KEGG PATHWAY: ko00360

PATHWAY: ko00360

Entry

ko00360 Pathway

Name

Phenylalanine metabolism

Class

Metabolism; Amino acid metabolism

Pathway map

ko00360

Phenylalanine metabolism

Module

M00350	Capsaicin biosynthesis, L-Phenylalanine => Capsaicin [PATH:ko00360]
M00545	Trans-cinnamate degradation, trans-cinnamate => 2-oxopent-4-enoate + fumarate [PATH:ko00360]

Disease

H00165

Tyrosinemia

Other DBs

BSID:

327

GO:

0006558

Orthology

K00500	phenylalanine-4-hydroxylase [EC:1.14.16.1]
K01593	aromatic-L-amino-acid decarboxylase [EC:4.1.1.28]
K00276	primary-amine oxidase [EC:1.4.3.21]
K00274	monoamine oxidase [EC:1.4.3.4]
K13371	aralkylamine dehydrogenase light chain [EC:1.4.9.2]
K13372	aralkylamine dehydrogenase heavy chain [EC:1.4.9.2]
K00129	aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]
K00146	phenylacetaldehyde dehydrogenase [EC:1.2.1.39]
K01912	phenylacetate-CoA ligase [EC:6.2.1.30]
K02614	acyl-CoA thioesterase [EC:3.1.2.-]
K02609	ring-1,2-phenylacetyl-CoA epoxidase subunit PaaA [EC:1.14.13.149]
K02610	ring-1,2-phenylacetyl-CoA epoxidase subunit PaaB
K02611	ring-1,2-phenylacetyl-CoA epoxidase subunit PaaC [EC:1.14.13.149]
K02612	ring-1,2-phenylacetyl-CoA epoxidase subunit PaaD
K02613	ring-1,2-phenylacetyl-CoA epoxidase subunit PaaE
K15866	2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase [EC:5.3.3.18]
K02618	oxepin-CoA hydrolase / 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase [EC:1.17.1.7 3.7.1.16]
K02615	acetyl-CoA acetyltransferase [EC:2.3.1.-]
K01692	enoyl-CoA hydratase [EC:4.2.1.17]
K00074	3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157]
K00628	glycine N-acyltransferase [EC:2.3.1.13]
K15517	glycine N-phenylacetyltransferase [EC:2.3.1.192]
K14454	aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]
K14455	aspartate aminotransferase, mitochondrial [EC:2.6.1.1]
K00811	aspartate aminotransferase, chloroplastic [EC:2.6.1.1]
K00812	aspartate aminotransferase [EC:2.6.1.1]
K00813	aspartate aminotransferase [EC:2.6.1.1]
K11358	aspartate aminotransferase [EC:2.6.1.1]
K15849	bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase [EC:2.6.1.79 2.6.1.78 2.6.1.1]
K00815	tyrosine aminotransferase [EC:2.6.1.5]
K00817	histidinol-phosphate aminotransferase [EC:2.6.1.9]
K00832	aromatic-amino-acid transaminase [EC:2.6.1.57]
K00838	aromatic amino acid aminotransferase I [EC:2.6.1.5 2.6.1.27 2.6.1.57]
K05821	aromatic amino acid aminotransferase II [EC:2.6.1.28 2.6.1.58]
K00270	phenylalanine dehydrogenase [EC:1.4.1.20]
K03334	L-amino-acid oxidase [EC:1.4.3.2]
K12732	phenylpyruvate decarboxylase [EC:4.1.1.-]
K00055	aryl-alcohol dehydrogenase [EC:1.1.1.90]
K00457	4-hydroxyphenylpyruvate dioxygenase [EC:1.13.11.27]
K00285	D-amino-acid dehydrogenase [EC:1.4.99.1]
K00824	D-alanine transaminase [EC:2.6.1.21]
K07253	phenylpyruvate tautomerase [EC:5.3.2.1]
K03782	catalase-peroxidase [EC:1.11.1.21]
K11188	peroxiredoxin 6, 1-Cys peroxiredoxin [EC:3.1.1.- 1.11.1.15 1.11.1.7]
K00430	peroxidase [EC:1.11.1.7]
K01426	amidase [EC:3.5.1.4]
K10437	phenylacetate 2-hydroxylase [EC:1.14.13.-]
K10775	phenylalanine ammonia-lyase [EC:4.3.1.24]
K13064	phenylalanine/tyrosine ammonia-lyase [EC:4.3.1.25]
K01451	hippurate hydrolase [EC:3.5.1.32]
K10797	2-enoate reductase [EC:1.3.1.31]
K05708	3-phenylpropionate/cinnamic acid dioxygenase subunit alpha [EC:1.14.12.19]
K05709	3-phenylpropionate/cinnamic acid dioxygenase subunit beta [EC:1.14.12.19]
K05710	dioxygenase ferredoxin subunit
K00529	ferredoxin--NAD+ reductase [EC:1.18.1.3]
K05711	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase [EC:1.3.1.87]
K05712	3-(3-hydroxy-phenyl)propionate hydroxylase [EC:1.14.13.127]
K05713	2,3-dihydroxyphenylpropionate 1,2-dioxygenase [EC:1.13.11.16]
K05714	2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase [EC:3.7.1.-]
K02554	2-keto-4-pentenoate hydratase [EC:4.2.1.80]
K01666	4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39]
K00487	trans-cinnamate 4-monooxygenase [EC:1.14.13.11]
K01904	4-coumarate--CoA ligase [EC:6.2.1.12]
K00588	caffeoyl-CoA O-methyltransferase [EC:2.1.1.104]

Compound

C00022	Pyruvate
C00024	Acetyl-CoA
C00042	Succinate
C00079	L-Phenylalanine
C00082	L-Tyrosine
C00083	Malonyl-CoA
C00084	Acetaldehyde
C00091	Succinyl-CoA
C00122	Fumarate
C00156	4-Hydroxybenzoate
C00166	Phenylpyruvate
C00180	Benzoate
C00223	p-Coumaroyl-CoA
C00323	Caffeoyl-CoA
C00406	Feruloyl-CoA
C00423	trans-Cinnamate
C00512	S-Benzoate coenzyme A
C00582	Phenylacetyl-CoA
C00596	2-Hydroxy-2,4-pentadienoate
C00601	Phenylacetaldehyde
C00630	2-Methylpropanoyl-CoA
C00642	4-Hydroxyphenylacetate
C00755	4-Hydroxy-3-methoxy-benzaldehyde
C00805	Salicylate
C00811	4-Coumarate
C01198	3-(2-Hydroxyphenyl)propanoate
C01575	Ephedrine
C01586	Hippurate
C01772	trans-2-Hydroxycinnamate
C02137	alpha-Oxo-benzeneacetic acid
C02232	3-Oxoadipyl-CoA
C02265	D-Phenylalanine
C02505	2-Phenylacetamide
C02763	2-Hydroxy-3-phenylpropenoate
C02765	(+)-Pseudoephedrine
C03519	N-Acetyl-L-phenylalanine
C03589	4-Hydroxy-2-oxopentanoate
C04044	3-(2,3-Dihydroxyphenyl)propanoate
C04148	Phenylacetylglutamine
C04351	(R)-2-Methylimino-1-phenylpropan-1-ol
C04479	2-Hydroxy-6-oxonona-2,4-diene-1,9-dioate
C05332	Phenethylamine
C05593	3-Hydroxyphenylacetate
C05598	Phenylacetylglycine
C05607	Phenyllactate
C05620	N-Acetyl-D-phenylalanine
C05629	Phenylpropanoate
C05852	2-Hydroxyphenylacetate
C05853	Phenylethyl alcohol
C06207	2,6-Dihydroxyphenylacetate
C06866	Capsaicin
C07086	Phenylacetic acid
C07303	4-Hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA
C08300	D-Cathine
C08301	D-Cathinone
C11457	3-(3-Hydroxyphenyl)propanoic acid
C11588	cis-3-(Carboxy-ethyl)-3,5-cyclo-hexadiene-1,2-diol
C12621	trans-3-Hydroxycinnamate
C12622	cis-3-(3-Carboxyethenyl)-3,5-cyclohexadiene-1,2-diol
C12623	trans-2,3-Dihydroxycinnamate
C12624	2-Hydroxy-6-ketononatrienedioate
C14144	5-Carboxy-2-pentenoyl-CoA
C14145	(3S)-3-Hydroxyadipyl-CoA
C15524	Phenylglyoxylyl-CoA
C16666	Vanillylamine
C16719	(-)-Norephedrine
C17268	Pyruvophenone
C18202	8-Methyl-6-nonenoic acid
C19945	3-Oxo-5,6-dehydrosuberyl-CoA
C19946	3-Oxo-5,6-dehydrosuberyl-CoA semialdehyde
C19975	2-Oxepin-2(3H)-ylideneacetyl-CoA
C20062	2-(1,2-Epoxy-1,2-dihydrophenyl)acetyl-CoA

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:10537203

Authors

Arai H, Yamamoto T, Ohishi T, Shimizu T, Nakata T, Kudo T.

Title

Genetic organization and characteristics of the 3-(3-hydroxyphenyl)propionic acid degradation pathway of Comamonas testosteroni TA441.

Journal

Microbiology 145 ( Pt 10):2813-20 (1999)

Reference

PMID:9603882

Authors

Diaz E, Ferrandez A, Garcia JL.

Title

Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.

Journal

J Bacteriol 180:2915-23 (1998)

Reference

PMID:9098055

Authors

Ferrandez A, Garcia JL, Diaz E.

Title

Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12.

Journal

J Bacteriol 179:2573-81 (1997)

Reference

PMID:19016485

Authors

Hwang JY, Park J, Seo JH, Cha M, Cho BK, Kim J, Kim BG

Title

Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway.

Journal

Biotechnol Bioeng 102:1323-9 (2009)

Reference

PMID:20660314

Authors

Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G

Title

Bacterial phenylalanine and phenylacetate catabolic pathway revealed.

Journal

Proc Natl Acad Sci U S A 107:14390-5 (2010)

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Ontology (2)   
   KEGG BRITE (1)   
   GO (1)   
Pathway (7)   
   KEGG PATHWAY (4)   
   KEGG MODULE (2)   
   BioSystems (1)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical substance (72)   
   KEGG COMPOUND (72)   
Chemical reaction (56)   
   KEGG ENZYME (56)   
Gene (64)   
   KEGG ORTHOLOGY (64)   
Literature (5)   
   PubMed (5)   
All databases (207)   

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