KEGG   ORTHOLOGY: K08014Help
Entry
K08014                      KO                                     

Name
RAPGEF3, EPAC1
Definition
Rap guanine nucleotide exchange factor 3
Pathway
ko04015  Rap1 signaling pathway
ko04024  cAMP signaling pathway
ko04072  Phospholipase D signaling pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04670  Leukocyte transendothelial migration
ko04720  Long-term potentiation
ko04726  Serotonergic synapse
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
   04072 Phospholipase D signaling pathway
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
   04024 cAMP signaling pathway
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
 Organismal Systems
  Immune system
   04670 Leukocyte transendothelial migration
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
  Nervous system
   04726 Serotonergic synapse
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
   04720 Long-term potentiation
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
BRITE hierarchy
Genes
HSA: 10411(RAPGEF3)
PTR: 467198(RAPGEF3)
PPS: 100979763(RAPGEF3)
GGO: 101153785(RAPGEF3)
PON: 100174087(RAPGEF3)
NLE: 100592347(RAPGEF3)
MCC: 703967(RAPGEF3)
MCF: 101865707(RAPGEF3)
CSAB: 103238211(RAPGEF3)
RRO: 104654834(RAPGEF3)
RBB: 108515949(RAPGEF3)
CJC: 100399583(RAPGEF3) 100408048
SBQ: 101043933(RAPGEF3)
MMU: 223864(Rapgef3)
RNO: 59326(Rapgef3)
CGE: 100767619(Rapgef3)
NGI: 103740631(Rapgef3)
HGL: 101711127(Rapgef3)
CCAN: 109691611(Rapgef3)
OCU: 100356363(RAPGEF3)
TUP: 102502265(RAPGEF3)
CFA: 486591(RAPGEF3)
AML: 100473947(RAPGEF3)
UMR: 103675595(RAPGEF3)
ORO: 101371953(RAPGEF3)
FCA: 101085387(RAPGEF3)
PTG: 102966186(RAPGEF3)
AJU: 106969310(RAPGEF3)
BTA: 535383(RAPGEF3)
BOM: 102282215(RAPGEF3)
BIU: 109559177(RAPGEF3)
PHD: 102320480(RAPGEF3)
CHX: 102178145(RAPGEF3)
OAS: 101109786(RAPGEF3)
SSC: 100620989(RAPGEF3)
CFR: 102524040(RAPGEF3)
CDK: 105103807(RAPGEF3)
BACU: 103005728(RAPGEF3)
LVE: 103080613(RAPGEF3)
OOR: 101278657(RAPGEF3)
ECB: 100050541(RAPGEF3)
EPZ: 103546793(RAPGEF3)
EAI: 106836844(RAPGEF3)
MYB: 102257237(RAPGEF3)
MYD: 102768579(RAPGEF3)
RSS: 109456218(RAPGEF3)
PALE: 102895678(RAPGEF3)
LAV: 100655802(RAPGEF3)
TMU: 101344659
SHR: 100925807(RAPGEF3)
GGA: 426888(RAPGEF3)
MGP: 100539538(RAPGEF3)
CJO: 107325717(RAPGEF3)
APLA: 101791788(RAPGEF3)
ACYG: 106047705(RAPGEF3)
GFR: 102039560(RAPGEF3)
FAB: 101814980(RAPGEF3)
PHI: 102110109(RAPGEF3)
PMAJ: 107198895
FPG: 101924930(RAPGEF3)
FCH: 102048878(RAPGEF3)
CLV: 102094087(RAPGEF3)
EGZ: 104132693(RAPGEF3)
AAM: 106485098(RAPGEF3)
ASN: 102381678(RAPGEF3)
AMJ: 102574517(RAPGEF3)
PSS: 102443863(RAPGEF3)
CMY: 102939607
CPIC: 101931835(RAPGEF3)
ACS: 100560594(rapgef3)
PVT: 110071318(RAPGEF3)
PBI: 103063904(RAPGEF3)
GJA: 107109551(RAPGEF3)
XLA: 108708626(rapgef3.L) 108709885(Epac) 733186(rapgef3.S)
XTR: 100491495(rapgef3)
NPR: 108800976(RAPGEF3)
DRE: 101886094(rapgef3)
IPU: 108275659
AMEX: 103025506
TRU: 101068679
LCO: 104919939
MZE: 101480994
OLA: 101158525
XMA: 102222768
PRET: 103467797
NFU: 107390402
CSEM: 103385263
LCF: 108886373
HCQ: 109513787(rapgef3)
BPEC: 110164588
ELS: 105022286
SFM: 108939388
LCM: 102351219
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Gloerich M, Bos JL
  Title
Epac: defining a new mechanism for cAMP action.
  Journal
Annu Rev Pharmacol Toxicol 50:355-75 (2010)
DOI:10.1146/annurev.pharmtox.010909.105714
Reference
PMID:9856955
  Authors
Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, Housman DE, Graybiel AM
  Title
A family of cAMP-binding proteins that directly activate Rap1.
  Journal
Science 282:2275-9 (1998)
DOI:10.1126/science.282.5397.2275
  Sequence
[hsa:10411]

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