KEGG   PATHWAY: ko00740Help
Entry
ko00740                     Pathway                                

Name
Riboflavin metabolism
Class
Metabolism; Metabolism of cofactors and vitamins
BRITE hierarchy
Pathway map
Riboflavin metabolism
ko00740

All organismsOrtholog table
Module
M00125  
Riboflavin biosynthesis, GTP => riboflavin/FMN/FAD [PATH:ko00740]
Disease
H01002  
Generalized arterial calcification of infancy
H01113  
Acid phosphatase deficiency
H01394  
Cole disease
Other DBs
BSID: 
GO: 
Orthology
K01497  
GTP cyclohydrolase II [EC:3.5.4.25]
K14652  
3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:3.5.4.25 4.1.99.12]
K08096  
GTP cyclohydrolase IIa [EC:3.5.4.29]
K14653  
2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase [EC:3.5.1.102]
K01498  
diaminohydroxyphosphoribosylaminopyrimidine deaminase [EC:3.5.4.26]
K00082  
5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:1.1.1.193]
K11752  
diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:1.1.1.193 3.5.4.26]
K14654  
2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase [EC:1.1.1.302]
K14655  
tRNA pseudouridine synthase 8 / 2,5-diamino-6-(5-phospho-D-ribitylamino)-pyrimidin-4(3H)-one deaminase [EC:5.4.99.-]
K20860  
FMN hydrolase / 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.104 3.1.3.102]
K20861  
FMN hydrolase / 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.104 3.1.3.102]
K20862  
FMN hydrolase / 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.104 3.1.3.102]
K21063  
5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.104]
K21064  
5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.104]
K02858  
3,4-dihydroxy 2-butanone 4-phosphate synthase [EC:4.1.99.12]
K00794  
6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78]
K00793  
riboflavin synthase [EC:2.5.1.9]
K00861  
riboflavin kinase [EC:2.7.1.26]
K20884  
riboflavin kinase / FMN hydrolase [EC:3.1.3.102 2.7.1.26]
K11753  
riboflavin kinase / FMN adenylyltransferase [EC:2.7.7.2 2.7.1.26]
K07732  
riboflavin kinase, archaea type [EC:2.7.1.161]
K01078  
acid phosphatase [EC:3.1.3.2]
K01093  
4-phytase / acid phosphatase [EC:3.1.3.2 3.1.3.26]
K03788  
acid phosphatase (class B) [EC:3.1.3.2]
K09474  
acid phosphatase (class A) [EC:3.1.3.2]
K14379  
tartrate-resistant acid phosphatase type 5 [EC:3.1.3.2]
K14394  
low molecular weight phosphotyrosine protein phosphatase [EC:3.1.3.48 3.1.3.2]
K14410  
lysosomal acid phosphatase [EC:3.1.3.2]
K00953  
FAD synthetase [EC:2.7.7.2]
K14656  
FAD synthetase [EC:2.7.7.2]
K01513  
ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 [EC:3.6.1.9 3.1.4.1]
K18453  
ADP-ribose/FAD diphosphatase [EC:3.6.1.18 3.6.1.13]
K00484  
flavin reductase (NADH) [EC:1.5.1.36]
K00299  
FMN reductase [EC:1.5.1.38]
K19285  
FMN reductase (NADPH) [EC:1.5.1.38]
K19286  
FMN reductase [NAD(P)H] [EC:1.5.1.39]
K20146  
nitrilotriacetate monooxygenase reductase component [EC:1.5.1.42]
K15245  
chlorophenol-4-monooxygenase component 1 [EC:1.5.1.37]
K16902  
FAD reductase [NAD(P)H] [EC:1.5.1.45]
K05901  
biliverdin reductase / flavin reductase [EC:1.5.1.30 1.3.1.24]
K05368  
aquacobalamin reductase / NAD(P)H-flavin reductase [EC:1.5.1.41 1.16.1.3]
K04719  
5,6-dimethylbenzimidazole synthase [EC:1.13.11.79]
Compound
C00016  
FAD
C00044  
GTP
C00061  
FMN
C00199  
D-Ribulose 5-phosphate
C00255  
Riboflavin
C00474  
Ribitol
C01007  
Reduced riboflavin
C01268  
5-Amino-6-(5'-phosphoribosylamino)uracil
C01304  
2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C01352  
FADH2
C01727  
Lumichrome
C01847  
Reduced FMN
C03114  
Dimethylbenzimidazole
C04332  
6,7-Dimethyl-8-(D-ribityl)lumazine
C04454  
5-Amino-6-(5'-phospho-D-ribitylamino)uracil
C04732  
5-Amino-6-(1-D-ribitylamino)uracil
C05995  
7-Hydroxy-6-methyl-8-ribityllumazine
C15556  
L-3,4-Dihydroxybutan-2-one 4-phosphate
C15563  
2-Amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C18910  
2,5-Diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one
Reference
  Authors
Vitreschak AG, Rodionov DA, Mironov AA, Gelfand MS.
  Title
Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation.
  Journal
Nucleic Acids Res 30:3141-51 (2002)
Reference
  Authors
Fischer M, Haase I, Feicht R, Richter G, Gerhardt S, Changeux JP, Huber R, Bacher A.
  Title
Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe.
  Journal
Eur J Biochem 269:519-26 (2002)
Reference
  Authors
Haase I, Fischer M, Bacher A, Schramek N.
  Title
Temperature-dependent presteady state kinetics of lumazine synthase from the hyperthermophilic eubacterium Aquifex aeolicus.
  Journal
J Biol Chem 278:37909-15 (2003)
Reference
  Authors
Fischer M, Romisch W, Illarionov B, Eisenreich W, Bacher A.
  Title
Structures and reaction mechanisms of riboflavin synthases of eubacterial and archaeal origin.
  Journal
Biochem Soc Trans 33:780-4 (2005)

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