KEGG   PATHWAY: ko00053Help
Entry
ko00053                     Pathway                                

Name
Ascorbate and aldarate metabolism
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Ascorbate and aldarate metabolism
ko00053

All organismsOrtholog table
Module
M00114  
Ascorbate biosynthesis, plants, glucose-6P => ascorbate [PATH:ko00053]
M00129  
Ascorbate biosynthesis, animals, glucose-1P => ascorbate [PATH:ko00053]
M00283  
PTS system, ascorbate-specific II component [PATH:ko00053]
M00550  
Ascorbate degradation, ascorbate => D-xylulose-5P [PATH:ko00053]
Other DBs
BSID: 
GO: 
Orthology
K00012  
UDPglucose 6-dehydrogenase [EC:1.1.1.22]
K12447  
UDP-sugar pyrophosphorylase [EC:2.7.7.64]
K16190  
glucuronokinase [EC:2.7.1.43]
K00699  
glucuronosyltransferase [EC:2.4.1.17]
K00469  
inositol oxygenase [EC:1.13.99.1]
K01053  
gluconolactonase [EC:3.1.1.17]
K00103  
L-gulonolactone oxidase [EC:1.1.3.8]
K10046  
GDP-D-mannose 3', 5'-epimerase [EC:5.1.3.- 5.1.3.18]
K14190  
GDP-L-galactose phosphorylase [EC:2.7.7.69]
K10047  
inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase [EC:3.1.3.93 3.1.3.25]
K18649  
inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase [EC:3.1.3.15 3.1.3.93 3.1.3.25]
K00064  
D-threo-aldose 1-dehydrogenase [EC:1.1.1.122]
K17744  
L-galactose dehydrogenase [EC:1.1.1.316]
K00225  
L-galactono-1,4-lactone dehydrogenase [EC:1.3.2.3]
K05276  
L-galactonolactone oxidase [EC:1.3.3.12]
K02821  
PTS system, ascorbate-specific IIA component [EC:2.7.1.69]
K02822  
PTS system, ascorbate-specific IIB component [EC:2.7.1.69]
K03475  
PTS system, ascorbate-specific IIC component
K03476  
L-ascorbate 6-phosphate lactonase [EC:3.1.1.-]
K03078  
3-dehydro-L-gulonate-6-phosphate decarboxylase [EC:4.1.1.85]
K03079  
L-ribulose-5-phosphate 3-epimerase [EC:5.1.3.22]
K03077  
L-ribulose-5-phosphate 4-epimerase [EC:5.1.3.4]
K08232  
monodehydroascorbate reductase (NADH) [EC:1.6.5.4]
K00423  
L-ascorbate oxidase [EC:1.10.3.3]
K00434  
L-ascorbate peroxidase [EC:1.11.1.11]
K08092  
3-dehydro-L-gulonate 2-dehydrogenase [EC:1.1.1.130]
K00880  
L-xylulokinase [EC:2.7.1.53]
K00128  
aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
K14085  
aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.3 1.2.1.8 1.2.1.31]
K00149  
aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.3 1.2.1.47]
K01706  
glucarate dehydratase [EC:4.2.1.40]
K01630  
2-dehydro-3-deoxyglucarate aldolase [EC:4.1.2.20]
K13873  
L-arabinose 1- dehydrogenase [EC:1.1.1.46]
K13874  
L-arabinonolactonase [EC:3.1.1.15]
K13875  
L-arabonate dehydrase [EC:4.2.1.25]
K13876  
2-keto-3-deoxy-L-arabinonate dehydratase [EC:4.2.1.43]
K13877  
alpha-ketoglutaric semialdehyde dehydrogenase [EC:1.2.1.26]
K01707  
5-dehydro-4-deoxyglucarate dehydratase [EC:4.2.1.41]
K01708  
galactarate dehydratase [EC:4.2.1.42]
Compound
C00022  
Pyruvate
C00026  
2-Oxoglutarate
C00029  
UDP-glucose
C00072  
Ascorbate
C00096  
GDP-mannose
C00137  
myo-Inositol
C00167  
UDP-glucuronate
C00191  
D-Glucuronate
C00231  
D-Xylulose 5-phosphate
C00259  
L-Arabinose
C00333  
D-Galacturonate
C00433  
2,5-Dioxopentanoate
C00545  
L-Arabinonate
C00618  
3-Dehydro-L-gulonate
C00679  
5-Dehydro-4-deoxy-D-glucarate
C00684  
2-Dehydro-3-deoxy-L-arabinonate
C00800  
L-Gulonate
C00818  
D-Glucarate
C00879  
D-Galactarate
C01040  
L-Gulono-1,4-lactone
C01041  
Monodehydroascorbate
C01101  
L-Ribulose 5-phosphate
C01114  
L-Arabinono-1,4-lactone
C01115  
L-Galactono-1,4-lactone
C01146  
2-Hydroxy-3-oxopropanoate
C01620  
Threonate
C01825  
L-Galactose
C02280  
GDP-L-galactose
C02670  
D-Glucuronolactone
C03064  
3-Dehydro-L-threonate
C03289  
L-xylo-Hexulonolactone
C03291  
L-Xylulose 5-phosphate
C03826  
2-Dehydro-3-deoxy-D-xylonate
C03921  
2-Dehydro-3-deoxy-D-glucarate
C04575  
(4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  
D-Glucuronate 1-phosphate
C05406  
5-Hydroxy-2,4-dioxopentanoate
C05411  
L-Xylonate
C05412  
L-Lyxonate
C05422  
Dehydroascorbate
C14899  
3-Dehydro-L-gulonate 6-phosphate
C15923  
L-Gulose
C15924  
L-Gulose 1-phosphate
C15925  
GDP-L-gulose
C15926  
beta-L-Galactose 1-phosphate
C15930  
L-Galactonate
C16186  
L-Ascorbate 6-phosphate
Reference
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
Reference
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
Reference
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
Reference
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
Reference
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
Reference
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
Reference
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)

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