KEGG   PATHWAY: ko00450Help
Entry
ko00450                     Pathway                                

Name
Selenocompound metabolism
Class
Metabolism; Metabolism of other amino acids
BRITE hierarchy
Pathway map
Selenocompound metabolism
ko00450

All organismsOrtholog table
Disease
H00183  
Homocystinuria
H00184  
Hypermethioninemia
H00761  
SEMD, Pakistani type
H01285  
Methylcobalamin deficiency type G (cblG)
Orthology
K01739  
cystathionine gamma-synthase [EC:2.5.1.48]
K01760  
cystathionine beta-lyase [EC:4.4.1.8]
K14155  
cystathione beta-lyase [EC:4.4.1.8]
K00548  
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]
K00549  
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [EC:2.1.1.14]
K01758  
cystathionine gamma-lyase [EC:4.4.1.1]
K01761  
methionine-gamma-lyase [EC:4.4.1.11]
K01763  
selenocysteine lyase [EC:4.4.1.16]
K11717  
cysteine desulfurase / selenocysteine lyase [EC:4.4.1.16 2.8.1.7]
K00816  
kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase [EC:2.6.1.64 4.4.1.13 2.6.1.7]
K08247  
methionine S-methyltransferase [EC:2.1.1.12]
K00384  
thioredoxin reductase (NADPH) [EC:1.8.1.9]
K00562  
methyltransferase [EC:2.1.1.96 2.1.1.49]
K07309  
Tat-targeted selenate reductase subunit YnfE [EC:1.97.1.9]
K07310  
Tat-targeted selenate reductase subunit YnfF [EC:1.97.1.9]
K12527  
putative selenate reductase [EC:1.97.1.9]
K12528  
putative selenate reductase molybdopterin-binding subunit
K12529  
putative selenate reductase FAD-binding subunit
K13811  
3'-phosphoadenosine 5'-phosphosulfate synthase [EC:2.7.1.25 2.7.7.4]
K00955  
bifunctional enzyme CysN/CysC [EC:2.7.1.25 2.7.7.4]
K00956  
sulfate adenylyltransferase subunit 1 [EC:2.7.7.4]
K00957  
sulfate adenylyltransferase subunit 2 [EC:2.7.7.4]
K00958  
sulfate adenylyltransferase [EC:2.7.7.4]
K01008  
selenide, water dikinase [EC:2.7.9.3]
K10837  
O-phosphoseryl-tRNA(Sec) kinase [EC:2.7.1.164]
K01042  
L-seryl-tRNA(Ser) seleniumtransferase [EC:2.9.1.1]
K03341  
O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase [EC:2.9.1.2]
K01874  
methionyl-tRNA synthetase [EC:6.1.1.10]
Compound
C00017  
Protein
C00041  
L-Alanine
C01528  
Hydrogen selenide
C02535  
Dimethyl selenide
C05172  
Selenophosphoric acid
C05335  
L-Selenomethionine
C05336  
Selenomethionyl-tRNA(Met)
C05684  
Selenite
C05686  
Adenylylselenate
C05688  
L-Selenocysteine
C05689  
Se-Methyl-L-selenocysteine
C05690  
Se-Methylselenomethionine
C05695  
gamma-Glutamyl-Se-methylselenocysteine
C05697  
Selenate
C05698  
Selenohomocysteine
C05699  
L-Selenocystathionine
C05703  
Methaneselenol
C06481  
L-Seryl-tRNA(Sec)
C06482  
L-Selenocysteinyl-tRNA(Sec)
C16638  
O-Phosphoseryl-tRNA(Sec)
C18870  
Selenodiglutathione
C18871  
Glutathioselenol
C18872  
Trimethylselenonium
C18893  
1-Methylseleno-N-acetyl-D-galactosamine
C18902  
Methylselenic acid
C18904  
Methylselenopyruvate
C18905  
Methylselenocysteine Se-oxide
Reference
  Authors
Hoefig CS, Renko K, Kohrle J, Birringer M, Schomburg L
  Title
Comparison of different selenocompounds with respect to nutritional value vs. toxicity using liver cells in culture.
  Journal
J Nutr Biochem (2010)
Reference
  Authors
McKenzie MJ, Hunter DA, Pathirana R, Watson LM, Joyce NI, Matich AJ, Rowan DD, Brummell DA
  Title
Accumulation of an organic anticancer selenium compound in a transgenic Solanaceous species shows wider applicability of the selenocysteine methyltransferase transgene from selenium hyperaccumulators.
  Journal
Transgenic Res 18:407-24 (2009)
Reference
  Authors
Pinto JT, Lee JI, Sinha R, MacEwan ME, Cooper AJ
  Title
Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring  organoselenium compounds.
  Journal
Amino Acids 41:29-41 (2011)
Reference
  Authors
Suzuki KT, Kurasaki K, Suzuki N
  Title
Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide.
  Journal
Biochim Biophys Acta 1770:1053-61 (2007)
Reference
  Authors
Gromer S, Gross JH
  Title
Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase. Implications for the antitumor effects of selenium.
  Journal
J Biol Chem 277:9701-6 (2002)

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