KEGG   PATHWAY: ko00623Help
Entry
ko00623                     Pathway                                

Name
Toluene degradation
Class
Metabolism; Xenobiotics biodegradation and metabolism
BRITE hierarchy
Pathway map
Toluene degradation
ko00623

All organismsOrtholog table
Module
M00418  
Toluene degradation, anaerobic, toluene => benzoyl-CoA [PATH:ko00623]
M00538  
Toluene degradation, toluene => benzoate [PATH:ko00623]
M00547  
Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol [PATH:ko00623]
Other DBs
BSID: 
GO: 
UMBBD: 
Orthology
K07540  
benzylsuccinate synthase [EC:4.1.99.11]
K07543  
benzylsuccinate CoA-transferase BbsE subunit [EC:2.8.3.15]
K07544  
benzylsuccinate CoA-transferase BbsF subunit [EC:2.8.3.15]
K07545  
(R)-benzylsuccinyl-CoA dehydrogenase [EC:1.3.8.3]
K07546  
E-phenylitaconyl-CoA hydratase [EC:4.2.1.-]
K07547  
2-[hydroxy(phenyl)methyl]-succinyl-CoA dehydrogenase BbsC subunit [EC:1.1.1.35]
K07548  
2-[hydroxy(phenyl)methyl]-succinyl-CoA dehydrogenase BbsD subunit [EC:1.1.1.35]
K07549  
benzoylsuccinyl-CoA thiolase BbsA subunit [EC:2.3.1.-]
K07550  
benzoylsuccinyl-CoA thiolase BbsB subunit [EC:2.3.1.-]
K16249  
phenol hydroxylase P0 protein
K16243  
Phenol hydroxylase P1 protein
K16244  
phenol hydroxylase P2 protein
K16242  
phenol hydroxylase P3 protein [EC:1.14.13.-]
K16245  
phenol hydroxylase P4 protein
K16246  
phenol hydroxylase P5 protein
K03268  
benzene/toluene dioxygenase alpha subunit [EC:1.14.12.11 1.14.12.3]
K16268  
benzene/toluene dioxygenase beta subunit [EC:1.14.12.11 1.14.12.3]
K18089  
benzene/toluene dioxygenase ferredoxin subunit
K18090  
benzene/toluene dioxygenase ferredoxin reductase subunit [EC:1.18.1.3]
K16269  
cis-1,2-dihydrobenzene-1,2-diol dehydrogenase [EC:1.3.1.19]
K15760  
toluene monooxygenase system protein A [EC:1.14.13.-]
K15761  
toluene monooxygenase system protein B [EC:1.14.13.-]
K15762  
toluene monooxygenase system ferredoxin subunit
K15763  
toluene monooxygenase system protein D [EC:1.14.13.-]
K15764  
toluene monooxygenase system protein E [EC:1.14.13.-]
K15765  
toluene monooxygenase electron transfer component [EC:1.18.1.3]
K03380  
phenol 2-monooxygenase [EC:1.14.13.7]
K00492  
[EC:1.14.13.-]
K15757  
xylene monooxygenase subunit XylM [EC:1.14.15.-]
K15758  
xylene monooxygenase electron transfer component [EC:1.18.1.3]
K00055  
aryl-alcohol dehydrogenase [EC:1.1.1.90]
K00141  
benzaldehyde dehydrogenase (NAD) [EC:1.2.1.28]
K05797  
4-cresol dehydrogenase (hydroxylating) [EC:1.17.99.1]
K15766  
2-aminobenzenesulfonate 2,3-dioxygenase subunit alpha [EC:1.14.12.14]
K15767  
2-aminobenzenesulfonate 2,3-dioxygenase subunit beta [EC:1.14.12.14]
K03381  
catechol 1,2-dioxygenase [EC:1.13.11.1]
K01856  
muconate cycloisomerase [EC:5.5.1.1]
K15768  
p-toluenesulfonate methyl-monooxygenase oxygenase component TsaM [EC:1.14.13.-]
K15769  
p-toluenesulfonate methyl-monooxygenase reductase component TsaB [EC:1.14.13.-]
K03384  
[EC:1.14.12.-]
K01860  
chloromuconate cycloisomerase [EC:5.5.1.7]
K01061  
carboxymethylenebutenolidase [EC:3.1.1.45]
K00217  
maleylacetate reductase [EC:1.3.1.32]
Compound
C00091  
Succinyl-CoA
C00156  
4-Hydroxybenzoate
C00180  
Benzoate
C00230  
3,4-Dihydroxybenzoate
C00261  
Benzaldehyde
C00512  
S-Benzoate coenzyme A
C00556  
Benzyl alcohol
C00587  
3-Hydroxybenzoate
C00633  
4-Hydroxybenzaldehyde
C01455  
Toluene
C01467  
3-Cresol
C01468  
4-Cresol
C01542  
o-Cresol
C02236  
4-Sulfobenzoate
C02923  
2,3-Dihydroxytoluene
C03067  
3-Hydroxybenzaldehyde
C03351  
3-Hydroxybenzyl alcohol
C04112  
3-Methyl-cis,cis-hexadienedioate
C04558  
3-Methylmuconolactone
C04559  
4-Methylmuconolactone
C04592  
Toluene-cis-dihydrodiol
C06677  
Toluene-4-sulfonate
C06678  
4-Sulfobenzyl alcohol
C06679  
4-Sulfobenzaldehyde
C06730  
4-Methylcatechol
C09816  
Benzylsuccinate
C09817  
Benzylsuccinyl-CoA
C09818  
E-Phenylitaconyl-CoA
C09819  
(Hydroxymethylphenyl)succinyl-CoA
C09820  
Benzoylsuccinyl-CoA
C18300  
2,4-Dichlorotoluene
C18301  
4,6-Dichloro-3-methyl-cis-1,2-dihydroxycyclohexa-3,5-diene
C18302  
4,6-Dichloro-3-methylcatechol
C18303  
3,5-Dichloro-2-methylmuconate
C18304  
2-Chloro-5-methyl-cis-dienelactone
C18305  
2-Chloro-5-methylmaleylacetate
C18306  
5-Methylmaleylacetate
C18307  
2-Methyl-3-oxoadipate
C18308  
3,5-Dichloro-2-methylmuconolactone
C18309  
3-Chloro-2-methyldienelactone
C18310  
3-Chloro-2-methylmaleylacetate
C18311  
4-Methyl-3-oxoadipate-enol-lactone
C18312  
4-Methyl-3-oxoadipate
Reference
  Authors
Vardar G, Wood TK
  Title
Protein engineering of toluene-o-xylene monooxygenase from Pseudomonas stutzeri OX1 for synthesizing 4-methylresorcinol, methylhydroquinone, and pyrogallol.
  Journal
Appl Environ Microbiol 70:3253-62 (2004)
Reference
  Authors
Leuthner B, Heider J
  Title
Anaerobic toluene catabolism of Thauera aromatica: the bbs operon codes for enzymes of beta oxidation of the intermediate benzylsuccinate.
  Journal
J Bacteriol 182:272-7 (2000)
Reference
  Authors
Leutwein C, Heider J
  Title
Succinyl-CoA:(R)-benzylsuccinate CoA-transferase: an enzyme of the anaerobic toluene catabolic pathway in denitrifying bacteria.
  Journal
J Bacteriol 183:4288-95 (2001)
Reference
  Authors
Kuhner S, Wohlbrand L, Fritz I, Wruck W, Hultschig C, Hufnagel P, Kube M, Reinhardt R, Rabus R
  Title
Substrate-dependent regulation of anaerobic degradation pathways for toluene and  ethylbenzene in a denitrifying bacterium, strain EbN1.
  Journal
J Bacteriol 187:1493-503 (2005)
Reference
PMID:2050632
  Authors
Locher HH, Leisinger T, Cook AM
  Title
4-Toluene sulfonate methyl-monooxygenase from Comamonas testosteroni T-2: purification and some properties of the oxygenase component.
  Journal
J Bacteriol 173:3741-8 (1991)
Reference
PMID:8828208
  Authors
Junker F, Saller E, Schlafli Oppenberg HR, Kroneck PM, Leisinger T, Cook AM
  Title
Degradative pathways for p-toluenecarboxylate and p-toluenesulfonate and their multicomponent oxygenases in Comamonas testosteroni strains PSB-4 and T-2.
  Journal
Microbiology 142 ( Pt 9):2419-27 (1996)
Reference
  Authors
Mampel J, Ruff J, Junker F, Cook AM.
  Title
The oxygenase component of the 2-aminobenzenesulfonate dioxygenase system from Alcaligenes sp. strain O-1.
  Journal
Microbiology 145 ( Pt 11):3255-64 (1999)
Reference
PMID:9006050
  Authors
Junker F, Kiewitz R, Cook AM
  Title
Characterization of the p-toluenesulfonate operon tsaMBCD and tsaR in Comamonas testosteroni T-2.
  Journal
J Bacteriol 179:919-27 (1997)

DBGET integrated database retrieval system