KEGG   PATHWAY: ko00740Help
Entry
ko00740                     Pathway                                

Name
Riboflavin metabolism
Class
Metabolism; Metabolism of cofactors and vitamins
BRITE hierarchy
Pathway map
Riboflavin metabolism
ko00740

All organismsOrtholog table
Module
M00125  
Riboflavin biosynthesis, GTP => riboflavin/FMN/FAD [PATH:ko00740]
Disease
H01002  
Generalized arterial calcification of infancy
H01113  
Acid phosphatase deficiency
Other DBs
BSID: 
GO: 
Orthology
K01497  
GTP cyclohydrolase II [EC:3.5.4.25]
K14652  
3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:3.5.4.25 4.1.99.12]
K08096  
GTP cyclohydrolase IIa [EC:3.5.4.29]
K14653  
2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase [EC:3.5.1.102]
K01498  
diaminohydroxyphosphoribosylaminopyrimidine deaminase [EC:3.5.4.26]
K00082  
5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:1.1.1.193]
K11752  
diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:1.1.1.193 3.5.4.26]
K14654  
2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase [EC:1.1.1.302]
K14655  
tRNA pseudouridine synthase 8 / 2,5-diamino-6-(5-phospho-D-ribitylamino)-pyrimidin-4(3H)-one deaminase [EC:5.4.99.-]
K02858  
3,4-dihydroxy 2-butanone 4-phosphate synthase [EC:4.1.99.12]
K00794  
6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78]
K00793  
riboflavin synthase [EC:2.5.1.9]
K00861  
riboflavin kinase [EC:2.7.1.26]
K11753  
riboflavin kinase / FMN adenylyltransferase [EC:2.7.7.2 2.7.1.26]
K07732  
riboflavin kinase, archaea type [EC:2.7.1.161]
K00953  
FAD synthetase [EC:2.7.7.2]
K14656  
FAD synthetase
K01513  
ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 [EC:3.6.1.9 3.1.4.1]
K01078  
acid phosphatase [EC:3.1.3.2]
K09474  
acid phosphatase (class A) [EC:3.1.3.2]
K03788  
acid phosphatase (class B) [EC:3.1.3.2]
K01093  
4-phytase / acid phosphatase [EC:3.1.3.2 3.1.3.26]
K14394  
low molecular weight phosphotyrosine protein phosphatase [EC:3.1.3.48 3.1.3.2]
K14379  
tartrate-resistant acid phosphatase type 5 [EC:3.1.3.2]
K14395  
lysophosphatidic acid phosphatase type 6 [EC:3.1.3.2]
K14410  
acid phosphatase [EC:3.1.3.2]
K00299  
FMN reductase [EC:1.5.1.38]
K05368  
aquacobalamin reductase / NAD(P)H-flavin reductase [EC:1.5.1.41 1.16.1.3]
K04719  
5,6-dimethylbenzimidazole synthase [EC:1.14.99.40]
K05901  
biliverdin reductase / flavin reductase [EC:1.5.1.30 1.3.1.24]
K00505  
tyrosinase [EC:1.14.18.1]
Compound
C00001  
H2O
C00007  
Oxygen
C00016  
FAD
C00044  
GTP
C00061  
FMN
C00199  
D-Ribulose 5-phosphate
C00255  
Riboflavin
C00472  
p-Benzoquinone
C00474  
Ribitol
C00530  
Hydroquinone
C01268  
5-Amino-6-(5'-phosphoribosylamino)uracil
C01304  
2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C01352  
FADH2
C01727  
Lumichrome
C01847  
Reduced FMN
C03114  
Dimethylbenzimidazole
C04332  
6,7-Dimethyl-8-(D-ribityl)lumazine
C04454  
5-Amino-6-(5'-phospho-D-ribitylamino)uracil
C04732  
5-Amino-6-(1-D-ribitylamino)uracil
C05995  
7-Hydroxy-6-methyl-8-ribityl lumazine
C15556  
L-3,4-Dihydroxybutan-2-one 4-phosphate
C15563  
2-Amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C18910  
2,5-Diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one
Reference
  Authors
Vitreschak AG, Rodionov DA, Mironov AA, Gelfand MS.
  Title
Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation.
  Journal
Nucleic Acids Res 30:3141-51 (2002)
Reference
  Authors
Fischer M, Haase I, Feicht R, Richter G, Gerhardt S, Changeux JP, Huber R, Bacher A.
  Title
Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe.
  Journal
Eur J Biochem 269:519-26 (2002)
Reference
  Authors
Haase I, Fischer M, Bacher A, Schramek N.
  Title
Temperature-dependent presteady state kinetics of lumazine synthase from the hyperthermophilic eubacterium Aquifex aeolicus.
  Journal
J Biol Chem 278:37909-15 (2003)
Reference
  Authors
Fischer M, Romisch W, Illarionov B, Eisenreich W, Bacher A.
  Title
Structures and reaction mechanisms of riboflavin synthases of eubacterial and archaeal origin.
  Journal
Biochem Soc Trans 33:780-4 (2005)

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