KEGG   PATHWAY: ko00310Help
Entry
ko00310                     Pathway                                

Name
Lysine degradation
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
Lysine degradation
ko00310

All organismsOrtholog table
Module
M00032  
Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:ko00310]
Disease
H00178  
Glutaric acidemia
H00188  
Hyperlysinemia
H00570  
Kabuki syndrome
H00718  
Sotos syndrome and Weaver syndrome
H00802  
Ehlers-Danlos syndrome (EDS)
H00907  
Kleefstra syndrome
H00980  
Nevo syndrome
H01192  
Lysyl hydroxylase 3 (LH3) deficiency
H01242  
Saccharopinuria
H01247  
Pyridoxine-dependent epilepsy (PDE)
H01364  
3-Hydroxyacyl-CoA dehydrogenase deficiency
Orthology
K00290  
saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7]
K00291  
saccharopine dehydrogenase (NADP+, L-lysine forming) [EC:1.5.1.8]
K00292  
saccharopine dehydrogenase (NAD+, L-glutamate forming) [EC:1.5.1.9]
K14157  
alpha-aminoadipic semialdehyde synthase [EC:1.5.1.9 1.5.1.8]
K00293  
saccharopine dehydrogenase (NADP+, L-glutamate forming) [EC:1.5.1.10]
K00143  
L-aminoadipate-semialdehyde dehydrogenase [EC:1.2.1.31]
K14085  
aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.3 1.2.1.8 1.2.1.31]
K00825  
kynurenine/2-aminoadipate aminotransferase [EC:2.6.1.39 2.6.1.7]
K00164  
2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
K00658  
2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]
K00252  
glutaryl-CoA dehydrogenase [EC:1.3.8.6]
K01692  
enoyl-CoA hydratase [EC:4.2.1.17]
K01825  
3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:5.3.3.8 5.1.2.3 4.2.1.17 1.1.1.35]
K01782  
3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:5.1.2.3 4.2.1.17 1.1.1.35]
K07515  
enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.211 4.2.1.17]
K07514  
enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:5.3.3.8 1.1.1.35 4.2.1.17]
K07511  
enoyl-CoA hydratase [EC:4.2.1.17]
K00022  
3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K00626  
acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
K18201  
hydroxylysine kinase [EC:2.7.1.81]
K18202  
5-phosphonooxy-L-lysine phospho-lyase [EC:4.2.3.134]
K01582  
lysine decarboxylase [EC:4.1.1.18]
K14268  
5-aminovalerate/4-aminobutyrate aminotransferase [EC:2.6.1.19 2.6.1.48]
K00135  
succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.20 1.2.1.79 1.2.1.16]
K03897  
lysine N6-hydroxylase [EC:1.14.13.59]
K03896  
acetyl CoA:N6-hydroxylysine acetyl transferase [EC:2.3.1.102]
K03894  
N2-citryl-N6-acetyl-N6-hydroxylysine synthase [EC:6.3.2.38]
K03895  
aerobactin synthase [EC:6.3.2.39]
K01843  
lysine 2,3-aminomutase [EC:5.4.3.2]
K01844  
beta-lysine 5,6-aminomutase alpha subunit [EC:5.4.3.3]
K18011  
beta-lysine 5,6-aminomutase beta subunit [EC:5.4.3.3]
K18012  
L-erythro-3,5-diaminohexanoate dehydrogenase [EC:1.4.1.11]
K18013  
3-keto-5-aminohexanoate cleavage enzyme
K18014  
3-aminobutyryl-CoA ammonia-lyase [EC:4.3.1.14]
K01034  
acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.9 2.8.3.8]
K01035  
acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.9 2.8.3.8]
K00824  
D-alanine transaminase [EC:2.6.1.21]
K13609  
delta1-piperideine-2-carboxylate reductase [EC:1.5.1.21]
K00306  
sarcosine oxidase / L-pipecolate oxidase [EC:1.5.3.7 1.5.3.1]
K06101  
histone-lysine N-methyltransferase ASH1L [EC:2.1.1.43]
K11427  
histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]
K11420  
euchromatic histone-lysine N-methyltransferase [EC:2.1.1.43]
K15588  
histone-lysine N-methyltransferase NSD1 [EC:2.1.1.43]
K11424  
histone-lysine N-methyltransferase NSD2 [EC:2.1.1.43]
K11425  
histone-lysine N-methyltransferase NSD3 [EC:2.1.1.43]
K11422  
histone-lysine N-methyltransferase SETD1 [EC:2.1.1.43]
K11423  
histone-lysine N-methyltransferase SETD2 [EC:2.1.1.43]
K11431  
histone-lysine N-methyltransferase SETD7 [EC:2.1.1.43]
K11428  
histone-lysine N-methyltransferase SETD8 [EC:2.1.1.43]
K11421  
histone-lysine N-methyltransferase SETDB [EC:2.1.1.43]
K11433  
histone-lysine N-methyltransferase SETMAR [EC:2.1.1.43]
K11419  
histone-lysine N-methyltransferase SUV39H [EC:2.1.1.43]
K11429  
histone-lysine N-methyltransferase SUV420H [EC:2.1.1.43]
K09186  
histone-lysine N-methyltransferase MLL1 [EC:2.1.1.43]
K09187  
histone-lysine N-methyltransferase MLL2 [EC:2.1.1.43]
K09188  
histone-lysine N-methyltransferase MLL3 [EC:2.1.1.43]
K14959  
histone-lysine N-methyltransferase MLL4 [EC:2.1.1.43]
K09189  
histone-lysine N-methyltransferase MLL5 [EC:2.1.1.43]
K01423  
[EC:3.4.-.-]
K00474  
trimethyllysine dioxygenase [EC:1.14.11.8]
K00128  
aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
K00149  
aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.3 1.2.1.47]
K00471  
gamma-butyrobetaine dioxygenase [EC:1.14.11.1]
K00473  
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 [EC:1.14.11.4]
K13645  
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [EC:1.14.11.4]
K13646  
lysyl hydroxylase/galactosyltransferase/glucosyltransferase [EC:2.4.1.66 2.4.1.50 1.14.11.4]
K13647  
procollagen-lysine,2-oxoglutarate 5-dioxygenase, invertebrate [EC:1.14.11.4]
K11703  
collagen beta-1,O-galactosyltransferase [EC:2.4.1.50]
Compound
C00024  
Acetyl-CoA
C00037  
Glycine
C00047  
L-Lysine
C00136  
Butanoyl-CoA
C00164  
Acetoacetate
C00322  
2-Oxoadipate
C00332  
Acetoacetyl-CoA
C00408  
L-Pipecolate
C00431  
5-Aminopentanoate
C00449  
N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  
(S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  
Carnitine
C00489  
Glutarate
C00527  
Glutaryl-CoA
C00739  
D-Lysine
C00877  
Crotonoyl-CoA
C00956  
L-2-Aminoadipate
C00990  
5-Aminopentanamide
C01028  
N6-Hydroxy-L-lysine
C01142  
(3S)-3,6-Diaminohexanoate
C01144  
(S)-3-Hydroxybutanoyl-CoA
C01149  
4-Trimethylammoniobutanal
C01181  
4-Trimethylammoniobutanoate
C01186  
(3S,5S)-3,5-Diaminohexanoate
C01211  
Procollagen 5-hydroxy-L-lysine
C01259  
3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  
Cadaverine
C02188  
Protein lysine
C02727  
N6-Acetyl-L-lysine
C03087  
5-Acetamidopentanoate
C03239  
6-Amino-2-oxohexanoate
C03273  
5-Oxopentanoate
C03366  
5-Phosphonooxy-L-lysine
C03656  
(S)-5-Amino-3-oxohexanoic acid
C03793  
N6,N6,N6-Trimethyl-L-lysine
C03955  
N6-Acetyl-N6-hydroxy-L-lysine
C04020  
D-Lysopine
C04076  
L-2-Aminoadipate 6-semialdehyde
C04092  
delta1-Piperideine-2-carboxylate
C04487  
5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  
2,5-Diaminohexanoate
C05231  
L-3-Aminobutyryl-CoA
C05544  
Protein N6-methyl-L-lysine
C05545  
Protein N6,N6-dimethyl-L-lysine
C05546  
Protein N6,N6,N6-trimethyl-L-lysine
C05548  
6-Acetamido-2-oxohexanoate
C05554  
Aerobactin
C05825  
2-Amino-5-oxohexanoate
C06157  
[Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C06181  
Piperideine
C16741  
L-Hydroxylysine
C20333  
N2-Citryl-N6-acetyl-N6-hydroxy-L-lysine
Reference
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)

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