KEGG   PATHWAY: ko00360Help
Entry
ko00360                     Pathway                                

Name
Phenylalanine metabolism
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
Phenylalanine metabolism
ko00360

All organismsOrtholog table
Module
M00350  
Capsaicin biosynthesis, L-Phenylalanine => Capsaicin [PATH:ko00360]
M00545  
Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA [PATH:ko00360]
Disease
H00165  
Tyrosinemia
Other DBs
BSID: 
GO: 
Orthology
K00500  
phenylalanine-4-hydroxylase [EC:1.14.16.1]
K01593  
aromatic-L-amino-acid decarboxylase [EC:4.1.1.28]
K00276  
primary-amine oxidase [EC:1.4.3.21]
K00274  
monoamine oxidase [EC:1.4.3.4]
K13371  
aralkylamine dehydrogenase light chain [EC:1.4.9.2]
K13372  
aralkylamine dehydrogenase heavy chain [EC:1.4.9.2]
K00129  
aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]
K00146  
phenylacetaldehyde dehydrogenase [EC:1.2.1.39]
K01912  
phenylacetate-CoA ligase [EC:6.2.1.30]
K02614  
acyl-CoA thioesterase [EC:3.1.2.-]
K02609  
ring-1,2-phenylacetyl-CoA epoxidase subunit PaaA [EC:1.14.13.149]
K02610  
ring-1,2-phenylacetyl-CoA epoxidase subunit PaaB
K02611  
ring-1,2-phenylacetyl-CoA epoxidase subunit PaaC [EC:1.14.13.149]
K02612  
ring-1,2-phenylacetyl-CoA epoxidase subunit PaaD
K02613  
ring-1,2-phenylacetyl-CoA epoxidase subunit PaaE
K15866  
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase [EC:5.3.3.18]
K02618  
oxepin-CoA hydrolase / 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase [EC:1.17.1.7 3.3.2.12]
K02615  
acetyl-CoA acetyltransferase [EC:2.3.1.-]
K01692  
enoyl-CoA hydratase [EC:4.2.1.17]
K00074  
3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157]
K18361  
phenylacetyl-CoA:acceptor oxidoreductase [EC:3.1.2.25 1.17.5.1]
K18362  
phenylacetyl-CoA:acceptor oxidoreductase 27-kDa subunit
K18363  
phenylacetyl-CoA:acceptor oxidoreductase 26-kDa subunit
K18360  
phenylacetyl-CoA:acceptor oxidoreductase accessory protein
K18355  
phenylglyoxylate dehydrogenase alpha subunit [EC:1.2.1.58]
K18356  
phenylglyoxylate dehydrogenase beta subunit [EC:1.2.1.58]
K18357  
phenylglyoxylate dehydrogenase gamma subunit [EC:1.2.1.58]
K18358  
phenylglyoxylate dehydrogenase delta subunit [EC:1.2.1.58]
K18359  
phenylglyoxylate dehydrogenase epsilon subunit [EC:1.2.1.58]
K00628  
glycine N-acyltransferase [EC:2.3.1.13]
K15517  
glycine N-phenylacetyltransferase [EC:2.3.1.192]
K14454  
aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]
K14455  
aspartate aminotransferase, mitochondrial [EC:2.6.1.1]
K00811  
aspartate aminotransferase, chloroplastic [EC:2.6.1.1]
K00812  
aspartate aminotransferase [EC:2.6.1.1]
K00813  
aspartate aminotransferase [EC:2.6.1.1]
K11358  
aspartate aminotransferase [EC:2.6.1.1]
K15849  
bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase [EC:2.6.1.79 2.6.1.78 2.6.1.1]
K00815  
tyrosine aminotransferase [EC:2.6.1.5]
K00817  
histidinol-phosphate aminotransferase [EC:2.6.1.9]
K00832  
aromatic-amino-acid transaminase [EC:2.6.1.57]
K00838  
aromatic amino acid aminotransferase I [EC:2.6.1.5 2.6.1.27 2.6.1.57]
K05821  
aromatic amino acid aminotransferase II [EC:2.6.1.28 2.6.1.58]
K00270  
phenylalanine dehydrogenase [EC:1.4.1.20]
K03334  
L-amino-acid oxidase [EC:1.4.3.2]
K12732  
phenylpyruvate decarboxylase [EC:4.1.1.-]
K00055  
aryl-alcohol dehydrogenase [EC:1.1.1.90]
K00457  
4-hydroxyphenylpyruvate dioxygenase [EC:1.13.11.27]
K00285  
D-amino-acid dehydrogenase [EC:1.4.99.1]
K00824  
D-alanine transaminase [EC:2.6.1.21]
K07253  
phenylpyruvate tautomerase [EC:5.3.2.1]
K18606  
hydroxyphenylpyruvate reductase [EC:1.1.1.237]
K03782  
catalase-peroxidase [EC:1.11.1.21]
K11188  
peroxiredoxin 6, 1-Cys peroxiredoxin [EC:3.1.1.- 1.11.1.15 1.11.1.7]
K00430  
peroxidase [EC:1.11.1.7]
K01426  
amidase [EC:3.5.1.4]
K10437  
phenylacetate 2-hydroxylase [EC:1.14.13.-]
K10775  
phenylalanine ammonia-lyase [EC:4.3.1.24]
K13064  
phenylalanine/tyrosine ammonia-lyase [EC:4.3.1.25]
K01451  
hippurate hydrolase [EC:3.5.1.32]
K10797  
2-enoate reductase [EC:1.3.1.31]
K05708  
3-phenylpropionate/trans-cinnamate dioxygenase alpha subunit [EC:1.14.12.19]
K05709  
3-phenylpropionate/trans-cinnamate dioxygenase beta subunit [EC:1.14.12.19]
K05710  
3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin subunit
K00529  
3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin reductase subunit [EC:1.18.1.3]
K05711  
2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase [EC:1.3.1.87]
K05712  
3-(3-hydroxy-phenyl)propionate hydroxylase [EC:1.14.13.127]
K05713  
2,3-dihydroxyphenylpropionate 1,2-dioxygenase [EC:1.13.11.16]
K05714  
2-hydroxy-6-oxonona-2,4-dienedioate hydrolase [EC:3.7.1.14]
K02554  
2-keto-4-pentenoate hydratase [EC:4.2.1.80]
K01666  
4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39]
K04073  
acetaldehyde dehydrogenase [EC:1.2.1.10]
K00487  
trans-cinnamate 4-monooxygenase [EC:1.14.13.11]
K01904  
4-coumarate--CoA ligase [EC:6.2.1.12]
K00588  
caffeoyl-CoA O-methyltransferase [EC:2.1.1.104]
K18383  
trans-feruloyl-CoA hydratase / vanillin synthase [EC:4.1.2.41 4.2.1.101]
Compound
C00022  
Pyruvate
C00024  
Acetyl-CoA
C00042  
Succinate
C00079  
L-Phenylalanine
C00082  
L-Tyrosine
C00083  
Malonyl-CoA
C00084  
Acetaldehyde
C00091  
Succinyl-CoA
C00122  
Fumarate
C00156  
4-Hydroxybenzoate
C00166  
Phenylpyruvate
C00180  
Benzoate
C00223  
p-Coumaroyl-CoA
C00323  
Caffeoyl-CoA
C00406  
Feruloyl-CoA
C00423  
trans-Cinnamate
C00512  
S-Benzoate coenzyme A
C00582  
Phenylacetyl-CoA
C00596  
2-Hydroxy-2,4-pentadienoate
C00601  
Phenylacetaldehyde
C00630  
2-Methylpropanoyl-CoA
C00642  
4-Hydroxyphenylacetate
C00755  
4-Hydroxy-3-methoxy-benzaldehyde
C00805  
Salicylate
C00811  
4-Coumarate
C01198  
3-(2-Hydroxyphenyl)propanoate
C01575  
Ephedrine
C01586  
Hippurate
C01772  
trans-2-Hydroxycinnamate
C02137  
alpha-Oxo-benzeneacetic acid
C02232  
3-Oxoadipyl-CoA
C02265  
D-Phenylalanine
C02505  
2-Phenylacetamide
C02763  
2-Hydroxy-3-phenylpropenoate
C02765  
(+)-Pseudoephedrine
C03519  
N-Acetyl-L-phenylalanine
C03589  
4-Hydroxy-2-oxopentanoate
C04044  
3-(2,3-Dihydroxyphenyl)propanoate
C04148  
Phenylacetylglutamine
C04351  
(R)-2-Methylimino-1-phenylpropan-1-ol
C04479  
2-Hydroxy-6-oxonona-2,4-diene-1,9-dioate
C05332  
Phenethylamine
C05593  
3-Hydroxyphenylacetate
C05598  
Phenylacetylglycine
C05607  
Phenyllactate
C05620  
N-Acetyl-D-phenylalanine
C05629  
Phenylpropanoate
C05852  
2-Hydroxyphenylacetate
C05853  
Phenylethyl alcohol
C06207  
2,6-Dihydroxyphenylacetate
C06866  
Capsaicin
C07086  
Phenylacetic acid
C07303  
4-Hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA
C08300  
D-Cathine
C08301  
D-Cathinone
C11457  
3-(3-Hydroxyphenyl)propanoic acid
C11588  
cis-3-(Carboxy-ethyl)-3,5-cyclo-hexadiene-1,2-diol
C12621  
trans-3-Hydroxycinnamate
C12622  
cis-3-(3-Carboxyethenyl)-3,5-cyclohexadiene-1,2-diol
C12623  
trans-2,3-Dihydroxycinnamate
C12624  
2-Hydroxy-6-ketononatrienedioate
C14144  
5-Carboxy-2-pentenoyl-CoA
C14145  
(3S)-3-Hydroxyadipyl-CoA
C15524  
Phenylglyoxylyl-CoA
C16666  
Vanillylamine
C16719  
(-)-Norephedrine
C17268  
Pyruvophenone
C18202  
8-Methyl-6-nonenoic acid
C19945  
3-Oxo-5,6-dehydrosuberyl-CoA
C19946  
3-Oxo-5,6-dehydrosuberyl-CoA semialdehyde
C19975  
2-Oxepin-2(3H)-ylideneacetyl-CoA
C20062  
2-(1,2-Epoxy-1,2-dihydrophenyl)acetyl-CoA
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Arai H, Yamamoto T, Ohishi T, Shimizu T, Nakata T, Kudo T.
  Title
Genetic organization and characteristics of the 3-(3-hydroxyphenyl)propionic acid degradation pathway of Comamonas testosteroni TA441.
  Journal
Microbiology 145 ( Pt 10):2813-20 (1999)
Reference
PMID:9603882
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J Bacteriol 180:2915-23 (1998)
Reference
PMID:9098055
  Authors
Ferrandez A, Garcia JL, Diaz E.
  Title
Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12.
  Journal
J Bacteriol 179:2573-81 (1997)
Reference
  Authors
Hwang JY, Park J, Seo JH, Cha M, Cho BK, Kim J, Kim BG
  Title
Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway.
  Journal
Biotechnol Bioeng 102:1323-9 (2009)
Reference
  Authors
Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G
  Title
Bacterial phenylalanine and phenylacetate catabolic pathway revealed.
  Journal
Proc Natl Acad Sci U S A 107:14390-5 (2010)

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