KEGG   ORTHOLOGY: K07208Help
Entry
K07208                      KO                                     

Name
RHEB
Definition
Ras homolog enriched in brain
Pathway
ko04072  Phospholipase D signaling pathway
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04218  Cellular senescence
ko04714  Thermogenesis
ko04910  Insulin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko05165  Human papillomavirus infection
ko05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04072 Phospholipase D signaling pathway
    K07208  RHEB; Ras homolog enriched in brain
   04151 PI3K-Akt signaling pathway
    K07208  RHEB; Ras homolog enriched in brain
   04152 AMPK signaling pathway
    K07208  RHEB; Ras homolog enriched in brain
   04150 mTOR signaling pathway
    K07208  RHEB; Ras homolog enriched in brain
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    K07208  RHEB; Ras homolog enriched in brain
  Cell growth and death
   04218 Cellular senescence
    K07208  RHEB; Ras homolog enriched in brain
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K07208  RHEB; Ras homolog enriched in brain
   04919 Thyroid hormone signaling pathway
    K07208  RHEB; Ras homolog enriched in brain
  Aging
   04211 Longevity regulating pathway - mammal
    K07208  RHEB; Ras homolog enriched in brain
  Environmental adaptation
   04714 Thermogenesis
    K07208  RHEB; Ras homolog enriched in brain
 Human Diseases
  Cancers
   05231 Choline metabolism in cancer
    K07208  RHEB; Ras homolog enriched in brain
  Infectious diseases
   05165 Human papillomavirus infection
    K07208  RHEB; Ras homolog enriched in brain
GTP-binding proteins [BR:ko04031]
 Small (Monomeric) G-proteins
  Ras Family
   Rheb
    K07208  RHEB; Ras homolog enriched in brain
BRITE hierarchy
Genes
HSA: 6009(RHEB)
PTR: 463880(RHEB)
PPS: 100974009 100982968(RHEB)
GGO: 101125222(RHEB)
PON: 100447214(RHEB)
NLE: 100598486(RHEB)
MCC: 715378(RHEB)
MCF: 102127243(RHEB)
CSAB: 103227259(RHEB)
RRO: 104678707(RHEB)
RBB: 108523126(RHEB)
CJC: 100410955(RHEB)
SBQ: 101048860(RHEB)
MMU: 19744(Rheb)
RNO: 26954(Rheb)
CGE: 100768233(Rheb)
NGI: 103745322(Rheb)
HGL: 101701441(Rheb)
CCAN: 109685266(Rheb)
OCU: 100348492(RHEB)
TUP: 102502516(RHEB)
CFA: 475545(RHEB)
AML: 100465977(RHEB)
UMR: 103660943(RHEB)
ORO: 101363732(RHEB)
FCA: 101083160(RHEB)
PTG: 102970146(RHEB)
AJU: 106969555(RHEB)
BTA: 528204(RHEB)
BOM: 102267219 102277658(RHEB)
BIU: 109557810(RHEB)
PHD: 102323490
CHX: 100861308(RHEB)
OAS: 100302069(RHEB)
SSC: 100516050(RHEB)
CFR: 102508479(RHEB)
CDK: 105098696(RHEB)
BACU: 103000566(RHEB)
LVE: 103069618 103080271(RHEB)
OOR: 101286490(RHEB)
ECB: 100064440(RHEB)
MYB: 102257160(RHEB)
MYD: 102758475(RHEB)
HAI: 109389671(RHEB)
RSS: 109435170(RHEB)
PALE: 102889101(RHEB)
LAV: 100671462(RHEB)
TMU: 101360739
MDO: 100018870(RHEB)
SHR: 100919006(RHEB)
OAA: 100082482(RHEB)
GGA: 420434(RHEB)
MGP: 100545017(RHEB)
CJO: 107308769(RHEB)
APLA: 101803921(RHEB)
ACYG: 106036836(RHEB)
TGU: 100190126(RHEB)
GFR: 102045581(RHEB)
PHI: 102105874(RHEB)
PMAJ: 107200479(RHEB)
CCW: 104686511(RHEB)
FPG: 101921352(RHEB)
FCH: 102048263(RHEB)
CLV: 102084555(RHEB)
EGZ: 104130996(RHEB)
AAM: 106490276(RHEB)
ASN: 102381385(RHEB)
AMJ: 102567948(RHEB)
PSS: 102461522(RHEB)
CMY: 102932877(RHEB)
CPIC: 101951075(RHEB)
ACS: 100555861(rheb)
PVT: 110071920(RHEB)
PBI: 103051580(RHEB)
GJA: 107123159(RHEB)
XLA: 108719819 380186(rheb.L)
XTR: 548676(rheb)
NPR: 108784341(RHEB)
DRE: 393702(rheb) 767781(rhebl1)
IPU: 100528708(rheb) 108271576(rheb)
TRU: 101063973(rhebl1) 101075993(rheb)
LCO: 104932042(rheb) 104938403(rhebl1) 109142442
NCC: 104941415(rhebl1) 104965680(rheb)
MZE: 101464515(rheb) 101476391
XMA: 102223809(rheb) 102234512
PRET: 103465263(rhebl1) 103479739
NFU: 107383555(rheb) 107385689(rhebl1)
CSEM: 103385951 103396512(rheb)
BPEC: 110153468(rheb) 110168392
ELS: 105017211(rhebl1) 105025720(rheb) 105030778
SFM: 108918197 108928021(rheb)
LCM: 102345677(RHEB) 102353752(RHEBL1)
CMK: 103187038(rheb) 103189260(rhebl1)
CIN: 100179217
SPU: 592590
APLC: 110977369
SKO: 102804111
DME: Dmel_CG1081(Rheb)
DSI: Dsimw501_GD19794(Dsim_GD19794)
MDE: 101896882
AAG: 5570234
AME: 409036(Rheb)
BIM: 100746263
BTER: 100644046
SOC: 105201599
AEC: 105149880
ACEP: 105621587
PBAR: 105432300
HST: 105184632
CFO: 105252603
LHU: 105668462
PGC: 109855242
NVI: 100113870
DPA: 109537728
BMOR: 100127024(Rheb)
PMAC: 106714900
PRAP: 110995865
PXY: 105383012
ZNE: 110836908
DPX: DAPPUDRAFT_198166(Rheb)
TUT: 107367736
CEL: CELE_F54C8.5(rheb-1)
CBR: CBG10088(Cbr-rheb-1)
BMY: Bm1_44625
TSP: Tsp_00127
CRG: 105325148
MYI: 110447426
OBI: 106871992
LAK: 106161031
EPA: 110254731
ADF: 107357711
HMG: 100205860
AQU: 100631568
SCE: YCR027C(RHB1)
KMX: KLMA_10557(rhb1)
NCS: NCAS_0A08470(NCAS0A08470)
NDI: NDAI_0G04930(NDAI0G04930)
TPF: TPHA_0O00870(TPHA0O00870)
TDL: TDEL_0B05600(TDEL0B05600)
PIC: PICST_64341(RHB1)
CAL: CAALFM_C305180WA(RHB1)
CAUR: QG37_00330
SLB: AWJ20_2962(RHB1)
NCR: NCU01444
NTE: NEUTE1DRAFT143897(NEUTE1DRAFT_143897)
SMP: SMAC_07014(rheB)
MGR: MGG_06914
MAW: MAC_02391
MAJ: MAA_11274
CMT: CCM_03942
MBE: MBM_08266
ANI: AN8868.2
ANG: ANI_1_352154(An17g02350)
ABE: ARB_00895
TVE: TRV_00200
SPO: SPBC428.16c(rhb1)
CNE: CNB03660
CNB: CNBB2050
ABP: AGABI1DRAFT115686(AGABI1DRAFT_115686) AGABI1DRAFT15291(AGABI1DRAFT_15291)
ABV: AGABI2DRAFT195039(AGABI2DRAFT_195039)
MGL: MGL_4136
DDI: DDB_G0277041(rheb)
DPP: DICPUDRAFT_147775(rheb)
DFA: DFA_00988(rheb)
PTI: PHATRDRAFT_9927(Ras1)
NGD: NGA_0641500(RHEB)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8543055
  Authors
Gromov PS, Madsen P, Tomerup N, Celis JE
  Title
A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog of rheb.
  Journal
FEBS Lett 377:221-6 (1995)
DOI:10.1016/0014-5793(95)01349-0
  Sequence
[hsa:6009]
Reference
  Authors
Inoki K, Li Y, Xu T, Guan KL
  Title
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
  Journal
Genes Dev 17:1829-34 (2003)
DOI:10.1101/gad.1110003
  Sequence
[hsa:6009]

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