KEGG   PATHWAY: ko00053Help
Entry
ko00053                     Pathway                                

Name
Ascorbate and aldarate metabolism
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
ko00053  Ascorbate and aldarate metabolism
ko00053

Ortholog table
Module
M00114  Ascorbate biosynthesis, plants, glucose-6P => ascorbate [PATH:ko00053]
M00129  Ascorbate biosynthesis, animals, glucose-1P => ascorbate [PATH:ko00053]
M00283  PTS system, ascorbate-specific II component [PATH:ko00053]
M00550  Ascorbate degradation, ascorbate => D-xylulose-5P [PATH:ko00053]
Other DBs
BSID: 293
GO: 0019852 0019572
Orthology
K00012  UDPglucose 6-dehydrogenase [EC:1.1.1.22]
K12447  UDP-sugar pyrophosphorylase [EC:2.7.7.64]
K16190  glucuronokinase [EC:2.7.1.43]
K00699  glucuronosyltransferase [EC:2.4.1.17]
K00469  inositol oxygenase [EC:1.13.99.1]
K01053  gluconolactonase [EC:3.1.1.17]
K00103  L-gulonolactone oxidase [EC:1.1.3.8]
K10046  GDP-D-mannose 3', 5'-epimerase [EC:5.1.3.- 5.1.3.18]
K14190  GDP-L-galactose phosphorylase [EC:2.7.7.69]
K10047  inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase [EC:3.1.3.93 3.1.3.25]
K18649  inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase [EC:3.1.3.15 3.1.3.93 3.1.3.25]
K00064  D-threo-aldose 1-dehydrogenase [EC:1.1.1.122]
K17744  L-galactose dehydrogenase [EC:1.1.1.316]
K00225  L-galactono-1,4-lactone dehydrogenase [EC:1.3.2.3]
K19642  D-galacturonate reductase [EC:1.1.1.365]
K02821  PTS system, ascorbate-specific IIA component [EC:2.7.1.194]
K02822  PTS system, ascorbate-specific IIB component [EC:2.7.1.194]
K03475  PTS system, ascorbate-specific IIC component
K03476  L-ascorbate 6-phosphate lactonase [EC:3.1.1.-]
K03078  3-dehydro-L-gulonate-6-phosphate decarboxylase [EC:4.1.1.85]
K03079  L-ribulose-5-phosphate 3-epimerase [EC:5.1.3.22]
K03077  L-ribulose-5-phosphate 4-epimerase [EC:5.1.3.4]
K08232  monodehydroascorbate reductase (NADH) [EC:1.6.5.4]
K00434  L-ascorbate peroxidase [EC:1.11.1.11]
K21888  glutathione dehydrogenase/transferase [EC:2.5.1.18 1.8.5.1]
K00423  L-ascorbate oxidase [EC:1.10.3.3]
K08092  3-dehydro-L-gulonate 2-dehydrogenase [EC:1.1.1.130]
K00880  L-xylulokinase [EC:2.7.1.53]
K00128  aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
K14085  aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.3 1.2.1.8 1.2.1.31]
K00149  aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.3 1.2.1.47]
K01706  glucarate dehydratase [EC:4.2.1.40]
K01630  2-dehydro-3-deoxyglucarate aldolase [EC:4.1.2.20]
K13873  L-arabinose 1-dehydrogenase [EC:1.1.1.376]
K19660  L-arabinose 1-dehydrogenase [NAD(P)+] [EC:1.1.1.376]
K13874  L-arabinonolactonase [EC:3.1.1.15]
K13875  L-arabonate dehydrase [EC:4.2.1.25]
K13876  2-keto-3-deoxy-L-arabinonate dehydratase [EC:4.2.1.43]
K13877  2,5-dioxopentanoate dehydrogenase [EC:1.2.1.26]
K19588  2,5-dioxopentanoate dehydrogenase [EC:1.2.1.26]
K01707  5-dehydro-4-deoxyglucarate dehydratase [EC:4.2.1.41]
K01708  galactarate dehydratase [EC:4.2.1.42]
K20023  L-talarate/galactarate dehydratase [EC:4.2.1.42 4.2.1.156]
K18981  uronate dehydrogenase [EC:1.1.1.203]
K18982  D-galactarolactone isomerase [EC:5.4.1.4]
K18983  D-galactarolactone cycloisomerase [EC:5.5.1.27]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00618  3-Dehydro-L-gulonate
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
Reference
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003

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