KEGG   PATHWAY: ko00380Help
Entry
ko00380                     Pathway                                

Name
Tryptophan metabolism
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
Tryptophan metabolism
ko00380

All organismsOrtholog table
Module
M00037  
Melatonin biosynthesis, tryptophan => serotonin => melatonin [PATH:ko00380]
M00038  
Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate [PATH:ko00380]
Disease
H00178  
Glutaric acidemia
H00203  
Acatalasia
H00548  
Brunner syndrome
H00689  
Delayed sleep phase syndrome
H01075  
Peters anomaly
H01161  
Aromatic L-amino acid decarboxylase (AADC) deficiency
H01203  
Primary congenital glaucoma (PCG)
H01364  
3-Hydroxyacyl-CoA dehydrogenase deficiency
Other DBs
BSID: 
GO: 
Orthology
K00453  
tryptophan 2,3-dioxygenase [EC:1.13.11.11]
K00463  
indoleamine 2,3-dioxygenase [EC:1.13.11.52]
K01432  
arylformamidase [EC:3.5.1.9]
K14263  
kynurenine formamidase [EC:3.5.1.9]
K07130  
arylformamidase [EC:3.5.1.9]
K00486  
kynurenine 3-monooxygenase [EC:1.14.13.9]
K01556  
kynureninase [EC:3.7.1.3]
K16901  
anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9 1.14.14.8]
K16902  
FAD reductase [NAD(P)H] [EC:1.5.1.45]
K00452  
3-hydroxyanthranilate 3,4-dioxygenase [EC:1.13.11.6]
K03392  
aminocarboxymuconate-semialdehyde decarboxylase [EC:4.1.1.45]
K10217  
aminomuconate-semialdehyde/2-hydroxymuconate-6-semialdehyde dehydrogenase [EC:1.2.1.85 1.2.1.32]
K15067  
2-aminomuconate deaminase [EC:3.5.99.5]
K00164  
2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
K00252  
glutaryl-CoA dehydrogenase [EC:1.3.8.6]
K01692  
enoyl-CoA hydratase [EC:4.2.1.17]
K01825  
3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:5.3.3.8 5.1.2.3 4.2.1.17 1.1.1.35]
K01782  
3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:5.1.2.3 4.2.1.17 1.1.1.35]
K07515  
enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.211 4.2.1.17]
K07514  
enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:5.3.3.8 1.1.1.35 4.2.1.17]
K07511  
enoyl-CoA hydratase [EC:4.2.1.17]
K00022  
3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K00626  
acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
K00816  
kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase [EC:2.6.1.64 4.4.1.13 2.6.1.7]
K00825  
kynurenine/2-aminoadipate aminotransferase [EC:2.6.1.39 2.6.1.7]
K14264  
kynurenine aminotransferase [EC:2.6.1.7]
K01667  
tryptophanase [EC:4.1.99.1]
K03393  
aromatic amino acid hydroxylase [EC:1.14.16.-]
K00502  
tryptophan 5-monooxygenase [EC:1.14.16.4]
K01593  
aromatic-L-amino-acid decarboxylase [EC:4.1.1.28]
K00274  
monoamine oxidase [EC:1.4.3.4]
K00128  
aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
K14085  
aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.3 1.2.1.8 1.2.1.31]
K00149  
aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.3 1.2.1.47]
K00157  
aldehyde oxidase [EC:1.2.3.1]
K00543  
acetylserotonin N-methyltransferase [EC:2.1.1.4]
K00669  
arylalkylamine N-acetyltransferase [EC:2.3.1.87]
K00493  
unspecific monooxygenase [EC:1.14.14.1]
K07408  
cytochrome P450, family 1, subfamily A, polypeptide 1 [EC:1.14.14.1]
K07409  
cytochrome P450, family 1, subfamily A, polypeptide 2 [EC:1.14.14.1]
K07410  
cytochrome P450, family 1, subfamily B, polypeptide 1 [EC:1.14.14.1]
K14338  
cytochrome P450 / NADPH-cytochrome P450 reductase [EC:1.6.2.4 1.14.14.1]
K00562  
methyltransferase [EC:2.1.1.96 2.1.1.49]
K11812  
tryptophan N-monooxygenase [EC:1.14.13.125]
K11813  
tryptophan N-monooxygenase [EC:1.14.13.125]
K11816  
indole-3-pyruvate monooxygenase [EC:1.14.13.168]
K03334  
L-amino-acid oxidase [EC:1.4.3.2]
K14265  
tryptophan aminotransferase [EC:2.6.1.27]
K00838  
aromatic amino acid aminotransferase I [EC:2.6.1.5 2.6.1.27 2.6.1.57]
K16903  
L-tryptophan---pyruvate aminotransferase [EC:2.6.1.99]
K04103  
indolepyruvate decarboxylase [EC:4.1.1.74]
K11182  
diamine oxidase [EC:1.4.3.22]
K11868  
indoleacetaldoxime dehydratase [EC:4.99.1.6]
K11817  
indole-3-acetaldehyde oxidase [EC:1.2.3.7]
K01426  
amidase [EC:3.5.1.4]
K01501  
nitrilase [EC:3.5.5.1]
K01721  
nitrile hydratase [EC:4.2.1.84]
K00466  
tryptophan 2-monooxygenase [EC:1.13.12.3]
K11818  
cytochrome P450, family 83, subfamily B, polypeptide 1 [EC:1.14.-.-]
K11819  
S-alkyl-thiohydroximate lyase SUR1 [EC:4.4.1.-]
K11820  
N-hydroxythioamide S-beta-glucosyltransferase [EC:2.4.1.195]
K11821  
desulfoglucosinolate sulfotransferase A/B/C [EC:2.8.2.-]
K01237  
myrosinase [EC:3.2.1.147]
K03781  
catalase [EC:1.11.1.6]
K03782  
catalase-peroxidase [EC:1.11.1.21]
Compound
C00016  
FAD
C00024  
Acetyl-CoA
C00078  
L-Tryptophan
C00108  
Anthranilate
C00322  
2-Oxoadipate
C00328  
L-Kynurenine
C00331  
Indolepyruvate
C00332  
Acetoacetyl-CoA
C00398  
Tryptamine
C00463  
Indole
C00527  
Glutaryl-CoA
C00632  
3-Hydroxyanthranilate
C00637  
Indole-3-acetaldehyde
C00643  
5-Hydroxy-L-tryptophan
C00780  
Serotonin
C00877  
Crotonoyl-CoA
C00954  
Indole-3-acetate
C00955  
Indole-3-ethanol
C00978  
N-Acetylserotonin
C01111  
7,8-Dihydroxykynurenate
C01144  
(S)-3-Hydroxybutanoyl-CoA
C01249  
7,8-Dihydro-7,8-dihydroxykynurenate
C01252  
4-(2-Aminophenyl)-2,4-dioxobutanoate
C01352  
FADH2
C01598  
Melatonin
C01717  
4-Hydroxy-2-quinolinecarboxylic acid
C01987  
2-Aminophenol
C02043  
Indolelactate
C02161  
2-Aminophenoxazin-3-one
C02172  
N-Acetylisatin
C02220  
2-Aminomuconate
C02298  
N-Acetylindoxyl
C02470  
Xanthurenic acid
C02693  
(Indol-3-yl)acetamide
C02700  
L-Formylkynurenine
C02775  
2,3-Dihydroxyindole
C02937  
Indole-3-acetaldehyde oxime
C02938  
3-Indoleacetonitrile
C03227  
3-Hydroxy-L-kynurenine
C03230  
(Indol-3-yl)glycolaldehyde
C03453  
gamma-Oxalocrotonate
C03574  
2-Formylaminobenzaldehyde
C03722  
Quinolinate
C03824  
2-Aminomuconate semialdehyde
C04409  
2-Amino-3-carboxymuconate semialdehyde
C05634  
5-Hydroxyindoleacetaldehyde
C05635  
5-Hydroxyindoleacetate
C05636  
3-Hydroxykynurenamine
C05637  
4,8-Dihydroxyquinoline
C05638  
5-Hydroxykynurenamine
C05639  
4,6-Dihydroxyquinoline
C05640  
Cinnavalininate
C05641  
5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate
C05642  
Formyl-N-acetyl-5-methoxykynurenamine
C05643  
6-Hydroxymelatonin
C05644  
3-Methylindolepyruvate
C05645  
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
C05646  
5-Hydroxyindolepyruvate
C05647  
Formyl-5-hydroxykynurenamine
C05648  
5-Hydroxy-N-formylkynurenine
C05651  
5-Hydroxykynurenine
C05652  
4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate
C05653  
Formylanthranilate
C05654  
5-(2'-Formylethyl)-4,6-dihydroxypicolinate
C05655  
5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate
C05656  
5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate
C05658  
Indoxyl
C05659  
5-Methoxytryptamine
C05660  
5-Methoxyindoleacetate
C05663  
6-Hydroxykynurenate
C05830  
8-Methoxykynurenate
C05831  
3-Methoxyanthranilate
C05832  
5-Hydroxyindoleacetylglycine
C05834  
3-Methyldioxyindole
C05835  
2-Formaminobenzoylacetate
C05837  
Glucobrassicin
C06212  
N-Methylserotonin
C06213  
N-Methyltryptamine
C16516  
Indolylmethylthiohydroximate
C16517  
Indolylmethyl-desulfoglucosinolate
C16518  
S-(Indolylmethylthiohydroximoyl)-L-cysteine
C17203  
N-Hydroxyl-tryptamine
Reference
  Authors
Woodward AW, Bartel B
  Title
Auxin: regulation, action, and interaction.
  Journal
Ann Bot 95:707-35 (2005)

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