KEGG PATHWAY: ko00562

PATHWAY: ko00562

Entry

ko00562 Pathway

Name

Inositol phosphate metabolism

Class

Metabolism; Carbohydrate metabolism

Pathway map

ko00562

Inositol phosphate metabolism

Module

M00130	Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 [PATH:ko00562]
M00131	Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol [PATH:ko00562]
M00132	Inositol phosphate metabolism, Ins(1,3,4)P3 => phytate [PATH:ko00562]

Disease

H00530	Joubert syndrome
H00692	Lowe syndrome
H00694	Dent disease
H00700	Centronuclear myopathy
H00865	Lethal congenital contractural syndrome (LCCS)
H00957	Fleck corneal dystrophy (FCD)
H01195	VACTERL/VATER association

Other DBs

BSID:

362

GO:

0006020

Orthology

K00914	phosphatidylinositol 3-kinase [EC:2.7.1.137]
K01108	phosphatidylinositol-3-phosphatase [EC:3.1.3.64]
K00888	phosphatidylinositol 4-kinase [EC:2.7.1.67]
K13711	phosphatidylinositol 4-kinase type 2 [EC:2.7.1.67]
K00889	1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
K13712	phosphatidylinositol-4-phosphate 5-kinase-like protein 1 [EC:2.7.1.68]
K01099	phosphatidylinositol-bisphosphatase [EC:3.1.3.36]
K05858	phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05857	phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
K05860	phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
K01116	phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859	phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K05861	phosphatidylinositol phospholipase C, zeta [EC:3.1.4.11]
K00922	phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K01110	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.67 3.1.3.48 3.1.3.16]
K00920	1-phosphatidylinositol-5-phosphate 4-kinase [EC:2.7.1.149]
K03084	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86]
K15909	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 [EC:3.1.3.86]
K00923	phosphatidylinositol-4-phosphate 3-kinase [EC:2.7.1.154]
K01109	inositol polyphosphate-4-phosphatase [EC:3.1.3.66]
K00921	1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
K01114	phospholipase C [EC:3.1.4.3]
K16619	phospholipase C / alpha-toxin [EC:3.1.4.3]
K01771	1-phosphatidylinositol phosphodiesterase [EC:4.6.1.13]
K01092	myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]
K10047	inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase [EC:3.1.3.- 3.1.3.25]
K15759	inositol monophosphatase 3 [EC:3.1.3.7 3.1.3.25]
K00999	CDP-diacylglycerol--inositol 3-phosphatidyltransferase [EC:2.7.8.11]
K01858	myo-inositol-1-phosphate synthase [EC:5.5.1.4]
K01107	inositol polyphosphate 1-phosphatase [EC:3.1.3.57]
K15422	3'(2'), 5'-bisphosphate nucleotidase / inositol polyphosphate 1-phosphatase [EC:3.1.3.57 3.1.3.7]
K01106	inositol-1,4,5-trisphosphate 5-phosphatase [EC:3.1.3.56]
K03103	multiple inositol-polyphosphate phosphatase [EC:3.1.3.62]
K00911	1D-myo-inositol-triphosphate 3-kinase [EC:2.7.1.127]
K00913	inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase [EC:2.7.1.134 2.7.1.159]
K00915	1D-myo-Inositol-tetrakisphosphate 5-kinase / inositol-polyphosphate multikinase [EC:2.7.1.151 2.7.1.140]
K00328	inositol-polyphosphate multikinase [EC:2.7.1.151]
K10572	inositol-pentakisphosphate 2-kinase [EC:2.7.1.158]
K01083	3-phytase [EC:3.1.3.8]
K01093	4-phytase / acid phosphatase [EC:3.1.3.2 3.1.3.26]
K00469	inositol oxygenase [EC:1.13.99.1]
K00010	myo-inositol 2-dehydrogenase [EC:1.1.1.18]
K06606	inosose isomerase [EC:5.3.99.-]
K16043	scyllo-inositol dehydrogenase (NAD+) [EC:1.1.1.-]
K16044	scyllo-inositol dehydrogenase (NADP+) [EC:1.1.1.-]
K03335	inosose dehydratase [EC:4.2.1.44]
K03336	3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase [EC:3.7.1.-]
K03337	5-deoxy-glucuronate isomerase [EC:5.3.1.-]
K03338	5-dehydro-2-deoxygluconokinase [EC:2.7.1.92]
K03339	6-phospho-5-dehydro-2-deoxy-D-gluconate aldolase [EC:4.1.2.29]
K00140	malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.27 1.2.1.18]
K01803	triosephosphate isomerase (TIM) [EC:5.3.1.1]

Compound

C00024	Acetyl-CoA
C00092	D-Glucose 6-phosphate
C00111	Glycerone phosphate
C00118	D-Glyceraldehyde 3-phosphate
C00137	myo-Inositol
C00191	D-Glucuronate
C00222	3-Oxopropanoate
C00641	1,2-Diacyl-sn-glycerol
C00691	2,4,6/3,5-Pentahydroxycyclohexanone
C01177	Inositol 1-phosphate
C01194	1-Phosphatidyl-D-myo-inositol
C01204	Phytic acid
C01220	1D-myo-Inositol 1,4-bisphosphate
C01243	1D-myo-Inositol 1,3,4-trisphosphate
C01245	D-myo-Inositol 1,4,5-trisphosphate
C01272	1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277	1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284	1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546	myo-Inositol 4-phosphate
C03659	1-O-Methyl-myo-inositol
C03660	3-O-Methyl-myo-inositol
C04006	1D-myo-Inositol 3-phosphate
C04062	D-myo-Inositol 1,3-bisphosphate
C04063	D-myo-Inositol 3,4-bisphosphate
C04287	3D-(3,5/4)-Trihydroxycyclohexane-1,2-dione
C04477	1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04520	1D-myo-Inositol 3,4,5,6-tetrakisphosphate
C04549	1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04563	D-myo-Inositol 1,2,4,5,6-pentakisphosphate
C04579	Inositol 1,2,3,5,6-pentakisphosphate
C04637	1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981	Phosphatidylinositol-3,4,5-trisphosphate
C06153	scyllo-Inositol
C06892	2-Deoxy-5-keto-D-gluconic acid
C06893	2-Deoxy-5-keto-D-gluconic acid 6-phosphate
C11554	1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555	1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556	1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557	1-Phosphatidyl-1D-myo-inositol 5-phosphate
C16737	5-Deoxy glucuronic acid
C19891	D-chiro-Inositol
C20251	1-Keto-D-chiro-inositol

Reference

PMID:14993306

Authors

Yoshida K, Yamaguchi M, Ikeda H, Omae K, Tsurusaki K, Fujita Y

Title

The fifth gene of the iol operon of Bacillus subtilis, iolE, encodes 2-keto-myo-inositol dehydratase.

Journal

Microbiology 150:571-80 (2004)

Reference

PMID:18310071

Authors

Yoshida K, Yamaguchi M, Morinaga T, Kinehara M, Ikeuchi M, Ashida H, Fujita Y.

Title

myo-Inositol catabolism in Bacillus subtilis.

Journal

J Biol Chem 283:10415-24 (2008)

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Ontology (2)   
   KEGG BRITE (1)   
   GO (1)   
Pathway (8)   
   KEGG PATHWAY (4)   
   KEGG MODULE (3)   
   BioSystems (1)   
Disease (7)   
   KEGG DISEASE (7)   
Chemical substance (42)   
   KEGG COMPOUND (42)   
Chemical reaction (46)   
   KEGG ENZYME (46)   
Gene (52)   
   KEGG ORTHOLOGY (52)   
Literature (2)   
   PubMed (2)   
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