KEGG   PATHWAY: ko00982Help
Entry
ko00982                     Pathway                                

Name
Drug metabolism - cytochrome P450
Class
Metabolism; Xenobiotics biodegradation and metabolism
BRITE hierarchy
Pathway map
Drug metabolism - cytochrome P450
ko00982

All organismsOrtholog table
Disease
H01171  
Poor drug metabolism (PM)
H01205  
Coumarin resistance
H01234  
Trimethylaminuria (TMAU)
Orthology
K17712  
cytochrome P450, family 2, subfamily D, polypeptide 6 [EC:1.14.14.1]
K17719  
cytochrome P450, family 2, subfamily C, polypeptide 9 [EC:1.14.13.- 1.14.13.80 1.14.13.49 1.14.13.48]
K17689  
cytochrome P450, family 3, subfamily A, polypeptide 4 [EC:1.14.13.- 1.14.13.157 1.14.13.97 1.14.13.67 1.14.13.32]
K00485  
dimethylaniline monooxygenase (N-oxide forming) [EC:1.14.13.8]
K17721  
cytochrome P450, family 2, subfamily C, polypeptide 19 [EC:1.14.13.- 1.14.13.80 1.14.13.49 1.14.13.48]
K17709  
cytochrome P450, family 2, subfamily B, polypeptide 6 [EC:1.14.13.-]
K17690  
cytochrome P450, family 3, subfamily A, polypeptide 5 [EC:1.14.14.1]
K00799  
glutathione S-transferase [EC:2.5.1.18]
K13299  
glutathione S-transferase kappa 1 [EC:2.5.1.18]
K13951  
alcohol dehydrogenase 1/7 [EC:1.1.1.1]
K13980  
alcohol dehydrogenase 4 [EC:1.1.1.1]
K00121  
S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.1 1.1.1.284]
K13952  
alcohol dehydrogenase 6 [EC:1.1.1.1]
K13953  
alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
K00001  
alcohol dehydrogenase [EC:1.1.1.1]
K00129  
aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]
K00274  
monoamine oxidase [EC:1.4.3.4]
K00157  
aldehyde oxidase [EC:1.2.3.1]
K00699  
glucuronosyltransferase [EC:2.4.1.17]
K07409  
cytochrome P450, family 1, subfamily A, polypeptide 2 [EC:1.14.14.1]
K07415  
cytochrome P450, family 2, subfamily E, polypeptide 1 [EC:1.14.13.-]
K17718  
cytochrome P450, family 2, subfamily C, polypeptide 8 [EC:1.14.14.1]
K17683  
cytochrome P450, family 2, subfamily A, polypeptide 6 [EC:1.14.13.-]
Compound
C01471  
Acrolein
C01516  
Morphine
C05011  
Hydroxytamoxifen
C06174  
Codeine
C06754  
Chloroacetaldehyde
C06868  
Carbamazepine
C07047  
Ifosfamide
C07073  
Lidocaine
C07108  
Tamoxifen
C07163  
Methadone
C07185  
Valproic acid
C07492  
Oxcarbazepine
C07493  
10-Hydroxycarbazepine
C07495  
Dihydroxycarbazepine
C07496  
Carbamazepine-10,11-epoxide
C07501  
Felbamate
C07572  
Citalopram
C07643  
4-Hydroxycyclophosphamide
C07644  
4-Ketocyclophosphamide
C07645  
Aldophosphamide
C07646  
Carboxyphosphamide
C07647  
Phosphoramide mustard
C07888  
Cyclophosphamide
C08012  
Levomethadyl acetate
C11004  
2,6-Dimethylaniline
C11583  
4-Glutathionyl cyclophosphamide
C11785  
Normorphine
C16544  
alpha-Hydroxytamoxifen
C16545  
Tamoxifen N-oxide
C16546  
N-Desmethyltamoxifen
C16547  
Endoxifen
C16548  
N,N-Didesmethyltamoxifen
C16549  
alpha-Hydroxy-N-desmethyltamoxifen
C16550  
Dechloroethylcyclophosphamide
C16551  
Alcophosphamide
C16552  
Nornitrogen mustard
C16553  
4-Hydroxyifosfamide
C16554  
4-Ketoifosfamide
C16555  
2-Dechloroethylifosfamide
C16556  
Aldoifosfamide
C16557  
Carboxyifosfamide
C16558  
Alcoifosfamide
C16559  
Isophosphamide mustard
C16560  
3-Hydroxylidocaine
C16561  
Monoethylglycinexylidide
C16569  
Glycinexylidide
C16570  
4-Hydroxy-2,6-dimethylaniline
C16571  
2-Amino-3-methylbenzoate
C16572  
3-Hydroxymonoethylglycinexylidide
C16576  
Norcodeine
C16577  
Codeine-6-glucuronide
C16578  
Morphine-6-glucuronide
C16582  
2-Hydroxyfelbamate
C16584  
p-Hydroxyfelbamate
C16586  
2-Phenyl-1,3-propanediol monocarbamate
C16587  
3-Carbamoyl-2-phenylpropionaldehyde
C16591  
3-Carbamoyl-2-phenylpropionic acid
C16592  
Atropaldehyde
C16595  
4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one
C16596  
5-Phenyl-1,3-oxazinane-2,4-dione
C16601  
2-Hydroxycarbamazepine
C16602  
3-Hydroxycarbamazepine
C16603  
2,3-Dihydroxycarbamazepine
C16604  
2-Hydroxyiminostilbene
C16605  
2H-Dibenz[b,f]azepin-2-one
C16606  
Carbamazepine-o-quinone
C16607  
Citalopram N-oxide
C16608  
Demethylcitalopram
C16609  
Didemethylcitalopram
C16610  
Citalopram propionic acid
C16612  
Citalopram aldehyde
C16643  
Morphine-3-glucuronide
C16648  
2-n-Propyl-4-pentenoic acid
C16649  
4-Hydroxyvalproic acid
C16650  
5-Hydroxyvalproic acid
C16651  
3-Hydroxyvalproic acid
C16652  
3-Oxovalproic acid
C16653  
2-n-Propyl-2-pentenoic acid
C16654  
2-n-Propyl-3-pentenoic acid
C16655  
2-n-Propyl-4-oxopentanoic acid
C16656  
2-Propyl-2,4-pentadienoic acid
C16657  
2-Propylsuccinic acid
C16658  
2-Propylglutaric acid
C16659  
2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
C16660  
2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
C16661  
L-alpha-Acetyl-N-normethadol
C16662  
L-alpha-Acetyl-N,N-dinormethadol
D00195  
Codeine (USP)
D00252  
Carbamazepine (JP16/USP/INN)
D00343  
Ifosfamide (JAN/USP/INN)
D00358  
Lidocaine (JP16/USP/INN)
D00399  
Valproic acid (USP)
D00533  
Oxcarbazepine (USAN/INN)
D00536  
Felbamate (USAN/INN)
D04716  
Levomethadyl acetate (USAN)
D07704  
Citalopram (USP/INN)
D07760  
Cyclophosphamide (INN)
D08195  
Methadone (BAN)
D08233  
Morphine (BAN)
D08559  
Tamoxifen (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Gjerde J, Kisanga ER, Hauglid M, Holm PI, Mellgren G, Lien EA.
  Title
Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.
  Journal
J Chromatogr A 1082:6-14 (2005)
Reference
  Authors
Buck MB, Coller JK, Murdter TE, Eichelbaum M, Knabbe C.
  Title
TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells.
  Journal
Breast Cancer Res Treat 107:15-24 (2008)
Reference
  Authors
Rodriguez-Antona C, Ingelman-Sundberg M.
  Title
Cytochrome P450 pharmacogenetics and cancer.
  Journal
Oncogene 25:1679-91 (2006)
Reference
  Authors
Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ.
  Title
Metabolism and transport of oxazaphosphorines and the clinical implications.
  Journal
Drug Metab Rev 37:611-703 (2005)
Reference
  Authors
Kosel M, Amey M, Aubert AC, Baumann P.
  Title
In vitro metabolism of citalopram by monoamine oxidase B in human blood.
  Journal
Eur Neuropsychopharmacol 11:75-8 (2001)
Reference
  Authors
Olesen OV, Linnet K.
  Title
Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.
  Journal
Pharmacology 59:298-309 (1999)
Reference
PMID:9698084
  Authors
Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P.
  Title
Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.
  Journal
Biochem Pharmacol 56:15-23 (1998)
Reference
  Authors
David AW, Thomas LL, William OF.
  Title
Foye's Principles of Medicinal Chemistry (5th ed)
  Journal
Lippincott Williams & Wilkins (2002)
Reference
  Authors
Oda Y, Kharasch ED.
  Title
Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
  Journal
J Pharmacol Exp Ther 298:1021-32 (2001)
Reference
  Authors
Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT.
  Title
Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
  Journal
Drug Metab Dispos 28:959-65 (2000)
Reference
  Authors
Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL.
  Title
Mechanisms of idiosyncratic drug reactions: the case of felbamate.
  Journal
Chem Biol Interact 142:99-117 (2002)
Reference
  Authors
Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS
  Title
Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
  Journal
Drug Metab Dispos 36:1637-49 (2008)
Reference
  Authors
Pearce RE, Vakkalagadda GR, Leeder JS.
  Title
Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
  Journal
Drug Metab Dispos 30:1170-9 (2002)
Reference
  Authors
Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.
  Title
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
  Journal
Drug Metab Dispos 28:857-64 (2000)
Reference
  Authors
Bernad T, Joachim M.
  Title
Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology
  Journal
Wiley-VCH (2003)

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