KEGG   PATHWAY: ko00945Help
Entry
ko00945                     Pathway                                

Name
Stilbenoid, diarylheptanoid and gingerol biosynthesis
Description
Stilbenoids are a group of phenolic compounds, biosynthetically interrelated through their common origin from a C6-C2-C6 intermediate, such as resveratol found in grapes. Stilbenoids can also exist as glycosides (e.g., piceid). Combretastatins are potentially useful stilbenoid natural products with known antitumor activity. Diarylheptanoid is a compound group having phenyl rings at 1,7 positions of n-heptane (C6-C7-C6), such as curcumin found in the ginger family. [6]-Gingerol is a major active component of ginger and has diverse pharmacologic effects.
Class
Metabolism; Biosynthesis of other secondary metabolites
BRITE hierarchy
Pathway map
Stilbenoid, diarylheptanoid and gingerol biosynthesis
ko00945

All organismsOrtholog table
Orthology
K13231  
pinosylvin synthase [EC:2.3.1.146]
K00487  
trans-cinnamate 4-monooxygenase [EC:1.14.13.11]
K13232  
stilbene synthase [EC:2.3.1.95]
K00517  
[EC:1.14.-.-]
K16040  
trans-resveratrol di-O-methyltransferase [EC:2.1.1.240]
K13233  
phenylpropanoylacetyl-CoA synthase [EC:2.3.1.218]
K13234  
curcumin synthase [EC:2.3.1.217]
K17211  
curcumin/demethoxycurcumin synthase [EC:2.3.1.219 2.3.1.217]
K17212  
bisdemethoxycurcumin synthase [EC:2.3.1.211]
K13235  
UDP-glucose glucosyltransferase [EC:2.4.1.-]
K13065  
shikimate O-hydroxycinnamoyltransferase [EC:2.3.1.133]
K09754  
coumaroylquinate(coumaroylshikimate) 3'-monooxygenase [EC:1.14.13.36]
K00588  
caffeoyl-CoA O-methyltransferase [EC:2.1.1.104]
Compound
C00223  
p-Coumaroyl-CoA
C00323  
Caffeoyl-CoA
C00406  
Feruloyl-CoA
C00540  
Cinnamoyl-CoA
C00852  
Chlorogenate
C01745  
Pinosylvin
C02947  
4-Coumaroylshikimate
C03582  
Resveratrol
C05901  
Piceatannol
C10287  
Pterostilbene
C10434  
5-O-Caffeoylshikimic acid
C10443  
Curcumin
C10462  
[6]-Gingerol
C12208  
p-Coumaroyl quinic acid
C17740  
p-Coumaroyl-diketide-CoA
C17741  
Feruloyl-diketide-CoA
C17742  
Demethoxycurcumin
C17743  
Bisdemethoxycurcumin
C17744  
1-(4-Hydroxyphenyl)-1-decene-3,5-dione
C17745  
1-(3,4-Dihydroxyphenyl)-1-decene-3,5-dione
C17746  
1-Dehydro-[6]-gingerdione
C17747  
5-Hydroxy-1-(4-hydroxyphenyl)-3-decanone
C17748  
1-(3,4-Dihydroxyphenyl)-5-hydroxy-3-decanone
C17749  
Curcumin monoglucoside
C17750  
Curcumin diglucoside
Reference
  Authors
Katsuyama Y, Kita T, Funa N, Horinouchi S
  Title
Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa.
  Journal
J Biol Chem 284:11160-70 (2009)
Reference
  Authors
Ramirez-Ahumada Mdel C, Timmermann BN, Gang DR
  Title
Biosynthesis of curcuminoids and gingerols in turmeric (Curcuma longa) and ginger (Zingiber officinale): identification of curcuminoid synthase and hydroxycinnamoyl-CoA thioesterases.
  Journal
Phytochemistry 67:2017-29 (2006)
Reference
  Authors
Masada S, Terasaka K, Mizukami H
  Title
A single amino acid in the PSPG-box plays an important role in the catalytic function of CaUGT2 (Curcumin glucosyltransferase), a Group D Family 1 glucosyltransferase from Catharanthus roseus.
  Journal
FEBS Lett 581:2605-10 (2007)

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