KEGG   PATHWAY: ko03015Help
Entry
ko03015                     Pathway                                

Name
mRNA surveillance pathway
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These  pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
mRNA surveillance pathway
ko03015

All organismsOrtholog table
Module
M00399  
Cap binding complex [PATH:ko03015]
M00430  
Exon junction complex (EJC) [PATH:ko03015]
Disease
H00658  
Syndromic X-linked mental retardation
H00704  
Oculopharyngeal muscular dystrophy (OPMD)
Other DBs
BSID: 
GO: 
Orthology
K12882  
nuclear cap-binding protein subunit 1
K12883  
nuclear cap-binding protein subunit 2
K14328  
regulator of nonsense transcripts 3
K12876  
RNA-binding protein 8A
K12877  
protein mago nashi
K14323  
protein CASC3
K13025  
ATP-dependent RNA helicase [EC:3.6.4.13]
K14324  
histone deacetylase complex subunit SAP18
K13114  
pinin
K12875  
apoptotic chromatin condensation inducer in the nucleus
K14325  
RNA-binding protein with serine-rich domain 1
K12881  
THO complex subunit 4
K14284  
nuclear RNA export factor 1/2
K14285  
NTF2-related export protein 1/2
K14543  
mRNA transport regulator MTR2
K12812  
ATP-dependent RNA helicase UAP56/SUB2 [EC:3.6.4.13]
K14294  
partner of Y14 and mago
K13171  
serine/arginine repetitive matrix protein 1
K13917  
mRNA-capping enzyme [EC:3.1.3.33 2.7.7.50]
K00565  
mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56]
K14396  
polyadenylate-binding protein 2
K14397  
cleavage and polyadenylation specificity factor subunit 5
K14398  
cleavage and polyadenylation specificity factor subunit 6/7
K14376  
poly(A) polymerase [EC:2.7.7.19]
K14399  
polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78]
K14400  
pre-mRNA cleavage complex 2 protein Pcf11
K14401  
cleavage and polyadenylation specificity factor subunit 1
K14402  
cleavage and polyadenylation specificity factor subunit 2
K14403  
cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
K14404  
cleavage and polyadenylation specificity factor subunit 4
K14405  
pre-mRNA 3'-end-processing factor FIP1
K15541  
protein MPE1
K15542  
polyadenylation factor subunit 2
K14962  
COMPASS component SWD2
K15543  
RNA end formation protein 2
K06269  
serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
K15544  
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16]
K14406  
cleavage stimulation factor subunit 1
K14407  
cleavage stimulation factor subunit 2
K14408  
cleavage stimulation factor subunit 3
K06100  
symplekin
K12595  
superkiller protein 7
K14411  
RNA-binding protein Musashi
K13126  
polyadenylate-binding protein
K03265  
peptide chain release factor subunit 1
K03267  
peptide chain release factor subunit 3
K14326  
regulator of nonsense transcripts 1 [EC:3.6.4.-]
K14327  
regulator of nonsense transcripts 2
K08873  
PI-3-kinase-related kinase SMG-1
K14409  
protein SMG7
K11125  
protein SMG5
K11124  
protein SMG6 [EC:3.1.-.-]
K04382  
serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
K03456  
serine/threonine-protein phosphatase 2A regulatory subunit A
K04354  
serine/threonine-protein phosphatase 2A regulatory subunit B
K11583  
serine/threonine-protein phosphatase 2A regulatory subunit B''
K11584  
serine/threonine-protein phosphatase 2A regulatory subunit B'
K14416  
elongation factor 1 alpha-like protein
K06965  
protein pelota
Reference
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
Reference
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
Reference
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
Reference
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
Reference
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)

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