KEGG   ORTHOLOGY: K08523Help
Entry
K08523                      KO                                     

Name
HBEGF
Definition
heparin-binding EGF-like growth factor
Pathway
ko01522  Endocrine resistance
ko04012  ErbB signaling pathway
ko04912  GnRH signaling pathway
ko04915  Estrogen signaling pathway
ko04928  Parathyroid hormone synthesis, secretion and action
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05205  Proteoglycans in cancer
ko05219  Bladder cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    K08523  HBEGF; heparin-binding EGF-like growth factor
 Organismal Systems
  Endocrine system
   04912 GnRH signaling pathway
    K08523  HBEGF; heparin-binding EGF-like growth factor
   04915 Estrogen signaling pathway
    K08523  HBEGF; heparin-binding EGF-like growth factor
   04928 Parathyroid hormone synthesis, secretion and action
    K08523  HBEGF; heparin-binding EGF-like growth factor
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    K08523  HBEGF; heparin-binding EGF-like growth factor
   05219 Bladder cancer
    K08523  HBEGF; heparin-binding EGF-like growth factor
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K08523  HBEGF; heparin-binding EGF-like growth factor
  Drug resistance
   01522 Endocrine resistance
    K08523  HBEGF; heparin-binding EGF-like growth factor
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Growth factors/receptors
   K08523  HBEGF; heparin-binding EGF-like growth factor
BRITE hierarchy
Genes
HSA: 1839(HBEGF)
PTR: 735979(HBEGF)
PPS: 100977885(HBEGF)
GGO: 101138938(HBEGF)
PON: 100437870(HBEGF)
NLE: 100600047(HBEGF)
MCC: 695559(HBEGF)
MCF: 102120009(HBEGF)
CSAB: 103244654(HBEGF)
RRO: 104681756(HBEGF)
RBB: 108530840(HBEGF)
CJC: 100392997(HBEGF)
SBQ: 101029484(HBEGF)
MMU: 15200(Hbegf)
RNO: 25433(Hbegf)
CGE: 100689423(Hbegf)
NGI: 103743072(Hbegf)
HGL: 101699647(Hbegf)
CCAN: 109682066(Hbegf)
OCU: 100008809(HBEGF)
TUP: 102498262(HBEGF)
CFA: 607007(HBEGF)
AML: 100467713(HBEGF)
UMR: 103663938(HBEGF)
ORO: 101380289(HBEGF)
FCA: 101093578(HBEGF)
PTG: 102950862(HBEGF)
AJU: 106968439(HBEGF)
BTA: 522921(HBEGF)
BOM: 102283032(HBEGF)
BIU: 109562095(HBEGF)
PHD: 102339878(HBEGF)
CHX: 102185462(HBEGF)
OAS: 101118185(HBEGF)
SSC: 397564(HBEGF)
CFR: 102510168(HBEGF)
CDK: 105098108(HBEGF)
BACU: 102998316(HBEGF)
LVE: 103074900(HBEGF)
OOR: 101272130(HBEGF)
ECB: 100629956(HBEGF)
EPZ: 103548009(HBEGF)
EAI: 106823779(HBEGF)
MYB: 102244188(HBEGF)
MYD: 102751834(HBEGF)
HAI: 109392466(HBEGF)
RSS: 109451856(HBEGF)
PALE: 102882842(HBEGF)
LAV: 100675899(HBEGF)
TMU: 101344556
MDO: 100026152(HBEGF)
SHR: 100933188(HBEGF)
OAA: 100093606(HBEGF)
GGA: 395654(HBEGF)
MGP: 100549227(HBEGF)
CJO: 107320476(HBEGF)
APLA: 101799901(HBEGF)
ACYG: 106042744(HBEGF)
TGU: 100232539(HBEGF)
GFR: 102031792(HBEGF)
FAB: 101808558(HBEGF)
PHI: 102106304(HBEGF)
PMAJ: 107210893(HBEGF)
CCW: 104693556(HBEGF)
FPG: 101923240(HBEGF)
FCH: 102052533(HBEGF)
CLV: 102094772(HBEGF)
EGZ: 104135803(HBEGF)
AAM: 106494293(HBEGF)
ASN: 102372604(HBEGF)
AMJ: 102565343(HBEGF)
PSS: 102455005(HBEGF)
CMY: 102931453(HBEGF)
CPIC: 101934074(HBEGF)
ACS: 100562149(hbegf)
PVT: 110082119(HBEGF)
PBI: 103051348(HBEGF)
GJA: 107119740(HBEGF)
XLA: 108710907(hbegf.L) 108713286(hbegf.S)
XTR: 100497436(hbegf)
DRE: 797938(hbegfa)
IPU: 108268609(HBEGF) 108278919(hbegf)
TRU: 101072713(hbegf)
LCO: 104924202
NCC: 104968122
MZE: 101471223
OLA: 101156096
XMA: 102236217(hbegf)
PRET: 103471128
NFU: 107396576
CSEM: 103391240
LCF: 108882842
HCQ: 109515923
BPEC: 110163727
LCM: 102353749(HBEGF)
CMK: 103186469(hbegf)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1840698
  Authors
Higashiyama S, Abraham JA, Miller J, Fiddes JC, Klagsbrun M
  Title
A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF.
  Journal
Science 251:936-9 (1991)
DOI:10.1126/science.1840698
  Sequence
[hsa:1839]
Reference
  Authors
Iwamoto R, Mekada E
  Title
Heparin-binding EGF-like growth factor: a juxtacrine growth factor.
  Journal
Cytokine Growth Factor Rev 11:335-44 (2000)
DOI:10.1016/S1359-6101(00)00013-7

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