KEGG PATHWAY: ko00300

PATHWAY: ko00300

Entry

ko00300 Pathway

Name

Lysine biosynthesis

Class

Metabolism; Amino acid metabolism

Pathway map

ko00300

Lysine biosynthesis

Module

M00016	Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine [PATH:ko00300]
M00030	Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine [PATH:ko00300]
M00031	Lysine biosynthesis, 2-aminoadipate => lysine [PATH:ko00300]
M00433	Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate [PATH:ko00300]
M00525	Lysine biosynthesis, acetyl-DAP pathway, aspartate => lysine [PATH:ko00300]
M00526	Lysine biosynthesis, DAP dehydrogenase pathway, aspartate => lysine [PATH:ko00300]
M00527	Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine [PATH:ko00300]

Disease

H00188

Hyperlysinemia

Other DBs

BSID:

319

GO:

0009085

Orthology

K00003	homoserine dehydrogenase [EC:1.1.1.3]
K00928	aspartate kinase [EC:2.7.2.4]
K12524	bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:1.1.1.3 2.7.2.4]
K12525	bifunctional aspartokinase / homoserine dehydrogenase 2 [EC:1.1.1.3 2.7.2.4]
K12526	bifunctional diaminopimelate decarboxylase / aspartate kinase [EC:2.7.2.4 4.1.1.20]
K00133	aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]
K01714	4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]
K00215	4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]
K00674	2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase [EC:2.3.1.117]
K00821	acetylornithine/N-succinyldiaminopimelate aminotransferase [EC:2.6.1.17 2.6.1.11]
K14267	N-succinyldiaminopimelate aminotransferase [EC:2.6.1.17]
K01439	succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]
K01778	diaminopimelate epimerase [EC:5.1.1.7]
K10206	LL-diaminopimelate aminotransferase [EC:2.6.1.83]
K01586	diaminopimelate decarboxylase [EC:4.1.1.20]
K05822	tetrahydrodipicolinate N-acetyltransferase [EC:2.3.1.89]
K00841	aminotransferase [EC:2.6.1.-]
K05823	N-acetyldiaminopimelate deacetylase [EC:3.5.1.47]
K03340	diaminopimelate dehydrogenase [EC:1.4.1.16]
K01655	homocitrate synthase [EC:2.3.3.14]
K02594	homocitrate synthase NifV [EC:2.3.3.14]
K10977	methanogen homocitrate synthase [EC:2.3.3.- 2.3.3.14]
K01681	aconitate hydratase 1 / homoaconitase [EC:4.2.1.- 4.2.1.3]
K01705	homoaconitate hydratase [EC:4.2.1.36]
K16792	homoaconitate hydratase / methanogen homoaconitase large subunit [EC:4.2.1.114 4.2.1.36]
K16793	homoaconitate hydratase / methanogen homoaconitase small subunit [EC:4.2.1.114 4.2.1.36]
K05824	homoisocitrate dehydrogenase [EC:1.1.1.87]
K00825	kynurenine/2-aminoadipate aminotransferase [EC:2.6.1.39 2.6.1.7]
K00838	aromatic amino acid aminotransferase I [EC:2.6.1.5 2.6.1.27 2.6.1.57]
K05825	2-aminoadipate transaminase [EC:2.6.1.-]
K00143	L-aminoadipate-semialdehyde dehydrogenase [EC:1.2.1.31]
K14085	aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.3 1.2.1.8 1.2.1.31]
K00293	saccharopine dehydrogenase (NADP+, L-glutamate forming) [EC:1.5.1.10]
K00290	saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7]
K05827	alpha-aminoadipate--LysW ligase LysX [EC:6.3.2.-]
K05828	acetylglutamate/LysW-gamma-L-alpha-aminoadipate kinase [EC:2.7.2.- 2.7.2.8]
K05829	N-acetyl-gamma-glutamyl-phosphate/LysW-gamma-L-alpha-aminoadipyl-6-phosphate reductase [EC:1.2.1.- 1.2.1.38]
K05830	acetylornithine/LysW-gamma-L-lysine aminotransferase [EC:2.6.1.- 2.6.1.11]
K05831	LysW-gamma-L-lysine carboxypeptidase
K01928	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13]
K01929	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]
K15792	murE/murF fusion protein [EC:6.3.2.10 6.3.2.13]
K16180	pyrrolysine biosynthesis protein PylB
K16181	pyrrolysine biosynthesis protein PylC
K16182	pyrrolysine biosynthesis protein PylD
K10978	threo-isocitrate dehydrogenase [EC:1.1.1.-]

Compound

C00024	Acetyl-CoA
C00026	2-Oxoglutarate
C00047	L-Lysine
C00049	L-Aspartate
C00263	L-Homoserine
C00322	2-Oxoadipate
C00441	L-Aspartate 4-semialdehyde
C00449	N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00666	LL-2,6-Diaminoheptanedioate
C00680	meso-2,6-Diaminoheptanedioate
C00956	L-2-Aminoadipate
C01251	(R)-2-Hydroxybutane-1,2,4-tricarboxylate
C03082	4-Phospho-L-aspartate
C03871	L-2-Amino-6-oxoheptanedioate
C03972	2,3,4,5-Tetrahydrodipicolinate
C04002	(Z)-But-1-ene-1,2,4-tricarboxylate
C04076	L-2-Aminoadipate 6-semialdehyde
C04390	N6-Acetyl-LL-2,6-diaminoheptanedioate
C04421	N-Succinyl-LL-2,6-diaminoheptanedioate
C04462	N-Succinyl-2-L-amino-6-oxoheptanedioate
C04877	UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate
C04882	UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine
C05535	alpha-Aminoadipoyl-S-acyl enzyme
C05539	N-Acetyl-L-2-amino-6-oxopimelate
C05560	L-2-Aminoadipate adenylate
C05662	Homoisocitrate
C16138	L-Pyrrolysine
C19886	LysW-gamma-L-alpha-aminoadipate
C19887	LysW-gamma-L-alpha-aminoadipyl-6-phosphate
C19888	LysW-gamma-L-alpha-aminoadipate 6-semialdehyde
C19889	LysW-gamma-L-lysine
C20258	(2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate
C20277	(2R,3R)-3-Methylornithine
C20278	(2R,3R)-3-Methylornithinyl-N6-lysine
C20279	(2R,3R)-3-Methylglutamyl-5-semialdehyde-N6-lysine

Reference

PMID:10074354

Authors

Ledwidge R, Blanchard JS.

Title

The dual biosynthetic capability of N-acetylornithine aminotransferase in arginine and lysine biosynthesis.

Journal

Biochemistry 38:3019-3024 (1999)

Reference

PMID:10850974

Authors

Fuchs TM, Schneider B, Krumbach K, Eggeling L, Gross R.

Title

Characterization of a bordetella pertussis diaminopimelate (DAP) biosynthesis locus identifies dapC, a novel gene coding for an N-succinyl-L,L-DAP aminotransferase.

Journal

J Bacteriol 182:3626-3631 (2000)

Reference

PMID:10714900

Authors

Zabriskie TM, Jackson MD.

Title

Lysine biosynthesis and metabolism in fungi.

Journal

Nat Prod Rep 17:85-97 (2000)

Reference

PMID:14627808

Authors

Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS.

Title

Regulation of lysine biosynthesis and transport genes in bacteria: yet another RNA riboswitch?

Journal

Nucleic Acids Res 31:6748-57 (2003)

Reference

PMID:12355264

Authors

Velasco AM, Leguina JI, Lazcano A.

Title

Molecular evolution of the lysine biosynthetic pathways.

Journal

J Mol Evol 55:445-59 (2002)

Reference

PMID:15256574

Authors

Miyazaki T, Miyazaki J, Yamane H, Nishiyama M.

Title

alpha-Aminoadipate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus.

Journal

Microbiology 150:2327-34 (2004)

Reference

PMID:12126930

Authors

Goh DL, Patel A, Thomas GH, Salomons GS, Schor DS, Jakobs C, Geraghty MT.

Title

Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT).

Journal

Mol Genet Metab 76:172-80 (2002)

Reference

PMID:15160885

Authors

Nishiyama M.

Title

[Novel lysine biosynthesis: a key to elucidate evolution of metabolic and biosynthetic pathways]

Journal

Tanpakushitsu Kakusan Koso 49:758-63 (2004)

Reference

PMID:10613839

Authors

Nishida H, Nishiyama M, Kobashi N, Kosuge T, Hoshino T, Yamane H.

Title

A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway: a key to the evolution of amino acid biosynthesis.

Journal

Genome Res 9:1175-83 (1999)

Reference

PMID:12963379

Authors

Sakai H, Vassylyeva MN, Matsuura T, Sekine S, Gotoh K, Nishiyama M, Terada T, Shirouzu M, Kuramitsu S, Vassylyev DG, Yokoyama S.

Title

Crystal structure of a lysine biosynthesis enzyme, LysX, from Thermus thermophilus HB8.

Journal

J Mol Biol 332:729-40 (2003)

Reference

PMID:16361515

Authors

Hudson AO, Singh BK, Leustek T, Gilvarg C.

Title

An LL-diaminopimelate aminotransferase defines a novel variant of the lysine biosynthesis pathway in plants.

Journal

Plant Physiol 140:292-301 (2006)

Reference

PMID:19620981

Authors

Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M

Title

Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus.

Journal

Nat Chem Biol 5:673-9 (2009)

Reference

PMID:21547300

Authors

Dairi T, Kuzuyama T, Nishiyama M, Fujii I

Title

Convergent strategies in biosynthesis.

Journal

Nat Prod Rep 28:1054-86 (2011)

Reference

PMID:21550296

Authors

Gaston MA, Jiang R, Krzycki JA

Title

Functional context, biosynthesis, and genetic encoding of pyrrolysine.

Journal

Curr Opin Microbiol 14:342-9 (2011)

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Ontology (2)   
   KEGG BRITE (1)   
   GO (1)   
Pathway (12)   
   KEGG PATHWAY (4)   
   KEGG MODULE (7)   
   BioSystems (1)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical substance (35)   
   KEGG COMPOUND (35)   
Chemical reaction (41)   
   KEGG ENZYME (41)   
Gene (47)   
   KEGG ORTHOLOGY (47)   
Literature (14)   
   PubMed (14)   
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