KEGG   PATHWAY: ko00540Help
Entry
ko00540                     Pathway                                

Name
Lipopolysaccharide biosynthesis
Class
Metabolism; Glycan biosynthesis and metabolism
BRITE hierarchy
Pathway map
Lipopolysaccharide biosynthesis
ko00540

All organismsOrtholog table
Module
M00060  
Lipopolysaccharide biosynthesis, KDO2-lipid A [PATH:ko00540]
M00063  
CMP-KDO biosynthesis [PATH:ko00540]
M00064  
ADP-L-glycero-D-manno-heptose biosynthesis [PATH:ko00540]
M00080  
Lipopolysaccharide biosynthesis, inner core => outer core => O-antigen [PATH:ko00540]
Other DBs
BSID: 
GO: 
Orthology
K00677  
UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129]
K02535  
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [EC:3.5.1.108]
K16363  
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase / 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59 3.5.1.108]
K02536  
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [EC:2.3.1.191]
K03269  
UDP-2,3-diacylglucosamine hydrolase [EC:3.6.1.54]
K00748  
lipid-A-disaccharide synthase [EC:2.4.1.182]
K00912  
tetraacyldisaccharide 4'-kinase [EC:2.7.1.130]
K01627  
2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55]
K03270  
3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC:3.1.3.45]
K00979  
3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38]
K02527  
3-deoxy-D-manno-octulosonic-acid transferase [EC:2.4.99.15 2.4.99.14 2.4.99.13 2.4.99.12]
K02517  
lipid A biosynthesis lauroyl acyltransferase [EC:2.3.1.-]
K02560  
lipid A biosynthesis (KDO)2-(lauroyl)-lipid iva acyltransferase [EC:2.3.1.-]
K11211  
3-deoxy-D-manno-octulosonic acid kinase [EC:2.7.1.166]
K03271  
D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28]
K03272  
D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate adenosyltransferase [EC:2.7.7.70 2.7.1.167]
K03273  
D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [EC:3.1.3.83 3.1.3.82]
K03274  
ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20]
K07031  
D-glycero-alpha-D-manno-heptose-7-phosphate kinase [EC:2.7.1.168]
K15669  
D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase [EC:2.7.7.71]
K02841  
heptosyltransferase I [EC:2.4.-.-]
K02843  
heptosyltransferase II [EC:2.4.-.-]
K02844  
UDP-glucose:(heptosyl)LPS alpha-1,3-glucosyltransferase [EC:2.4.1.-]
K02850  
heptose (II) phosphotransferase [EC:2.7.1.-]
K02848  
heptose (I) phosphotransferase [EC:2.7.1.-]
K02849  
heptosyltransferase III [EC:2.4.-.-]
K02840  
UDP-D-galactose:(glucosyl)LPS alpha-1,6-D-galactosyltransferase [EC:2.4.1.-]
K03275  
UDP-glucose:(glucosyl)LPS alpha-1,3-glucosyltransferase [EC:2.4.1.-]
K03276  
UDP-glucose/galactose:(glucosyl)LPS alpha-1,2-glucosyl/galactosyltransferase [EC:2.4.1.-]
K03277  
heptosyltransferase IV [EC:2.4.-.-]
K03278  
UDP-D-galactose:(glucosyl)LPS alpha-1,3-D-galactosyltransferase [EC:2.4.1.44]
K03279  
UDP-glucose:(galactosyl)LPS alpha-1,2-glucosyltransferase [EC:2.4.1.58]
K03280  
UDP-N-acetylglucosamine:(glucosyl)LPS alpha-1,2-N-acetylglucosaminyltransferase [EC:2.4.1.56]
K02847  
O-antigen ligase [EC:6.-.-.-]
Compound
C00043  
UDP-N-acetyl-alpha-D-glucosamine
C00229  
Acyl-carrier protein
C01112  
D-Arabinose 5-phosphate
C01187  
3-Deoxy-D-manno-octulosonate
C04121  
CMP-3-deoxy-D-manno-octulosonate
C04478  
3-Deoxy-D-manno-octulosonate 8-phosphate
C04652  
UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine
C04738  
UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine
C04824  
Lipid X
C04919  
2,3,2'3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate
C04932  
Lipid A disaccharide
C05223  
Dodecanoyl-[acyl-carrier protein]
C05382  
Sedoheptulose 7-phosphate
C05761  
Tetradecanoyl-[acp]
C06022  
UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine
C06024  
3-Deoxy-D-manno-octulosonyl-lipid IV(A)
C06025  
Di[3-deoxy-D-manno-octulosonyl]-lipid IV(A)
C06026  
Di[3-deoxy-D-manno-octulosonyl]-lipid A
C06251  
Lauroyl-KDO2-lipid IV(A)
C06397  
ADP-D-glycero-beta-D-manno-heptose
C06398  
ADP-L-glycero-beta-D-manno-heptose
C07836  
D-glycero-beta-D-manno-Heptose 7-phosphate
C07838  
D-glycero-beta-D-manno-Heptose 1-phosphate
C11472  
D-glycero-beta-D-manno-Heptose 1,7-bisphosphate
C19877  
4-O-Phospho-alpha-Kdo-(2->6)-lipid IVA
C19878  
D-glycero-alpha-D-manno-Heptose 7-phosphate
C19879  
D-glycero-alpha-D-manno-Heptose 1,7-bisphosphate
C19880  
D-glycero-alpha-D-manno-Heptose 1-phosphate
C19881  
GDP-D-glycero-alpha-D-manno-heptose
Reference
PMID:9791168
  Authors
Heinrichs DE, Yethon JA, Whitfield C.
  Title
Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica.
  Journal
Mol Microbiol 30:221-32 (1998)
Reference
  Authors
Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P.
  Title
Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli.
  Journal
J Bacteriol 184:363-9 (2002)
Reference
PMID:9587193
  Authors
Wyckoff TJ, Raetz CR, Jackman JE.
  Title
Antibacterial and anti-inflammatory agents that target endotoxin.
  Journal
Trends Microbiol 6:154-9 (1998)
Reference
PMID:9765561
  Authors
Shibayama K, Ohsuka S, Tanaka T, Arakawa Y, Ohta M.
  Title
Conserved structural regions involved in the catalytic mechanism of Escherichia coli K-12 WaaO (RfaI).
  Journal
J Bacteriol 180:5313-8 (1998)

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