KEGG   ORTHOLOGY: K07206Help
Entry
K07206                      KO                                     

Name
TSC1
Definition
tuberous sclerosis 1
Pathway
ko04072  Phospholipase D signaling pathway
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04218  Cellular senescence
ko04714  Thermogenesis
ko04910  Insulin signaling pathway
ko05165  Human papillomavirus infection
ko05231  Choline metabolism in cancer
Disease
H00896  Lymphangioleiomyomatosis (LAM)
H00915  Tuberous sclerosis complex (TSC)
H01251  Focal cortical dysplasia of Taylor
H01691  Renal angiomyolipoma
H01692  Subependymal giant cell astrocytoma (SEGA)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04072 Phospholipase D signaling pathway
    K07206  TSC1; tuberous sclerosis 1
   04151 PI3K-Akt signaling pathway
    K07206  TSC1; tuberous sclerosis 1
   04152 AMPK signaling pathway
    K07206  TSC1; tuberous sclerosis 1
   04150 mTOR signaling pathway
    K07206  TSC1; tuberous sclerosis 1
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    K07206  TSC1; tuberous sclerosis 1
  Cell growth and death
   04218 Cellular senescence
    K07206  TSC1; tuberous sclerosis 1
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K07206  TSC1; tuberous sclerosis 1
  Aging
   04211 Longevity regulating pathway - mammal
    K07206  TSC1; tuberous sclerosis 1
  Environmental adaptation
   04714 Thermogenesis
    K07206  TSC1; tuberous sclerosis 1
 Human Diseases
  Cancers
   05231 Choline metabolism in cancer
    K07206  TSC1; tuberous sclerosis 1
  Infectious diseases
   05165 Human papillomavirus infection
    K07206  TSC1; tuberous sclerosis 1
BRITE hierarchy
Genes
HSA: 7248(TSC1)
PTR: 464818(TSC1)
PPS: 100975575(TSC1)
GGO: 101137273(TSC1)
PON: 100147742(TSC1)
NLE: 100587112(TSC1)
MCC: 714645(TSC1)
MCF: 102124229(TSC1)
CSAB: 103239711(TSC1)
RRO: 104669743(TSC1)
RBB: 108513580(TSC1)
CJC: 100407741(TSC1)
SBQ: 101028002(TSC1)
MMU: 64930(Tsc1)
RNO: 60445(Tsc1)
CGE: 100767621(Tsc1)
NGI: 103742835(Tsc1)
HGL: 101708424(Tsc1)
CCAN: 109691000(Tsc1)
OCU: 100338695(TSC1)
TUP: 102483474(TSC1)
CFA: 480688(TSC1)
AML: 100471530(TSC1)
UMR: 103670250(TSC1)
ORO: 101363167(TSC1)
FCA: 101101514(TSC1)
PTG: 102953770(TSC1)
AJU: 106985348(TSC1)
BTA: 533440(TSC1)
BOM: 102280709(TSC1)
BIU: 109566571(TSC1)
PHD: 102315907(TSC1)
CHX: 102178739(TSC1)
OAS: 101119127(TSC1)
SSC: 100154726(TSC1)
CFR: 102504505(TSC1)
CDK: 105085191(TSC1)
BACU: 103010162(TSC1)
LVE: 103088278(TSC1)
OOR: 101275677(TSC1)
ECB: 100066615(TSC1)
EPZ: 103553676(TSC1)
EAI: 106845368(TSC1)
MYB: 102245381(TSC1)
MYD: 102752713(TSC1)
HAI: 109380979(TSC1)
RSS: 109445966(TSC1)
PALE: 102878835(TSC1)
LAV: 100667008(TSC1)
TMU: 101347417
MDO: 100017591(TSC1)
SHR: 100918165(TSC1)
OAA: 100080641(TSC1)
GGA: 417166(TSC1)
MGP: 100539473(TSC1)
CJO: 107321823(TSC1)
APLA: 101798545(TSC1)
ACYG: 106044091(TSC1)
TGU: 100228268(TSC1)
GFR: 102040493(TSC1)
FAB: 101806512(TSC1)
PHI: 102103020(TSC1)
PMAJ: 107212076(TSC1)
CCW: 104688322(TSC1)
FPG: 101921096(TSC1)
FCH: 102050812(TSC1)
CLV: 102094746(TSC1)
EGZ: 104128282(TSC1)
AAM: 106483762(TSC1)
ASN: 102383470(TSC1)
AMJ: 102560300(TSC1)
PSS: 102453047(TSC1)
CMY: 102939516(TSC1)
CPIC: 101947761(TSC1)
ACS: 100560493(tsc1)
PVT: 110079595(TSC1)
PBI: 103052506(TSC1)
GJA: 107112796(TSC1)
XLA: 108698219(tsc1.L) 108699932(tsc1.S)
XTR: 100380126(tsc1)
NPR: 108794671(TSC1)
DRE: 100330617(tsc1b) 337167(tsc1a)
AMEX: 103023802 103025705(tsc1)
TRU: 101064275(tsc1) 101070860
LCO: 104923614(tsc1)
NCC: 104947275 104947658(tsc1)
OLA: 101174436 101175335(tsc1)
PRET: 103460566 103473966(tsc1)
HCQ: 109525278 109530634(tsc1)
BPEC: 110161175(tsc1) 110168809
SASA: 100380649(tsc1) 106565454 106587014(tsc1)
SFM: 108922678 108938614(tsc1)
LCM: 102358393(TSC1)
CMK: 103184683(tsc1)
CIN: 100187265
SPU: 583100
APLC: 110976296
SKO: 100378717
DME: Dmel_CG6147(Tsc1)
DSI: Dsimw501_GD21066(Dsim_GD21066)
MDE: 101894607
AAG: 5580190
AME: 724223(Tsc1)
BIM: 100742364
BTER: 100647028
SOC: 105200235
AEC: 105149474
ACEP: 105626702
PBAR: 105432913
HST: 105188459
CFO: 105253445
LHU: 105675360
PGC: 109853729
NVI: 100117824
TCA: 662868
DPA: 109538899
NVL: 108561625
BMOR: 101739907
PRAP: 111000914
PXY: 105388230
API: 100164018
DNX: 107169785
ZNE: 110828006
FCD: 110849974
DPX: DAPPUDRAFT_42685(TSC-1)
BMY: Bm1_31440
CRG: 105327465
MYI: 110458194
OBI: 106876567
EPA: 110245765
ADF: 107357403
HMG: 100204754
AQU: 109586668
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9242607
  Authors
van Slegtenhorst M, de Hoogt R, Hermans C, Nellist M, Janssen B, Verhoef S, Lindhout D, van den Ouweland A, Halley D, Young J, Burley M, Jeremiah S, Woodward K, Nahmias J, Fox M, Ekong R, Osborne J, Wolfe J, Povey S, Snell RG, Cheadle JP, Jones AC, Tachataki M, Ravine D, Sampson JR, Reeve MP, Richardson P, Wilmer F, Munro C, Hawkins TL, Sepp T, Ali JB, Ward S, Green AJ, Yates JR, Kwiatkowska J, Henske EP, Short MP, Haines JH, Jozwiak S, Kwiatkowski DJ
  Title
Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34.
  Journal
Science 277:805-8 (1997)
DOI:10.1126/science.277.5327.805
  Sequence
[hsa:7248]
Reference
  Authors
Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J
  Title
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.
  Journal
Proc Natl Acad Sci U S A 99:13571-6 (2002)
DOI:10.1073/pnas.202476899
  Sequence
[hsa:7248]

DBGET integrated database retrieval system