KEGG   PATHWAY: ko00523Help
Entry
ko00523                     Pathway                                

Name
Polyketide sugar unit biosynthesis
Class
Metabolism; Metabolism of terpenoids and polyketides
BRITE hierarchy
Pathway map
Polyketide sugar unit biosynthesis
ko00523

All organismsOrtholog table
Orthology
K00973  
glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]
K01710  
dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]
K01790  
dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]
K00067  
dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]
K12451  
3,5-epimerase/4-reductase [EC:1.1.1.- 5.1.3.-]
K17947  
dTDP-L-rhamnose 4-epimerase [EC:5.1.3.25]
K12710  
novobiocin biosynthesis protein NovU
K17625  
novobiocin biosynthesis protein NovS
K13306  
dTDP-4-dehydro-6-deoxyglucose reductase [EC:1.1.1.266]
K13307  
dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase [EC:2.1.1.235]
K13308  
dTDP-4-amino-4,6- dideoxyglucose [EC:2.6.1.33]
K13309  
reductase
K13310  
transaminase
K13311  
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase [EC:2.1.1.234]
K13312  
epimerase
K13313  
dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase [EC:1.1.1.364]
K13314  
2,3-dehydratase
K13315  
NDP-hexose 2,3-enoyl reductase
K13316  
NDP-hexose 3,5-(Or5-) epimerasee
K13317  
NDP-4-keto-2,6-dideoxyhexose 3-C-methyltransferase
K13318  
dTDP-4-keto-6-deoxy-L-hexose 4-reductase
K13319  
4-ketoreductase
K13320  
L-olivosyl-oleandolide 3-O-methyltransferase [EC:2.1.1.239]
K13321  
dTDP-4-keto-6-deoxyhexose 3,5-epimerase
K13322  
dTDP-4-keto-6-deoxyhexose 4-ketoreductase
K13323  
dTDP-4-keto-6-deoxyhexose 2,3-reductase
K13324  
dTDP-4-keto-6-deoxyhexose 3,4-isomerase
K13325  
dTDP-3-keto-6-deoxyhexose 3-aminotransaminase
K13326  
daunosaminyl-N,N-dimethyltransferase
K13327  
NDP-hexose-3-ketoreductase
K13328  
NDP-hexose-3,4-dehydratase
K13329  
aminotransferase
K13330  
N-dimethyltransferase
K13331  
NDP-deoxyhexose 3-aminotransferase
K13332  
N-methyltransferase
Compound
C00103  
D-Glucose 1-phosphate
C00688  
dTDP-4-dehydro-beta-L-rhamnose
C00842  
dTDP-glucose
C03187  
dTDP-6-deoxy-beta-L-talose
C03319  
dTDP-L-rhamnose
C04268  
dTDP-4-amino-4,6-dideoxy-D-glucose
C07277  
dTDP-D-fucose
C11460  
dTDP-4-oxo-5-C-methyl-L-rhamnose
C11907  
dTDP-4-oxo-6-deoxy-D-glucose
C11908  
3,6-Dideoxy-3-oxo-dTDP-D-glucose
C11909  
dTDP-3-oxo-4,6-dideoxy-D-glucose
C11910  
dTDP-3-amino-3,4,6-trideoxy-D-glucose
C11911  
dTDP-D-desosamine
C11912  
dTDP-6-deoxy-D-allose
C11915  
dTDP-3-methyl-4-oxo-2,6-dideoxy-L-glucose
C11916  
dTDP-L-mycarose
C11918  
Maltol
C11919  
dTDP-L-megosamine
C11920  
dTDP-L-olivose
C11921  
dTDP-L-oleandrose
C11922  
dTDP-4-oxo-2,6-dideoxy-D-glucose
C11925  
dTDP-3-amino-3,6-dideoxy-D-glucose
C11926  
dTDP-4-oxo-6-deoxy-D-allose
C11927  
dTDP-4-oxo-2,6-dideoxy-L-mannose
C11928  
dTDP-4-oxo-2,6-dideoxy-D-allose
C11930  
dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose
C11931  
dTDP-2,6-dideoxy-L-glycero-hex-2-enos-4-ulose
C11932  
dTDP-2,6-dideoxy-L-erythro-hexos-3-ulose
C11933  
dTDP-D-mycaminose
C12481  
dTDP-5-dimethyl-L-lyxose
C18029  
dTDP-3-oxo-2,6-dideoxy-D-glucose
C18030  
dTDP-2,6-dideoxy-D-kanosamine
C18031  
dTDP-D-angolosamine
C18032  
dTDP-4-oxo-2,3,6-trideoxy-D-glucose
C18033  
dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose
C18034  
dTDP-D-forosamine
C18092  
dTDP-L-ristosamine
Reference
  Authors
Rawlings BJ.
  Title
Type I polyketide biosynthesis in bacteria (Part A--erythromycin biosynthesis).
  Journal
Nat Prod Rep 18:190-227 (2001)
Reference
  Authors
Rawlings BJ.
  Title
Type I polyketide biosynthesis in bacteria (part B).
  Journal
Nat Prod Rep 18:231-81 (2001)
Reference
  Authors
Wohlert S, Lomovskaya N, Kulowski K, Fonstein L, Occi JL, Gewain KM, MacNeil DJ, Hutchinson CR
  Title
Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans.
  Journal
Chem Biol 8:681-700 (2001)
Reference
  Authors
Aguirrezabalaga I, Olano C, Allende N, Rodriguez L, Brana AF, Mendez C, Salas JA
  Title
Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus.
  Journal
Antimicrob Agents Chemother 44:1266-75 (2000)
Reference
  Authors
Bate N, Butler AR, Smith IP, Cundliffe E
  Title
The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin.
  Journal
Microbiology 146 ( Pt 1):139-46 (2000)
Reference
  Authors
Amann S, Drager G, Rupprath C, Kirschning A, Elling L
  Title
(Chemo)enzymatic synthesis of dTDP-activated 2,6-dideoxysugars as building blocks of polyketide antibiotics.
  Journal
Carbohydr Res 335:23-32 (2001)
Reference
  Authors
Thibodeaux CJ, Melancon CE, Liu HW
  Title
Unusual sugar biosynthesis and natural product glycodiversification.
  Journal
Nature 446:1008-16 (2007)
Reference
  Authors
Volchegursky Y, Hu Z, Katz L, McDaniel R
  Title
Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.
  Journal
Mol Microbiol 37:752-62 (2000)
Reference
(PMID:15609849 (Article in Russian))
  Authors
Mironov VA, Sergienko OV, Nastasiak IN, Danilenko VN.
  Title
Biogenesis and regulation of biosynthesis of erythromycins in Saccharopolyspora.
  Journal
Applied Biochemistry and Microbiology 40(6): 531-541 (2004)

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