KEGG   PATHWAY: ko00982Help
ko00982                     Pathway                                

Drug metabolism - cytochrome P450
Metabolism; Xenobiotics biodegradation and metabolism
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ko00982  Drug metabolism - cytochrome P450

Ortholog table
H01171  Poor drug metabolism (PM)
H01205  Coumarin resistance
H01234  Trimethylaminuria (TMAU)
K17712  cytochrome P450 family 2 subfamily D polypeptide 6 [EC:]
K17719  cytochrome P450 family 2 subfamily C polypeptide 9 [EC:1.14.14.-]
K17689  cytochrome P450 family 3 subfamily A polypeptide 4 [EC:1.14.13.-]
K00485  dimethylaniline monooxygenase (N-oxide forming) [EC:]
K17721  cytochrome P450 family 2 subfamily C polypeptide 19 [EC:1.14.14.-]
K17709  cytochrome P450 family 2 subfamily B polypeptide 6 [EC:1.14.13.-]
K17690  cytochrome P450 family 3 subfamily A polypeptide 5 [EC:]
K00799  glutathione S-transferase [EC:]
K13299  glutathione S-transferase kappa 1 [EC:]
K04097  prostaglandin-H2 D-isomerase / glutathione transferase [EC:]
K13951  alcohol dehydrogenase 1/7 [EC:]
K13980  alcohol dehydrogenase 4 [EC:]
K00121  S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:]
K13952  alcohol dehydrogenase 6 [EC:]
K13953  alcohol dehydrogenase, propanol-preferring [EC:]
K00001  alcohol dehydrogenase [EC:]
K00129  aldehyde dehydrogenase (NAD(P)+) [EC:]
K00274  monoamine oxidase [EC:]
K00157  aldehyde oxidase [EC:]
K00699  glucuronosyltransferase [EC:]
K07409  cytochrome P450 family 1 subfamily A polypeptide 2 [EC:]
K07415  cytochrome P450 family 2 subfamily E polypeptide 1 [EC:1.14.13.-]
K17718  cytochrome P450 family 2 subfamily C polypeptide 8 [EC:]
K17683  cytochrome P450 family 2 subfamily A polypeptide 6 [EC:1.14.13.-]
C01471  Acrolein
C01516  Morphine
C05011  Hydroxytamoxifen
C06174  Codeine
C06754  Chloroacetaldehyde
C06868  Carbamazepine
C07047  Ifosfamide
C07073  Lidocaine
C07108  Tamoxifen
C07163  Methadone
C07185  Valproic acid
C07492  Oxcarbazepine
C07493  10-Hydroxycarbazepine
C07495  Dihydroxycarbazepine
C07496  Carbamazepine-10,11-epoxide
C07501  Felbamate
C07572  Citalopram
C07643  4-Hydroxycyclophosphamide
C07644  4-Ketocyclophosphamide
C07645  Aldophosphamide
C07646  Carboxyphosphamide
C07647  Phosphoramide mustard
C07888  Cyclophosphamide
C08012  Levomethadyl acetate
C11004  2,6-Dimethylaniline
C11583  4-Glutathionyl cyclophosphamide
C11785  Normorphine
C16544  alpha-Hydroxytamoxifen
C16545  Tamoxifen N-oxide
C16546  N-Desmethyltamoxifen
C16547  Endoxifen
C16548  N,N-Didesmethyltamoxifen
C16549  alpha-Hydroxy-N-desmethyltamoxifen
C16550  Dechloroethylcyclophosphamide
C16551  Alcophosphamide
C16552  Nornitrogen mustard
C16553  4-Hydroxyifosfamide
C16554  4-Ketoifosfamide
C16555  2-Dechloroethylifosfamide
C16556  Aldoifosfamide
C16557  Carboxyifosfamide
C16558  Alcoifosfamide
C16559  Isophosphoramide mustard
C16560  3-Hydroxylidocaine
C16561  Monoethylglycinexylidide
C16569  Glycinexylidide
C16570  4-Hydroxy-2,6-dimethylaniline
C16571  2-Amino-3-methylbenzoate
C16572  3-Hydroxymonoethylglycinexylidide
C16576  Norcodeine
C16577  Codeine-6-glucuronide
C16578  Morphine-6-glucuronide
C16582  2-Hydroxyfelbamate
C16584  p-Hydroxyfelbamate
C16586  2-Phenyl-1,3-propanediol monocarbamate
C16587  3-Carbamoyl-2-phenylpropionaldehyde
C16591  3-Carbamoyl-2-phenylpropionic acid
C16592  Atropaldehyde
C16595  4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one
C16596  5-Phenyl-1,3-oxazinane-2,4-dione
C16601  2-Hydroxycarbamazepine
C16602  3-Hydroxycarbamazepine
C16603  2,3-Dihydroxycarbamazepine
C16604  2-Hydroxyiminostilbene
C16605  2H-Dibenz[b,f]azepin-2-one
C16606  Carbamazepine-o-quinone
C16607  Citalopram N-oxide
C16608  Demethylcitalopram
C16609  Didemethylcitalopram
C16610  Citalopram propionic acid
C16612  Citalopram aldehyde
C16643  Morphine-3-glucuronide
C16648  2-n-Propyl-4-pentenoic acid
C16649  4-Hydroxyvalproic acid
C16650  5-Hydroxyvalproic acid
C16651  3-Hydroxyvalproic acid
C16652  3-Oxovalproic acid
C16653  2-n-Propyl-2-pentenoic acid
C16654  2-n-Propyl-3-pentenoic acid
C16655  2-n-Propyl-4-oxopentanoic acid
C16656  2-Propyl-2,4-pentadienoic acid
C16657  2-Propylsuccinic acid
C16658  2-Propylglutaric acid
C16659  2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
C16660  2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
C16661  L-alpha-Acetyl-N-normethadol
C16662  L-alpha-Acetyl-N,N-dinormethadol
D00195  Codeine (USP)
D00252  Carbamazepine (JP17/USP/INN)
D00343  Ifosfamide (JAN/USP/INN)
D00358  Lidocaine (JP17/USP/INN)
D00399  Valproic acid (USP)
D00533  Oxcarbazepine (JAN/USAN/INN)
D00536  Felbamate (USAN/INN)
D04716  Levomethadyl acetate (USAN)
D07704  Citalopram (USP/INN)
D07760  Cyclophosphamide (INN)
D08195  Methadone (BAN)
D08233  Morphine (BAN)
D08559  Tamoxifen (INN)
Kato R, Kamatari T (eds).
[Drug Metabolism] (In Japanese)
Tokyo Kagaku Dojin (2000)
Gjerde J, Kisanga ER, Hauglid M, Holm PI, Mellgren G, Lien EA.
Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.
J Chromatogr A 1082:6-14 (2005)
Buck MB, Coller JK, Murdter TE, Eichelbaum M, Knabbe C.
TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells.
Breast Cancer Res Treat 107:15-24 (2008)
Rodriguez-Antona C, Ingelman-Sundberg M.
Cytochrome P450 pharmacogenetics and cancer.
Oncogene 25:1679-91 (2006)
Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ.
Metabolism and transport of oxazaphosphorines and the clinical implications.
Drug Metab Rev 37:611-703 (2005)
Kosel M, Amey M, Aubert AC, Baumann P.
In vitro metabolism of citalopram by monoamine oxidase B in human blood.
Eur Neuropsychopharmacol 11:75-8 (2001)
Olesen OV, Linnet K.
Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.
Pharmacology 59:298-309 (1999)
Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P.
Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.
Biochem Pharmacol 56:15-23 (1998)
David AW, Thomas LL, William OF.
Foye's Principles of Medicinal Chemistry (5th ed)
Lippincott Williams & Wilkins (2002)
Oda Y, Kharasch ED.
Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
J Pharmacol Exp Ther 298:1021-32 (2001)
Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT.
Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
Drug Metab Dispos 28:959-65 (2000)
Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL.
Mechanisms of idiosyncratic drug reactions: the case of felbamate.
Chem Biol Interact 142:99-117 (2002)
Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS
Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
Drug Metab Dispos 36:1637-49 (2008)
Pearce RE, Vakkalagadda GR, Leeder JS.
Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
Drug Metab Dispos 30:1170-9 (2002)
Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
Drug Metab Dispos 28:857-64 (2000)
Bernad T, Joachim M.
Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology
Wiley-VCH (2003)

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