KEGG   PATHWAY: ko00670Help
Entry
ko00670                     Pathway                                

Name
One carbon pool by folate
Class
Metabolism; Metabolism of cofactors and vitamins
BRITE hierarchy
Pathway map
ko00670  One carbon pool by folate
ko00670

Ortholog table
Module
M00126  Tetrahydrofolate biosynthesis, GTP => THF [PATH:ko00670]
M00140  C1-unit interconversion, prokaryotes [PATH:ko00670]
M00141  C1-unit interconversion, eukaryotes [PATH:ko00670]
Disease
H00183  Homocystinuria
H00262  Spina bifida
H00966  AICA-ribosiduria
H01197  Dihydrofolate reductase (DHFR) deficiency
H01262  Formiminotransferase deficiency
H01285  Methylcobalamin deficiency type G (cblG)
Drug
D00145  Trimethoprim (JAN/USP/INN)
D00488  Pyrimethamine (JAN/USP/INN)
D02487  Proguanil hydrochloride (JAN)
D03771  Diaveridine (USAN/INN)
D06236  Trimethoprim sulfate (USP)
D08337  Iclaprim (USAN/INN)
D08428  Proguanil (INN)
D08563  Iclaprim mesylate (USAN)
D08644  Trimethoprim lactate
Orthology
K00287  dihydrofolate reductase [EC:1.5.1.3]
K18589  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19643  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18590  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19644  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19645  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18591  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K13998  dihydrofolate reductase / thymidylate synthase [EC:2.1.1.45 1.5.1.3]
K13938  dihydromonapterin reductase / dihydrofolate reductase [EC:1.5.1.3 1.5.1.50]
K01938  formate--tetrahydrofolate ligase [EC:6.3.4.3]
K13402  monofunctional C1-tetrahydrofolate synthase, mitochondrial [EC:6.3.4.3]
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:6.3.4.3 3.5.4.9 1.5.1.5]
K01491  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:3.5.4.9 1.5.1.5]
K13403  methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase [EC:3.5.4.9 1.5.1.15]
K00295  methylenetetrahydrofolate dehydrogenase (NAD+) [EC:1.5.1.15]
K00600  glycine hydroxymethyltransferase [EC:2.1.2.1]
K11787  phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1 2.1.2.2 6.3.4.13]
K00601  phosphoribosylglycinamide formyltransferase [EC:2.1.2.2]
K11175  phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]
K08289  phosphoribosylglycinamide formyltransferase 2 [EC:2.1.2.2]
K01492  phosphoribosylglycinamide/phosphoribosylaminoimidazolecarboxamide formyltransferase [EC:2.1.2.3 2.1.2.2]
K00602  phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:3.5.4.10 2.1.2.3]
K00603  glutamate formiminotransferase [EC:2.1.2.5]
K13990  glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase [EC:4.3.1.4 2.1.2.5]
K00604  methionyl-tRNA formyltransferase [EC:2.1.2.9]
K00605  aminomethyltransferase [EC:2.1.2.10]
K00548  5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]
K00560  thymidylate synthase [EC:2.1.1.45]
K03465  thymidylate synthase (FAD) [EC:2.1.1.148]
K00289  formyltetrahydrofolate dehydrogenase [EC:1.5.1.6]
K01433  formyltetrahydrofolate deformylase [EC:3.5.1.10]
K00297  methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20]
K01746  formiminotetrahydrofolate cyclodeaminase [EC:4.3.1.4]
K01934  5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]
Compound
C00101  Tetrahydrofolate
C00143  5,10-Methylenetetrahydrofolate
C00234  10-Formyltetrahydrofolate
C00415  Dihydrofolate
C00440  5-Methyltetrahydrofolate
C00445  5,10-Methenyltetrahydrofolate
C00504  Folate
C00664  5-Formiminotetrahydrofolate
C03479  Folinic acid

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