Novobiocin biosynthesis

Metabolism; Biosynthesis of other secondary metabolites

PMID:12480894

Pojer F, Li SM, Heide L.

Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics.

Microbiology 148:3901-11 (2002)

PMID:11325587

Chen H, Walsh CT.

Coumarin formation in novobiocin biosynthesis: beta-hydroxylation of the aminoacyl enzyme tyrosyl-S-NovH by a cytochrome P450 NovI.

Chem Biol 8:301-12 (2001)

PMID:14622269

Schmutz E, Steffensky M, Schmidt J, Porzel A, Li SM, Heide L.

An unusual amide synthetase (CouL) from the coumermycin A1 biosynthetic gene cluster from Streptomyces rishiriensis DSM 40489.

Eur J Biochem 270:4413-9 (2003)

PMID:12904558

Xu H, Kahlich R, Kammerer B, Heide L, Li SM.

CloN2, a novel acyltransferase involved in the attachment of the pyrrole-2-carboxyl moiety to the deoxysugar of clorobiocin.

Microbiology 149:2183-91 (2003)

PMID:12436260

Xu H, Wang ZX, Schmidt J, Heide L, Li SM.

Genetic analysis of the biosynthesis of the pyrrole and carbamoyl moieties of coumermycin A1 and novobiocin.

Mol Genet Genomics 268:387-96 (2002)

PMID:14694473

Freel Meyers CL, Oberthur M, Xu H, Heide L, Kahne D, Walsh CT.

Characterization of NovP and NovN: completion of novobiocin biosynthesis by sequential tailoring of the noviosyl ring.

Angew Chem Int Ed Engl 43:67-70 (2004)

PMID:12777382

Pojer F, Kahlich R, Kammerer B, Li SM, Heide L.

CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis.

J Biol Chem 278:30661-8 (2003)

PMID:12368465

Li SM, Westrich L, Schmidt J, Kuhnt C, Heide L.

Methyltransferase genes in Streptomyces rishiriensis: new coumermycin derivatives from gene-inactivation experiments.

Microbiology 148:3317-26 (2002)

PMID:12618544

Pojer F, Wemakor E, Kammerer B, Chen H, Walsh CT, Li SM, Heide L.

CloQ, a prenyltransferase involved in clorobiocin biosynthesis.

Proc Natl Acad Sci U S A 100:2316-21 (2003)