KEGG   PATHWAY: ko03008Help
Entry
ko03008                     Pathway                                

Name
Ribosome biogenesis in eukaryotes
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is  assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
Ribosome biogenesis in eukaryotes
ko03008

All organismsOrtholog table
Module
M00425  
H/ACA ribonucleoprotein complex [PATH:ko03008]
Disease
H00063  
Spinocerebellar ataxia (SCA)
H00439  
Shwachman-Diamond syndrome (SDS)
H00507  
Dyskeratosis congenita (DC)
H00518  
RMRP related disorders
H00610  
Treacher Collins syndrome
H00612  
Primary open angle glaucoma
H00616  
Bowen-Conradi syndrome (BCS)
H00621  
Alopecia neurologic defects and endocrinopathy syndrome (ANE syndrome)
H00624  
Familial cholestasis
H00788  
Hoyeraal-Hreidarsson syndrome
Orthology
K03115  
casein kinase II subunit beta
K03097  
casein kinase II subunit alpha [EC:2.7.11.1]
K14544  
U3 small nucleolar RNA-associated protein 22
K14545  
ribosomal RNA-processing protein 7
K14546  
U3 small nucleolar RNA-associated protein 5
K14547  
U3 small nucleolar RNA-associated protein 8
K14548  
U3 small nucleolar RNA-associated protein 4
K14549  
U3 small nucleolar RNA-associated protein 15
K14550  
U3 small nucleolar RNA-associated protein 10
K14551  
U3 small nucleolar RNA-associated protein 9
K14552  
NET1-associated nuclear protein 1 (U3 small nucleolar RNA-associated protein 17)
K14553  
U3 small nucleolar RNA-associated protein 18
K14554  
U3 small nucleolar RNA-associated protein 21
K14555  
U3 small nucleolar RNA-associated protein 13
K14556  
U3 small nucleolar RNA-associated protein 12
K14557  
U3 small nucleolar RNA-associated protein 6
K14558  
periodic tryptophan protein 2
K14559  
U3 small nucleolar RNA-associated protein MPP10
K14560  
U3 small nucleolar ribonucleoprotein protein IMP3
K14561  
U3 small nucleolar ribonucleoprotein protein IMP4
K14562  
Treacher Collins syndrome protein
K14563  
rRNA 2'-O-methyltransferase fibrillarin [EC:2.1.1.-]
K14564  
nucleolar protein 56
K14565  
nucleolar protein 58
K12845  
U4/U6 small nuclear ribonucleoprotein SNU13
K11131  
H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
K11129  
H/ACA ribonucleoprotein complex subunit 2
K11128  
H/ACA ribonucleoprotein complex subunit 1
K11130  
H/ACA ribonucleoprotein complex subunit 3
K14566  
U3 small nucleolar RNA-associated protein 24
K14567  
U3 small nucleolar RNA-associated protein 14
K03685  
ribonuclease III [EC:3.1.26.3]
K14568  
rRNA small subunit pseudouridine methyltransferase Nep1 [EC:2.1.1.260]
K14569  
ribosome biogenesis protein BMS1
K14521  
N-acetyltransferase 10 [EC:2.3.1.-]
K11108  
RNA 3'-terminal phosphate cyclase-like protein
K01164  
ribonuclease P/MRP protein subunit POP1 [EC:3.1.26.5]
K14522  
ribonuclease P/MRP protein subunit POP3 [EC:3.1.26.5]
K14523  
ribonucleases P/MRP protein subunit RPP38 [EC:3.1.26.5]
K03538  
ribonuclease P protein subunit POP4 [EC:3.1.26.5]
K03537  
ribonuclease P/MRP protein subunit POP5 [EC:3.1.26.5]
K14524  
ribonuclease P/MRP protein subunit POP6 [EC:3.1.26.5]
K14525  
ribonucleases P/MRP protein subunit RPP25 [EC:3.1.26.5]
K14526  
ribonuclease P/MRP protein subunit POP7 [EC:3.1.26.5]
K14527  
ribonuclease P/MRP protein subunit RPP20 [EC:3.1.26.5]
K14528  
ribonuclease P/MRP protein subunit POP8 [EC:3.1.26.5]
K03539  
ribonuclease P/MRP protein subunit RPP1 [EC:3.1.26.5]
K14531  
ribonuclease MRP protein subunit SNM1
K14532  
ribonuclease MRP protein subunit RMP1
K14530  
ribonucleases P/MRP protein subunit RPP40 [EC:3.1.26.5]
K14570  
RNA exonuclease 1 [EC:3.1.-.-]
K13288  
oligoribonuclease [EC:3.1.-.-]
K12618  
5'-3' exoribonuclease 1 [EC:3.1.13.-]
K12619  
5'-3' exoribonuclease 2 [EC:3.1.13.-]
K06943  
nucleolar GTP-binding protein
K14537  
nuclear GTP-binding protein
K14538  
nuclear GTP-binding protein
K14571  
ribosome biogenesis ATPase
K14572  
midasin
K14573  
nucleolar protein 4
K11883  
RNA-binding protein NOB1
K14758  
casein kinase I homolog HRR25 [EC:2.7.11.1]
K07936  
GTP-binding nuclear protein Ran
K14290  
exportin-1
K07562  
nonsense-mediated mRNA decay protein 3
K14284  
nuclear RNA export factor
K14543  
mRNA transport regulator MTR2
K14285  
NTF2-related export protein 1/2
K03264  
translation initiation factor 6
K14574  
ribosome maturation protein SDO1
K14536  
ribosome assembly protein 1 [EC:3.6.5.-]
K14539  
large subunit GTPase 1 [EC:3.6.1.-]
K14575  
AAA family ATPase
K18532  
adenylate kinase [EC:2.7.4.3]
K07178  
RIO kinase 1 [EC:2.7.11.1]
K07179  
RIO kinase 2 [EC:2.7.11.1]
K01979  
small subunit ribosomal RNA
K01986  
large subunit ribosomal RNA, 5.8S
K01982  
large subunit ribosomal RNA
K01981  
large subunit ribosomal RNA, 5S
K14483  
U3 small nucleolar RNA
K14576  
small nucleolar RNA MRP
Reference
  Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
  Title
When ribosomes go bad: diseases of ribosome biogenesis.
  Journal
Mol Biosyst 6:481-93 (2010)
Reference
  Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  Journal
Mol Cell Biol 27:5414-29 (2007)
Reference
  Authors
Strunk BS, Karbstein K
  Title
Powering through ribosome assembly.
  Journal
RNA 15:2083-104 (2009)
Reference
  Authors
Granneman S, Baserga SJ
  Title
Ribosome biogenesis: of knobs and RNA processing.
  Journal
Exp Cell Res 296:43-50 (2004)
Reference
  Authors
Kressler D, Hurt E, Bassler J
  Title
Driving ribosome assembly.
  Journal
Biochim Biophys Acta 1803:673-83 (2010)

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