KEGG PATHWAY: ko00564

PATHWAY: ko00564

Entry

ko00564 Pathway

Name

Glycerophospholipid metabolism

Class

Metabolism; Lipid metabolism

Pathway map

ko00564

Glycerophospholipid metabolism

Module

M00090	Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:ko00564]
M00091	Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:ko00564]
M00092	Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:ko00564]
M00093	Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE [PATH:ko00564]

Disease

H00158	Lecithin:cholesterol acyltransferase deficiency
H00207	Rhizomelic chondrodysplasia punctata
H00654	Barth syndrome (BTHS)
H00770	Congenital myasthenic syndrome
H00833	Neurodegeneration with brain iron accumulation (NBIA)
H01117	Majeed syndrome
H01290	Acute recurrent myoglobinuria

Drug

D00534	Malathion (USP)
D00805	Metrifonate (USP/INN)
D03791	Dichlorvos (USAN/INN)

Other DBs

BSID:

364

GO:

0006650 0046474 0046475

Orthology

K00006	glycerol-3-phosphate dehydrogenase (NAD+) [EC:1.1.1.8]
K00057	glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94]
K00105	alpha-glycerophosphate oxidase [EC:1.1.3.21]
K00111	glycerol-3-phosphate dehydrogenase [EC:1.1.5.3]
K00112	glycerol-3-phosphate dehydrogenase subunit B [EC:1.1.5.3]
K00113	glycerol-3-phosphate dehydrogenase subunit C [EC:1.1.5.3]
K00629	glycerol-3-phosphate O-acyltransferase 1/2 [EC:2.3.1.15]
K13506	glycerol-3-phosphate O-acyltransferase 3/4 [EC:2.3.1.15]
K13507	glycerol-3-phosphate O-acyltransferase / dihydroxyacetone phosphate acyltransferase [EC:2.3.1.42 2.3.1.15]
K00630	glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15]
K13508	glycerol-3-phosphate acyltransferase [EC:2.3.1.15]
K00631	glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15]
K03621	glycerol-3-phosphate acyltransferase PlsX [EC:2.3.1.15]
K08591	glycerol-3-phosphate acyltransferase PlsY [EC:2.3.1.15]
K13509	lysophosphatidate acyltransferase [EC:2.3.1.51]
K13513	lysocardiolipin and lysophospholipid acyltransferase [EC:2.3.1.51 2.3.1.-]
K13517	lysophospholipid acyltransferase 1/2 [EC:2.3.1.- 2.3.1.51]
K13519	lysophospholipid acyltransferase [EC:2.3.1.- 2.3.1.23 2.3.1.51]
K13523	lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase [EC:2.3.1.- 2.3.1.51]
K00655	1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]
K00649	glyceronephosphate O-acyltransferase [EC:2.3.1.42]
K06123	1-acylglycerone phosphate reductase [EC:1.1.1.101]
K00980	glycerol-3-phosphate cytidylyltransferase [EC:2.7.7.39]
K01517	manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [EC:3.6.1.53 3.6.1.16 3.6.1.13]
K01080	phosphatidate phosphatase [EC:3.1.3.4]
K15728	phosphatidate phosphatase LPIN [EC:3.1.3.4]
K00901	diacylglycerol kinase (ATP dependent) [EC:2.7.1.107]
K16368	diacylglycerol kinase (CTP dependent) [EC:2.7.1.174]
K00994	diacylglycerol cholinephosphotransferase [EC:2.7.8.2]
K13644	choline/ethanolamine phosphotransferase [EC:2.7.8.2 2.7.8.1]
K01114	phospholipase C [EC:3.1.4.3]
K16619	phospholipase C / alpha-toxin [EC:3.1.4.3]
K01115	phospholipase D1/2 [EC:3.1.4.4]
K16860	phospholipase D3/4 [EC:3.1.4.4]
K00650	lecithin-cholesterol acyltransferase [EC:2.3.1.43]
K01047	secretory phospholipase A2 [EC:3.1.1.4]
K16342	cytosolic phospholipase A2 [EC:3.1.1.4]
K16343	calcium-independent phospholipase A2 [EC:3.1.1.4]
K14621	phospholipase B1, membrane-associated [EC:3.1.1.5 3.1.1.4]
K14674	TAG lipase / steryl ester hydrolase / phospholipase A2 / LPA acyltransferase [EC:2.3.1.51 3.1.1.4 3.1.1.13 3.1.1.3]
K16817	HRAS-like suppressor 3 [EC:3.1.1.4 3.1.1.32]
K01058	phospholipase A1 [EC:3.1.1.4 3.1.1.32]
K13510	lysophosphatidylcholine acyltransferase / lyso-PAF acetyltransferase [EC:2.3.1.67 2.3.1.23]
K13512	lysophospholipid acyltransferase [EC:2.3.1.- 2.3.1.23]
K13515	lysophospholipid acyltransferase 5 [EC:2.3.1.- 2.3.1.23]
K16818	phospholipase A1 [EC:3.1.1.32]
K06128	lysophospholipase I [EC:3.1.1.5]
K06129	lysophospholipase III [EC:3.1.1.5]
K06130	lysophospholipase II [EC:3.1.1.5]
K13333	lysophospholipase [EC:3.1.1.5]
K01048	lysophospholipase [EC:3.1.1.5]
K14676	lysophospholipid hydrolase [EC:3.1.1.5]
K01126	glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46]
K00623	choline O-acetyltransferase [EC:2.3.1.6]
K01049	acetylcholinesterase [EC:3.1.1.7]
K00866	choline kinase [EC:2.7.1.32]
K14156	choline/ethanolamine kinase [EC:2.7.1.82 2.7.1.32]
K06124	phosphoethanolamine/phosphocholine phosphatase [EC:3.1.3.75]
K00968	choline-phosphate cytidylyltransferase [EC:2.7.7.15]
K00993	ethanolaminephosphotransferase [EC:2.7.8.1]
K05939	acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase / long-chain-fatty-acid--[acyl-carrier-protein] ligase [EC:6.2.1.20 2.3.1.40]
K00894	ethanolamine kinase [EC:2.7.1.82]
K00967	ethanolamine-phosphate cytidylyltransferase [EC:2.7.7.14]
K05929	phosphoethanolamine N-methyltransferase [EC:2.1.1.103]
K04019	ethanolamine utilization protein EutA
K03735	ethanolamine ammonia-lyase large subunit [EC:4.3.1.7]
K03736	ethanolamine ammonia-lyase small subunit [EC:4.3.1.7]
K00551	phosphatidylethanolamine N-methyltransferase [EC:2.1.1.17]
K16369	phosphatidylethanolamine N-methyltransferase [EC:2.1.1.17]
K00550	methylene-fatty-acyl-phospholipid synthase [EC:2.1.1.16]
K00570	phosphatidylethanolamine/phosphatidyl-N-methylethanolamine N-methyltransferase [EC:2.1.1.71 2.1.1.17]
K01521	CDP-diacylglycerol pyrophosphatase [EC:3.6.1.26]
K00981	phosphatidate cytidylyltransferase [EC:2.7.7.41]
K01004	phosphatidylcholine synthase [EC:2.7.8.24]
K00998	phosphatidylserine synthase [EC:2.7.8.8]
K08729	phosphatidylserine synthase 1 [EC:2.7.8.-]
K08730	phosphatidylserine synthase 2 [EC:2.7.8.29]
K01613	phosphatidylserine decarboxylase [EC:4.1.1.65]
K00995	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]
K01095	phosphatidylglycerophosphatase A [EC:3.1.3.27]
K01096	phosphatidylglycerophosphatase B [EC:3.1.3.27]
K06131	cardiolipin synthase [EC:2.7.8.-]
K06132	putative cardiolipin synthase [EC:2.7.8.-]
K08744	cardiolipin synthase [EC:2.7.8.-]
K13511	monolysocardiolipin acyltransferase [EC:2.3.1.-]
K13535	cardiolipin-specific phospholipase [EC:3.1.1.-]
K13514	lysophosphatidylglycerol acyltransferase 1 [EC:2.3.1.-]
K00999	CDP-diacylglycerol--inositol 3-phosphatidyltransferase [EC:2.7.8.11]
K13516	lysophospholipid acyltransferase 7 [EC:2.3.1.-]
K13621	betaine lipid synthase
K13622	S-adenosylmethionine-diacylglycerol 3-amino-3-carboxypropyl transferase
K13623	S-adenosylmethionine-diacylgycerolhomoserine-N-methlytransferase

Compound

C00040	Acyl-CoA
C00084	Acetaldehyde
C00093	sn-Glycerol 3-phosphate
C00111	Glycerone phosphate
C00114	Choline
C00157	Phosphatidylcholine
C00189	Ethanolamine
C00269	CDP-diacylglycerol
C00307	CDP-choline
C00344	Phosphatidylglycerol
C00346	Ethanolamine phosphate
C00350	Phosphatidylethanolamine
C00416	Phosphatidate
C00513	CDP-glycerol
C00570	CDP-ethanolamine
C00588	Choline phosphate
C00641	1,2-Diacyl-sn-glycerol
C00670	sn-glycero-3-Phosphocholine
C00681	1-Acyl-sn-glycerol 3-phosphate
C01194	1-Phosphatidyl-D-myo-inositol
C01210	N-Methylethanolamine phosphate
C01233	sn-glycero-3-Phosphoethanolamine
C01241	Phosphatidyl-N-methylethanolamine
C01996	Acetylcholine
C02737	Phosphatidylserine
C03372	Acylglycerone phosphate
C03819	1-Acylglycerophosphoinositol
C03872	L-Serine-phosphoethanolamine
C03892	Phosphatidylglycerophosphate
C03974	2-Acyl-sn-glycerol 3-phosphate
C04230	1-Acyl-sn-glycero-3-phosphocholine
C04233	2-Acyl-sn-glycero-3-phosphocholine
C04308	Phosphatidyl-N-dimethylethanolamine
C04438	1-Acyl-sn-glycero-3-phosphoethanolamine
C05973	2-Acyl-sn-glycero-3-phosphoethanolamine
C05974	2-Acyl-sn-glycero-3-phosphoserine
C05976	Aminoacyl-phosphatidylglycerol
C05980	Cardiolipin
C06771	Triethanolamine
C06772	Diethanolamine
C13482	Phosphodimethylethanolamine
C18125	1-Acyl-sn-glycero-3-phosphoserine
C18126	1-Acyl-sn-glycero-3-phosphoglycerol
C18129	Monolysocardiolipin
C18168	Diacylglycerylhomoserine
C18169	Diacylglyceryl-N,N,N-trimethylhomoserine

Reference

PMID:1512203

Authors

Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.

Title

The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.

Journal

J Bacteriol 174:5702-10 (1992)

Reference

PMID:10092508

Authors

Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.

Title

Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.

Journal

Biochem Biophys Res Commun 257:50-6 (1999)

Reference

PMID:10542045

Authors

Athenstaedt K, Daum G.

Title

Phosphatidic acid, a key intermediate in lipid metabolism.

Journal

Eur J Biochem 266:1-16 (1999)

Reference

PMID:12431977

Authors

Shields DJ, Lehner R, Agellon LB, Vance DE.

Title

Membrane topography of human phosphatidylethanolamine N-methyltransferase.

Journal

J Biol Chem 278:2956-62 (2003)

Reference

PMID:14663079

Authors

Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.

Title

Pathways for phosphatidylcholine biosynthesis in bacteria.

Journal

Microbiology 149:3461-71 (2003)

Reference

PMID:15522832

Authors

Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.

Title

Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.

Journal

Biochim Biophys Acta 1686:161-8 (2004)

Reference

PMID:1649829

Authors

Hsu L, Jackowski S, Rock CO.

Title

Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.

Journal

J Biol Chem 266:13783-8 (1991)

Reference

PMID:10938271

Authors

Stone SJ, Vance JE.

Title

Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.

Journal

J Biol Chem 275:34534-40 (2000)

All links

Ontology (4)   
   KEGG BRITE (1)   
   GO (3)   
Pathway (9)   
   KEGG PATHWAY (4)   
   KEGG MODULE (4)   
   BioSystems (1)   
Disease (7)   
   KEGG DISEASE (7)   
Drug (3)   
   KEGG DRUG (3)   
Chemical substance (46)   
   KEGG COMPOUND (46)   
Chemical reaction (54)   
   KEGG ENZYME (54)   
Gene (92)   
   KEGG ORTHOLOGY (92)   
Literature (8)   
   PubMed (8)   
All databases (223)   

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