KEGG   ORTHOLOGY: K08845Help
Entry
K08845                      KO                                     

Name
ARAF, ARAF1
Definition
A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04068  FoxO signaling pathway
ko04270  Vascular smooth muscle contraction
ko04650  Natural killer cell mediated cytotoxicity
ko04720  Long-term potentiation
ko04726  Serotonergic synapse
ko04730  Long-term depression
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04914  Progesterone-mediated oocyte maturation
ko04928  Parathyroid hormone synthesis, secretion and action
ko05034  Alcoholism
ko05160  Hepatitis C
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05219  Bladder cancer
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Module
M00687  MAPK (ERK1/2) signaling
Disease
H00523  Noonan syndrome and related disorders
H01738  Noonan syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04012 ErbB signaling pathway
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04068 FoxO signaling pathway
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  Endocrine system
   04910 Insulin signaling pathway
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04914 Progesterone-mediated oocyte maturation
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04928 Parathyroid hormone synthesis, secretion and action
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  Circulatory system
   04270 Vascular smooth muscle contraction
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  Nervous system
   04726 Serotonergic synapse
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04720 Long-term potentiation
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04730 Long-term depression
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05205 Proteoglycans in cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05210 Colorectal cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05212 Pancreatic cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05225 Hepatocellular carcinoma
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05226 Gastric cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05214 Glioma
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05221 Acute myeloid leukemia
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05220 Chronic myeloid leukemia
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05218 Melanoma
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05211 Renal cell carcinoma
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05219 Bladder cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05215 Prostate cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05213 Endometrial cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05224 Breast cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05223 Non-small cell lung cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  Substance dependence
   05034 Alcoholism
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  Infectious diseases
   05160 Hepatitis C
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   01522 Endocrine resistance
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00687  MAPK (ERK1/2) signaling
     K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
BRITE hierarchy
Genes
HSA: 369(ARAF)
PTR: 100614256(ARAF)
PPS: 100990590(ARAF)
GGO: 101134493(ARAF)
PON: 100431871(ARAF)
NLE: 100595311(ARAF)
MCC: 707169(ARAF)
MCF: 101925249(ARAF)
CSAB: 103231895(ARAF)
RRO: 104664593(ARAF)
RBB: 108530908(ARAF)
CJC: 100387961(ARAF)
SBQ: 101043605(ARAF)
MMU: 11836(Araf)
RNO: 64363(Araf)
CGE: 100751432(Araf)
NGI: 103741627(Araf)
HGL: 101723157(Araf)
CCAN: 109696670(Araf)
OCU: 100340437(ARAF)
TUP: 102493239(ARAF)
CFA: 491857(ARAF)
AML: 100475955(ARAF)
UMR: 103664348(ARAF)
ORO: 101372839(ARAF)
FCA: 101089839(ARAF)
PTG: 102956086(ARAF)
BTA: 540421(ARAF)
BOM: 102285079(ARAF)
BIU: 109555027(ARAF)
PHD: 102320566(ARAF)
CHX: 102169370(ARAF)
OAS: 100305131(ARAF)
SSC: 397601(ARAF)
CFR: 102506774(ARAF)
CDK: 105102848(ARAF)
BACU: 103020975(ARAF)
LVE: 103090018(ARAF)
OOR: 101271966(ARAF)
ECB: 100061212(ARAF)
EPZ: 103545299(ARAF)
EAI: 106847984(ARAF)
MYB: 102241454(ARAF)
MYD: 102755690(ARAF)
HAI: 109376563(ARAF)
RSS: 109437463(ARAF)
PALE: 102877877(ARAF)
LAV: 100671404(ARAF)
TMU: 101351589
MDO: 100017615(ARAF)
SHR: 100913901(ARAF)
OAA: 100084423(ARAF)
CPIC: 101949192(ARAF)
ACS: 100562070(araf)
PVT: 110081172(ARAF)
PBI: 103066155(ARAF)
GJA: 107119310(ARAF) 107120717
XLA: 398892(araf.L) 399056(araf.S)
XTR: 100495479(araf)
NPR: 108795925 108801347(ARAF)
DRE: 403063(araf)
IPU: 108255753
AMEX: 103043654(araf)
TRU: 654307(araf)
LCO: 104930864(araf)
NCC: 104953267
MZE: 101471760
OLA: 101159594(araf)
XMA: 102235904
PRET: 103469576
NFU: 107393473(araf)
LCF: 108878154(araf)
HCQ: 109510536
BPEC: 110162179
ELS: 105014388(araf)
SFM: 108931249(araf)
LCM: 102351967
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8020955
  Authors
Lee JE, Beck TW, Brennscheidt U, DeGennaro LJ, Rapp UR
  Title
The complete sequence and promoter activity of the human A-raf-1 gene (ARAF1).
  Journal
Genomics 20:43-55 (1994)
DOI:10.1006/geno.1994.1125
  Sequence
[hsa:369]
Reference
  Authors
Roskoski R Jr
  Title
RAF protein-serine/threonine kinases: structure and regulation.
  Journal
Biochem Biophys Res Commun 399:313-7 (2010)
DOI:10.1016/j.bbrc.2010.07.092

KEGG   ORTHOLOGY: K04365Help
Entry
K04365                      KO                                     

Name
BRAF
Definition
B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04013  MAPK signaling pathway - fly
ko04015  Rap1 signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04068  FoxO signaling pathway
ko04150  mTOR signaling pathway
ko04214  Apoptosis - fly
ko04270  Vascular smooth muscle contraction
ko04320  Dorso-ventral axis formation
ko04510  Focal adhesion
ko04650  Natural killer cell mediated cytotoxicity
ko04720  Long-term potentiation
ko04722  Neurotrophin signaling pathway
ko04726  Serotonergic synapse
ko04730  Long-term depression
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04914  Progesterone-mediated oocyte maturation
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing's syndrome
ko05034  Alcoholism
ko05160  Hepatitis C
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05216  Thyroid cancer
ko05218  Melanoma
ko05219  Bladder cancer
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Module
M00687  MAPK (ERK1/2) signaling
Disease
H00032  Thyroid cancer
H00038  Melanoma
H00523  Noonan syndrome and related disorders
H01512  Langerhans cell histiocytosis
H01738  Noonan syndrome
H01984  Leopard syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04010 MAPK signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04013 MAPK signaling pathway - fly
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04012 ErbB signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04068 FoxO signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04024 cAMP signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04150 mTOR signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
 Cellular Processes
  Cell growth and death
   04214 Apoptosis - fly
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04062 Chemokine signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Endocrine system
   04910 Insulin signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04914 Progesterone-mediated oocyte maturation
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04928 Parathyroid hormone synthesis, secretion and action
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Circulatory system
   04270 Vascular smooth muscle contraction
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Nervous system
   04726 Serotonergic synapse
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04720 Long-term potentiation
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04730 Long-term depression
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04722 Neurotrophin signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Development
   04320 Dorso-ventral axis formation
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05205 Proteoglycans in cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05210 Colorectal cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05212 Pancreatic cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05225 Hepatocellular carcinoma
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05226 Gastric cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05214 Glioma
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05216 Thyroid cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05221 Acute myeloid leukemia
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05220 Chronic myeloid leukemia
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05218 Melanoma
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05211 Renal cell carcinoma
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05219 Bladder cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05215 Prostate cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05213 Endometrial cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05224 Breast cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05223 Non-small cell lung cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Substance dependence
   05034 Alcoholism
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Infectious diseases
   05160 Hepatitis C
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   01522 Endocrine resistance
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00687  MAPK (ERK1/2) signaling
     K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
BRITE hierarchy
Genes
HSA: 673(BRAF)
PTR: 463781(BRAF)
PPS: 100971666(BRAF)
GGO: 101145098(BRAF)
PON: 100442288(BRAF)
NLE: 100582848(BRAF)
MCC: 693554(BRAF)
MCF: 101866436(BRAF)
CSAB: 103227022(BRAF)
RRO: 104659700(BRAF)
RBB: 108541537(BRAF)
CJC: 100403091(BRAF)
SBQ: 101052142(BRAF)
MMU: 109880(Braf)
RNO: 114486(Braf)
CGE: 100771486(Braf)
NGI: 103726107(Braf)
HGL: 101702762(Braf)
OCU: 100351964(BRAF)
TUP: 102477389(BRAF)
CFA: 475526(BRAF)
AML: 100469346(BRAF)
UMR: 103669103(BRAF)
ORO: 101377465(BRAF)
FCA: 101092346(BRAF)
PTG: 102951082(BRAF)
AJU: 106970441(BRAF)
BTA: 536051(BRAF)
BOM: 102278631(BRAF)
BIU: 109557698(BRAF)
PHD: 102329974(BRAF)
CHX: 102174360(BRAF)
OAS: 101107438(BRAF)
SSC: 100514612(BRAF)
CFR: 102524100(BRAF)
CDK: 105091663(BRAF)
BACU: 103002372(BRAF)
LVE: 103079256(BRAF)
OOR: 101277195(BRAF)
ECB: 100065760(BRAF)
EPZ: 103555338(BRAF)
EAI: 106842618(BRAF)
MYB: 102260644(BRAF)
MYD: 102760422(BRAF)
HAI: 109395605(BRAF)
RSS: 109457172(BRAF)
PALE: 102878393(BRAF)
LAV: 100664119(BRAF)
TMU: 101353421
MDO: 100024057(BRAF)
SHR: 100934801(BRAF)
OAA: 100086380(BRAF)
GGA: 396239(BRAF)
MGP: 100550268(BRAF)
CJO: 107315883(BRAF)
APLA: 101794380(BRAF)
ACYG: 106030997(BRAF)
TGU: 100219601(BRAF)
GFR: 102032961(BRAF)
FAB: 101806469(BRAF)
PHI: 102104959(BRAF)
PMAJ: 107204658(BRAF)
CCW: 104696191(BRAF)
FPG: 101919653(BRAF)
FCH: 102056938(BRAF)
CLV: 102088487(BRAF)
EGZ: 104135588(BRAF)
AAM: 106488842(BRAF)
ASN: 102380007(BRAF)
AMJ: 106737102(BRAF)
PSS: 102448997(BRAF)
CMY: 102938595(BRAF)
CPIC: 101945568(BRAF)
ACS: 100556317(braf)
PVT: 110082693(BRAF)
PBI: 103054585(BRAF)
GJA: 107108795(BRAF)
XLA: 398973(braf.S) 447268(braf.L)
XTR: 779570(braf)
NPR: 108793029(BRAF)
DRE: 403065(braf)
SANH: 107655608 107694295(braf)
SGH: 107560707 107594271(braf)
IPU: 108279928(braf)
AMEX: 103036930(braf)
TRU: 653021(braf)
LCO: 104938610(braf) 109142428
NCC: 104967463(braf)
MZE: 101476445(braf)
OLA: 101155814(braf)
XMA: 102231368(braf)
PRET: 103459555(braf)
NFU: 107381355(braf)
CSEM: 103383021(braf)
LCF: 108897545(braf)
HCQ: 109513640(braf)
BPEC: 110162539(braf)
ELS: 105006078(braf)
SFM: 108936526(braf)
LCM: 102365161(BRAF) 102366102
CMK: 103181856(braf)
CIN: 778741(raf1)
SPU: 575613(braf)
APLC: 110986911
SKO: 100370381
DME: Dmel_CG2845(Raf)
DSI: Dsimw501_GD16607(Dsim_phl)
MDE: 101891362
AAG: 5579530
AME: 413448(Raf1)
BIM: 100741263
BTER: 100645437
SOC: 105202082
AEC: 105146178
ACEP: 105623044
HST: 105192683
CFO: 105253402
LHU: 105678021
PGC: 109860595
NVI: 100121496
TCA: 655334(raf)
NVL: 108559414
BMOR: 100529216(raf)
PRAP: 110991813
PXY: 105394443
API: 100169206
DNX: 107170145
ZNE: 110836363
FCD: 110858255
CEL: CELE_Y73B6A.5(lin-45)
CBR: CBG05382(Cbr-lin-45)
BMY: Bm1_40290
TSP: Tsp_05804
OBI: 106874195
LAK: 106171322
SHX: MS3_01526
EPA: 110238451
ADF: 107343857
HMG: 100201878
PMUM: 103334870
MDM: 103419723
MNG: MNEG_0685
SMIN: v1.2.012701.t1(symbB.v1.2.012701.t1) v1.2.019335.t1(symbB.v1.2.019335.t1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2284096
  Authors
Sithanandam G, Kolch W, Duh FM, Rapp UR
  Title
Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies.
  Journal
Oncogene 5:1775-80 (1990)
  Sequence
[hsa:673]
Reference
  Authors
Brennan DF, Dar AC, Hertz NT, Chao WC, Burlingame AL, Shokat KM, Barford D
  Title
A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.
  Journal
Nature 472:366-9 (2011)
DOI:10.1038/nature09860
  Sequence
[hsa:673]

KEGG   ORTHOLOGY: K04366Help
Entry
K04366                      KO                                     

Name
RAF1
Definition
RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04068  FoxO signaling pathway
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04218  Cellular senescence
ko04270  Vascular smooth muscle contraction
ko04360  Axon guidance
ko04370  VEGF signaling pathway
ko04371  Apelin signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04625  C-type lectin receptor signaling pathway
ko04630  Jak-STAT signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04720  Long-term potentiation
ko04722  Neurotrophin signaling pathway
ko04726  Serotonergic synapse
ko04730  Long-term depression
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04912  GnRH signaling pathway
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04917  Prolactin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko04921  Oxytocin signaling pathway
ko04926  Relaxin signaling pathway
ko04928  Parathyroid hormone synthesis, secretion and action
ko05034  Alcoholism
ko05152  Tuberculosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05167  Kaposi's sarcoma-associated herpesvirus infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05219  Bladder cancer
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
Module
M00687  MAPK (ERK1/2) signaling
Disease
H01984  Leopard syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04015 Rap1 signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04010 MAPK signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04012 ErbB signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04370 VEGF signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04371 Apelin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04630 Jak-STAT signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04068 FoxO signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04072 Phospholipase D signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04071 Sphingolipid signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04024 cAMP signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04022 cGMP - PKG signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04151 PI3K-Akt signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04150 mTOR signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  Cell growth and death
   04210 Apoptosis
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04218 Cellular senescence
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04540 Gap junction
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04550 Signaling pathways regulating pluripotency of stem cells
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
 Organismal Systems
  Immune system
   04625 C-type lectin receptor signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04650 Natural killer cell mediated cytotoxicity
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04660 T cell receptor signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04662 B cell receptor signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04664 Fc epsilon RI signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04666 Fc gamma R-mediated phagocytosis
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04062 Chemokine signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  Endocrine system
   04910 Insulin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04912 GnRH signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04915 Estrogen signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04914 Progesterone-mediated oocyte maturation
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04917 Prolactin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04921 Oxytocin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04926 Relaxin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04919 Thyroid hormone signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04928 Parathyroid hormone synthesis, secretion and action
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04916 Melanogenesis
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  Circulatory system
   04270 Vascular smooth muscle contraction
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  Nervous system
   04726 Serotonergic synapse
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04720 Long-term potentiation
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04730 Long-term depression
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04722 Neurotrophin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  Development
   04360 Axon guidance
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05230 Central carbon metabolism in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05231 Choline metabolism in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05206 MicroRNAs in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05205 Proteoglycans in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05210 Colorectal cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05212 Pancreatic cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05225 Hepatocellular carcinoma
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05226 Gastric cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05214 Glioma
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05221 Acute myeloid leukemia
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05220 Chronic myeloid leukemia
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05218 Melanoma
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05211 Renal cell carcinoma
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05219 Bladder cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05215 Prostate cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05213 Endometrial cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05224 Breast cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05223 Non-small cell lung cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  Substance dependence
   05034 Alcoholism
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  Infectious diseases
   05152 Tuberculosis
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05164 Influenza A
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05161 Hepatitis B
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05160 Hepatitis C
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05165 Human papillomavirus infection
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   01522 Endocrine resistance
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00687  MAPK (ERK1/2) signaling
     K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
BRITE hierarchy
Genes
HSA: 5894(RAF1)
PTR: 460182(RAF1)
PPS: 100972902(RAF1)
GGO: 101136454(RAF1)
PON: 100173732(RAF1)
NLE: 100582599(RAF1)
MCC: 694725(RAF1)
MCF: 102125312(RAF1)
CSAB: 103228031(RAF1)
RRO: 104673299(RAF1)
RBB: 108517986(RAF1)
CJC: 100415300(RAF1)
SBQ: 101054052(RAF1)
MMU: 110157(Raf1)
RNO: 24703(Raf1)
CGE: 100769018(Raf1)
NGI: 103751450(Raf1)
HGL: 101721841(Raf1)
CCAN: 109694940(Raf1)
OCU: 100347407(RAF1)
TUP: 102497488(RAF1)
CFA: 484648(RAF1)
AML: 100482255(RAF1)
UMR: 103669540(RAF1)
ORO: 101372149(RAF1)
FCA: 101096047(RAF1)
PTG: 102955852(RAF1)
AJU: 106977129(RAF1)
BTA: 107131151(RAF1) 521196(RAF1)
BOM: 102288216(RAF1)
BIU: 109576053(RAF1)
PHD: 102317072(RAF1)
CHX: 108638619(RAF1)
OAS: 101103190(RAF1)
SSC: 100737448(RAF1)
CFR: 102517521(RAF1)
CDK: 105093099(RAF1)
BACU: 103014337(RAF1)
LVE: 103087933(RAF1)
OOR: 101272984(RAF1)
ECB: 100051110(RAF1)
EPZ: 103554541(RAF1)
EAI: 106829345(RAF1)
MYB: 102254003(RAF1)
MYD: 102772748(RAF1)
HAI: 109384548(RAF1)
RSS: 109447912(RAF1)
PALE: 102893439(RAF1)
LAV: 100655727(RAF1)
TMU: 101357840
MDO: 100015410(RAF1)
SHR: 100935202(RAF1)
OAA: 100089456
GGA: 396245(RAF1)
MGP: 100541264(RAF1)
CJO: 107319673(RAF1)
APLA: 101795633(RAF1)
ACYG: 106040056(RAF1)
TGU: 100218264(RAF1)
GFR: 102034977(RAF1)
FAB: 101816261(RAF1)
PHI: 102103825(RAF1)
PMAJ: 107210130(RAF1)
CCW: 104695743(RAF1)
FPG: 101911761(RAF1)
FCH: 102051503(RAF1)
CLV: 102096788(RAF1)
EGZ: 104124306(RAF1)
AAM: 106488826(RAF1)
ASN: 102374398(RAF1)
AMJ: 102576986(RAF1)
PSS: 102458748(RAF1)
CMY: 102929883(RAF1)
CPIC: 101933019(RAF1)
ACS: 100557613(raf1)
PVT: 110083799(RAF1)
PBI: 103054563(RAF1)
GJA: 107118023(RAF1)
XLA: 397857(raf1.S)
XTR: 549871(raf1)
NPR: 108787573 108792927(RAF1)
DRE: 30716(raf1a) 557109(raf1b)
IPU: 108255012(raf1) 108276324(RAF1)
TRU: 654310(raf1)
LCO: 104940217(raf1)
NCC: 104958741(raf1)
MZE: 101470685(raf1)
OLA: 101173784(raf1)
XMA: 102234445(raf1)
PRET: 103467582(raf1)
NFU: 107391092(raf1)
CSEM: 103385533(raf1)
LCF: 108900163(raf1)
HCQ: 109507267(raf1)
BPEC: 110164922(raf1)
SASA: 100136351(raf1) 106566757(RAF1a) 106571905(RAF1b)
ELS: 105013076(raf1) 105029139
SFM: 108925552 108929807(raf1)
LCM: 102357545(RAF1)
CMK: 103185022(raf1)
PPP: 112292929
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3003687
  Authors
Bonner TI, Oppermann H, Seeburg P, Kerby SB, Gunnell MA, Young AC, Rapp UR
  Title
The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene.
  Journal
Nucleic Acids Res 14:1009-15 (1986)
DOI:10.1093/nar/14.2.1009
  Sequence
[hsa:5894]
Reference
  Authors
Chen J, Fujii K, Zhang L, Roberts T, Fu H
  Title
Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism.
  Journal
Proc Natl Acad Sci U S A 98:7783-8 (2001)
DOI:10.1073/pnas.141224398

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