KEGG   PATHWAY: ko00100Help
Entry
ko00100                     Pathway                                

Name
Steroid biosynthesis
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
ko00100  Steroid biosynthesis
ko00100

Ortholog table
Module
M00101  Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol [PATH:ko00100]
M00102  Ergocalciferol biosynthesis [PATH:ko00100]
M00103  Cholecalciferol biosynthesis [PATH:ko00100]
Disease
H00148  Lysosomal acid lipase deficiency
H00161  Smith-Lemli-Opitz syndrome
H00496  Congenital hemidysplasia with ichthyosiform nevus and limb defects (CHILD)
H00617  Desmosterolosis
H01143  Vitamin D-dependent rickets
H01194  X-linked chondrodysplasia punctata
H01281  Lathosterolosis
H01371  Hypercalcemia infantile
H01917  CK syndrome
Drug
D00282  Clotrimazole (JP17/USP/INN)
D00322  Fluconazole (JP17/USAN/INN)
D00350  Itraconazole (JP17/USAN)
D00351  Ketoconazole (JP17/USP)
D00381  Tolnaftate (JP17/USP/INN)
D00416  Miconazole (JP17/USP/INN)
D00578  Voriconazole (JP17/USAN/INN)
D00880  Butoconazole nitrate (USP)
D00881  Econazole nitrate (JAN/USP)
D00882  Miconazole nitrate (JP17/USP)
D00883  Naftifine hydrochloride (USP)
D00885  Oxiconazole nitrate (JAN/USAN)
D00886  Sulconazole nitrate (JAN/USP)
D00888  Terconazole (USAN/INN)
D00890  Tioconazole (JAN/USP/INN)
D01092  Lanoconazole (JAN/INN)
D01093  Butenafine hydrochloride (JP17/USAN)
D01384  Tolciclate (JAN/USAN/INN)
D01429  Fosfluconazole (JAN/INN)
D01480  Isoconazole nitrate (JAN)
D01550  Liranaftate (JAN/INN)
D01620  Neticonazole hydrochloride (JAN)
D01664  Omoconazole nitrate (JAN/USAN)
D01720  Amorolfine hydrochloride (JAN)
D01775  Bifonazole (JP17/USAN/INN)
D02169  Croconazole hydrochloride (JP17)
D02219  Terbinafine hydrochloride (JP17/USP)
D02375  Terbinafine (USAN/INN)
D02555  Posaconazole (JAN/USAN/INN)
D02556  Ravuconazole (prop.INN)
D02557  Chlormidazole (INN)
D02582  Fenticonazole (INN)
D02583  Fenticonazole nitrate (USAN)
D02584  Aliconazole (INN)
D02585  Vibunazole
D02923  Amorolfine (USAN/INN)
D03025  Azalanstat dihydrochloride (USAN)
D03526  Cisconazole (USAN/INN)
D03936  Econazole (USAN/INN)
D04624  Isoconazole (USAN/INN)
D06630  Pramiconazole (USAN/INN)
D07596  Butenafine (INN)
D07598  Butoconazole (INN)
D07676  Chlormidazole hydrochloride
D07752  Croconazole (INN)
D08245  Naftifine (INN)
D08296  Omoconazole (INN)
D08313  Oxiconazole (INN)
D08535  Sulconazole (INN)
Other DBs
BSID: 298
GO: 0016126
Orthology
K00801  farnesyl-diphosphate farnesyltransferase [EC:2.5.1.21]
K00511  squalene monooxygenase [EC:1.14.14.17]
K01852  lanosterol synthase [EC:5.4.99.7]
K05917  sterol 14-demethylase [EC:1.14.13.70]
K00222  Delta14-sterol reductase [EC:1.3.1.70]
K07750  methylsterol monooxygenase [EC:1.14.18.9]
K07748  sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) [EC:1.1.1.170]
K09827  3-keto steroid reductase [EC:1.1.1.270]
K13373  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase [EC:1.1.1.270 1.1.1.62]
K01824  cholestenol Delta-isomerase [EC:5.3.3.5]
K09828  Delta24-sterol reductase [EC:1.3.1.- 1.3.1.72]
K00227  Delta7-sterol 5-desaturase [EC:1.14.19.20]
K00213  7-dehydrocholesterol reductase [EC:1.3.1.21]
K01052  lysosomal acid lipase/cholesteryl ester hydrolase [EC:3.1.1.13]
K12298  bile salt-stimulated lipase [EC:3.1.1.3 3.1.1.13]
K14674  TAG lipase / steryl ester hydrolase / phospholipase A2 / LPA acyltransferase [EC:2.3.1.51 3.1.1.4 3.1.1.13 3.1.1.3]
K00637  sterol O-acyltransferase [EC:2.3.1.26]
K07419  vitamin D 25-hydroxylase [EC:1.14.14.24]
K07438  calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase) [EC:1.14.15.18]
K21146  vitamin D 1,25-hydroxylase [EC:1.14.15.22]
K07436  vitamin D3 24-hydroxylase [EC:1.14.15.16]
K00559  sterol 24-C-methyltransferase [EC:2.1.1.41]
K09829  C-8 sterol isomerase [EC:5.-.-.-]
K09831  sterol 22-desaturase [EC:1.14.19.41]
K00223  Delta24(24(1))-sterol reductase [EC:1.3.1.71]
K01853  cycloartenol synthase [EC:5.4.99.8]
K14423  methylsterol monooxygenase 1
K08246  cycloeucalenol cycloisomerase [EC:5.5.1.9]
K08242  24-methylenesterol C-methyltransferase [EC:2.1.1.143]
K14424  methylsterol monooxygenase 2
K09832  sterol 22-desaturase [EC:1.14.19.41]
Compound
C00187  Cholesterol
C00448  trans,trans-Farnesyl diphosphate
C00751  Squalene
C01054  (S)-2,3-Epoxysqualene
C01164  7-Dehydrocholesterol
C01189  Lathosterol
C01561  Calcidiol
C01673  Calcitriol
C01694  Ergosterol
C01724  Lanosterol
C01753  beta-Sitosterol
C01789  Campesterol
C01802  Desmosterol
C01902  Cycloartenol
C01943  Obtusifoliol
C02141  Cycloeucalenol
C02530  Cholesterol ester
C03428  Presqualene diphosphate
C03845  5alpha-Cholest-8-en-3beta-ol
C04525  Fecosterol
C05103  4alpha-Methylzymosterol
C05107  7-Dehydrodesmosterol
C05108  14-Demethyllanosterol
C05109  24,25-Dihydrolanosterol
C05437  Zymosterol
C05439  5alpha-Cholesta-7,24-dien-3beta-ol
C05440  Ergosta-5,7,22,24(28)-tetraen-3beta-ol
C05441  Vitamin D2
C05442  Stigmasterol
C05443  Vitamin D3
C07712  Secalciferol
C08813  Brassicasterol
C08821  Isofucosterol
C08830  24-Methylenecycloartanol
C11455  4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
C11508  4alpha-Methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol
C11522  24-Methylenelophenol
C11523  24-Ethylidenelophenol
C15776  4alpha-Methylfecosterol
C15777  Episterol
C15778  5,7,24(28)-Ergostatrienol
C15780  5-Dehydroepisterol
C15781  24-Methylenecholesterol
C15782  Delta7-Avenasterol
C15783  5-Dehydroavenasterol
C15808  4alpha-Methylzymosterol-4-carboxylate
C15816  3-Keto-4-methylzymosterol
C15915  4,4-Dimethyl-5alpha-cholesta-8-en-3beta-ol
C18231  Calcitetrol
C21106  24-epi-Campesterol
Reference
  Authors
Koshiba K, Kamiya Y.
  Title
[Atarasii Syokubutuhorumon no Kagaku] (In Japanese)
  Journal
Koudansya saientific:199-138 (2002)
Reference
  Authors
Morikawa T, Mizutani M, Aoki N, Watanabe B, Saga H, Saito S, Oikawa A, Suzuki H, Sakurai N, Shibata D, Wadano A, Sakata K, Ohta D.
  Title
Cytochrome P450 CYP710A encodes the sterol C-22 desaturase in Arabidopsis and tomato.
  Journal
Plant Cell 18:1008-22 (2006)
DOI:10.1105/tpc.105.036012
Reference
  Authors
Lange BM, Ghassemian M.
  Title
Genome organization in Arabidopsis thaliana: a survey for genes involved in isoprenoid and chlorophyll metabolism.
  Journal
Plant Mol Biol 51:925-48 (2003)
DOI:10.1023/A:1023005504702

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