KEGG ORTHOLOGY: K14001

ORTHOLOGY: K14001

Entry

K14001                      KO

Symbol

SIL1, SLS1

Name

nucleotide exchange factor SIL1

Pathway

map04141

Protein processing in endoplasmic reticulum

Disease

H01284

Marinesco-Sjogren syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K14001  SIL1, SLS1; nucleotide exchange factor SIL1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K14001  SIL1, SLS1; nucleotide exchange factor SIL1
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Proteins involved in Fe-S cluster biogenesis
    K14001  SIL1, SLS1; nucleotide exchange factor SIL1

Genes

HSA:	64374(SIL1)

PTR:	747459(SIL1)

PPS:	100984527(SIL1)

GGO:	101128584(SIL1)

PON:	100459383(SIL1)

NLE:	100580727(SIL1)

HMH:	116471563(SIL1)

MCC:	714762(SIL1)

MCF:	102134370(SIL1)

MTHB:

126957317

MNI:	105467071(SIL1)

CSAB:

103244629(SIL1)

CATY:

105599851(SIL1)

PANU:

101022209(SIL1)

TGE:	112626615(SIL1)

MLEU:

105551827(SIL1)

RRO:	104681734(SIL1)

RBB:	108541686(SIL1)

TFN:	117065789(SIL1)

PTEH:

111528592(SIL1)

CANG:

105506985(SIL1)

CJC:	100389735(SIL1)

SBQ:	101037829(SIL1)

CIMI:

108284245 108310057

CSYR:

103258763(SIL1) 103262302

MMUR:

105862513(SIL1)

LCAT:

123637829(SIL1)

PCOQ:

105812015(SIL1)

OGA:	100959806(SIL1)

MMU:	81500(Sil1)

MCAL:

110284669(Sil1)

MPAH:

110333136(Sil1)

RNO:	291673(Sil1)

MCOC:

116086992(Sil1)

ANU:	117720155(Sil1)

MUN:	110554087(Sil1)

CGE:	100751151(Sil1)

MAUA:

101836579(Sil1)

PROB:

127235100(Sil1)

PLEU:

114705103(Sil1)

MORG:

121443007 121453333

MFOT:

126497147

AAMP:

119815578(Sil1)

NGI:	103735150(Sil1)

HGL:	101716450(Sil1)

CPOC:

100722382(Sil1)

CCAN:

109681361(Sil1)

DORD:

105988739(Sil1)

DSP:	122118126(Sil1)

PLOP:

125340188(Sil1)

NCAR:

124987162

MMMA:

107151162(Sil1)

OCU:

100347643

OPI:	101518225(SIL1)

TUP:	102484648 102502830

GVR:

103608450

CFA:	474699(SIL1)

CLUD:

112649694(SIL1)

VVP:	112921973(SIL1)

VLG:	121495727(SIL1)

NPO:	129494806(SIL1)

AML:	100476109(SIL1)

UMR:	103663776(SIL1)

UAH:	113261798(SIL1)

UAR:	123790300(SIL1)

ELK:

111141025

LLV:

125100017

MPUF:

101672571(SIL1)

MNP:	132028560(SIL1)

MLK:	131832103(SIL1)

NVS:	122891084(SIL1)

ORO:	101362901(SIL1)

EJU:	114209611(SIL1)

ZCA:	113929794(SIL1)

MLX:	118016691(SIL1)

NSU:	110590987(SIL1)

LWW:	102734796(SIL1)

FCA:	101089979(SIL1)

PYU:	121010781(SIL1)

PCOO:

112861112(SIL1)

PBG:	122487994(SIL1)

PVIV:

125150573(SIL1)

LRUF:

124516206

PTG:	102970974(SIL1)

PPAD:

109252142(SIL1)

PUC:

125935558

AJU:

106967922

HHV:	120245623(SIL1)

BTA:	520650(SIL1)

BOM:	102276485(SIL1)

BIU:

109561079

BBUB:

102396125(SIL1)

BBIS:

104996178(SIL1)

CHX:	102190218(SIL1)

OAS:	101112978(SIL1)

BTAX:

128050272(SIL1)

ODA:	120863597(SIL1)

CCAD:

122439859(SIL1)

MBEZ:

129559470(SIL1)

SSC:	100626868(SIL1)

CFR:	102524000(SIL1)

CBAI:

105082176(SIL1)

CDK:	105090764(SIL1)

VPC:

102531529

BACU:

103018076(SIL1)

BMUS:

118892138(SIL1)

LVE:	103069393(SIL1)

OOR:	101269667(SIL1)

DLE:	111182506(SIL1)

PCAD:

102980465(SIL1) 114485282

PSIU:

116751548(SIL1)

NASI:

112404408(SIL1)

ECB:	100072543(SIL1)

EPZ:	103551342(SIL1)

EAI:	106839223(SIL1)

MYB:	102261850(SIL1)

MYD:	102758126(SIL1)

MMYO:

118657611(SIL1)

MLF:	102437566(SIL1)

PKL:	118711646(SIL1)

EFUS:

103286226(SIL1)

MNA:	107530132(SIL1)

DRO:	112318182(SIL1)

SHON:

118997659(SIL1)

AJM:	119051038(SIL1)

PDIC:

114509470(SIL1)

PHAS:

123808737(SIL1)

MMF:	118615833(SIL1)

PPAM:

129066645(SIL1)

HAI:	109392490(SIL1)

RFQ:	117016546(SIL1)

PALE:

102891254(SIL1)

PGIG:

120581363(SIL1)

PVP:	105306946(SIL1)

RAY:	107518706(SIL1)

MJV:	108405118(SIL1)

TOD:	119243416(SIL1)

SARA:

101545946(SIL1)

SETR:

126027036(SIL1)

LAV:	100669245(SIL1)

TMU:

101361880

ETF:	101641869(SIL1)

DNM:	101444582(SIL1)

MDO:	100025398(SIL1)

GAS:	123237571(SIL1)

SHR:	100925743(SIL1)

AFZ:

127549970

PCW:	110220865(SIL1)

OAA:	114807380(SIL1)

GGA:	416185(SIL1)

PCOC:

116231962(SIL1)

MGP:	100550865(SIL1)

CJO:	107320309(SIL1)

TPAI:

128081555(SIL1)

LMUT:

125700465(SIL1)

NMEL:

110405550(SIL1)

APLA:

101796384(SIL1)

ACYG:

106034352(SIL1)

CATA:

118256136(SIL1)

AFUL:

116494783(SIL1)

TGU:	100232187(SIL1)

LSR:	110478307(SIL1)

SCAN:

103823782(SIL1)

PMOA:

120497673(SIL1)

OTC:	121343100(SIL1)

PRUF:

121354949(SIL1)

GFR:	102032406(SIL1) 102045431

FAB:	101810820(SIL1)

OMA:	130258635(SIL1)

PHI:	102108661 102109744(SIL1)

PMAJ:

107198703 107210794

CCAE:

111935694(SIL1)

CCW:	104696051(SIL1)

CBRC:

103618356(SIL1)

ETL:	114065806(SIL1)

ZAB:	102073486(SIL1)

SVG:	106861318(SIL1)

MMEA:

130580910(SIL1)

HRT:	120759401(SIL1)

FPG:	101913077(SIL1)

FCH:	102054198(SIL1)

CLV:	102095260(SIL1)

EGZ:	104121760(SIL1)

NNI:	104016565(SIL1)

PCRI:

104033991(SIL1)

PLET:

104617285

EHS:	104510428(SIL1)

PCAO:

104041607(SIL1)

ACUN:

113485420(SIL1)

TALA:

104364655(SIL1)

PADL:

103921954(SIL1)

AFOR:

103893897(SIL1)

ACHC:

115334224(SIL1)

HALD:

104316556(SIL1)

HLE:	104839050(SIL1)

AGEN:

126050913

GCL:

127021888

CCRI:

104164441(SIL1)

CSTI:

104556403(SIL1)

MUI:	104539931(SIL1)

BREG:

104636537(SIL1)

FGA:	104074174(SIL1)

GSTE:

104264605(SIL1)

OHA:	104338328(SIL1)

NNT:

104411867

SHAB:

115616103(SIL1)

DPUB:

104305413(SIL1)

PGUU:

104471394(SIL1)

CPEA:

104390751(SIL1)

AVIT:

104276659(SIL1)

CVF:	104282611(SIL1)

RTD:	128916274(SIL1)

CUCA:

104065715(SIL1)

TEO:	104377392(SIL1)

AAM:	106488083(SIL1)

AROW:

112968412(SIL1)

NPD:	112944359(SIL1)

TGT:	104578913(SIL1)

DNE:	112981819(SIL1)

SCAM:

104154033(SIL1)

ASN:	102374365(SIL1)

AMJ:	102564894(SIL1)

CPOO:

109309932(SIL1)

GGN:	109290166(SIL1)

PSS:	102461286(SIL1)

CMY:	102947819(SIL1)

CCAY:

125641049(SIL1)

DCC:	119860265(SIL1)

CPIC:

101948987(SIL1)

TST:	117881355(SIL1)

CABI:

116824421(SIL1)

MRV:	120370508(SIL1)

ACS:	100567374(sil1)

ASAO:

132781874(SIL1)

PVT:	110076133(SIL1)

SUND:

121918937(SIL1)

PBI:	103050867(SIL1)

PMUR:

107289866(SIL1)

CTIG:

120318887(SIL1)

TSR:	106547227(SIL1)

PGUT:

117674323(SIL1)

APRI:

131196942(SIL1)

PTEX:

113442706(SIL1)

NSS:

113412753

VKO:	123030403(SIL1)

PMUA:

114593629(SIL1)

PRAF:

128409952(SIL1)

ZVI:	118082527(SIL1)

HCG:	128340151(SIL1)

GJA:	107110258(SIL1)

STOW:

125434478(SIL1)

EMC:	129340643(SIL1)

XLA:	414657(sil1.L)

XTR:	100124924(sil1)

MUO:	115476562(SIL1)

GSH:	117351806(SIL1)

DRE:	568308(si:ch211-195b11.7)

SRX:	107740135 107742487

SANH:

107680335 107680960

SGH:	107554832 107580120

CCAR:

109056714 109087938

CAUA:

113075398 113078522 113114129

CGIB:

127971565 128027455

PTET:

122358109(sil1)

LROH:

127176368(sil1)

OMC:	131552979(sil1)

PPRM:

120466276 120466309

RKG:	130103931(sil1)

MAMB:

125258683(sil1)

CIDE:

127494786

MASI:

127412978

TROS:

130563486(sil1)

TDW:	130437626(sil1)

MANU:

129422963(sil1)

IPU:

108268829

IFU:	128611787(sil1)

PHYP:

113542762(sil1)

SMEO:

124386051(sil1)

TFD:	113635940(sil1)

TVC:	132855791(sil1)

AMEX:

103036316(sil1)

CMAO:

118807231(sil1)

EEE:	113590584(sil1)

CHAR:

105908145(sil1)

TRU:	101063920(sil1)

TFS:	130531792(sil1)

TNG:	GSTEN00012053G001

LCO:	104934871(sil1)

NCC:	104959897(sil1)

TBEN:

117470862(sil1)

CGOB:

115014717(sil1)

PGEO:

117454408(sil1)

GACU:

117550426(sil1)

EMAC:

134860179(sil1)

ELY:	117260672(sil1)

EFO:	125894918(sil1)

PLEP:

121948217(sil1)

SLUC:

116064448(sil1)

ECRA:

117951525(sil1)

ESP:	116697091(sil1)

PFLV:

114562864(sil1)

GAT:	120817119(sil1)

PPUG:

119210866(sil1)

AFB:	129090133(sil1)

CLUM:

117737878(sil1)

PSWI:

130209744(sil1)

MSAM:

119888152(sil1)

SCHU:

122880746(sil1)

CUD:	121516402(sil1)

ALAT:

119007851(sil1)

MZE:	101475354(sil1)

ONL:	100691567(sil1)

OAU:	116315371(sil1)

OLA:	101169618(sil1)

OML:	112137815(sil1)

CSAI:

133447308 133447707

XMA:	102217448(sil1)

XCO:	114153105(sil1)

XHE:	116714179(sil1)

PRET:

103470986(sil1)

PFOR:

103131634 103156532

PLAI:

106938199 106938780

PMEI:

106908706(sil1)

GAF:	122837043(sil1)

PPRL:

129353874(sil1)

CVG:	107100412(sil1)

CTUL:

119777237(sil1)

GMU:	124860103(sil1)

NFU:	107386503(sil1)

KMR:	108240009(sil1)

ALIM:

106530993(sil1)

NWH:	119408334(sil1)

AOCE:

111578724(sil1)

MCEP:

125007981(sil1)

CSEM:

103391475(sil1)

POV:	109623982(sil1)

SSEN:

122778024(sil1)

HHIP:

117769696(sil1)

HSP:	118112769(sil1)

SMAU:

118319967(sil1)

LCF:

108895528

SDU:	111230379(sil1)

SLAL:

111663560(sil1)

XGL:	120785560(sil1)

BPEC:

110158947(sil1)

MALB:

109966465(sil1)

BSPL:

114864561(sil1)

SJO:	128363490(sil1)

SASA:

106604943 106611970(sil1)

STRU:

115174834 115205448(sil1)

OTW:	112220691 112256045

OMY:	110488567 110504777

OGO:	123994033 124010836

ONE:	115129305(sil1) 115131131

OKI:	109864790 109905051(sil1)

OKE:	118363337 118375440

SALP:

111965358 111967342(sil1)

SNH:	120048227 120062542

CCLU:

123492842(sil1)

ELS:	105027182(sil1)

SFM:	108923202(sil1)

PKI:	111835058(sil1)

AANG:

118224167(sil1)

LOC:	102683658(sil1)

PSPA:

121308020(sil1)

ARUT:

117431679 117973774

PSEX:

120543407(sil1)

LCM:	102345334(SIL1)

CMK:	103177284(sil1)

RTP:	109914872(sil1)

CPLA:

122556812(sil1)

HOC:	132823330(sil1)

LERI:

129701450(sil1)

PMRN:

116947169(SIL1)

LRJ:	133359967(SIL1)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

SKO:

DME:	Dmel_CG10420(Sil1)

DER:

6555382

DSE:

6619681

DSI:	Dsimw501_GD18223(Dsim_GD18223)

DYA:	Dyak_GE10724

DAN:

DSR:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI23669

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:	101889087 131803063

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ012670

CPII:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:	115881288 115891896

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM446250

FOC:

TPAL:

ZNE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_230313

DMK:

DPZ:

PVM:

PJA:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

TCF:

DSV:

RSAN:

RMP:

VDE:

VJA:

DPTE:

DFR:

CSCU:

PTEP:

SDM:

LPOL:

PMEO:

HRO:	HELRODRAFT_194324

LGI:	LOTGIDRAFT_237555

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_180180

OVI:	T265_03040

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_61500

AQU:

100633949

SCE:	YOL031C(SIL1)

SEUB:

DI49_2369

SPAO:

SPAR_O01180

AGO:	AGOS_AEL340W

ERC:

Ecym_2628

KLA:	KLLA0_F07931g

KMX:	KLMA_20353(SIL1)

LTH:	KLTH0D02750g

VPO:	Kpol_206p1

ZRO:	ZYRO0D05764g

CGR:	CAGL0F01089g

NCS:	NCAS_0I00540(NCAS0I00540)

NDI:	NDAI_0A08490(NDAI0A08490)

TPF:	TPHA_0H02570(TPHA0H02570)

TBL:	TBLA_0A04780(TBLA0A04780)

TGB:	HG536_0F03680

TDL:	TDEL_0H03520(TDEL0H03520)

KAF:	KAFR_0D01300(KAFR0D01300)

KNG:	KNAG_0L00600(KNAG0L00600)

ZMK:	HG535_0E03020

PPA:	PAS_chr1-1_0237

DHA:	DEHA2C15664g

PIC:	PICST_57312

PGU:	PGUG_01003 PGUG_01004

SPAA:

SPAPADRAFT_59237

LEL:	PVL30_002550(SIL1)

CAL:	CAALFM_CR08350WA(CaO19.6403)

CTP:	CTRG_03090

COT:	CORT_0G02300

CDU:	CD36_33940

CTEN:

CANTEDRAFT_113470

YLI:	YALI0E32703g

CLU:	CLUG_00917

CLUS:

A9F13_10g01991

CAUR:

CJI96_0003790

SLB:	AWJ20_3472(SIL1)

PKZ:	C5L36_0C03220

BNN:	FOA43_002605

BBRX:

BRETT_000166

OPA:	HPODL_00969

NCR:

NCU00968

NTE:	NEUTE1DRAFT71556(NEUTE1DRAFT_71556)

SMP:	SMAC_00245

PAN:	PODANSg4140

PBEL:

PPSD:

PPSP:

PPSA:

TTT:	THITE_2112292

MTM:	MYCTH_2296861

CTHR:

MGR:

PGRI:

SSCK:

FGR:	FGSG_01169

FPU:	FPSE_02598

FPOA:

FPOAC1_001255

FVN:	FVRRES_01443

FVR:	FVEG_01294

FOX:	FOXG_17835

NHE:	NECHADRAFT_74599

FFC:	NCS54_00068800

FKR:	NCS57_00067000

FMU:	J7337_000725

TRE:	TRIREDRAFT_22560

TRR:	M419DRAFT_137683

MAW:

MAJ:

PCHM:

CMT:

AMUS:

PLJ:	VFPFJ_03465

PTKZ:

JDV02_001595(SIL1)

VAL:	VDBG_06160

VDA:	VDAG_03318

CFJ:	CFIO01_10943

CLUP:

CLUP02_12232

CHIG:

CH63R_11647

PFY:	PFICI_01806

SSL:	SS1G_01707

BFU:	BCIN_02g03430

MBE:

MBM_02246

PSCO:

LY89DRAFT_700408

GLZ:	GLAREA_08746

MBR:	MONBRDRAFT_34124

PTI:	PHATRDRAFT_44879

FCY:	FRACYDRAFT_264163

TPS:	THAPSDRAFT_25599

PIF:	PITG_05672

PSOJ:

PHYSODRAFT_324781

SPAR:

SPRG_07521

» show all

Reference

PMID:19801575

Authors

Zhao L, Rosales C, Seburn K, Ron D, Ackerman SL

Title

Alteration of the unfolded protein response modifies neurodegeneration in a mouse model of Marinesco-Sjogren syndrome.

Journal

Hum Mol Genet 19:25-35 (2010)
DOI:10.1093/hmg/ddp464

Sequence

[mmu:81500]

Reference

PMID:12356756

Authors

Chung KT, Shen Y, Hendershot LM

Title

BAP, a mammalian BiP-associated protein, is a nucleotide exchange factor that regulates the ATPase activity of BiP.

Journal

J Biol Chem 277:47557-63 (2002)
DOI:10.1074/jbc.M208377200

Sequence

[hsa:64374]

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   KEGG DISEASE (1)   
Gene (1437)   
   KEGG GENES (700)   
   KEGG MGENES (124)   
   RefGene (603)   
   OC (10)   
Literature (2)   
   PubMed (2)   
All databases (1444)   

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