KEGG PATHWAY: ko03008

PATHWAY: ko03008

Entry

ko03008 Pathway

Name

Ribosome biogenesis in eukaryotes

Description

Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.

Class

Genetic Information Processing; Translation

Pathway map

ko03008

Ribosome biogenesis in eukaryotes

Module

M00425

H/ACA ribonucleoprotein complex [PATH:ko03008]

Disease

H00063	Spinocerebellar ataxia (SCA)
H00439	Shwachman-Diamond syndrome (SDS)
H00507	Dyskeratosis congenita (DC)
H00518	RMRP related disorders
H00610	Treacher Collins syndrome
H00612	Primary open angle glaucoma
H00616	Bowen-Conradi syndrome (BCS)
H00621	Alopecia neurologic defects and endocrinopathy syndrome (ANE syndrome)
H00624	Familial cholestasis
H00788	Hoyeraal-Hreidarsson syndrome

Orthology

K03115	casein kinase II subunit beta
K03097	casein kinase II subunit alpha [EC:2.7.11.1]
K14544	U3 small nucleolar RNA-associated protein 22
K14545	ribosomal RNA-processing protein 7
K14546	U3 small nucleolar RNA-associated protein 5
K14547	U3 small nucleolar RNA-associated protein 8
K14548	U3 small nucleolar RNA-associated protein 4
K14549	U3 small nucleolar RNA-associated protein 15
K14550	U3 small nucleolar RNA-associated protein 10
K14551	U3 small nucleolar RNA-associated protein 9
K14552	NET1-associated nuclear protein 1 (U3 small nucleolar RNA-associated protein 17)
K14553	U3 small nucleolar RNA-associated protein 18
K14554	U3 small nucleolar RNA-associated protein 21
K14555	U3 small nucleolar RNA-associated protein 13
K14556	U3 small nucleolar RNA-associated protein 12
K14557	U3 small nucleolar RNA-associated protein 6
K14558	periodic tryptophan protein 2
K14559	U3 small nucleolar RNA-associated protein MPP10
K14560	U3 small nucleolar ribonucleoprotein protein IMP3
K14561	U3 small nucleolar ribonucleoprotein protein IMP4
K14562	Treacher Collins syndrome protein
K14563	rRNA 2'-O-methyltransferase fibrillarin [EC:2.1.1.-]
K14564	nucleolar protein 56
K14565	nucleolar protein 58
K12845	U4/U6 small nuclear ribonucleoprotein SNU13
K11131	H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
K11129	H/ACA ribonucleoprotein complex subunit 2
K11128	H/ACA ribonucleoprotein complex subunit 1
K11130	H/ACA ribonucleoprotein complex subunit 3
K14566	U3 small nucleolar RNA-associated protein 24
K14567	U3 small nucleolar RNA-associated protein 14
K03685	ribonuclease III [EC:3.1.26.3]
K14568	rRNA small subunit pseudouridine methyltransferase Nep1 [EC:2.1.1.260]
K14569	ribosome biogenesis protein BMS1
K14521	N-acetyltransferase 10 [EC:2.3.1.-]
K11108	RNA 3'-terminal phosphate cyclase-like protein
K01164	ribonuclease P/MRP protein subunit POP1 [EC:3.1.26.5]
K14522	ribonuclease P/MRP protein subunit POP3 [EC:3.1.26.5]
K14523	ribonucleases P/MRP protein subunit RPP38 [EC:3.1.26.5]
K03538	ribonuclease P protein subunit POP4 [EC:3.1.26.5]
K03537	ribonuclease P/MRP protein subunit POP5 [EC:3.1.26.5]
K14524	ribonuclease P/MRP protein subunit POP6 [EC:3.1.26.5]
K14525	ribonucleases P/MRP protein subunit RPP25 [EC:3.1.26.5]
K14526	ribonuclease P/MRP protein subunit POP7 [EC:3.1.26.5]
K14527	ribonuclease P/MRP protein subunit RPP20 [EC:3.1.26.5]
K14528	ribonuclease P/MRP protein subunit POP8 [EC:3.1.26.5]
K03539	ribonuclease P/MRP protein subunit RPP1 [EC:3.1.26.5]
K14531	ribonuclease MRP protein subunit SNM1
K14532	ribonuclease MRP protein subunit RMP1
K14530	ribonucleases P/MRP protein subunit RPP40 [EC:3.1.26.5]
K14570	RNA exonuclease 1 [EC:3.1.-.-]
K13288	oligoribonuclease [EC:3.1.-.-]
K12618	5'-3' exoribonuclease 1 [EC:3.1.13.-]
K12619	5'-3' exoribonuclease 2 [EC:3.1.13.-]
K06943	nucleolar GTP-binding protein
K14537	nuclear GTP-binding protein
K14538	nuclear GTP-binding protein
K14571	ribosome biogenesis ATPase
K14572	midasin
K14573	nucleolar protein 4
K11883	RNA-binding protein NOB1
K14758	casein kinase I homolog HRR25 [EC:2.7.11.1]
K07936	GTP-binding nuclear protein Ran
K14290	exportin-1
K07562	nonsense-mediated mRNA decay protein 3
K14284	nuclear RNA export factor 1/2
K14543	mRNA transport regulator MTR2
K14285	NTF2-related export protein 1/2
K03264	translation initiation factor 6
K14574	ribosome maturation protein SDO1
K14536	ribosome assembly protein 1 [EC:3.6.5.-]
K14539	large subunit GTPase 1 [EC:3.6.1.-]
K14575	AAA family ATPase
K14535	transcription initiation factor TFIID subunit 9 / adenylate kinase [EC:2.7.4.3]
K07178	RIO kinase 1 [EC:2.7.11.1]
K07179	RIO kinase 2 [EC:2.7.11.1]
K01979	small subunit ribosomal RNA
K01986	large subunit ribosomal RNA, 5.8S
K01982	large subunit ribosomal RNA
K01981	large subunit ribosomal RNA, 5S
K14483	U3 small nucleolar RNA
K14576	small nucleolar RNA MRP

Reference

PMID:20174677

Authors

Freed EF, Bleichert F, Dutca LM, Baserga SJ

Title

When ribosomes go bad: diseases of ribosome biogenesis.

Journal

Mol Biosyst 6:481-93 (2010)

Reference

PMID:17515605

Authors

Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M

Title

The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.

Journal

Mol Cell Biol 27:5414-29 (2007)

Reference

PMID:19850913

Authors

Strunk BS, Karbstein K

Title

Powering through ribosome assembly.

Journal

RNA 15:2083-104 (2009)

Reference

PMID:15120992

Authors

Granneman S, Baserga SJ

Title

Ribosome biogenesis: of knobs and RNA processing.

Journal

Exp Cell Res 296:43-50 (2004)

Reference

PMID:19879902

Authors

Kressler D, Hurt E, Bassler J

Title

Driving ribosome assembly.

Journal

Biochim Biophys Acta 1803:673-83 (2010)

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (4)   
   KEGG PATHWAY (2)   
   KEGG MODULE (1)   
   BioSystems (1)   
Disease (10)   
   KEGG DISEASE (10)   
Chemical reaction (12)   
   KEGG ENZYME (12)   
Gene (82)   
   KEGG ORTHOLOGY (82)   
Literature (5)   
   PubMed (5)   
All databases (114)   

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