KEGG   PATHWAY: ko00232Help
Entry
ko00232                     Pathway                                

Name
Caffeine metabolism
Class
Metabolism; Biosynthesis of other secondary metabolites
BRITE hierarchy
Pathway map
Caffeine metabolism
ko00232

All organismsOrtholog table
Other DBs
BSID: 
UMBBD: 
Orthology
K12729  
7-methylxanthosine synthase [EC:2.1.1.158]
K12730  
theobromine synthase [EC:2.1.1.159]
K12731  
caffeine synthase [EC:2.1.1.160]
K07409  
cytochrome P450, family 1, subfamily A, polypeptide 2 [EC:1.14.14.1]
K00622  
arylamine N-acetyltransferase [EC:2.3.1.5]
K17683  
cytochrome P450, family 2, subfamily A, polypeptide 6 [EC:1.14.13.-]
K00106  
xanthine dehydrogenase/oxidase [EC:1.17.3.2 1.17.1.4]
K00365  
urate oxidase [EC:1.7.3.3]
K16838  
urate oxidase / 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [EC:4.1.1.97 1.7.3.3]
Compound
C00048  
Glyoxylate
C00385  
Xanthine
C01762  
Xanthosine
C07130  
Theophylline
C07480  
Theobromine
C07481  
Caffeine
C13747  
1,7-Dimethylxanthine
C16352  
7-Methylxanthosine
C16353  
7-Methylxanthine
C16355  
7-Methyluric acid
C16356  
1,7-Dimethyluric acid
C16357  
3-Methylxanthine
C16358  
1-Methylxanthine
C16359  
1-Methyluric acid
C16360  
3,7-Dimethyluric acid
C16361  
1,3,7-Trimethyluric acid
C16362  
3,6,8-Trimethylallantoin
C16363  
N-Methylurea
C16364  
N,N'-Dimethylurea
C16365  
5-Acetylamino-6-formylamino-3-methyluracil
C16366  
5-Acetylamino-6-amino-3-methyluracil
Reference
PMID:9705852
  Authors
Madyastha KM, Sridhar GR.
  Title
A novel pathway for the metabolism of caffeine by a mixed culture consortium.
  Journal
Biochem Biophys Res Commun 249:178-81 (1998)
Reference
  Authors
Mazzafera P.
  Title
Catabolism of caffeine in plants and microorganisms.
  Journal
Front Biosci 9:1348-59 (2004)
Reference
  Authors
Nyeki A, Biollaz J, Kesselring UW, Decosterd LA.
  Title
Extractionless method for the simultaneous high-performance liquid chromatographic determination of urinary caffeine metabolites for N-acetyltransferase 2, cytochrome P450 1A2 and xanthine oxidase activity assessment.
  Journal
J Chromatogr B Biomed Sci Appl 755:73-84 (2001)
Reference
  Authors
Ashihara H, Crozier A.
  Title
Caffeine: a well known but little mentioned compound in plant science.
  Journal
Trends Plant Sci 6:407-13 (2001)
Reference
  Authors
Yoneyama N, Morimoto H, Ye CX, Ashihara H, Mizuno K, Kato M.
  Title
Substrate specificity of N-methyltransferase involved in purine alkaloids synthesis is dependent upon one amino acid residue of the enzyme.
  Journal
Mol Genet Genomics 275:125-35 (2006)

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