR: 
MBR: 
SRE: 
DDI: 
DPP: 
DFA: 
EHI: 
EHI_169320(177.t00028)
EDI: 
EIV: 
ACAN: 
TET: 
PTM: 
PTI: 
FCY: 
TPS: 
AAF: 
PIF: 
PSOJ: 
SPAR: 
EHX: 
GTT: 
TBR: 
Tb10.6k15.2060 Tb927.4.420(Tb04.5D20.520) Tb927.4.800(Tb04.5E12.820)
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
TVA: 
GLA: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8008069
  Authors
Brown EJ, Albers MW, Shin TB, Ichikawa K, Keith CT, Lane WS, Schreiber SL
  Title
A mammalian protein targeted by G1-arresting rapamycin-receptor complex.
  Journal
Nature 369:756-8 (1994)
DOI:10.1038/369756a0
  Sequence
[hsa:2475]
Reference
  Authors
Jiang Y, Broach JR
  Title
Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast.
  Journal
EMBO J 18:2782-92 (1999)
DOI:10.1093/emboj/18.10.2782

DBGET integrated database retrieval system